Patents Assigned to Wyeth
  • Treatment of pain
    Publication number: 20060258713
    Abstract: This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula I: or a pharmaceutically acceptable salt thereof, wherein each of R1, R2, R3, n, y, and Ar is as defined and described herein. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula I.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 16, 2006
    Applicant: Wyeth
    Inventors: Sharon Rosenzweig-Lipson, Michael Brandt
  • Truncated aggrecanase molecules
    Publication number: 20060257989
    Abstract: Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: July 18, 2006
    Publication date: November 16, 2006
    Applicant: Wyeth
    Inventors: Katy Georgiadis, Tara Crawford, Kathleen Tomkinson, Lisa Collins-Racie, Christopher Corcoran, Bethany Freeman, Edward LaVallie
  • Pyrrolobenzodiazepines and heteroaryl, aryl and cycloalkylamino ketone derivatives as follicle stimulating hormone receptor (FSH-R) antagonists
    Publication number: 20060258644
    Abstract: The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, A, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.
    Type: Application
    Filed: May 11, 2006
    Publication date: November 16, 2006
    Applicant: Wyeth
    Inventors: Amedeo Failli, Arthur Santilli, Dominick Quagliato, Emily Shen
  • Therapeutic combinations for the treatment or prevention of depression
    Publication number: 20060258715
    Abstract: Therapeutic combinations useful in the treatment or prevention of depression or other mood disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment or prophylaxis of depression or other mood disorders are provided. Such compounds are of formula I: or a pharmaceutically acceptable salt thereof, wherein each of R1, R2, R3, n, y, and Ar are as defined and described herein.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 16, 2006
    Applicant: Wyeth
    Inventors: Janet Jandura, Sharon Rosenzweig-Lipson
  • Dihydrobenzofuran derivatives and uses therof
    Publication number: 20060258739
    Abstract: The present invention provides a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein each of R1, R2, R3, y, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 16, 2006
    Applicant: Wyeth
    Inventors: Jiu Ai, Yanning Lin
  • Therapeutic combinations for the treatment or prevention of psychotic disorders
    Publication number: 20060258639
    Abstract: Therapeutic combinations useful in the treatment or prevention of psychotic disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment or prophylaxis of psychotic disorders are provided.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 16, 2006
    Applicant: Wyeth
    Inventors: Sheree Logue, Sharon Rosenzweig-Lipson
  • 1,3-disubstituted-2- thioxo-imidazolidine-4,5-dione derivatives useful in the treatment of atherosclerosis
    Patent number: 7135492
    Abstract: Antiatherosclerotic compounds of Formula I are provided: wherein: R is lower alkyl, alkenyl, alkynyl, or —O—(CH2)n—COOR?; R? is lower alkyl; n is an integer of 1–3; Ar is phenyl, or phenyl substituted with one or more of halogen, lower alkyl, alkenyl, alkynyl, alkoxy, perfluoroalkyl, perfluoroalkoxy, or alkylthio; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: November 14, 2006
    Assignee: Wyeth
    Inventors: Hassan M. Elokdah, Theodore S. Sulkowski
  • Crystals of an acyl carrier protein synthase/acyl carrier protein complex
    Patent number: 7135319
    Abstract: This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: November 14, 2006
    Assignee: Wyeth
    Inventors: Kevin Delos Parris, William Stuart Somers, Amy Szepui Tam, Laura Long Lin, Mark Lloyd Stahl
  • Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
    Patent number: 7135479
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: November 14, 2006
    Assignee: Wyeth
    Inventors: Dahui Zhou, Gary Paul Stack
  • Methods of selecting compounds for modulation of bladder function
    Publication number: 20060252104
    Abstract: The present invention involves an assay system and method of selecting compounds useful in the treatment of bladder instability and related bladder conditions through the activation of KCNQ potassium channels in the bladder smooth muscle.
    Type: Application
    Filed: May 22, 2006
    Publication date: November 9, 2006
    Applicant: Wyeth
    Inventors: Thomas Argentieri, Jeffrey Sheldon
  • Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
    Publication number: 20060252825
    Abstract: The present invention is directed to crystalline forms of the 5-HT2C agonist {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride, as well as compositions, processes of preparation, and uses thereof.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 9, 2006
    Applicant: Wyeth
    Inventors: Abdolsamad Tadayon, Qing Yu, Michel Bernatchez
  • Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
    Publication number: 20060252154
    Abstract: The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity.
    Type: Application
    Filed: June 21, 2006
    Publication date: November 9, 2006
    Applicant: Wyeth
    Inventors: Douglas Harnish, Marshall Scicchitano, Sotirios Karathanasis, Chu-Lai Hsiao
  • Delivery of tigecycline in the presence of heparin
    Publication number: 20060251705
    Abstract: The present disclosure is directed to combination therapies of tigecycline and heparin and methods of administration of tigecycline and heparin.
    Type: Application
    Filed: May 5, 2006
    Publication date: November 9, 2006
    Applicant: Wyeth
    Inventors: Stephen Ludwig, Maja Vencl-Joncic, Pooja Gandhi, Joseph Gross, Julianna Koczone
  • 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
    Patent number: 7132417
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in treating uterine leiomyoma.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: November 7, 2006
    Assignee: Wyeth
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Arthur A. Santilli
  • Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
    Patent number: 7132402
    Abstract: This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: November 7, 2006
    Assignee: Wyeth
    Inventors: Scott Christian Mayer, Robert E. McDevitt, Paul J. Dollings
  • Substituted acetic acid derivatives
    Publication number: 20060247298
    Abstract: The present invention relates generally to substituted acetic acid derivatives and methods of using them.
    Type: Application
    Filed: September 23, 2004
    Publication date: November 2, 2006
    Applicant: WYETH
    Inventors: Ariamala Gopalsamy, Scott Kincaid
  • Dihydrobenzofuran derivatives and uses thereof
    Publication number: 20060246551
    Abstract: Compounds of formula I are provided: wherein each of R1, R2, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of melatoninergic receptors. The compounds, and compositions containing the compounds, can be used to treat melatoninergic disorders.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 2, 2006
    Applicant: Wyeth
    Inventors: Gary Stack, Jonathan Gross
  • Beta-amyloid peptide-binding proteins and polynucleotides encoding the same
    Publication number: 20060248605
    Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
    Type: Application
    Filed: July 12, 2006
    Publication date: November 2, 2006
    Applicant: Wyeth
    Inventors: Bradley Ozenberger, Jonathan Bard, Eileen Kajkowski, Jack Jacobsen, Stephen Walker, Heidi Sofia, David Howland
  • Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles
    Publication number: 20060247441
    Abstract: Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile. Also provided are methods for preparing iminobenzo[b]thiophene and benzo[b]thiophenone compounds.
    Type: Application
    Filed: April 27, 2006
    Publication date: November 2, 2006
    Applicant: Wyeth
    Inventor: Bogdan Wilk
  • Compositions containing micronized tanaproget prepared by wet granulation
    Publication number: 20060247234
    Abstract: Compositions, preferably pharmaceutical compositions, containing micronized tanaproget, or pharmaceutically acceptable salt thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, butylated hydroxyanisole, povidone, and magnesium stearate, are provided. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor. Additional uses include stimulation of food intake.
    Type: Application
    Filed: April 26, 2006
    Publication date: November 2, 2006
    Applicant: Wyeth
    Inventors: Arwinder Nagi, Ramarao Chatlapalli, Shamim Hasan, Rolland Carson, Mohamed Ghorab