Patents Assigned to Wayne State University
  • Biomarker test for prediction or early detection of preeclampsia and/or HELLP syndrome
    Patent number: 10670610
    Abstract: Disclosed are specific biomarkers that allow for early testing of preeclampsia/HELLP syndrome. Thus, a method is provided predicting preeclampsia in a pregnant woman. Also disclosed is a kit comprising means for assaying a sample from a pregnant woman for the concentrations of the specific biomarkers.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: June 2, 2020
    Assignees: Wayne State University, The United States of America as represented by The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institutes of Health, Semmelweis University, Genesis Theranostix Korlatolt Felelossegu Tarsasag
    Inventors: Adi L. Tarca, Nandor Than, Gabor Juhasz, Adrienna Katalin Kekesi, Hamutal Meiri, Zoltan Papp, Roberto Romero
  • HER2 ANTIGENIC POLYPEPTIDE COMPOSITIONS, AND METHODS FOR THEIR USE IN TREATMENT AND PREVENTION OF CARCINOMAS
    Publication number: 20200164052
    Abstract: Antigenic polypeptides of the growth factor receptor HER2, for breaking the tolerance of a host against self HER2. The antigenic polypeptides include HER2 polypeptides with single amino acid substitutions of lysine for glutamine, arginine for glutamine, or aspartic acid for asparagine. Gene expression constructs, vaccine compositions, and immunization methods including the substituted HER2 polypeptides. Methods for immunizing mammalian subjects with heterologous unsubstituted HER2 antigenic polypeptides, including polypeptides of feline and bear HER2. A diagnostic method of determining whether a mammalian subject is sufficiently immunocompetent to respond to immunotherapies directed at breaking tolerance to self HER2.
    Type: Application
    Filed: October 7, 2019
    Publication date: May 28, 2020
    Applicant: Wayne State University
    Inventors: Wei-Zen WEI, Heather GIBSON, Richard JONES, Joyce REYES
  • METHODS AND COMPOSITIONS RELATING TO STEROID HORMONE RECEPTOR-DEPENDENT CANCERS
    Publication number: 20200155501
    Abstract: There is a continuing need for methods and compositions relating to hormone-receptor-dependent cancers, including pharmaceutical compositions including one or more compounds having activity against steroid hormone-receptor-dependent cancer and methods of treatment of a steroid hormone-receptor-dependent cancer in a subject using said pharmaceutical compositions. ELK1 Is a steroid hormone receptor tethering, protein that is implicated in hormone receptor dependent cancers. Compositions and methods according to aspects of the present invention inhibit the association of steroid hormone receptors with ELKL providing activity against steroid hormone-receptor-dependent cancer.
    Type: Application
    Filed: June 26, 2018
    Publication date: May 21, 2020
    Applicant: Wayne State University
    Inventor: Manohar Ratnam
  • Methods and compositions relating to anti-HcTnT-N69 antibody for detection of cardiac disorders
    Patent number: 10648987
    Abstract: Methods for detecting a cardiac condition in a human subject are provided according to aspects of the present invention which include providing an immunological reagent characterized by specific binding to: an N-terminal fragment of human cardiac troponin T (HcTnT-N69) or a neoepitope of human cardiac troponin T generated by removal of HcTnT-N69 from HcTnT (HcTnT-neo); contacting the immunological reagent with a biological sample of the human subject under binding conditions; and detecting binding of the immunological reagent with HcTnT-N69 or HcTnT-neo, wherein detection of HcTnT-N69 or HcTnT-neo in the biological sample is indicative of a cardiac condition in the subject. Antibodies and antigen binding fragments thereof characterized by specific binding to HcTnT-N69 or HcTnT-neo, or a variant of either thereof, are provided according to aspects of the present invention.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: May 12, 2020
    Assignee: Wayne State University
    Inventor: Jian-Ping Jin
  • SYSTEM AND METHOD FOR CHARACTERIZATION OF A BRAIN TISSUE SAMPLE USING RAMAN MARKER REGIONS
    Publication number: 20200138293
    Abstract: A system for characterization of a brain tissue sample includes a laser having an excitation fiber and a probe coupled to the excitation fiber for irradiating the brain tissue sample with light at an excitation wavelength. The probe further includes a plurality of return fibers for receiving light scattered from the brain tissue sample, wherein each return fiber includes a microfilter that permits light to pass for a different, spaced apart marker region. A Raman spectrometer is in communication with the plurality of return fibers, and a processor is in communication with the Raman spectrometer for analyzing Raman spectra within the marker regions to identify a tissue type of the brain tissue sample as one of normal white matter brain tissue, normal grey matter brain tissue, brain tumor tissue, infiltrating tumor tissue, and necrotic tissue.
    Type: Application
    Filed: April 20, 2018
    Publication date: May 7, 2020
    Applicants: HENRY FORD HEALTH SYSTEM, WAYNE STATE UNIVERSITY
    Inventors: Gregory William AUNER, Michelle BRUSATORI, Steven N. KALKANIS, Lisa SCARPACE
  • Protein-induced pluripotent cell technology and uses thereof
    Patent number: 10640751
    Abstract: A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPS cells formed using this method and uses thereof.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: May 5, 2020
    Assignee: Wayne State University
    Inventors: Jianjun Wang, Qianqian Li
  • Method of making injectable cements
    Patent number: 10632227
    Abstract: A discovery of the conversion of amorphous calcium polyphosphate (ACPP) or/and other polyphosphate salts with various type of calcium phosphate to new calcium phosphate product (i.e. dicalcium phosphate dihydrate (DCPD)) in a liquid environment. The discovery includes mixing a various type of calcium phosphate with an aqueous ACPP or/and other polyphosphate salts gel, which is fast setting and possessing strong mechanical strength, and can be gradually converted to DCPD/hydroxyapatites in physiological condition. This injectable past can be applied as alternative of conventional CPC bone cement that is suitable for bone void repair due to its excellent properties in osteoconductivity and osseointegration. It can also be applied as drug delivery device in tissue engineering for its strong bonding to drug molecules.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: April 28, 2020
    Assignee: Wayne State University
    Inventors: Weiping Ren, Wei Song
  • Valproate as a topical anti-fungal treatment
    Patent number: 10617659
    Abstract: Valproate is useful as an antifungal agent. The valproate compositions can be used to treat fungal infections. The valproate compositions can be formulated as topical antifungals.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: April 14, 2020
    Assignee: Wayne State University
    Inventors: Miriam L. Greenberg, Rania M. Deranieh
  • Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
    Patent number: 10611767
    Abstract: Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I: These compounds are useful in methods for treating cancer, selectively targeting cancerous cells via the proton coupled folate transporter, folate receptor alpha, and/or folate receptor beta pathways, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthritis.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: April 7, 2020
    Assignees: Duquesne University of the Holy Spirit, Wayne State University
    Inventors: Aleem Gangjee, Larry H. Matherly
  • Methods and compositions relating to biocompatible implants
    Patent number: 10596300
    Abstract: Biocompatible hydrogel compositions according to aspects of the present invention are provided wherein the biocompatible hydrogel composition is or includes a physical hydrogel, a chemical hydrogel or both a physical hydrogel and a chemical hydrogel, along with biocompatible hydrogel compositions encapsulating a therapeutic agent and methods of use thereof.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: March 24, 2020
    Assignee: Wayne State University
    Inventors: Zhiqiang Cao, Wei Wang, Zhanguo Yue
  • Compositions and methods relating to RAD6 inhibition
    Patent number: 10588985
    Abstract: Pharmaceutical compositions, methods of treatment of proliferative diseases and commercial packages are provided according to aspects of the present invention which relate to a first therapeutic agent coupled to a nanoparticle, wherein the first therapeutic agent is SMI #8 or SMI #9 a pharmaceutically acceptable salt, ester, amide, stereoisomer, hydrate, or derivative of either thereof. According to particular aspects, the SMI #8 or SMI #9 is conjugated to gold nanoparticles.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: March 17, 2020
    Assignee: Wayne State University
    Inventors: Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
  • ULTRASOUND AND MULTISPECTRAL PHOTOACOUSTIC SYSTEMS AND METHODS FOR BRAIN AND SPINAL CORD IMAGING THROUGH ACOUSTIC WINDOWS
    Publication number: 20200077974
    Abstract: Methods and systems are described for multispectral, non-invasive, and real-time assessment to diagnose hemorrhaging and/or hypoxia through PA imaging through an acoustic window defined in a body, such as through transfontanelle PA imaging of a neonatal infant brain. Such methods and systems include transmitting a plurality of ultrasound (US) waves and light between the probe device and the acoustic window, converting, via the probe device, a plurality of reflected US waves and generated PA waves into a plurality of US and PA signals, displaying in real-time on an US machine communicatively coupled to the probe device one or more images of the brain or spinal cord through the acoustic window, such as the neonatal infant brain through the fontanelle, and diagnosing at least one of one or more hemorrhages and hypoxia in the neonatal infant brain at least partially based on the one or more images.
    Type: Application
    Filed: September 10, 2019
    Publication date: March 12, 2020
    Applicant: Wayne State University
    Inventors: Kamran Avanaki, Juri G. Gelovani
  • APRAMYCIN DERIVATIVES
    Publication number: 20200062793
    Abstract: The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.
    Type: Application
    Filed: May 1, 2018
    Publication date: February 27, 2020
    Applicants: WAYNE STATE UNIVERSITY, UNIVERSITAT ZURICH
    Inventors: Erik C. BOTTGER, Sven N. HOBBIE, Andrea VASELLA, David CRICH, Amr SONOUSI, Takayuki KATO, Jonathan QUIRKE, Parasuraman RAJASEKARAN, Vikram Ashok SARPE
  • EPIMERIZATION-FREE N TO C SOLID-PHASE PEPTIDE SYNTHESIS
    Publication number: 20200062801
    Abstract: The present disclosure provides a method of solid-phase peptide synthesis from the N terminus to C terminus without detectable epimerization of the C-terminal amino acid.
    Type: Application
    Filed: August 21, 2019
    Publication date: February 27, 2020
    Applicant: Wayne State University
    Inventors: Jennifer L. Stockdill, Christine A. Arbour
  • Dendrimer based nanodevices for therapeutic and imaging purposes
    Patent number: 10561673
    Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: February 18, 2020
    Assignees: Wayne State University, The United States of America as Represented by the Secretary, Department of Health and Human Service
    Inventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra S Navath, Hui Dai, Anupa R. Menjoge
  • Methods, systems and compositions relating to cell conversion via protein-induced in-vivo cell reprogramming
    Patent number: 10548983
    Abstract: Methods for treating a subject in need thereof are provided which include administering a pharmaceutical composition comprising a protein transduction reagent-modified reprogramming protein to the subject, wherein the protein transduction reagent is non-covalently bound to the reprogramming protein and wherein the protein transduction reagent comprises a cation reagent and a lipid. According to aspects, such methods provide delivery of protein-transduction reagent-modified reprogramming proteins to cancer cells, such as tumor cells, as well as diseased cells of diseased tissues and provide in vivo conversion of diseased cells into normal cells via protein-induced in situ cell reprogramming without administration of nucleic acids to the subject.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: February 4, 2020
    Assignee: Wayne State University
    Inventors: Jianjun Wang, Qianqian Li, Michael Chopp, Feng Jiang, Guojun Wu
  • Automated viability testing system
    Patent number: 10550417
    Abstract: The invention provides an automated device for accessing the viability of a wide range of organisms based on the metabolic production of fluorescent products from non-fluorescent substrates. Also provide are methods for detecting contaminants in a fluid and measuring the viability of organisms in a fluid or liquid. Components of the invention include the incorporation of a reusable filter to concentrate the organisms, the back flush of the filter to collect the organisms for assay, and the addition of the substrate in a fluorescent detection chamber to detect the enzymatic activity produced by viable organisms to detect the presence of such organisms.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: February 4, 2020
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Jeffrey Ram, Alice Hudder
  • METHOD AND APPARATUS FOR DETERMINING BLOOD PRESSURE ON MEASURED HEART SOUNDS
    Publication number: 20200022659
    Abstract: A system and method of determining blood pressure includes measuring heart sounds, separating the measured heart sounds into a first heart sound (S1) and a second heart sound (S2), mathematically characterizing S1 and S2, and determining a blood pressure based on the characterization.
    Type: Application
    Filed: February 7, 2018
    Publication date: January 23, 2020
    Applicant: Wayne State University
    Inventors: William D. Lyman, Gaurav Kapur, Yong Xu, Sean F. Wu, Lingguang Chen
  • Bis(trimethylsilyl) six-membered ring systems and related compounds as reducing agents for forming layers on a substrate
    Patent number: 10533023
    Abstract: A first compound having an atom in an oxidized state is reacted with a bis(trimethylsilyl) six-membered ring system or related compound to form a second compound having the atom in a reduced state relative to the first compound. The atom in an oxidized state is selected from the group consisting of Groups 2-12 of the Periodic Table, the lanthanides, As, Sb, Bi, Te, Si, Ge, Sn, and Al.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: January 14, 2020
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Charles H. Winter, Joseph Peter Klesko
  • PINS: a perturbation clustering approach for data integration and disease subtyping
    Patent number: 10529451
    Abstract: Disease subtyping is accomplished by a computer-implemented algorithm that manipulates a first genetic dataset to construct a set of first connectivity matrices. To this set of matrices Gaussian noise is introduced to generate a perturbed dataset. The computer-implemented algorithm assesses which of the set of first connectivity matrices was least affected by introduction of noise and that matric is used to define the optimal clustering. Once the optimal clustering is determined, computer-implemented supervised classification is performed to determine, for a particular patient, with which disease subtype cluster that person's genetic data most closely aligns. Armed with this knowledge, the treatment regimen is specified with much higher likelihood of success.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: January 7, 2020
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Sorin Draghici, Tin Chi Nguyen