Patents Assigned to Waters Technologies Corporation
  • Publication number: 20240226845
    Abstract: Provided herein are compositions, kits and methods that may be useful for improving the efficiency of solid phase extraction to separate oligonucleotides from a complex matrix. Particularly, the present technology relates to a sorbent material including porous particles, the surface of which is modified with a ligand that includes one or more bridging alkyl substituted amines and at least two siloxyl terminal groups.
    Type: Application
    Filed: January 9, 2024
    Publication date: July 11, 2024
    Applicant: Waters Technologies Corporation
    Inventors: Matthew Lauber, Nicole Lawrence, Daniel Walsh, Jessica Field
  • Publication number: 20240230645
    Abstract: Provided herein is a tubular protein capture device including a continuous tubular body having an inner surface and an outer surface and methods of using thereof for cell clarification purposes. A protein selected from protein A, protein G, protein L or combination thereof is attached to the inner surface of the tubular protein capture device described herein. The devices and methods provided herein are useful for improving the efficiency and/or capacity of cell clarification to separate proteins. In some embodiments, the continuous tubular body of the present technology has a helical shape. In other embodiments, the continuous tubular body of the present technology includes a plurality of tubes aligned within a hollow enclosure.
    Type: Application
    Filed: October 19, 2023
    Publication date: July 11, 2024
    Applicant: Waters Technologies Corporation
    Inventor: Lindsay Morrison
  • Publication number: 20240219273
    Abstract: The present disclosure describes a system for purifying and enriching a sample and methods of making and using thereof. The system has immunoaffinity ligands immobilized on one or more of a three-dimensional porous membrane secured in a device such that the membrane is capable of immunoaffinity binding a target compound when a sample is aspirated or expelled from the device as the sample passes through the membrane.
    Type: Application
    Filed: December 20, 2023
    Publication date: July 4, 2024
    Applicant: Waters Technologies Corporation
    Inventor: Lingyun Chen
  • Publication number: 20240219275
    Abstract: The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample—and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating of the flow path. The applied coating can increase the chromatographic peak area for the sample of the chromatographic system.
    Type: Application
    Filed: March 13, 2024
    Publication date: July 4, 2024
    Applicant: Waters Technologies Corporation
    Inventors: Paul Rainville, Kerri Smith
  • Patent number: 12025593
    Abstract: Described herein are a selectable flow restriction device and a fluidic network for chromatographic sample dilution during injection. A selectable flow restriction device is used in combination with a splitter to define an adjustable splitter for separating a high-pressure solvent flow into two separate solvent flows having the same solvent composition. The first solvent flow passes to a sample manager where a sample is injected as a discrete fluidic plug at an injection valve into a flow comprising at least one solvent. The second solvent flow is merged downstream from the location of injection with the first solvent carrying the sample fluidic plug. The second solvent flow dilutes the sample plug during the mixture of the two solvent flows.
    Type: Grant
    Filed: November 11, 2020
    Date of Patent: July 2, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Jason F. Hill, Sylvain Gilles Cormier, Martin Gilar
  • Patent number: 12025625
    Abstract: Described is an interface module for robotic loading and unloading of a liquid chromatography sample manager. The module includes a transfer drawer receiving apparatus having a device track and a drawer drive system configured to transport a transfer drawer along the device track into and out from a sample tray of a sample manager. The transfer drawer receives a sample-vial carrier that holds samples to be analyzed. The module further includes a window apparatus that has a window controllable to be in an open state or a closed state. When in the open state, transport of the transfer drawer through the window into or out from the sample manager permits loading of the sample-vial carrier into the sample tray and unloading of the sample-vial carrier from the sample tray. In the closed state, the window apparatus substantially seals the internal environment of the sample manager from the ambient environment.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: July 2, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Jeffrey Musacchio, Scott Kelley
  • Patent number: 12019047
    Abstract: The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture. This method relies on first selectively reacting one or more component in a sample with a chemical tag having two or more sites for ionization, followed by separation of components based on charge status, and finally characterization of each component to identify the same. Additionally disclosed are compounds useful as chemical tags in the disclosed methods.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: June 25, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Giuseppe Astarita, Darryl W. Brousmiche
  • Patent number: 12019071
    Abstract: Disclosed is a composition for extracting mycotoxins or aflatoxins from a food sample. The methods using the composition to detect and analyze the aflatoxins are also provided.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: June 25, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Xinwen Wang, Jianmin Liu, Stephen P. Powers
  • Patent number: 12013380
    Abstract: The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: June 18, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Theodore A. Dourdeville
  • Patent number: 12013379
    Abstract: A seal pack of a sample manager of a liquid chromatography system having a plurality of wash flow pathways fluidically connected to a central pathway that accommodates a sample needle, wherein a first wash flow pathway is vertically offset from a second wash flow pathway, such that a wash solution flows axially along an exterior surface of the sample needle in a vertical direction to wash the sample needle when flowing from the first wash flow pathway to the vertically offset second wash flow pathway, is provided. Furthermore, an autosampler and associated methods are also provided.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: June 18, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Joshua A. Burnett, Marc E. Lemelin, Sylvain Gilles Cormier
  • Publication number: 20240189740
    Abstract: The present disclosure discusses a method of separating a sample including oligonucleotides including coating a flow path of a chromatographic system; injecting the sample comprising oligonucleotides into the chromatographic system; flowing the sample through the chromatographic system; and separating the oligonucleotides. In some examples, the coating of the flow path is non-binding with respect to the analyte, such as oligonucleotides. Consequently, the analyte does not bind to the coating of the flow path. The non-binding coating eliminates the need for passivation, which can eliminate the formerly needed time to passivate as well. In addition, analyte can be recovered with a first injection in a system, such as chromatographic system.
    Type: Application
    Filed: February 9, 2024
    Publication date: June 13, 2024
    Applicant: Waters Technologies Corporation
    Inventors: Michael Donegan, Martin Gilar, Armand Gatien Ngounou Wetie
  • Patent number: 12007371
    Abstract: A removable seal device for fluidic coupling includes a seal body extending between a first end and a second end, the seal body including an inner channel configured to receive a flow of a fluid. The first end of the seal body includes a first sealing surface configured to create a first seal with a fitting sealing surface of a receiver fitting, and the seal body includes a second sealing surface configured to create a second seal with an end of a fluidic tube. The removable seal is configured to be removably secured to at least one of the fluidic tube, a support feature fixed to the fluidic tube, and a compression screw, such that untightening of the compression screw from the receiver fitting causes the removable seal device to be removed from the receiver fitting.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: June 11, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Sylvain Gilles Cormier, Joseph D. Antocci, Wade P. Leveille, Sr.
  • Patent number: 12007370
    Abstract: Exemplary embodiments may compensate for expected frictional heating or Joule-Thomson cooling in chromatography columns. Frictional heating or Joule Thomson cooling are the same thing for a fluid decompressing along a porous material. Either heat is absorbed from or released to the external environment. The exemplary embodiments may cool the mobile phase to a sub-ambient temperature before the mobile phase passes through a chromatography column to compensate for the frictional heating or heat the mobile phase to a super-ambient temperature to compensate for Joule-Thomson cooling. The amount of temperature increase expected from the frictional heating or the amount of temperature decrease expected from the Joule-Thomson cooling may be calculated or estimated. Based on the amount of temperature increase or decrease expected, the set point for the heater/cooler may be determined and applied to the mobile phase.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: June 11, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Wade P. Leveille, Joseph D. Michienzi, Fabrice Gritti
  • Patent number: 12000806
    Abstract: Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module. The interface module includes a valve module, a collection needle, a modifier module and a sample storage element. The valve module has a first port configured to receive an eluent from a first chromatography system, a second port configured to provide a fraction obtained from the eluent, a third port and a fourth port. The collection needle and the modifier module are in fluidic communication with the valve module at the third and fourth ports, respectively. The modifier module includes a source of a modifier solvent. The sample storage element is in fluidic communication with the valve module and is configured to receive a volume of the fraction for injection as a sample into a second chromatography system.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: June 4, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Sylvain Gilles Cormier, Charles H. Phoebe, Jr.
  • Patent number: 11999808
    Abstract: The current invention provides a novel method to synthesize a mono-disperse non-porous polymer particles with a unique gradient composition from the core to the shell. In particular, The present invention offers the flexibility to design the chemical and physical properties of different sections of the particle. This flexibility allows for significant latitude in the design of particles for analyzing a large variety of samples in different fields—through using these particles in different chromatography techniques including, but not limited to, ion exchange HPLC (e.g., bio-separation at different modes), reversed-phase HPLC, narrow bore and capillary HPLC, hydrophilic/hydrophobic interaction liquid chromatography, capillary electrochromatography separation, and two dimensional liquid chromatography.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: June 4, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Darryl W. Brousmiche, Kevin Daniel Wyndham, Mingcheng Xu, Michael F. Morris
  • Patent number: 11998862
    Abstract: The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device. The present disclosure also pertains to kits that contain and methods that use such sample preparation devices.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: June 4, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Raymond P. Fisk, Timothy J. Becker, Mary Elizabeth Lame, Frank John Marszalkowski, Matthew A. Lauber
  • Patent number: 11994500
    Abstract: Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: May 28, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Mark J. Basile, Jeffrey Musacchio, Michael O. Fogwill, Sebastien Besner, Joseph D. Michienzi, Wade P. Leveille
  • Patent number: 11994453
    Abstract: The present technology relates to a method for improved recovery of phosphorylated compounds (e.g., phosphorylated glycans). In particular, the present technology utilizes certain chelator additives in a solution to wash and elute the phosphorylated compounds from a solid phase extraction cartridge.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 28, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Xiaoxiao Liu, Matthew Lauber, Michael Donegan
  • Patent number: 11986751
    Abstract: Described are apparatuses, devices, and systems implementing seals for separation devices. An apparatus for a separation device may include an end nut shaped to be positioned on one of an inlet side and an outlet side of the separation device. The end nut may be further shaped to mate with a connecting fitting. The apparatus may further include a face seal having a device side and a fitting side. The face seal may be positioned, at least in part, in the end nut on the device side of the face seal. The face seal may be positioned to interface with the connecting fitting on the fitting side of the face seal upon the end nut being mated with the connecting fitting. The apparatus may also include a face seal bore of the face seal being axially alignable with at least one of an inlet and an outlet of the separation device.
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: May 21, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Jonathan L. Belanger, Wade P. Leveille, Sr., Michael O. Fogwill, Joseph D. Michienzi, Jeffrey Musacchio
  • Patent number: 11988647
    Abstract: A mixer arrangement for use in a chromatography system includes a first frequency targeting mixer including a first flow channel coupled between an inlet and an outlet and a second flow channel coupled between the inlet and the outlet, the second flow channel including a volume offset region configured to delay fluid propagation through the second flow channel, wherein the volume offset region is configured to reduce or eliminate fluidic compositional oscillations in a compositional solvent stream that depart from a desired composition at a first target frequency, and a residual noise targeting mixer fluidically connected in series to the frequency targeting mixer, the residual noise targeting mixer configured to dampen aperiodic baseline noise in the compositional solvent stream.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: May 21, 2024
    Assignee: Waters Technologies Corporation
    Inventor: Fabrice Gritti