Patents Assigned to Wyeth
  • Heterocyclic sulfonamide inhibitors of ? amyloid production
    Patent number: 7691884
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for determining ?-amyloid levels in a subject are described.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: April 6, 2010
    Assignees: Wyeth, ArQule, Inc.
    Inventors: Anthony Frank Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier
  • Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
    Patent number: 7691848
    Abstract: This invention provides pyrrolobenzodiazepine arylcarboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists, as well as pharmaceutical compositions and methods of treatment utilizing these compounds.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: April 6, 2010
    Assignee: Wyeth
    Inventors: Amedeo A. Failli, Dominick Quagliato, Patrick Andrae, Gavin D. Heffernan, Richard D. Coghlan, Emily S. Shen
  • Tricyclic 6-alkylidene-penems as ?-lactamase inhibitors
    Patent number: 7691842
    Abstract: The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof, wherein one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is O.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: April 6, 2010
    Assignee: Wyeth LLC
    Inventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Ado Mihira, Atul Agarwal, Hideki Ushirogochi, Yansong Gu, Satoshi Tamai, Fuk-Wah Sum
  • Recombinant Lubricin Molecules and Uses Thereof
    Publication number: 20100080848
    Abstract: Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.
    Type: Application
    Filed: November 23, 2009
    Publication date: April 1, 2010
    Applicant: WYETH
    Inventors: Carl Ralph Flannery, Christopher John Corcoran, Bethany Annis Freeman, Lisa A. Collins-Racie
  • GITR LIGAND AND GITR LIGAND-RELATED MOLECULES AND ANTIBODIES AND USES THEREOF
    Publication number: 20100080809
    Abstract: The present invention provides novel isolated and purified polynucleotides and polypeptides related to a novel ligand for glucocorticoid-induced TNF receptor (GITR). The invention also provides antibodies to the GITR ligand (GITRL). The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating disorders arising from disregulation of the immune system (e.g., autoimmune disorders, inflammatory diseases, and transplant rejection, and cancers and infectious diseases) using GITRL and/or modulators of GITRL. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of said disorders arising from disregulation of the immune system, as related to GITRL and GITR.
    Type: Application
    Filed: August 28, 2009
    Publication date: April 1, 2010
    Applicants: Wyeth, The Government of the United States
    Inventors: Mary Collins, Ethan Menahem Shevach, Rebecca Suzanne McHugh, Matthew James Whitters, Deborah Ann Young, Michael Chapman Byrne, Padmalatha S. Reddy, Geoffrey Laurence Stephens, Beatriz M. Carreno
  • SRC ACTIVATION FOR DETERMINING CANCER PROGNOSIS AND AS A TARGET FOR CANCER THERAPY
    Publication number: 20100081666
    Abstract: Methods of cancer diagnosis and prognosis using biomarkers.
    Type: Application
    Filed: July 14, 2009
    Publication date: April 1, 2010
    Applicant: Wyeth
    Inventors: Christina M. COUGHLIN, Michael E. BURCZYNSKI, Marisa P. DOLLED-FILHART, Robert PINARD, Donald WALDROM, Charles ZACHARCHUK, Frederick IMMERMANN, Maha KARNOUB, Jason CHRISTIANSEN, Mark GUSTAVSON, Annette MOLINARO, Alpana Waldron
  • Serotonin and norepinephrine reuptake inhibitors and uses thereof
    Patent number: 7687520
    Abstract: Selective dual serotonin and norepinephrine reuptake inhibitors are provided. These compounds have a lower side-effect profile and are useful in compositions and products for use in treatment of a variety of conditions including depression, fibromyalgia, anxiety, panic disorder, agorophobia, post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette Syndrome, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction, borderline personality disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, pain, Shy Drager syndrome, Raynaud's syndrome, Parkinson's Disease, and epilepsy.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: March 30, 2010
    Assignee: Wyeth LLC
    Inventors: Syed M. Shah, Mahdi B. Fawzi, Panolil Raveendranath, Eric C. Ehrnsperger
  • Substituted propylamine derivatives and methods of their use
    Patent number: 7687529
    Abstract: The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: March 30, 2010
    Assignee: Wyeth LLC
    Inventors: Casey Cameron McComas, Puwen Zhang, Eugene Anthony Terefenko, An Thien Vu, Stephen Todd Cohn
  • Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (FSH-R) antagonists
    Patent number: 7687623
    Abstract: The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: March 30, 2010
    Assignee: Wyeth LLC
    Inventors: Amedeo A. Failli, Dominick A. Quagliato, Gavin Heffernan, Richard D. Coghlan, Emily S. Shen
  • Methods for preparing sulfonamide substituted alcohols and intermediates thereof
    Patent number: 7687666
    Abstract: Processes for preparing amino alcohols or salts thereof and sulfonamide substituted alcohol compounds are provided. Desirably, the sulfonamide substituted alcohol compounds are heterocyclic sulfonamide trifluoroalkyl-substituted alcohol compounds or phenyl sulfonamide trifluoroalkyl-substituted alcohol compounds.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: March 30, 2010
    Assignee: Wyeth
    Inventors: Anita Wai-Yin Chan, Jianxin Ren, Mousumi Ghosh, Arkadiy Rubezhov, Panolil Raveendranath, Joseph Zeldis
  • Benzimidazole non-aqueous compositions
    Patent number: 7687471
    Abstract: The present invention provides a stable veterinary oral composition which comprises one or more surfactants, a water-miscible solvent, optionally an oil and an effective amount of each of a benzimidazole antihelmintic compound, such as triclabendazole and a macrocyclic lactone, such as moxidectin. Said composition is useful for treating and controlling endo- and ectoparasitic infection and infestation in a homeothermic animal.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: March 30, 2010
    Assignee: Wyeth LLC
    Inventors: Jon C. Hayes, Debora L. Guido, Jacob A. Zupan
  • Process for increasing RSV surface glycoprotein yields using a mutant strain of RSV
    Patent number: 7687240
    Abstract: A process for producing isolated and purified respiratory syncytial virus (RSV) fusion (F) and attachment (G) glycoproteins in eukaryotic cell cultures infected with RSV cold-passaged, temperature-sensitive mutant subgroup A2 strain cpts-248/404 results in at least a 5-fold increase in F and G protein yields when compared with the parent A2 strain. Immunogenic compositions comprising the F and/or G protein(s) produced by this process can be formulated for in vivo administration to a host to confer protection against disease caused by RSV.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: March 30, 2010
    Assignee: Wyeth Holdings Corporation
    Inventors: Firelli Alonso-Caplen, Mark Cutler, Mirelli Fino, Earl Pursell, Robert Repetto
  • [1,4]diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents
    Patent number: 7687620
    Abstract: Compounds of Formula I or a pharmaceutically acceptable salt thereof are provided: where R1 through R7 are defined herein. The compounds of Formula I are 5HT2c agonists or partial agonists, and are useful for treating a variety of disorders.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: March 30, 2010
    Assignee: Wyeth LLC
    Inventor: P. Sivaramakrishnan Ramamoorthy
  • CALCIUM PHOSPHATE DELIVERY VEHICLES FOR OSTEOINDUCTIVE PROTEINS
    Publication number: 20100074876
    Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Application
    Filed: September 23, 2009
    Publication date: March 25, 2010
    Applicants: Wyeth, Etex Corporation
    Inventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
  • RECOMBINANT LUBRICIN MOLECULES AND USES THEREOF
    Publication number: 20100074935
    Abstract: Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.
    Type: Application
    Filed: November 19, 2009
    Publication date: March 25, 2010
    Applicant: Wyeth
    Inventors: Carl Ralph Flannery, Christopher John Corcoran, Bethany Annis Freeman, Lisa A. Collins-Racie
  • Crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
    Patent number: 7683182
    Abstract: The present invention is directed to monohydrate and anhydrate crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: March 23, 2010
    Assignee: Wyeth LLC
    Inventors: Abdolsamad Tadayon, Silvio Iera, Hong Wen, Marc S. Tesconi, Mannching Sherry Ku
  • Crystalline polymorph of bazedoxifene acetate
    Patent number: 7683052
    Abstract: The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: March 23, 2010
    Assignee: Wyeth
    Inventors: Kadum A. Ali, Pietro Allegrini, Aldo Belli, Roberto Brescello, Vincenzo Cannata, Malama K. Chibwe, Livius Cotarca, Shridhar G. Gangolli, Carl E. Longfellow, Giorgio Soriato, Massimo Verzini
  • Substituted indoles and methods of their use
    Patent number: 7683091
    Abstract: The present invention relates generally to substituted indoles and methods of using them.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: March 23, 2010
    Assignee: Wyeth
    Inventors: Baihua Hu, James W. Jetter
  • Crystalline polymorph of bazedoxifene acetate
    Patent number: 7683051
    Abstract: The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: March 23, 2010
    Assignee: Wyeth
    Inventors: Christopher Demerson, Silvio Iera, Kadum A. Ali
  • Bottle
    Patent number: D612254
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: March 23, 2010
    Assignee: Wyeth
    Inventor: William Maskell