Patents Assigned to Wyeth
  • CIRCOVIRUS SEQUENCES ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)
    Publication number: 20100221276
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Application
    Filed: January 11, 2010
    Publication date: September 2, 2010
    Applicant: WYETH
    Inventors: André JESTIN, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec
  • O-DESMETHYLVENLAFAXINE AND BAZEDOXIFENE COMBINATION PRODUCT AND USES THEREOF
    Publication number: 20100221445
    Abstract: A combination product containing at least two active compounds, O-desmethylvenlafaxine or a pharmaceutically acceptable salt thereof and bazedoxifene or a pharmaceutically acceptable salt thereof is described. Also described are methods of making and using this combination product to treat a variety of conditions associated with low circulating estrogen levels or low estrogen receptor activity.
    Type: Application
    Filed: April 30, 2010
    Publication date: September 2, 2010
    Applicant: Wyeth LLC
    Inventors: Syed M. Shah, Mahdi B. Fawzi, Christopher Richard Diorio
  • Therapeutic methods for muscular or neuromuscular disorders
    Patent number: 7785587
    Abstract: The disclosure provides methods for treating neuromuscular disorders in mammals. The disclosed methods include administering therapeutically effective amounts of a GDF-8 inhibitor and a corticosteroid to a subject susceptible to, or having, a neuromuscular disorder, so as to maintain desirable levels of muscle function.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: August 31, 2010
    Assignee: Wyeth
    Inventors: Lisa-Anne Whittemore, Xiangping Li
  • Purified form of tanaproget
    Patent number: 7786297
    Abstract: Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: August 31, 2010
    Assignee: Wyeth LLC
    Inventors: Ramarao Chatlapalli, Arwinder Nagi, John Potoski, Jean Louise Helom, Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Vladimir Dragan
  • Immunogenic compositions for the prevention and treatment of meningococcal disease
    Patent number: 7785608
    Abstract: The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
    Type: Grant
    Filed: September 2, 2003
    Date of Patent: August 31, 2010
    Assignee: Wyeth Holdings Corporation
    Inventors: Gary W. Zlotnick, Leah Diane Fletcher, John Erwin Farley, Liesel A. Bernfield, Robert J. Zagursky, Benjamin J. Metcalf
  • POLYMORPHS OF N2-(1,1'-BIPHENYL-4-YLCARBONYL)-N1-[2-(4-FLUOROPHENYL)-1,1-DIMETHYLETHYL]-L-ALPHA-GLUTAMINE
    Publication number: 20100216886
    Abstract: Disclosed are novel polymorphic forms of N2-(1,1?-biphenyl-4-ylcarbonyl)-N1-[2-(4-fluorophenyl)-1,1-dimethylethyl]-L-?-glutamine, methods of preparing the polymorphic forms, compositions containing the polymorphic forms, and methods of treatment using the polymorphic forms.
    Type: Application
    Filed: November 9, 2007
    Publication date: August 26, 2010
    Applicant: Wyeth
    Inventors: Qiuxia Wang, Jennifer Qianying Liang, Mannching Sherry Ku, Ronald Stanley Michalak, Wen James Huang
  • CIRCOVIRUS SEQUENCES ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)
    Publication number: 20100215690
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Application
    Filed: December 11, 2009
    Publication date: August 26, 2010
    Applicant: WYETH
    Inventors: André Jestin, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec
  • Substituted 3-cyanopyridines as protein kinase inhibitors
    Patent number: 7781591
    Abstract: The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: August 24, 2010
    Assignee: Wyeth LLC
    Inventors: Derek Cecil Cole, Diane Harris Boschelli, Yanong Daniel Wang, Magda Asselin, Diane Marie Joseph-McCarthy, Amarnauth Shastrie Prashad, Allan Wissner, Russell Dushin, Biqi Wu, Lawrence Nathan Tumey, Chuan S. Niu, Joan Chen
  • Use of CCI-779 as an antineoplastic agent
    Patent number: 7781446
    Abstract: This invention provides the use of CCI-779 in the treatment of neoplasms.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: August 24, 2010
    Assignee: Wyeth LLC
    Inventors: Gary Dukart, James J. Gibbons, Jr., Lisa Anne Speicher, Philip Frost, Carolyn Mary Discafani-Marro
  • Process for preparing quinoline compounds and products obtained therefrom
    Patent number: 7781427
    Abstract: Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: August 24, 2010
    Assignee: Wyeth LLC
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Jerry Sun
  • CIRCOVIRUS SEQUENCE ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)
    Publication number: 20100209453
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-strucutral polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccines, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Application
    Filed: April 28, 2010
    Publication date: August 19, 2010
    Applicant: WYETH
    Inventors: André JESTIN, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec
  • CIRCOVIRUS SEQUENCES ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)
    Publication number: 20100203072
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Application
    Filed: January 8, 2010
    Publication date: August 12, 2010
    Applicant: WYETH
    Inventors: André JESTIN, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec
  • Aryl Sulfonamides Useful for Modulation of the Progesterone Receptor
    Publication number: 20100204228
    Abstract: In one embodiment, compounds of the following structure are described, wherein R1 to R7 are described herein. Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; treating or preventing uterine leiomyomata; treating or preventing endometriosis, dysfunctional bleeding, and polycystic ovary syndrome; treating or preventing hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms using the compounds described herein.
    Type: Application
    Filed: April 15, 2010
    Publication date: August 12, 2010
    Applicant: Wyeth LLC
    Inventors: Casey Cameron McComas, Andrew Fensome, Michael Anthony Marella
  • Amino-pyridines As Inhibitors Of Beta-secretase
    Publication number: 20100204245
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: April 20, 2010
    Publication date: August 12, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, William Floyd Fobare, William Ronald Solvibile, JR., Frank Eldridge Lovering, Jeffrey Scott Condon, Albert Jean Robichaud
  • Bazedoxifene acetate formulations
    Patent number: 7771744
    Abstract: Bazedoxifene acetate formulations and compositions thereof having improved properties relating to reduction, elimination, or prevention of polymorphic conversion of bazedoxifene acetate, and processes for making such formulations and compositions. Components used in the formulations and compositions include a filler/diluent, an optional second filler/diluent, an optional antioxidant, a glidant/disintegrant, and a lubricant.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: August 10, 2010
    Assignee: Wyeth LLC
    Inventors: Syed M. Shah, Christopher R. Diorio, Eric C. Ehrnsperger, Kadum A. Ali
  • Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
    Patent number: 7771755
    Abstract: Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: August 10, 2010
    Assignees: Wyeth, Etex Corporation
    Inventors: Rebecca Li, Howard Seeherman, Hyun Kim
  • Altered fibronectin-binding protein of
    Patent number: 7771731
    Abstract: An isolated, altered fibronectin-binding protein (Fnb) of S. aureus having at least one mutation in an amino acid selected from residues corresponding to Gln103, Gln105, Lys157, Lys503, Lys620, Lys702, Lys762, Gln783 and Gln830 of FnbA of S. aureus strain ATCC49525 is described. Replacement of these reactive residues within the fibronectin-binding protein renders this protein less capable than wild-type Fnb of covalently cross-linking with fibronectin and fibrin. The altered fibronectin-binding protein effectively interferes with adhesion of S. aureus to fibronectin and fibrin, and therefore, an immunogenic composition comprising such altered Fnb exhibits improved immunogenic properties and is safer to use.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: August 10, 2010
    Assignee: Wyeth LLC
    Inventors: Yury Vladimirovich Matsuka, Steven Morris Baker, Elizabeth Teremy Anderson
  • Immunophilin Ligands and Methods for Modulating Immunophilin and Calcium Channel Activity
    Publication number: 20100196355
    Abstract: Immunophilin ligands and their uses as modulators of calcium channel activity are disclosed. Screening, therapeutic and prophylactic methods for conditions associated with calcium channel dysfunction, e.g., neurodegenerative and cardiovascular disorders, are also disclosed.
    Type: Application
    Filed: January 29, 2007
    Publication date: August 5, 2010
    Applicant: Wyeth
    Inventors: Edmund Idris Graziani, Benfang Helen Ruan, Kevin Pong, Mark Robert Bowlby
  • PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM
    Publication number: 20100196714
    Abstract: Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.
    Type: Application
    Filed: April 7, 2010
    Publication date: August 5, 2010
    Applicant: Wyeth
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Jerry Sun
  • Thioamide Derivatives as Progesterone Receptor Modulators
    Publication number: 20100197645
    Abstract: Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 5, 2010
    Applicant: Wyeth LLC
    Inventor: Bogdan Kazimierz Wilk