Patents Assigned to Wayne State University
  • 6-MEMBERED CYCLIC DIENES AS STRONGLY REDUCING PRECURSORS FOR THE GROWTH OF ELEMENT FILMS BY VAPOR PHASE DEPOSITION
    Publication number: 20180230592
    Abstract: A method for reducing an atom to a reduced oxidation state includes a step of providing a vapor of a first compound having an atom in an oxidized state. A vapor of a reducing agent is provided. The reducing agent is selected from the group consisting of compounds described by formulae I, II, and III: where R1, R2 R3, R4 are each independently H, C1-10 alkyl, C6-14 aryl, or C4-14 heteroaryl. The vapor of the first compound is reacted with the vapor of the reducing agent to form a second compound having the atom in a reduced state relative to the first compound.
    Type: Application
    Filed: August 3, 2016
    Publication date: August 16, 2018
    Applicant: WAYNE STATE UNIVERSITY
    Inventor: Charles H. WINTER
  • ULTRASOUND AND PHOTOACOUSTIC SYSTEMS AND METHODS FOR FETAL BRAIN ASSESSMENT DURING DELIVERY
    Publication number: 20180214119
    Abstract: Methods and system are described for multi-parametric, non-invasive, and real-time assessment of blood perfusion and oxygenation in the fetal brain during labor and delivery of a fetus through a vaginal birth canal of a maternal pelvis, and include positioning a probe device in the maternal pelvis during active labor, transmitting and receiving a plurality of ultrasound (US) and photoacoustic (PA) signals between the probe device and fetal brain, displaying in real-time on an US machine communicatively coupled to the probe device one or more images of venous and arterial blood flow of respective blood vessels in the fetal brain, measuring oxygen saturation of the respective venous and arterial blood vessels based on data from the one or more images, and estimating the oxygen measurement in the fetal brain during active labor based on the measured oxygen saturation.
    Type: Application
    Filed: January 26, 2018
    Publication date: August 2, 2018
    Applicant: Wayne State University
    Inventors: Mohammad Mehrmohammadi, Edgar Hernandez-Andrade, Juri G. Gelovani, Sonia S. Hassan, Yan Yan
  • Thermally stable volatile precursors
    Patent number: 9982344
    Abstract: A method of forming a thin film on a substrate which includes a step of contacting a surface with a precursor compound having a transition metal and one or more alkyl-1,3-diazabutadiene ligands is provided. The resulting modified surface is then contacted with an activating compound.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: May 29, 2018
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Charles H. Winter, Thomas J. Knisley
  • AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
    Patent number: 9968689
    Abstract: Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells upon transduction using recombinant AAV vectors. Selective targeting of these transgenes for expression in discrete subcellular regions or sites is achieved by including a sorting motif in the vector that can target either the central area or surround (off-center) area of these cells. Nucleic acid molecules comprising nucleotide sequences encoding such rhodopsins and sorting motifs and their use in methods of differential expression of the transgene are disclosed. These compositions and methods provide significant improvements for restoring visual perception and various aspects of vision, particular in patients with retinal disease.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: May 15, 2018
    Assignee: WAYNE STATE UNIVERSITY
    Inventor: Zhuo-Hua Pan
  • Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor
    Patent number: 9963433
    Abstract: A novel class of drugs for treating androgen receptor (AR) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity androgen receptor ligand and a histone deacetylase inhibitor. Also described are compositions including the novel drugs and methods of treating AR positive cancer using the compositions.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 8, 2018
    Assignee: Wayne State University
    Inventor: Zhihui Qin
  • Predictive correction in internal combustion engines
    Patent number: 9951741
    Abstract: A method and system for reducing cycle to cycle variation of an engine is provided. The system may determine fuel injection characteristics and predict a gas burning rate or flame speed based on the fuel injection characteristics. The system may adjust an ignition timing in response to the predicted gas burning rate within the same engine cycle.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: April 24, 2018
    Assignee: Wayne State University
    Inventors: Fadi Adly Anis Estefanous, Shenouda Mekhael, Naeim A. Henein
  • Self-confining ceramic articles using advanced material reinforcements and method of manufacture
    Patent number: 9951521
    Abstract: A self-confining structural article includes a ceramic matrix with a reinforcement member disposed within the ceramic matrix. The reinforcement member is continuous, and has a mesh with holes not exceeding 4 mm in size.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: April 24, 2018
    Assignee: Wayne State University
    Inventor: Hwai-Chung Wu
  • DETECTORS OF SERUM BIOMARKERS FOR PREDICTING OVARIAN CANCER RECURRENCE
    Publication number: 20180106810
    Abstract: Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at least one autoantibody marker. An antibody binding assay for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, and methods for performing the assay. Methods for determining ovarian cancer recurrence in an ovarian cancer patient. A method for isolating antibodies specific for ovarian cancer by their affinity to the polypeptide marker antigens, and antibodies isolated by that method.
    Type: Application
    Filed: September 6, 2017
    Publication date: April 19, 2018
    Applicant: Wayne State University
    Inventors: Michael Tainsky, Madhumita Chatterjee, Gregory Dyson, Nancy Levin
  • Simultaneous ion sensing and gas sampling in combustion engine cylinders and other combustion systems
    Patent number: 9945812
    Abstract: A system and method is provided for simultaneous ion current sensing and gas analysis. The system acquires an ion current signal and analyzes the composition of a corresponding gas sample.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: April 17, 2018
    Assignee: Wayne State University
    Inventors: Tamer H. Badawy, Fadi Estefanous, Naeim A. Henein
  • Composite anode for lithium ion batteries
    Patent number: 9911974
    Abstract: A composite anode for a lithium-ion battery is manufactured from silicon nanoparticles having diameters mostly under 10 nm; providing an oxide layer on the silicon nanoparticles; dispersing the silicon nanoparticles in a polar liquid; providing a graphene oxide suspension; mixing the polar liquid containing the dispersed silicone nanoparticles with the graphene oxide suspension to obtain a composite mixture; probe-sonicating the mixture for a predetermined time; filtering the composite mixture to obtain a solid composite; drying the composite; and reducing the composite to obtain graphene and silicon.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: March 6, 2018
    Assignee: Wayne State University
    Inventors: Rhet C. de Guzman, K. Y. Simon Ng, Steven O. Salley
  • METHOD OF PREVENTION AND INHIBITION OF PRETERM LABOR
    Publication number: 20180055910
    Abstract: Methods for preventing and/or inhibiting preterm labor in a pregnant subject, such as a human subject, are disclosed according to the invention including administering a therapeutically effective amount of a protein selected from the group consisting of: PIBF1, a fragment or variant thereof; IL-33, a fragment or variant thereof; and a combination of any two or more thereof. Pharmaceutical compositions for preventing and/or inhibiting preterm labor in a pregnant subject, such as a human subject, are disclosed according to the invention including a therapeutically effective amount of a protein selected from the group consisting of: PIBF1, a fragment or variant thereof; IL-33, a fragment or variant thereof; and a combination of any two or more thereof.
    Type: Application
    Filed: August 31, 2017
    Publication date: March 1, 2018
    Applicant: Wayne State University
    Inventor: Kang Chen
  • DETECTORS OF SERUM BIOMARKERS FOR PREDICTING OVARIAN CANCER RECURRENCE
    Publication number: 20180031565
    Abstract: Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at least one autoantibody marker. An antibody binding assay for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, and methods for performing the assay. Methods for determining ovarian cancer recurrence in an ovarian cancer patient. A method for isolating antibodies specific for ovarian cancer by their affinity to the polypeptide marker antigens, and antibodies isolated by that method.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 1, 2018
    Applicant: Wayne State University
    Inventors: Michael Tainsky, Madhumita Chatterjee, Gregory Dyson, Nancy Levin
  • NOVEL SYNTHETIC ANTICANCER, ANTIFUNGAL, AND ANTIBACTERIAL VACCINES
    Publication number: 20170348414
    Abstract: Described herein are compounds for use in vaccine compositions which contain natural or synthetic carbohydrate antigens. Such vaccines may be highly immunologically active due to the conjugation with an immune-stimulating protein or with a monophosphorylated lipid A derivative, and may be self-adjuvanting due to the presence of a monophosphorylated lipid A derivative. Treatments for cancer and fungal and bacterial infections are described herein.
    Type: Application
    Filed: September 14, 2015
    Publication date: December 7, 2017
    Applicant: Wayne State University
    Inventors: Zhongwu Guo, Guochao Liao, Zhifang Zhou, Mohabul Mondal, Srinivas Burgula
  • Thermally stable volatile precursors
    Patent number: 9822446
    Abstract: A method of forming a thin film on a substrate which includes a step of contacting a surface with a precursor compound having a transition metal and one or more alkyl-1,3-diazabutadiene ligands is provided. The resulting modified surface is then contacted with an activating compound.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: November 21, 2017
    Assignee: Wayne State University
    Inventors: Charles H. Winter, Thomas J. Knisley
  • Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
    Patent number: 9824872
    Abstract: A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: November 21, 2017
    Assignee: Wayne State University
    Inventor: Sarah Trimpin
  • Protein-induced pluripotent cell technology and uses thereof
    Patent number: 9816076
    Abstract: A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: November 14, 2017
    Assignee: Wayne State University
    Inventors: Jianjun Wang, Qianqian Li
  • Detectors of serum biomarkers for predicting ovarian cancer recurrence
    Patent number: 9797906
    Abstract: Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at least one autoantibody marker. An antibody binding assay for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, and methods for performing the assay. Methods for determining ovarian cancer recurrence in an ovarian cancer patient. A method for isolating antibodies specific for ovarian cancer by their affinity to the polypeptide marker antigens, and antibodies isolated by that method.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: October 24, 2017
    Assignee: Wayne State University
    Inventors: Michael Tainsky, Madhumita Chatterjee, Gregory Dyson, Nancy Levin
  • Green diesel production from hydrothermal catalytic decarboxylation on a supported Pd—Co catalyst
    Patent number: 9790435
    Abstract: Materials and methods for converting brown grease to useful diesel fuel are described. One material is a palladium catalyst on a silicon/carbon support. A method comprises flowing fresh hydrogen over a reaction of diluted brown grease on a palladium/carbon catalyst.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: October 17, 2017
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Elvan Sari, Steven O. Salley, K. Y. Simon Ng
  • Bimetal catalysts
    Patent number: 9776177
    Abstract: A catalyst comprises a carbide or nitride of a metal and a promoter element. The metal is selected from the group consisting of Mo, W, Co, Fe, Rh or Mn, and the promoter element is selected from the group consisting of Ni, Co, Al, Si, S or P, provided that the metal and the promoter element are different. The catalyst also comprises a mesoporous support having a surface area of at least about 170 m2 g?1, wherein the carbide or nitride of the metal and the promoter element is supported by the mesoporous support, and is in a non-sulfided form and in an amorphous form.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: October 3, 2017
    Assignee: Wayne State University
    Inventors: K. Y. Simon Ng, Steve O. Salley, Huali Wang
  • Static interferometer with step-style reflective element
    Patent number: 9778105
    Abstract: An apparatus for performing Raman spectral analysis of a sample is described, comprising a coherent light source, an first optical chain to direct the coherent light to impinge on the sample, a second optical chain to direct the scattered light onto a diffraction grating, and a third optical chain to direct the diffracted light onto detection array. The diffraction grating is a stairstep with a metalized surface, and a plurality of metalized stripes on a flat surface is disposed in a direction orthogonal to the long dimension of the stairsteps. The region between the flat surface and the stairstep is transparent. The zeroth-order fringe is selected by a slit and directed onto camera. The resultant interferogram is Fourier transformed to produce a representation of the Raman spectrum.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: October 3, 2017
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Gregory W. Auner, Changhe Huang, Christopher M. Thrush, Michelle Brusatori