Patents Assigned to Wyeth
  • Multi composition stick product and a process and system for manufacturing the same
    Patent number: 6955489
    Abstract: A multi-composition stick product, such as a lip balm, sun screen, deodorant, or glue stick. The multi-composition stick product including a stick composition molded in the container so as to contact the walls thereof and be advanceable or ejected therefrom. The stick composition includes a first composition and a second composition. The first and second compositions differ in at least one component, such as a medicament, colorant, fragrance, flavorant, sunscreen, preservative, conditioner, moisturizer, emollient, or surfactant. Furthermore the first and second compositions are arranged in a predetermined non-random pattern that is reproducible. Also described is the method and apparatus for manufacturing the multi-composition stick product.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: October 18, 2005
    Assignee: Wyeth
    Inventors: Jee Loon Look, Paul Joseph Cooper, Khawla Abdullah Abu-Izza, Joyce H. Wilson, Krishna P. Raman, Vincent Hon-Kin Li
  • Thioamide derivatives as progesterone receptor modulators
    Publication number: 20050227971
    Abstract: Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventor: Bogdan Wilk
  • Bazedoxifene acetate formulations
    Publication number: 20050227966
    Abstract: The present invention is directed to solid dispersions of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Syed Shah, Kadum Ali, Christian Ofslager, Mahdi Fawzi
  • Crystalline polymorph of bazedoxifene acetate
    Publication number: 20050227965
    Abstract: The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Application
    Filed: April 6, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Christopher Demerson, Silvio Iera, Kadum Ali
  • Process for making chiral 1,4-disubstituted piperazines
    Publication number: 20050228181
    Abstract: A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders.
    Type: Application
    Filed: June 7, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Joseph Zeldis, Gregg Feigelson, Ivo Jirkovsky
  • Methods for minimizing thioamide impurities
    Publication number: 20050228179
    Abstract: Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrite groups, are provided.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventor: Bogdan Wilk
  • Bazedoxifene ascorbate
    Publication number: 20050227964
    Abstract: The present invention is directed to bazedoxifene ascorbate, compositions containing the same, dispersions thereof, preparations thereof, and uses thereof.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Mahdi Fawzi, Kadum Ali, Syed Shah
  • Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
    Publication number: 20050228010
    Abstract: Compounds of the formula useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction (including premature ejaculation), and related illnesses.
    Type: Application
    Filed: June 6, 2005
    Publication date: October 13, 2005
    Applicant: WYETH
    Inventors: Rulin Zhao, Megan Tran, Gary Stack, Richard Mewshaw
  • Method for preparing 3-cyclopentyloxy-4-methoxybenzaldehyde
    Publication number: 20050228199
    Abstract: Processes for coupling phenol and cycloalkyls including combining an optionally substituted phenol, a cycloalkyl substituted with a leaving group, carbonate salt, tetrahydrofuran, and an optional phase transfer agent are provided. Also provided are processes for preparing 3-cyclopentyloxy-4-methoxybenzaldehyde by combining 3-hydroxy-4-methoxybenzaldehyde, a cyclopentyl compound, a carbonate salt, a solvent, and an optional phase transfer agent.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Bogdan Wilk, Nalukui Mwisiya, Jean Helom
  • Antidepressant piperidine derivatives of heterocyclefused benzodioxans
    Publication number: 20050228009
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Application
    Filed: June 1, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Michael Webb, Gary Stack, Magda Asselin, Deborah Evrard
  • Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4
    Patent number: 6953802
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: October 11, 2005
    Assignees: Elan Pharmaceuticals, Inc., Wyeth
    Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu
  • Phenylaminopropanol derivatives and methods of their use
    Publication number: 20050222142
    Abstract: The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Application
    Filed: March 28, 2005
    Publication date: October 6, 2005
    Applicant: Wyeth
    Inventors: An Vu, Paige Mahaney, Stephen Cohn
  • Nucleic acid arrays for monitoring expression profiles of drug target genes
    Publication number: 20050221354
    Abstract: The present invention provides nucleic acid arrays and methods of using the same for detecting or monitoring expression profiles of drug target genes. Non-limiting examples of drug target genes include kinase genes, phosphatase genes, protease genes, G-protein coupled receptor genes, nuclear hormone receptor genes, and ion channel genes. The present invention also provides methods of using nucleic acid arrays for the identification or validation of drugs or drug targets. In one embodiment, a nucleic acid array of the present invention is concentrated with probes for drug target genes. These probes constitute a substantial portion of all of the polynucleotide probes that are stably attached to the nucleic acid array, and can hybridize under stringent or nucleic acid array hybridization conditions to the tiling sequences selected from Attachment C, or the complements thereof.
    Type: Application
    Filed: February 18, 2005
    Publication date: October 6, 2005
    Applicant: Wyeth
    Inventor: William Mounts
  • Phenylaminopropanol derivatives and methods of their use
    Publication number: 20050222148
    Abstract: The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Application
    Filed: March 28, 2005
    Publication date: October 6, 2005
    Applicant: Wyeth
    Inventors: Callain Kim, Paige Mahaney, Eugene Trybulski, Puwen Zhang, Eugene Terefenko, Casey McComas, Michael Marella, Richard Coghlan, Gavin Heffernan, Stephen Cohn, An Vu, Joseph Sabatucci, Fei Ye
  • Synthesis of pyrrole-2-carbonitriles
    Publication number: 20050222432
    Abstract: The instant invention concerns processes for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonitrile. Such processes preferably comprise the steps of reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent and contacting the resulting product with a molar excess of an amide such as N,N-dimethylformamide. The product of this contacting step is then contacted with a molar excess of an organic base to produce a precipitate and a solution phase. The precipitate is then separated from the solution phase and the corresponding pyrrole-2-carbonitrile is isolated from the resulting solution phase.
    Type: Application
    Filed: March 22, 2005
    Publication date: October 6, 2005
    Applicant: Wyeth
    Inventors: Jean Helom, Arkadiy Rubezhov, Anthony Pilcher, Bogdan Wilk
  • 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indoles as estrogenic agents
    Patent number: 6951852
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in the treatment or inhibition of osteoarthritis.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: October 4, 2005
    Assignee: Wyeth
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Arthur A. Santilli
  • Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors
    Patent number: 6951955
    Abstract: The invention is a process for the preparation of compounds of the Formula I: where R1, R2, R3, R4 and R5 are defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors which are useful in the treatment of cancer.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: October 4, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Yanzhong Wu, Sreenivasulu Megati, Constantine Gletsos, John Thomas Kendall, Bogdan Kazimierz Wilk, Thurairajah Padmanathan, Panolil Raveendranath
  • (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 6951881
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: October 4, 2005
    Assignee: Wyeth
    Inventors: Derek Cecil Cole, Michael Gerard Kelly, Byron Abel Bravo, Yvette Latko Palmer
  • 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
    Publication number: 20050215616
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in treating vaginal and skin atrophy.
    Type: Application
    Filed: May 19, 2005
    Publication date: September 29, 2005
    Applicant: Wyeth
    Inventors: Chris Miller, Michael Collini, Bach Tran, Arthur Santilli
  • Substituted benzofuran oximes
    Publication number: 20050215626
    Abstract: The present invention relates to substituted benzofuran oximes and methods of using them.
    Type: Application
    Filed: September 23, 2004
    Publication date: September 29, 2005
    Applicant: WYETH
    Inventors: Lisa Havran, John Butera, Hassan Elokdah, Douglas Jenkins, Eric Gundersen