Abstract: The present invention discloses a method for the preparation and application of modified extracellular vesicles specifically targeted to the kidneys. These modified extracellular vesicles are derived from fibroblastic reticular cells in the mesentery tissue and express anti-inflammatory proteins after being modified with anchor peptides. By combining the extracellular vesicles secreted from fibroblastic reticular cells in the mesentery tissue with anchor peptides, the present invention ensures the effective targeting of the exosomes to the kidneys. Additionally, through genetic engineering of fibroblastic reticular cells, the exosomes secreted by these cells can carry the target molecule, anti-inflammatory protein CD5L, achieving precise targeted therapy for the kidneys. This innovative treatment strategy holds promising potential for the treatment of sepsis-associated acute kidney injury, bringing positive impacts to patients' health.

Abstract: A method and system for 3D contour reconstruction of AM parts based on light field imaging, belonging to the field of image reconstruction technology is provided. The method includes constructing an EPI-UNet framework, where a preset light field dataset is used to construct a training set, learning labels from the disparity maps corresponding to the preset light field dataset are obtained, and EPI-UNet framework is trained to obtain a predicted disparity vector with the training set and learning labels. Two mappings including disparity and depth mapping, and disparity and 3D mapping, are established to get 3D contour of the AM part. The experiments of validation for accuracy and 3D contour reconstruction of AM parts were performed. By applying light field multi-view vision to the AM process and combining the rich angle and spatial domain view information of the light field, this disclosure provides a reliable quality assurance for AM monitoring.

Abstract: An automatic pressure regulating valve for an electro-pneumatic braking system of a commercial vehicle comprises an upper valve body and a lower valve body. The upper valve body includes a normally open switching valve, a quick-acting intake valve, a normally open quick-acting intake valve, a quick-acting exhaust valve, and a control chamber A. A lower valve body includes a relay valve and a working chamber B. The normally open switching valve has a manually controlled air inlet a and an electronically controlled air inlet b, and an air outlet c connected to an air inlet d of the normally open quick-acting intake valve. An air outlet e of the normally open quick-acting intake valve, an air inlet f of the quick-acting exhaust valve and an air outlet i of the quick-acting air intake valve are connected together to the control chamber A.

Abstract: A method and system for fingerprint positioning based on 5G multi-beam downlink signals, includes: extracting multi-beam SSB from 5G downlink signals, and obtaining multi-beam SSS signal and DM-RS signal from multi-beam SSB; calculating multi-beam reference signal received power RSRP based on multi-beam SSS signal and DM-RS signal; calculating the RSSI of 5G downlink synchronization channel based on multi-beam SSB autocorrelation, and calculating the multi-beam reference signal received quality RSRQ based on multi-beam RSRP and RSSI; stacking the multi-beam RSRP and RSRQ to form multi-beam fingerprint features; inputting multi-beam fingerprint characteristic into neural networks, and the neural networks output positioning results.

Abstract: A semantics-based high resolution reconstruction method of a nighttime light remote sensing image includes: constructing a sample data set; the sample data set includes a plurality of data groups, and each data group includes a LR NTL image, and a HR NTL image and light semantics information consistent in spatial position with the LR NTL image; constructing a reconstruction model; performing training and validation on the reconstruction model by using the sample data set to obtain an optimized reconstruction model; and taking a to-be-reconstructed LR NTL image and light semantic information corresponding to the to-be-reconstructed LR NTL image as an input of the optimized reconstruction model, and outputting, by the optimized reconstructed model, a HR NTL image obtained through resolution reconstruction.

Abstract: The invention discloses a method and system for detecting and repairing sun glint in UAV optical RGB ocean image, introduces a sun glint attention module, and constructs a semantic segmentation network model based on attention mechanism. The sun glint region is segmtioned by semantic segmentation network model based on attention mechanism, and the optical flow field of high-resolution UAV optical RGB ocean image is extracted by RAFT optical flow estimation network. sun glint region and optical flow field are used for optical flow propagation to repair the sun glint in UAV optical RGB ocean images and restore the real benthic image features.

Abstract: The embodiment of the present invention discloses Hangtaimycin derivatives and their preparation and application. Hangtaimycin derivatives are obtained by fermentation of Streptomyces spectabilis CCTCC M2017417 and its genetically knockout mutant strain in SFMR medium, with further isolation, purification, and alcoholysis. Through screening, Hangtaimycin derivatives showed excellent anti-inflammatory and analgesic, anti-tumor, liver injury protection, cell membrane protection, and drug addiction prevention activities, providing new drug leads for developing related drugs.

Abstract: Provided are a method and system for automatically estimating a mammary gland volume based on a mammary gland magnetic resonance imaging (MRI) image, to automatically segment a mammary gland region in a three-dimensional MRI image of a subject's chest by means of morphological prior knowledge of a breast MRI image and a computer image processing technology, calculate a voxel volume of a segmented part and an actual volume, and guide a doctor in selecting an appropriate fake breast mold. Compared with manual framing of the mammary gland region in conventional practice, the present disclosure can automatically complete marking and volume calculation of the mammary gland region, and greatly improve working efficiency.

Abstract: Provided is a method and a system for evaluating enzymatic reaction feasibility based on multiple tasks and molecular multi-modal features. An enzymatic reaction feasibility dataset is constructed with a public dataset and a bioengineering reaction rule template library; SMILES sequence features and Morgan fingerprint spatial structure features of a product molecule and a substrate molecule of a reaction are used as inputs to a neural network; a dual-branch network is constructed based on an attention mechanism and a convolutional neural network to extract molecular multi-modal features; a product SMILES sequence generation task is taken as a secondary task to strengthen the capability of a model learning sequence feature; richer features are provided for an enzymatic reaction feasibility evaluation task; and the trained model is effectively enabled to accurately determine reaction feasibility by taking the molecular multi-modal features into overall consideration.

Abstract: The present disclosure relates to the field of frequency control technologies of power grid systems and in particular to a platform and method for power grid frequency regulation with participation of large-scale energy storage based on MADDPG. Firstly, based on a scene of power grid frequency regulation with participation of large-scale energy storage, a control platform architecture for power grid frequency regulation with participation of large-scale energy storage based on MADDPG is designed. Then, based on the multiple agents deep deterministic policy gradient algorithm, under the drive of environmental interaction data, training and learning are performed to obtain optimal control multiple agents for power grid frequency regulation with participation of energy storage. Finally, by using the optimal control multiple agents, control on the output power of the thermal power unit and the charge and discharge of the large-scale energy storage is performed for participation of power grid frequency regulation.

Abstract: The disclosure aligns a processing laser beam and a measurement laser beam coaxially, and directs the processing laser beam and the measurement laser beam respectively onto the metal powder and melt pool surface for manufacturing and measuring the 3D of melt pool. A light beam is formed by the reference laser beam interfered with the measurement laser beam reflected by the melt pool, and is directed to the image acquisition unit to obtain an interference image of the melt pool surface. The contour accuracy was proved to be 15 nm under case of lateral resolution of 15.63 ?m by the resolution board. The experiment of 3D melt pool was performed. This disclosure enables in-situ measurement of the 3D morphology of the melt pool during additive manufacturing. The disclosure is to incorporate a filter to eliminate high-temperature thermal radiation emitted from the melt pool, significantly enhancing the accuracy of morphology measurements.

Abstract: The present invention provides a method and system for multi-modal remote sensing image hybrid matching with multi-dimensional oriented self-similarity features. The method comprises: hybrid feature coarse matching is executed by rapidly extracting the image's self-similarity features using the offset mean filtering method and describing the feature points using the directional information of the self-similarity features. Through this coarse matching, an affine transformation model between multi-modal images is estimated, and an initial affine transformation is applied to the matched image. Next, the multi-dimensional oriented self-similarity feature fine matching is performed by constructing multi-dimensional oriented self-similarity template features using the multi-channel self-similarity map obtained from the hybrid feature coarse matching stage.

Abstract: The application provides drugs, expression vectors, and their applications in the treatment of NAFLD and related diseases, pertaining to the technical field of targeted drugs. The drugs include streptavidin or a recombinant expression vector for streptavidin. Streptavidin can bind to acetyl CoA carboxylase 1, alter its subcellular localization within mammalian cells, and ultimately inhibit de novo lipogenesis. Ectopic expression of streptavidin can inhibit lipid accumulation within mammalian cells. Compared with chemical small-molecule drugs, streptavidin, as a protein drug, exhibits relatively lower liver and kidney toxicity. Streptavidin might be a relatively mild inhibitor of acetyl CoA carboxylase, avoiding a severe side effect of hyperlipidemia. Furthermore, streptavidin is very stable, which might be conducive to drug delivery and adaptable to different administration methods.

Abstract: An aluminum alloy pre-strengthening and hot forming production line is provided, including a pre-strengthening heat treatment mechanism, a forging mechanism, and a trim press. The pre-strengthening heat treatment mechanism includes a roll forging machine, a solid solution furnace, a quenching water tank, an aging furnace, and a heat preservation furnace. The forging mechanism includes an upsetting press machine, and a forging press machine. The upsetting press machine is configured for blanking an heat preserved aluminum alloy bar-shaped blank, and the forging press machine is configured for forging and forming the blanked aluminum alloy bar-shaped blank. The trim press is configured for trimming the forged and formed aluminum alloy rod-shaped blank, so as to obtain an aluminum alloy member meeting a requirement.

Abstract: An aluminum alloy pre-strengthening and hot forming production line is provided, including a pre-strengthening heat treatment mechanism, a forging mechanism, and a trim press. The pre-strengthening heat treatment mechanism includes a roll forging machine, a solid solution furnace, a quenching water tank, an aging furnace, and a heat preservation furnace. The forging mechanism includes an upsetting press machine, and a forging press machine. The upsetting press machine is configured for blanking an heat preserved aluminum alloy bar-shaped blank, and the forging press machine is configured for forging and forming the blanked aluminum alloy bar-shaped blank. The trim press is configured for trimming the forged and formed aluminum alloy rod-shaped blank, so as to obtain an aluminum alloy member meeting a requirement.

Abstract: The disclosure discloses a single-ended fault positioning method and system for a HVDC power transmission line based on a hybrid deep network. The method comprises the following: collecting rectification side bus output voltage and current signals of a HVDC power transmission system under different fault types, fault distances and transition resistances as an original data set; eliminating electromagnetic coupling of the bipolar direct-current line by using phase-mode transformation, extracting IMF components of fault voltage and current signals under different fault scenes by using variational mode decomposition, and calculating TEO of the IMF components to obtain a fault data set after feature engineering; normalizing the fault data set, and dividing the fault data set into a training set and a test set; and successively inputting the training set and the test set into a hybrid network of a convolutional neural network and a long short-term memory network for training and testing.

Abstract: A method for laser-induced growth of nano-units to form oriented, chiral, and complex structures is provided. Through a laser-induced photochemical reaction, a metal precursor undergoes photolysis to produce inorganic nanoparticles, and these nanoparticles are orientally deposited on a substrate along a polarization direction in a linearly polarized laser to form fusiform nano-units. Through mixed polarized light generated by a vortex plate, the nano-units can grow rapidly and form a specific arrangement to obtain special three-dimensional (3D) nanostructures with chiral features and complex patterns. This method can be implemented in a room temperature environment, has the characteristics of simple operation, short reaction time, high repeatability, long storage time, low cost, and controllable orientations and sites, and shows promising application prospects in the fields of optical devices, chiral catalysis, sensing, integrated circuits, and the like.

Abstract: The present disclosure provides a weakly-centralized frequency regulation control method of a charge station cluster based on virtual leader and a medium. Firstly, based on the control strategy of the virtual synchronous generator and the requirements of the electric vehicles and the charge stations, an architecture of the virtual synchronous generator of the electric vehicles and the charge stations is established. Secondly, based on the control strategy of the collaborative topology design of multiple charge stations, a virtual leader is determined and a weakly-centralized consistency algorithm is designed. Finally, a control strategy of the collaborative frequency regulation of the charge station cluster is proposed to achieve the weakly-centralized frequency regulation control of the charge station cluster.

Abstract: The disclosure relates to a phase change thermal storage ceramic having high service temperature and improved utilization rate and utilization efficiency of heat. It is prepared at a low cost with a simple, easy-to-industrially-realized method. A mixture is obtained by mixing and stirring evenly 50-85 wt % of fused mullite powder, 10-45 wt % of pretreated aluminum-silicon alloy powder, and 3-8 wt % of ball clay. A ceramic body is formed by press molding the mixture at 80-150 MPa. The ceramic body is cured at 25-28° C. and a relative humidity of 70-75 RH for 24-36 h, dried at 80-120° C. for 24-36 h, and held at 1,100-1,300° C. for 3-5 h to prepare the phase change thermal storage ceramic. The pretreated aluminum-silicon alloy powder is prepared by holding aluminum-silicon alloy powder in water vapor at 0.02-0.20 MPa for 0.5-3 h to impregnate in an alkaline silica sol and drying the impregnated powder.

Abstract: A Ni-free micro-alloyed high-strength steel with ultra-low temperature toughness and a preparation method thereof are provided. The micro-alloyed high-strength steel includes the following chemical components by mass percentage: 0.011% to 0.099% of C, 0.051% to 0.24% of Si, 1.21% to 1.49% of Mn, 0.030% to 0.059% of Nb, 0.009% to 0.016% of Ti, 0.001% to 0.018% of Zr, 0.001% to 0.018% of rare earth (RE), and the balance of Fe and inevitable impurities. The mass percentage also meet the following formulas: 0.21%<C+Si<0.24%, and Si/C=1 to 8; 0.02%<Nb+Ti<0.05%, and Nb/Ti=1 to 3; 0.010%<Zr+RE<0.019%, and Zr/RE=1 to 6. The micro-alloyed high-strength steel uses a completely different composition design (i.e., a simple low-cost Ni-free composition design) to realize ultra-low temperature toughness, and with the help of Zr+RE compound deoxidation and Nb+Ti compound micro-alloying technologies, realizes ultra-low temperature toughness at ?100° C. to ?120° C.