Patents Assigned to Wyeth
  • Hormonal contraceptive product
    Publication number: 20040243606
    Abstract: The present invention relates to a hormonal contraceptive product having two hormonal components, an estrogen and a gestagen, and a method for the continuous suppression of the menstrual cycle by uninterrupted administration of the product of the invention.
    Type: Application
    Filed: June 15, 2004
    Publication date: December 2, 2004
    Applicant: Wyeth Pharmaceuticals, Inc.
    Inventor: Rolf-Dieter Hesch
  • Process for synthesizing beta-lactamase inhibitor intermediates
    Publication number: 20040242874
    Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification 1
    Type: Application
    Filed: May 12, 2004
    Publication date: December 2, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
  • Method of treating hepatic fibrosis
    Publication number: 20040242621
    Abstract: This invention provides the use of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) in the treatment or inhibition of hepatic fibrosis and hepatic cirrhosis.
    Type: Application
    Filed: January 29, 2004
    Publication date: December 2, 2004
    Applicant: Wyeth
    Inventors: Brenda Cooperstone, Robert Clare, George Stanley
  • Methods for diagnosing mood disorders
    Publication number: 20040241737
    Abstract: The present invention relates generally to the fields of neuroscience, proteomics and mood disorders. More particularly, the present invention relates to the identification of a group of proteins modulated in subjects with a mood disorder; methods for detecting or screening mRNA encoding these proteins and methods for diagnosing mood disorders.
    Type: Application
    Filed: May 21, 2004
    Publication date: December 2, 2004
    Applicant: Wyeth
    Inventors: Xavier Zafar Khawaja, Jun Xu, Jinjun Liang
  • Conditional knockout method for gene trapping and gene targeting using an inducible gene silencer
    Publication number: 20040241851
    Abstract: A method for conditionally knocking out and altering gene function and genetic sequences that can be used in such methods, for use in gene trapping and gene targeting. Specifically, the genetic sequence is a inducible gene silencer comprising: (a) a splice acceptor sequence; (b) an internal ribosomal entry site (IRES) sequence; (c) a nucleotide sequence coding for a reporter protein; (d) a polyadenylation sequence; and (e) a pair of oppositely oriented recombination site sequences, which cause single cycle inversions in the presence of a suitable recombinase enzyme, flanking elements (a) through (d).
    Type: Application
    Filed: May 30, 2003
    Publication date: December 2, 2004
    Applicant: Wyeth
    Inventors: G. Roger Askew, Kim L. Kanki
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and TACE inhibitors
    Patent number: 6825354
    Abstract: Compounds of the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: November 30, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, Derek C. Cole, James M. Chen, Jamie M. Davis, George T. Grosu
  • 1-(aminoalkyl)-3-sulfonylazaindoles as 5-hydroxytryptamine-6 ligands
    Patent number: 6825212
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: November 30, 2004
    Assignee: Wyeth
    Inventors: Ronald Charles Bernotas, Steven Edward Lenicek, Schuyler A. Antane
  • Preparation and use of ortho-sulfonamido arylhydroxamic acids as matrix metalloproteinase inhibitors
    Patent number: 6825352
    Abstract: Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: November 30, 2004
    Assignee: Wyeth
    Inventors: Frances Christy Nelson, Arie Zask, James Ming Chen, Dominick Mobilio, Ramaswamy Nilakantan
  • Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
    Publication number: 20040235851
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: June 28, 2004
    Publication date: November 25, 2004
    Applicant: WYETH
    Inventors: Rulin Zhao, Megan Tran, Gary P. Stack, Richard E. Mewshaw
  • Compositions and methods for diagnosing and treating asthma or other allergic or inflammatory diseases
    Publication number: 20040234517
    Abstract: The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the present invention include inhibiting the activity or expression of a component of an arginine metabolic pathway in tissues affected by asthma or other allergic or inflammatory diseases. In many embodiments, the component being inhibited is a cationic amino acid transporter, an arginase, or a component downstream of the arginase. In many other embodiments, the activity or expression of the component is inhibited by an agent that binds to the component. In still many other embodiments, the activity or expression of the component is inhibited by an agent that binds a polynucleotide encoding the component.
    Type: Application
    Filed: March 4, 2004
    Publication date: November 25, 2004
    Applicant: WYETH
    Inventors: Michael R. Bowman, Maximillian T. Follettie, Hang Chen, Cara Williams, Aaron Winkler, Debra Ellis, Wei Liu
  • Avian E. coli vaccine for protection against colibacillosis
    Publication number: 20040234534
    Abstract: A genetic deletion mutant live E. coli vaccine suitable for mass application to poultry, including chickens, is provided. Also provided is a safe and effective method to protect poultry against the ravages of Escherichia coli bacillosis infection and disease in which a live mutant aroA-gene deleted E. coli immunogen is administered to chickens, turkeys and the like via mass application routes such as coarse sprays and drinking water.
    Type: Application
    Filed: May 3, 2004
    Publication date: November 25, 2004
    Applicant: Wyeth
    Inventors: Henry H. Fan, Mahesh Kumar, Roberto Marcello La Ragione, Martin John Woodward
  • Avian vaccine composition for the protection of poultry against disease and infection caused by E. coli and Salmonella
    Publication number: 20040234550
    Abstract: There is provided a vaccine composition comprising a combination of a genetic deletion mutant S. typhimurium microorganism and a genetic deletion mutant E. coli microorganism, suitable for mass application to poultry. Also provided is a safe and effective method to protect poultry against the ravages of E. coli and Salmonella infection and disease.
    Type: Application
    Filed: May 3, 2004
    Publication date: November 25, 2004
    Applicant: Wyeth
    Inventors: Henry H. Fan, Mahesh Kumar
  • 3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases
    Patent number: 6821988
    Abstract: This invention provides compounds of Formula (I), represented by the structure wherein G1, G2, G3, G4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: November 23, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Allan Wissner, Hwei-Ru Tsou, Middleton Brawner Floyd, Jr., Bernard D. Johnson, Elsebe Geraldine Overbeek-Klumpers
  • 2-substituted thiazolidinones as &bgr;-3 adrenergic receptor agonists
    Patent number: 6821991
    Abstract: This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: November 23, 2004
    Assignee: Wyeth
    Inventor: Baihua Hu
  • Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
    Patent number: 6821981
    Abstract: Compounds of the formula useful for the treatment of disorders, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: November 23, 2004
    Assignee: Wyeth
    Inventors: Gary P. Stack, Megan Tran, Jonathan L. Gross, George E. M. Husbands
  • Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis of prostate cancer
    Patent number: 6821731
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of expression of one or more of the FKBP markers is correlated with the presence of prostate cancer.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: November 23, 2004
    Assignee: Wyeth
    Inventors: Kimberly A. Gillis, Yixian Zhang
  • Process for producing anticancer agent LL-D45042
    Publication number: 20040229323
    Abstract: The disclosure describes the production of anticancer agent LL-D45042, having the structure: 1
    Type: Application
    Filed: May 10, 2004
    Publication date: November 18, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Valerie S. Bernan, Edmund I. Graziani
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/TACE inhibitors
    Publication number: 20040229924
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: June 17, 2004
    Publication date: November 18, 2004
    Applicant: WYETH
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, James M. Chen, Arie Zask, Vincent P. Sandanayaka, Mila T. Du, Jannie L. Baker
  • 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indoles as estrogenic agents
    Publication number: 20040229932
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below: 1
    Type: Application
    Filed: October 24, 2003
    Publication date: November 18, 2004
    Applicant: Wyeth
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Arthur A. Santilli
  • Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
    Publication number: 20040229865
    Abstract: This invention provides compounds of formula I having the structure 1
    Type: Application
    Filed: June 18, 2004
    Publication date: November 18, 2004
    Applicant: Wyeth
    Inventors: Annmarie Louise Sabb, Robert Lewis Vogel