Patents Assigned to Wyeth
  • Process for producing anticancer agent LL-D45042
    Publication number: 20040229323
    Abstract: The disclosure describes the production of anticancer agent LL-D45042, having the structure: 1
    Type: Application
    Filed: May 10, 2004
    Publication date: November 18, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Valerie S. Bernan, Edmund I. Graziani
  • Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
    Publication number: 20040229865
    Abstract: This invention provides compounds of formula I having the structure 1
    Type: Application
    Filed: June 18, 2004
    Publication date: November 18, 2004
    Applicant: Wyeth
    Inventors: Annmarie Louise Sabb, Robert Lewis Vogel
  • 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indoles as estrogenic agents
    Publication number: 20040229932
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below: 1
    Type: Application
    Filed: October 24, 2003
    Publication date: November 18, 2004
    Applicant: Wyeth
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Arthur A. Santilli
  • B-ring estratrienes
    Patent number: 6818636
    Abstract: This invention provides 3&bgr;-hydroxy-5,7,9-estratriene-17-one and a pharmaceutically acceptable salt of its 3-sulfate ester, which is useful as an estrogen.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: November 16, 2004
    Assignee: Wyeth
    Inventors: Syed M. Shah, Panolil Raveendranath, Michael Z. Kagan
  • Azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists
    Patent number: 6815448
    Abstract: Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia. The compounds of the invention are also useful for the treatment of disorders such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: November 9, 2004
    Assignee: Wyeth
    Inventors: Gary P. Stack, Megan Tran
  • Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 6815456
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: November 9, 2004
    Assignee: Wyeth
    Inventors: Ping Zhou, Boyd Lynn Harrison, Yanfang Li
  • Antibiotic P175-A and semisynthetic derivatives thereof
    Publication number: 20040220195
    Abstract: This invention relates to a new antibiotic designated P175-A, to production of fermentation of Micromonospora echinospora NRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic esters and ethers of P175-A.
    Type: Application
    Filed: April 28, 2004
    Publication date: November 4, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Hui Yu Yang, Scott William Luckman, Valerie S. Bernan
  • In ovo protection against infectious bronchitis
    Publication number: 20040219171
    Abstract: The present invention is directed to processes and compositions for protecting host animals (e.g., chickens) from exposure to virulent infectious bronchitis virus. In ovo administration of live, avirulent strains of IB at appropriate dosage levels on a per egg basis provides an effective and efficient vaccination having acceptable safety and efficacy features.
    Type: Application
    Filed: June 1, 2004
    Publication date: November 4, 2004
    Applicant: Wyeth
    Inventors: Berend Jongsma, Frans Gerrit Davelaar, Marinus Wynand Weststrate
  • Acetylenic &agr;-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Patent number: 6812227
    Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: November 2, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • 4-Substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid derivatives as beta-lactamase inhibitors
    Publication number: 20040214812
    Abstract: The present invention relates to novel, low molecular weight broad spectrum compounds in particular to a class of 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid or their derivatives which have &bgr;-lactamase inhibitory and antibacterial properties. The compounds are therefore useful in the treatment of antibacterial infections in humans or animals, either alone or in combination with other antibiotics.
    Type: Application
    Filed: April 28, 2004
    Publication date: October 28, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Tarek Suhayl Mansour, Aranapakam Mudumbai Venkatesan
  • 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
    Publication number: 20040214869
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: May 11, 2004
    Publication date: October 28, 2004
    Applicant: Wyeth
    Inventors: John A. Butera, Craig E. Caufield, Russell F. Graceffa, Alexander Greenfield, Eric G. Gundersen, Lisa Marie Havran, Alan H. Katz, Joseph R. Lennox, Scott C. Mayer, Robert E. McDevitt
  • Water soluble wortmannin derivatives
    Publication number: 20040213757
    Abstract: This invention relates to soluble derivatives of wortmannin that utilizes water-soluble polymers as carriers for a drug and includes compounds having the structures as described within the specification.
    Type: Application
    Filed: April 20, 2004
    Publication date: October 28, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Tianmin Zhu, Ker Yu, Judy Lucas, Jianxin Gu, Arie Zask
  • Antibodies against PD-1 and uses therefor
    Publication number: 20040213795
    Abstract: This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
    Type: Application
    Filed: December 22, 2003
    Publication date: October 28, 2004
    Applicants: Wyeth, Cambridge Antibody Technology
    Inventors: Mary Collins, Clive R. Wood, Beatriz M. Carreno, Deborah Luxenberg, Jason Jussif, Laura L. Carter, Frances K. Bennett, Viia Valge-Archer, John Andrews, Caroline Russell
  • Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20040209867
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: April 20, 2004
    Publication date: October 21, 2004
    Applicant: Wyeth
    Inventors: Derek Cecil Cole, Joseph Raymond Stock, William Joseph Lennox, Ping Zhou
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Patent number: 6806366
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: October 19, 2004
    Assignee: Wyeth
    Inventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan
  • Compositions containing pipercillin and tazobactam sodium useful for injection
    Publication number: 20040204372
    Abstract: The invention pertains to pharmaceutical compositions of Zosyn® in the presence of a buffer, preferably citrate, a particulate formation inhibitor, preferably EDTA optionally an aminoglycoside which when frozen and thawed or lyophilized and reconstituted reform a solution which has decreased particulate formation.
    Type: Application
    Filed: April 14, 2003
    Publication date: October 14, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Jonathan Marc Cohen, Syed M. Shah, Christian Luther Ofslager, Mahdi Fawzi
  • Process for the synthesis of 3-cyano-6-alkoxy-7-nitro-4-quinolones
    Publication number: 20040204587
    Abstract: There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4-quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula: 1
    Type: Application
    Filed: April 7, 2004
    Publication date: October 14, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Scott Mason Duncan, Miguel Angel Pagan, Middleton Brawner Floyd
  • Tablet dispenser
    Patent number: D497803
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: November 2, 2004
    Assignee: Wyeth
    Inventors: Mark A. Nichols, David G. Honan, Faith C. David-Hegerich
  • Tablet dispenser
    Patent number: D497806
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: November 2, 2004
    Assignee: Wyeth
    Inventors: Mark A. Nichols, David G. Honan
  • Tablet dispenser
    Patent number: D497807
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: November 2, 2004
    Assignee: Wyeth
    Inventors: Mark A. Nichols, David G. Honan