Patents Assigned to Wyeth
  • Patent number: 6927226
    Abstract: Compounds of the formula: are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: August 9, 2005
    Assignee: Wyeth
    Inventor: Gary P. Stack
  • Publication number: 20050171077
    Abstract: The invention pertains to pharmaceutical compositions of Zosyn® having substantially free or reduced levels of galactomannan and processes to prepare said pharmaceutical compositions.
    Type: Application
    Filed: January 28, 2005
    Publication date: August 4, 2005
    Applicant: Wyeth
    Inventors: Mark Ruppen, Yu Wang, Sam George
  • Publication number: 20050170408
    Abstract: Novel proteins which contain a structural module conserved in the G protein coupled receptor superfamily, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.
    Type: Application
    Filed: February 7, 2005
    Publication date: August 4, 2005
    Applicant: Wyeth
    Inventors: Bradley Ozenberger, Eileen Kajkowski, Ching-Hsiung Lo, Heidi Sofia
  • Publication number: 20050171180
    Abstract: Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: wherein, R1 is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO2R5; R5 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, alkyl, or substituted alkyl; R2 is lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; R3 is hydrogen, lower alkyl, or substituted lower alkyl; R4 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; R6 is hydrogen, lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, cycloalkyl, or substituted cycloalkyl; W, X and Y are independently CR7 or N; and R7 is hydrogen, halogen, lower alkyl, or substituted lower alkyl.
    Type: Application
    Filed: January 13, 2005
    Publication date: August 4, 2005
    Applicant: Wyeth
    Inventors: Lynn Resnick, Donna Huryn, Joan Sabalski, Joshua Berkowitz, Anthony Kreft, Dennis Kubrak, Thomas Caggiano, Koi Morris
  • Publication number: 20050171186
    Abstract: This invention relates to methods of co-administering compounds of formula 1 which are agonists of the progesterone receptor which have the general structure: wherein: R1, R2, R3, R4, R5 and Q1 are as defined herein, or a pharmaceutically acceptable salt thereof, with estrogen, an estrone, or an estrogen receptor agonist for contraception, hormone replacement therapy, or treating progesterone-related carcinomas and adenocarcinomas.
    Type: Application
    Filed: March 17, 2005
    Publication date: August 4, 2005
    Applicants: Wyeth, Ligand Pharmaceuticals, Inc.
    Inventors: Andrew Fensome, Puwen Zhang, Marci Koko, Lin Zhi, Todd Jones, Jay Wrobel, Christopher Tegley, James Edwards, Edward Melenski
  • Publication number: 20050171115
    Abstract: The present invention is directed to alkanoyl and cycloalkanoyl-amine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Application
    Filed: October 12, 2004
    Publication date: August 4, 2005
    Applicant: Wyeth
    Inventors: Eugene Trybulski, Paige Mahaney, Lori Gavrin, William Moore, Joseph Sabatucci
  • Publication number: 20050169858
    Abstract: A multi-composition stick product, such as a lip balm, sun screen, deodorant, or glue stick. The multi-composition stick product including a stick composition molded in the container so as to contact the walls thereof and be advanceable or ejected therefrom. The stick composition includes a first composition and a second composition. The first and second compositions differ in at least one component, such as a medicament, colorant, fragrance, flavorant, sunscreen, preservative, conditioner, moisturizer, emollient, or surfactant. Furthermore the first and second compositions are arranged in a predetermined non-random pattern that is reproducible. Also described is the method and apparatus for manufacturing the multi-composition stick product.
    Type: Application
    Filed: February 28, 2005
    Publication date: August 4, 2005
    Applicant: Wyeth
    Inventors: Jee Look, Paul Cooper, Khawla Abu-Izza, Joyce Wilson, Krishna Raman, Vincent Li
  • Patent number: 6924281
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in treating male pattern baldness.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: August 2, 2005
    Assignee: Wyeth
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Arthur A. Santilli
  • Patent number: 6924303
    Abstract: The present invention is directed to an analgesic composition which consists essentially of a cyclooxygenase-2 inhibitor and a compound selected from the group consisting of non-steroidal anti-inflammatory drugs, acetaminophen and mixtures thereof. The present invention further is directed to a method for inducing analgesia through the administration of such a composition to a patient.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: August 2, 2005
    Assignee: Wyeth
    Inventor: Stephen Allen Cooper
  • Publication number: 20050165082
    Abstract: The present invention relates to methods of treating at least one vasomotor symptom such as hot flush, caused by, inter alia, thermoregulatory dysfunction, in a subject in need thereof by administering to the subject a compound or composition of compounds that modulate the V1b receptor.
    Type: Application
    Filed: December 15, 2004
    Publication date: July 28, 2005
    Applicant: Wyeth
    Inventors: Liza Leventhal, Robert Ring
  • Publication number: 20050164323
    Abstract: Methods for agents useful for treating asthma are disclosed. The methods include screening for agents that inhibit the production of a PKC-? protein, as well as for agents that inhibit the kinase activity of a PKC-? protein, or a functional fragment thereof, wherein such agents are useful for treating asthma. The methods also include screening for agents that inhibit the production of a reporter gene product encoded by a nucleic acid sequence operably linked to a PKC-? promoter. Also disclosed are methods of treating asthma that include administering an agent that inhibits the production of a functional PKC-? protein or the kinase activity of a PKC-? protein or a functional fragment thereof. An isolated mast cell lacking expression of endogenous PKC-? is also disclosed.
    Type: Application
    Filed: December 22, 2004
    Publication date: July 28, 2005
    Applicant: Wyeth
    Inventors: Divya Chaudhary, Marion Kasaian, Cara Williams, Suzana Marusic, Robert Czerwinski
  • Publication number: 20050164920
    Abstract: Cyclic peptides and peptidomimetics are provided that bind to and/or modulate activities associated with Trk receptors, including processes associated with the growth and repair of the central nervous system (e.g., neuronal growth and survival, axonal growth, neurite outgrowth and synaptic plasticity). Cyclic peptides and peptidomimetics are also provided that block or reduce the effect of other factors that inhibit growth and/or repair of the central nervous system. Pharmaceutical compositions and other formulations comprising these compounds are provided. In addition, the invention provides methods for using the cyclic peptides and peptidomimetics to modulate Trk mediated activities, including processes such as neuronal growth, survival and recover, axonal growth, neurite outgrowth, and synaptic plasticity. Further, the invention provides methods for promoting central nervous system (CNS) neuron growth by administering a p75 receptor binding agent.
    Type: Application
    Filed: September 9, 2004
    Publication date: July 28, 2005
    Applicant: Wyeth
    Inventors: Patrick Doherty, Gareth Williams
  • Publication number: 20050165221
    Abstract: Methods are provided for purification of Factor VIII polypeptides by affinity chromatography and ion exchange chromatography, in which the eluate from the affinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The affinity matrix may comprise a monoclonal antibody or a peptide ligand. The methods result in improved purification without significant yield loss.
    Type: Application
    Filed: January 26, 2005
    Publication date: July 28, 2005
    Applicant: Wyeth
    Inventors: James Booth, Suresh Vunnum, Brian Kelley
  • Patent number: 6921537
    Abstract: Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram-negative cocci, such as Neisseria meningitidis. LOS-depleted outer membranes and LOS-depleted soluble outer membrane proteins can be prepared, which are able to elicit bactericidal antibodies against homologous strains of bacteria. Vaccines and other uses of the preparations are further described.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: July 26, 2005
    Assignee: Wyeth
    Inventor: Gary W. Zlotnick
  • Publication number: 20050159465
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, and R3 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 1, 2005
    Publication date: July 21, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Tam Dinh, Iwan Gunawan, Michael Collini, Heather Harris, James Keith, Leo Albert
  • Publication number: 20050159613
    Abstract: A process for making a compound of formula (I) in which process the compound HC?C—(CH2)n—NH2 is reacted with the compound R1—SO2Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of formula to produce the compound of formula (I), and compounds produced by the process of this invention. The terms R1, R2, R3, R4 and n have the definitions set forth in the specification.
    Type: Application
    Filed: March 8, 2005
    Publication date: July 21, 2005
    Applicant: Wyeth
    Inventors: Yanzhong Wu, Panolil Raveendranath
  • Patent number: 6919354
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: July 19, 2005
    Assignee: Wyeth
    Inventors: Ping Zhou, Michael Gerard Kelly
  • Patent number: 6919334
    Abstract: Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: July 19, 2005
    Assignee: Wyeth
    Inventors: Hong Gao, Gary Paul Stack
  • Publication number: 20050152983
    Abstract: Micronized CCI-779 is described. This directly compressible rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid provides a convenient and effective method to deliver therapeutic levels of CCI-779 to a patient.
    Type: Application
    Filed: January 6, 2005
    Publication date: July 14, 2005
    Applicant: Wyeth
    Inventors: Muhammad Ashraf, Eric Benjamin
  • Publication number: 20050153944
    Abstract: This invention provides compounds of the formula: wherein A?, X and Y are defined in the specification. These compounds are useful as antibacterial agents.
    Type: Application
    Filed: December 8, 2004
    Publication date: July 14, 2005
    Applicant: Wyeth
    Inventors: Phaik-Eng Sum, David How, Darrin Hopper, Matthew Vera, Joshua Sabatini