Patents Assigned to Wyeth
  • QUINOXALINE-BASED LXR MODULATORS
    Publication number: 20100120778
    Abstract: Disclosed are quinoxaline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): wherein: each of L1 and L2 is, independently, a bond, —O— or —NH—; R2 is C6-C10 aryl or heteroaryl including 5-10 atoms, each of which is (i) substituted with 1 R9, and (ii) optionally further substituted with from 1-4 Re; and each of R4 and R5 is, independently (i) hydrogen; or (ii) halo; or (iii) C1-C6 alkyl or C1-C6 haloalkyl, each of which is optionally substituted with from 1-3 Ra; and R1, R3, R6, R9, Ra and Re are defined herein. In general, these compounds can be used for treating or preventing one or more diseases, disorders, conditions or symptoms mediated by LXRs.
    Type: Application
    Filed: November 6, 2009
    Publication date: May 13, 2010
    Applicant: Wyeth
    Inventors: Baihua Hu, Jay Edward Wrobel, James Winfield Jetter, David John O'Neill, Charles William Mann, Rayomand Jal Unwalla
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20100120813
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: September 30, 2009
    Publication date: May 13, 2010
    Applicant: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • ENDOPARASITICIDAL GEL COMPOSITION
    Publication number: 20100120782
    Abstract: A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture of parasiticidal agents in a single application. This composition is useful for treating and controlling endoparasiticidal infection and infestation in a homeothermic animal.
    Type: Application
    Filed: January 22, 2010
    Publication date: May 13, 2010
    Applicant: Wyeth LLC
    Inventors: Shobhan S. Sabnis, Jon Hayes, Jack A. Zupan
  • 1-(ARYLSULFONYL)-4-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
    Publication number: 20100120779
    Abstract: The invention relates to 1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazole compounds of the Formula I: or a tautomer, stereoisomer, or pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: November 11, 2009
    Publication date: May 13, 2010
    Applicant: Wyeth
    Inventors: Simon Nicolas Haydar, Patrick Michael Andrae, Heedong Yun, Albert Jean Robichaud
  • Substituted Phenylsulfonamide Inhibitors of Beta Amyloid Production
    Publication number: 20100120725
    Abstract: Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer's disease and Down's syndrome are also described.
    Type: Application
    Filed: January 21, 2010
    Publication date: May 13, 2010
    Applicants: Wyeth LLC, ArQule, Inc.
    Inventors: Anthony Frank Kreft, Derek Cecil Cole, Kevin Roger Woller, Joseph Raymond Stock, Kristina Martha Kutterer, Dennis Martin Kubrak, Charles William Mann, William Jay Moore, David Scott Casebier
  • IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES
    Publication number: 20100120763
    Abstract: The invention relates to imidazo[5,1-c][1,2,4]benzotriazine derivatives of formula I: which are inhibitors of phosphodiesterase 2 or 10 useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type 2 diabetes, metabolic syndrome, glucose intolerance, and pain.
    Type: Application
    Filed: November 6, 2009
    Publication date: May 13, 2010
    Applicant: WYETH
    Inventors: Hans Stange, Barbara Langen, Ute Egerland, Norbert Hoefgen, Martina Priebs, Michael S. Malamas, James Joseph Erdei, Yike Ni
  • Triazine derivatives as inhibitors of phosphodiesterases
    Publication number: 20100120762
    Abstract: The invention relates to triazine derivatives of formula (I): which are inhibitors of phosphodiesterase 2 or 10, useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type 2 diabetes, metabolic syndrome, glucose intolerance, and pain.
    Type: Application
    Filed: November 6, 2009
    Publication date: May 13, 2010
    Applicant: WYETH
    Inventors: Hans Stange, Barbara Langen, Ute Egerland, Norbert Hoefgen, Martina Priebs, Michael S. Malamas, James Joseph Erdei, Yike Ni
  • MULTICOMPONENT IMMUNOGENIC COMPOSITION FOR THE PREVENTION OF BETA-HEMOLYTIC STREPTOCOCCAL (BHS) DISEASE
    Publication number: 20100119534
    Abstract: A number of ?-hemolytic streptococci polynucleotides and polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, are described. Two or more of the polypeptides of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing infection caused by ?-hemolytic streptococci.
    Type: Application
    Filed: November 4, 2009
    Publication date: May 13, 2010
    Applicant: Wyeth
    Inventors: Ingrid Lea Dodge, Eduardo Arturo Rojas, Annaliesa Sybil Anderson, Michael Hagen, Guyanand Singh
  • COMPATIBLE DISPLAY VECTOR SYSTEMS
    Publication number: 20100120634
    Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.
    Type: Application
    Filed: September 25, 2009
    Publication date: May 13, 2010
    Applicant: Wyeth
    Inventors: Simon Evan HUFTON, William James Jonathan FINLAY
  • Methods for treating asthmatic conditions
    Patent number: 7713964
    Abstract: This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: May 11, 2010
    Assignee: Wyeth LLC
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Arginine derivative wash in protein purification using affinity chromatography
    Patent number: 7714111
    Abstract: The invention relates to methods for isolating a product and/or reducing turbidity and/or impurities from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising an arginine derivative, and collecting the product using an elution solution. The invention further relates to a product prepared using a method as described herein.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: May 11, 2010
    Assignee: Wyeth LLC
    Inventors: Shujun Sun, Christopher Gallo
  • Processes for preparing gonadotropin releasing hormone receptor antagonists
    Patent number: 7714130
    Abstract: Methods of making Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists, comprising reacting a compound having Formula I: with a compound having formula Lg—(CR13R14)k—D, are disclosed.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: May 11, 2010
    Assignee: Wyeth
    Inventors: Alexander V. Gontcharov, Gulnaz Khafizova, John R. Potoski, Donna Mary Huryn
  • Substituted isoquinoline-1,3(2,4)-diones, 1-thioxo,1,4-dihydro-2-isoquinoline-3-ones and 1,4-dihyro-3 (2)-isoquinolones and methods of use thereof
    Patent number: 7713994
    Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: May 11, 2010
    Assignee: Wyeth LLC
    Inventors: Hwei-Ru Tsou, Semiramis Ayral-Kaloustian, Gary Harold Birnberg, Middleton Brawner Floyd, Joshua Kaplan, Kristina M. Kutterer, Xiaoxiang Liu, Ramaswamy Nilakantan, Mercy Adufa Otteng, Zhilian Tang, Arie Zask, Tritin Tran, Scott Christian Mayer, Annette L. Banker, Marvin Reich
  • COMPATIBLE DISPLAY VECTOR SYSTEMS
    Publication number: 20100113304
    Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.
    Type: Application
    Filed: September 25, 2009
    Publication date: May 6, 2010
    Applicant: WYETH
    Inventors: Simon Evan Hufton, William James Jonathan Finlay
  • LIQUID FORMULATIONS OF PHOSPHOLIPASE ENZYME INHIBITORS
    Publication number: 20100113443
    Abstract: The present invention relates to liquid formulations of inhibitors of phospholipase enzymes, such as cytosolic PLA2, compositions containing the same and processes for manufacture thereof.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 6, 2010
    Applicant: Wyeth
    Inventors: Mannching Sherry Ku, Frances Anne Donahue, Eugene Lee
  • CRYSTAL FORMS OF 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
    Publication number: 20100113541
    Abstract: The present invention is directed to monohydrate and anhydrate crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
    Type: Application
    Filed: December 18, 2009
    Publication date: May 6, 2010
    Applicant: Wyeth LLC
    Inventors: Abdolsamad TADAYON, Silvio IERA, Hong WEN, Marc S. TESCONI, Mannching Sherry KU
  • Antineoplastic Combinations of 4-Anilino-3-Cyanoquinolines and Capecitabine
    Publication number: 20100113474
    Abstract: A combination of a 4-anilino-3-cyanoquinoline compound (e.g. HKI-272, SKI-606, EKB-569) and a capecitabine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described.
    Type: Application
    Filed: August 4, 2009
    Publication date: May 6, 2010
    Applicant: Wyeth
    Inventors: Charles Michael Zacharhuk, Susan Elizabeth Quinn, Kenneth Kuan-Yuen Wang, Florence Marie Helene Binlich
  • PURIFICATION OF ACIDIC PROTEINS USING CERAMIC HYDROXYAPATITE CHROMATOGRAPHY
    Publication number: 20100113751
    Abstract: The present invention provides a method of removing product-related inactive or partially active species, high molecular weight aggregates, as well as other process-related impurities from preparations of acidic proteins by using ceramic hydroxyapatite chromatography.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Applicant: Wyeth
    Inventors: Shujun Sun, Yin Luo, Priscilla Jennings
  • Non-ribosomal peptide synthetases and associated biosynthetic genes
    Patent number: 7709620
    Abstract: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: May 4, 2010
    Assignee: Wyeth
    Inventors: John A. Hucul, Nathan Magarvey, Michael Greenstein
  • Multivalent pneumococcal polysaccharide-protein conjugate composition
    Patent number: 7709001
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 3 polysaccharide covalently linked to a carrier protein, the method including periodic acid oxidation of the polysaccharide in the presence of bivalent cations.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: May 4, 2010
    Assignee: Wyeth LLC
    Inventors: William P. Hausdorff, George Rainer Siber, Peter R. Paradiso, A. Krishna Prasad