Patents Assigned to Wyeth
  • Inhibitors of cytosolic phospholipase A2
    Publication number: 20070004719
    Abstract: This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2?). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.
    Type: Application
    Filed: May 26, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventors: John McKew, Katherine Lee, Lihren Chen, Richard Vargas, James Clark, Cara Williams, Valerie Clerin, Suzan Marusic, Kevin Pong
  • Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
    Publication number: 20070004702
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Application
    Filed: August 31, 2006
    Publication date: January 4, 2007
    Applicant: WYETH
    Inventors: Dahui Zhou, Gary Stack
  • Formulations of conjugated estrogens and bazedoxifene
    Publication number: 20070003623
    Abstract: The present invention relates to solid dosage formulations containing conjugated estrogens and bazedoxifene, or a salt thereof. In some embodiments, the compositions include a core comprising conjugated estrogens, and at least one coating that comprises bazedoxifene, or a salt thereof.
    Type: Application
    Filed: June 28, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventors: Ramarao Chatlapalli, Arwinder Nagi, Lawrence Van Pelt
  • METHODS OF DETERMINING PHARMACOKINETICS OF TARGETED THERAPIES
    Publication number: 20070003559
    Abstract: Methods for determining pharmacokinetics of targeted therapies.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventors: Kiran Khandke, Nitin Damle, Erwin Boghaert
  • Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
    Publication number: 20070004730
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventors: Ping Zhou, Michael Malamas, Yanfang Li, Albert Robichaud, Dominick Quagliato
  • HEMORRHOIDAL COMPOSITIONS AND METHOD OF USE
    Publication number: 20070003627
    Abstract: The present invention is directed to gel compositions useful in the preparation of medicated gel products. Such medicated gel products are suitable for use in the treatment of anorectal disorders such as hemorrhoids. Also disclosed is a method for the treatment of such anorectal disorders using the claimed medicated gel products.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventor: Amparo Blanco
  • Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents
    Patent number: 7157491
    Abstract: This invention provides estrogen receptor modulators having the structure where R1–R5 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: January 2, 2007
    Assignee: Wyeth
    Inventors: Richard Eric Mewshaw, Stephen Todd Cohn
  • Dibenzo chromene derivatives and their use as ER? selective ligands
    Patent number: 7157492
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure where R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: January 2, 2007
    Assignee: Wyeth
    Inventors: Richard Eric Mewshaw, Richard James Edsall, Jr.
  • Compositions, organisms and methodologies employing a novel human kinase
    Publication number: 20060294601
    Abstract: This invention provides compositions, organisms and methodologies employing a novel human protein kinase, HPK3P23. The novel human kinase has sequence homology to the catalytic domains of several protein kinases. The gene encoding this novel protein kinase is localized in or near the 3p23 locus of the human chromosome 3. The sequence similarity between the novel human protein and the catalytic domain of protein kinases indicates that the novel human protein may function as a protein kinase.
    Type: Application
    Filed: August 17, 2006
    Publication date: December 28, 2006
    Applicant: Wyeth
    Inventors: Wei Liu, Leeying Wu
  • Device and method for controlling insects
    Publication number: 20060288955
    Abstract: The present invention provides novel insecticidal animal ear tags, neck collars or pendants, and a method for controlling insects in a homeothermic animal.
    Type: Application
    Filed: May 17, 2006
    Publication date: December 28, 2006
    Applicant: Wyeth
    Inventors: Robert Albright, Shobhan Sabnis, Jacob Zupan
  • Murine genomic polynucleotide sequence encoding a G-protein coupled receptor and methods of use therefor
    Publication number: 20060294614
    Abstract: The present invention particularly relates to a newly identified murine genomic polynucleotide that encodes an ortholog of the human P2T receptor which is expressed at high levels in the central nervous system, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. The invention relates also to identifying compounds which may be agonists, antagonists and/or inhibitors of P2T, and therefore potentially useful in therapy.
    Type: Application
    Filed: August 14, 2006
    Publication date: December 28, 2006
    Applicant: Wyeth
    Inventor: Mark Pausch
  • Useful high load concentrate compositions for control of ecto-and endo-parasites
    Publication number: 20060293260
    Abstract: High load concentrate compositions comprising metaflumizone, a substantially water-insoluble anti-parasitic macrolide compound,such as moxidectin, an optional bridging agent, a surfactant, and a suitable carrier solvent are prepared. These compositions may be topically administered to animals, and are useful for preventing or treating ectoparasitic infestations in warm-blooded animals for prolonged periods of time. Additionally, they may be further diluted to provide other types of formulations useable for both topical and oral administration.
    Type: Application
    Filed: May 17, 2006
    Publication date: December 28, 2006
    Applicant: Wyeth
    Inventor: Robert Albright
  • Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
    Publication number: 20060293301
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Application
    Filed: August 31, 2006
    Publication date: December 28, 2006
    Applicant: WYETH
    Inventors: Dahui Zhou, Gary Stack
  • Regioselective synthesis of CCI-779
    Patent number: 7153957
    Abstract: A method for regioselective synthesis of CCl-779 based on boronate chemistry is provided. Also provided are novel intermediates useful in this method.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventors: Warren Chew, Chia-Cheng Shaw
  • Crystal structure of yqeJ and uses thereof
    Patent number: 7155346
    Abstract: This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such agents may be useful as antibacterial agents.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: December 26, 2006
    Assignees: Wyeth, Millennium Pharmaceuticals, Inc.
    Inventors: Andrea M. Olland, Mark L. Stahl, Francis X. Sullivan, Kathryn W. Underwood, Rajiv Chopra
  • West nile vaccine
    Patent number: 7153513
    Abstract: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventor: Hsien-Jue Chu
  • Compositions and methods for modulating connexin hemichannels
    Patent number: 7153822
    Abstract: Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventors: Peter Holme Jensen, Bjarne Due Larsen, Lars Bo Laurenborg Hansen, Jørgen Søberg Petersen, Soren Neve, Morten Schak Nielsen, Eddi Meier, Eva Steiness
  • Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
    Patent number: 7153849
    Abstract: Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventors: Deborah Ann Evrard, Dahui Zhou, Gary Paul Stack, Aranapakam Madumbai Venkatesan, Amedeo A. Failli, Susan Christman Croce
  • Formate salt of O-desmethyl-venlafaxine
    Patent number: 7154001
    Abstract: A novel salt of O-desmethylvenlafaxine, O-desmethylvenlafaxine formate, is provided. Pharmaceutical compositions, dosage forms and methods of use are also provided.
    Type: Grant
    Filed: October 21, 2005
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventors: Anthony Francis Hadfield, Michael William Winkley
  • Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists
    Publication number: 20060287522
    Abstract: This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).
    Type: Application
    Filed: June 8, 2006
    Publication date: December 21, 2006
    Applicant: WYETH
    Inventors: Amedeo Failli, Gavin Heffernan, Arthur Santilli, Dominick Quagliato, Richard Coghlan, Patrick Andrae, Susan Croce, Emily Shen, Eugene Trybulski