Patents Assigned to Wyeth
  • Process for the preparation of 2-[alkyl(aryl)]sulfonylbenzene-sulfonyl chlorides and their intermediates
    Patent number: 6642416
    Abstract: A process for the preparation of 2-[alkyl(aryl)]sulfonylbenzene sulfonyl chlorides of the following formula is provided: in which R is alkyl or aryl substituted at the ortho or meta positions with alkyl, aryl, NHAc or alkoxy, comprising the steps of: a) reacting 2-chloronitrobenzene, 2-fluoronitrobenzene or 2-bromonitrobenzene with a compound of the following formula: RSO2−M+ wherein R is defined above; and M is sodium, potassium, lithium, ammonium or quaternary ammonium, in a polar aprotic solvent at a temperature of about 50 to 190° C.; b) reacting the material prepared in step (a) with hydrogen at a pressure of about 20 to about 60 psi in a polar aprotic solvent at a temperature of about 20 to about 60° C.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: November 4, 2003
    Assignee: Wyeth
    Inventors: Lalitha Krishnan, Bogdan K. Wilk, Jennifer P. Varriano
  • Selective oxidation process with enhanced safety
    Publication number: 20030204064
    Abstract: A safe and effective process for the oxidation of a primary or secondary alcohol to the corresponding aldehyde or ketone via the reaction of said alcohol with an anhydride solution of a 1,1,1-tri(C2-C4 alkanoyloxy-1,1 -dihydro-1,2-benziodoxol-3(1H)-one, and a composition useful in this process.
    Type: Application
    Filed: April 3, 2003
    Publication date: October 30, 2003
    Applicant: Wyeth
    Inventors: Ugo Chiacchio, Antonio Rescifina, Giuseppe Miraglia, Mariangela Magnano, Paola Di Raimondo
  • Coating system
    Publication number: 20030203098
    Abstract: The present invention provides a coating system for solid pharmaceutical dosage units, such as tablets. The coating system comprising (a) a subcoat; (b) an optional colorcoat; and (c) a polish coat. In a preferred embodiment, the present invention provides (a) a subcoat comprising (i) hydroxypropyl methylcellulose (HPMC) and (ii) a polysaccharide; (b) a colorcoat comprising (i) a colorant and (ii) a polysaccharide which may be the same as or different from the polysaccharide of the subcoat; and (c) a polish coat comprising (i) a polyethylene glycol and, optionally, (ii) a wax. Also disclosed is a method for providing gloss to a coated pharmaceutical solid dosage unit by coating a pharmaceutical core with the aforementioned polish coat.
    Type: Application
    Filed: May 20, 2003
    Publication date: October 30, 2003
    Applicant: WYETH
    Inventors: Roger Berlin, Justin Bianco
  • 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
    Publication number: 20030203883
    Abstract: The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below: 1
    Type: Application
    Filed: October 3, 2002
    Publication date: October 30, 2003
    Applicant: Wyeth
    Inventors: James Harrison Pickar, Barry Samuel Komm
  • Enantiomers of N-desmethyl venlafaxine
    Publication number: 20030203972
    Abstract: The present invention provides enantiomers of N-Desmethyl venlafaxine, as well as their use in pharmaceutical compositions and medically useful treatments, particularly including central nervous system uses.
    Type: Application
    Filed: April 21, 2003
    Publication date: October 30, 2003
    Applicant: Wyeth
    Inventors: John P. Yardley, Andre A. Asselin
  • Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
    Publication number: 20030204087
    Abstract: A process for making an N1-(2′-pyridyl)-1,2-alkanediamine sulfamic acid of formula II by reacting a compound of formula I with NH2R′ 1
    Type: Application
    Filed: March 10, 2003
    Publication date: October 30, 2003
    Applicant: Wyeth
    Inventors: Anita Wai-Yin Chan, Gregg Brian Feigelson, Joseph Zeldis, Ivo Jirkovsky
  • Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20030203895
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: February 13, 2003
    Publication date: October 30, 2003
    Applicant: Wyeth
    Inventors: Michael Gerard Kelly, Ping Zhou
  • Substituted phenyl compounds for the treatment of non-insulin dependent diabetes mellitus
    Publication number: 20030203941
    Abstract: This invention provides compounds of formula I, having the structure 1
    Type: Application
    Filed: April 8, 2003
    Publication date: October 30, 2003
    Applicant: Wyeth
    Inventors: Joseph P. Sabatucci, Craig E. Caufield, Alexander A. Greenfield, Koi M. Morris, Eamonn P. Morrison
  • Tricyclic protein kinase inhibitors
    Patent number: 6638929
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: October 28, 2003
    Assignee: Wyeth
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 6638972
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: October 3, 2002
    Date of Patent: October 28, 2003
    Assignee: Wyeth
    Inventors: Michael Gerard Kelly, Lynne Padilla Greenblatt, Gan Zhang, Yvette L. Palmer, Steven Edward Lenicek
  • Substituted benzoxazoles as estrogenic agents
    Publication number: 20030199562
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 4, 2002
    Publication date: October 23, 2003
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini, Heather A. Harris, James C. Keith, Leo M. Albert, C. Richard Lyttle
  • Adjuvant and vaccine compositions containing monophosphoryl lipid A
    Patent number: 6635261
    Abstract: The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission of greater than or equal to 88% as measured spectrophotometrically.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: October 21, 2003
    Assignee: Wyeth Holdings Corporation
    Inventors: Vincent James LaPosta, John Hayward Eldridge
  • N-benzhydryl indole compounds
    Patent number: 6635771
    Abstract: Compounds of the formula in which R, R′, R7-R11, X, n1 and n3 are as defined herein. These compounds are useful as intermediates for preparing pharmaceutical compounds having pharmacological activity as chemical inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: October 21, 2003
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Methods of inhibiting sphincter incontinence
    Patent number: 6635660
    Abstract: This invention comprises methods of inducing or maintaining sphincter continence, or inhibiting or alleviating incontinence, in a mammal comprising administration of 2-(4-Hydroxy phenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl-1H-indol-5-ol
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: October 21, 2003
    Assignee: Wyeth
    Inventors: Simon Nicholas Jenkins, Timothy Michael Argentieri
  • Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
    Patent number: 6632824
    Abstract: The present invention includes compounds of formula I wherein A, X, n, Ar1, and Ar2 are defined as set forth herein. These compounds may be used to treat depression. The invention also includes formulations containing these compounds, and methods for making and using compounds of this invention.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: October 14, 2003
    Assignee: Wyeth
    Inventor: Adam M. Gilbert
  • Hormone replacement therapy
    Publication number: 20030191103
    Abstract: This invention relates to methods and pharmaceutical compositions for providing hormone replacement therapy in perimenopausal, menopausal, and postmenopausal women through the continuous administration of combinations of conjugated estrogens and trimegestone.
    Type: Application
    Filed: April 1, 2003
    Publication date: October 9, 2003
    Applicant: Wyeth
    Inventors: Gary S. Grubb, James H. Pickar, Ginger D. Constantine, Michael S. Dey
  • Serotonergic agents with long-acting in vivo effects
    Publication number: 20030191135
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: April 2, 2002
    Publication date: October 9, 2003
    Applicant: Wyeth
    Inventors: Wayne E. Childers, Michael G. Kelly, Lee E. Schechter, Sharon J. Rosenzweig-Lipson
  • Pablo, a polypeptide that interacts with Bcl-xL, and uses related thereto
    Publication number: 20030190709
    Abstract: The present invention relates, at least in part, to polypeptides which include Bcl-xL binding domains, novel Bcl-xL binding domains of Pablo polypeptides, nucleic acid molecules encoding such polypeptides, and uses thereof. For example, such polypeptides and nucleic acid molecules are useful in modulating apoptosis, particularly in neural cells, as well as in the treatment or prevention of disorders that can benefit from modulation of cell death.
    Type: Application
    Filed: April 4, 2002
    Publication date: October 9, 2003
    Applicant: Wyeth
    Inventors: Robert Mark, Kathleen H. Young, Andrew T. Wood
  • Treatment of Kaposi's sarcoma with IL-12
    Publication number: 20030190305
    Abstract: Methods are provided for using IL-12 to treat Kaposi's sarcoma (KS), particularly AIDS-associated KS.
    Type: Application
    Filed: December 2, 2002
    Publication date: October 9, 2003
    Applicant: Wyeth and National Institutes of Health
    Inventors: Robert Yarchoan, James M. Pluda, Kathleen Wyvill, Jill Lietzau, Gene M. Shearer, Ellen Feigal, Giovanna Tosato, Richard Little, Matthew L. Sherman
  • Hormone replacement therapy
    Publication number: 20030191097
    Abstract: This invention relates to methods and pharmaceutical compositions for providing hormone replacement therapy in perimenopausal, menopausal, and postmenopausal women through the continuous administration of combinations of conjugated estrogens and trimegestone.
    Type: Application
    Filed: April 1, 2003
    Publication date: October 9, 2003
    Applicant: Wyeth
    Inventors: Gary S. Grubb, James H. Pickar, Ginger D. Constantine, Michael S. Dey