Patents Assigned to Wyeth
  • Analgesic and anti-inflammatory compositions containing Cox-2-inhibitors
    Patent number: 7754753
    Abstract: The present invention is directed to an analgesic composition which consists essentially of a cyclooxygenase-2 inhibitor and a compound selected from the group consisting of non-steroidal anti-inflammatory drugs, acetaminophen and mixtures thereof. The present invention further is directed to a method for inducing analgesia through the administration of such a composition to a patient.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: July 13, 2010
    Assignee: Wyeth LLC
    Inventor: Stephen Allen Cooper
  • Finger-1 peptide analogs of the TGF-? superfamily
    Patent number: 7754689
    Abstract: Members of the TGF-? superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: July 13, 2010
    Assignee: Wyeth LLC
    Inventors: Zhijian Lu, Wei Liu, Jimin Zhang, Paul John Yaworsky, Stephane H. Olland, Christopher Todd Brown, Emily Sheng-ming Shen
  • Oxazolo-naphthyl acids
    Patent number: 7754747
    Abstract: The present invention relates to oxazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: July 13, 2010
    Assignee: Wyeth LLC
    Inventors: Thomas J. Commons, Richard P. Woodworth, Jr.
  • Process for the synthesis of progesterone receptor modulators
    Patent number: 7754895
    Abstract: Processes for preparing oxindoles, which can be utilized in the preparation of a variety of useful compounds, and methods for minimizing or preventing N-alkylation of amide containing compounds, including oxindoles, are provided.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: July 13, 2010
    Assignee: Wyeth LLC
    Inventors: Yanzhong Wu, Bogdan Kazimierz Wilk, Zhixian Ding, Xinxu Shi, Charles Chao Wu, Panolil Raveendranath, Haris Durutlic
  • Compositions and methods of use of ORF 554 from beta hemolytic streptococcal strains
    Patent number: 7754226
    Abstract: The present invention relates to compositions and methods of use comprising peptidyl-prolyl isomerase (PPI) polypeptides of group C and G streptococci and polynucleotides encoding same. The invention also relates to immunogenic compositions comprising the PPI polypeptides and polynucleotides, as well as antibodies and antibody fragments that bind the PPI polypeptides. In addition, the invention relates to methods of inducing an immune response in a subject against beta hemolytic streptococci using the immunogenic compositions, as well as conferring passive immunity by administering a therapeutic antibody or antibody fragment.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: July 13, 2010
    Assignee: Wyeth LLC
    Inventors: Ellen Murphy, Emily Mara Braunstein, Dorys Garcia-Hand, Annaliesa Sybil Anderson, Ingrid Lea Dodge, Eduardo Arturo Rojas
  • HUMANIZED ANTI-5T4 ANTIBODIES AND ANTI-5T4/CALICHEAMICIN CONJUGATES
    Publication number: 20100173382
    Abstract: Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.
    Type: Application
    Filed: October 16, 2009
    Publication date: July 8, 2010
    Applicant: Wyeth
    Inventors: Erwin R. Boghaert, Nitin K. Damle, Davinder S. Gill, Kimberly A. Marquette, Lioudmila Tchistiakova, Philip Ross Hamann, Arthur Kunz
  • METHODS FOR PURIFICATION OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES
    Publication number: 20100172894
    Abstract: Processes and methods of purifying or separating Single Domain Antigen Binding (SDAB) molecules that include one or more single binding domains (e.g., one or more nanobody molecules), substantially devoid of a complementary antibody domain and an immunoglobulin constant region, using Protein A-based affinity chromatography, are disclosed.
    Type: Application
    Filed: October 29, 2009
    Publication date: July 8, 2010
    Applicant: WYETH
    Inventors: Paul R. Brown, Scott Andreas Tobler, Andrew M. Wood, Austin Wayne Boesch
  • CIRCOVIRUS SEQUENCES ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)
    Publication number: 20100172924
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection is further provided. Pharmaceutical, including vaccines, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 8, 2010
    Applicant: WYETH
    Inventors: ANDRÉ JESTIN, EMMANUEL ALBINA, PIERRE LE CANN, PHILIPPE BLANCHARD, EVELYNE HUTET, CLAIRE ARNAULD, CATHERINE TRUONG, DOMINIQUE MAHE, ROLAND CARIOLET, FRANÇOIS MADEC
  • Sulfonylated heterocycles useful for modulation of the progesterone receptor
    Patent number: 7750038
    Abstract: Compounds of the following structure are provided, wherein n, R1-R3 and R6-R9 are defined below, as are methods of preparing and using these compounds for contraception; treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: July 6, 2010
    Assignee: Wyeth LLC
    Inventors: Casey Cameron McComas, Andrew Fensome
  • Methods and compositions for healing and repair of articular cartilage
    Patent number: 7749964
    Abstract: Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration and/or functional repair of articular cartilage tissue.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: July 6, 2010
    Assignee: Wyeth LLC
    Inventors: Renwen Zhang, Diane Peluso, Elisabeth Morris
  • N- or C- terminally modified small peptides
    Patent number: 7749969
    Abstract: N- or C-terminally modified small peptides having antiarrhythmic properties are disclosed, and in particular small peptides that possess improved pharmacokinetic properties such as having a reduced tendency to inhibit the activity of isozyme 3A4 of cytochrome P 450 oxidase. The invention further relates to uses of said compounds in the preparation of a medicament, and to pharmaceutical compositions comprising said compounds.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: July 6, 2010
    Assignees: Zealand Pharma A/S, Wyeth
    Inventors: Bjarne Due Larsen, Edward H. Kerns
  • Gel compositions for control of ecto-parasites
    Patent number: 7749527
    Abstract: Semi-solid compositions comprising metaflumizone, a gelling agent and a non-aqueous solvent. The semi-solid compositions of this invention may be topically administered to animals, and are useful for preventing or treating, ectoparasitic infestations in warm-blooded animals for prolonged periods of time.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: July 6, 2010
    Assignee: Wyeth LLC
    Inventors: Nahla Fattohi, Debora L. Guido, Shobhan Sabnis
  • Anti-TrkB monoclonal antibodies and uses thereof
    Patent number: 7750122
    Abstract: The present invention provides monoclonal antibodies for human TrkB. In certain embodiments the inventive antibodies bind and activate human TrkB. In certain embodiments the inventive antibodies are selective for human TrkB in that they do not bind (or activate) human TrkA or human TrkC. In some embodiments the inventive monoclonal antibodies cross-react with murine TrkB. Humanized or veneered versions of the inventive antibodies are also encompassed. Pharmaceutical compositions that comprise inventive antibodies are provided as are methods for preparing the inventive antibodies and methods of using these for treatment, detection or purification purposes.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: July 6, 2010
    Assignee: Wyeth LLC
    Inventors: Seongeun Cho, Davinder Singh Gill, Xiang Yang Tan, Ming Diana Qian
  • Imidazole Amines As Inhibitors Of Beta-secretase
    Publication number: 20100168091
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated 3-amyloid deposits or 3-amyloid levels in a patient.
    Type: Application
    Filed: March 5, 2010
    Publication date: July 1, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Keith Douglas Barnes, Matthew Robert Johnson
  • Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone Compounds For The Inhibition Of Beta-secretase
    Publication number: 20100168194
    Abstract: The present invention provides compounds and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: March 10, 2010
    Publication date: July 1, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Albert Jean Robichaud, Alexander Michael Porte, Koi Michele Morris, William R. Solvibile, Ji-In Kim, Schuyler Adam Antane
  • Anti A Beta Antibody Formulation
    Publication number: 20100166752
    Abstract: The present invention provides formulations for maintaining the stability of A? binding polypeptides, for example, A? antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration.
    Type: Application
    Filed: December 14, 2009
    Publication date: July 1, 2010
    Applicants: Janssen Alzheimer Immunotherapy, Wyeth LLC
    Inventors: Nicholas W. Warne, Donna Luisi, Angela Kantor
  • CIRCOVIRUS SEQUENCES ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)
    Publication number: 20100166791
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection is further provided. Pharmaceutical, including vaccines, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 1, 2010
    Applicant: WYETH
    Inventors: André Jestin, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec
  • Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation
    Publication number: 20100168106
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: March 8, 2010
    Publication date: July 1, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Methods and compositions with reduced opalescence
    Patent number: 7744890
    Abstract: Methods for reducing the opalescent appearance of a protein preparation by modifying the ionic strength of the preparation, as well as compositions, e.g., pharmaceutical compositions, of concentrated protein with decreased opalescence are disclosed. Purification methods which monitor and/or reduce the salt concentrations at selected steps are also disclosed.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: June 29, 2010
    Assignee: Wyeth LLC
    Inventors: Pilarin Elizabeth Nichols, Donna L. Luisi
  • Alpha amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4
    Patent number: 7745454
    Abstract: Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: June 29, 2010
    Assignees: Elan Pharmaceuticals, Inc., Wyeth
    Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Farouz, Christopher M. Semko, Ying-Zi Xu