Patents Assigned to Wyeth
  • Patent number: 9480736
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 1 polysaccharide covalently linked to a carrier protein, the method including partial de-O-acetylation of the polysaccharide by mild hydrolysis in an alkaline pH buffer.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: November 1, 2016
    Assignee: Wyeth LLC
    Inventors: William P. Hausdorff, George Rainer Siber, Peter R. Paradiso, A. Krishna Prasad
  • Publication number: 20160303051
    Abstract: Solid dose compositions comprising at least one low solubility pharmaceutically active ingredient, at least one low solubility filler and at least one controlled release agent. comprising at least one poorly soluble pharmaceutically active ingredient, a insoluble binder and at least one controlled release agent along with a method of manufacturing said composition are disclosed. Methods for making these compositions are also disclosed.
    Type: Application
    Filed: April 20, 2016
    Publication date: October 20, 2016
    Applicant: Wyeth LLC
    Inventors: Kevin Scott Kinter, Peter J. Ramsey
  • Publication number: 20160303252
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: May 3, 2016
    Publication date: October 20, 2016
    Applicant: Wyeth Holdings LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Patent number: 9469672
    Abstract: This invention relates to the application of hydroxyapatite chromatography to the purification of at least one antibody from a preparation containing high molecular weight aggregates. Further, this invention relates to an integration of ceramic hydroxyapatite chromatography into a combination chromatographic protocol for the removal of high molecular weight aggregates from an antibody preparation.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: October 18, 2016
    Assignee: Wyeth LLC
    Inventors: Shujun Sun, Christopher Gallo, Brian Kelley
  • Patent number: 9427416
    Abstract: The invention provides an oil-in-water emulsion useful in the treatment of anorectal disorders comprising a local anesthetic, vasoconstrictor, glycerin and water, and method of preparation of the emulsion and a method for treating hemorrhoids using the composition of the invention.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: August 30, 2016
    Assignee: Wyeth LLC
    Inventors: Gary Robert Agisim, Richard John Kenny, Miron Gerard Still, Ellen Bland Gilliam, Helen Elizabeth Taylor
  • Patent number: 9420819
    Abstract: The present invention relates to nutritional supplements that provide an adult with essential vitamins and minerals that may be lacking in the adult's diet and prevent chronic diseases, such as osteoporosis. A number of combinations of nutrients in set ratios are provided to increase the body's ability to absorb and use the nutrients. These combinations are important in helping the body reach the proper balance required for maximized function. Because adults over the age of 50 years have different nutritional needs, nutritional supplements specifically designed for them are also provided.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: August 23, 2016
    Assignee: Wyeth LLC
    Inventors: Richard Cotter, Randy Stodard
  • Patent number: 9398776
    Abstract: A nutritional supplement for adults fifty years and older, and methods of use thereof, are provided that are designed to be most effective in optimizing health, improving vitality and immunity, and improving, aiding, eye and bone health.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: July 26, 2016
    Assignee: Wyeth LLC
    Inventors: Richard Cotter, Charles Mohs, Lisa Dispensa, Paula Ziegler
  • Patent number: 9399060
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: July 26, 2016
    Assignee: Wyeth LLC
    Inventors: William P. Hausdorff, George Rainer Siber, Peter R. Paradiso
  • Patent number: 9399008
    Abstract: The present invention provides a taste-masked sunscreen composition comprising at least one sunscreen and a spider ester wherein the sunscreen and the spider ester are in intimate association. A method of making the taste—masked sunscreen composition is provided.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: July 26, 2016
    Assignee: Wyeth LLC
    Inventors: Bhalchandra Somabhai Patel, Jay Roberts Dickerson, Gary Robert Agisim, Richard John Kenny
  • Publication number: 20160185859
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: December 16, 2015
    Publication date: June 30, 2016
    Applicant: WYETH LLC
    Inventors: Erwin R. BOGHAERT, Nitin K. DAMLE, Philip Ross HAMANN, Kiran KHANDKE, Arthur KUNZ, Kimberly A. MARQUETTE, Lioudmila TCHISTIAKOVA, Davinder GILL, Sreekumar R. KODANGATTIL
  • Publication number: 20160176809
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 23, 2016
    Applicant: WYETH LLC
    Inventors: George Anello CHIARELLO, Ayman SAHLI
  • Publication number: 20160158345
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 9, 2016
    Applicant: Wyeth LLC
    Inventors: William P. Hausdorff, George Rainer Siber, Peter R. Paradiso
  • Patent number: 9351986
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 31, 2016
    Assignee: WYETH HOLDINGS LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis DiJoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Publication number: 20160144036
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Application
    Filed: January 29, 2016
    Publication date: May 26, 2016
    Applicant: Wyeth LLC
    Inventors: Mahdi B. FAWZI, Tianmin ZHU, Syed M. SHAH
  • Patent number: 9340774
    Abstract: Isolated and enriched tumor-initiating cell populations, methods for preparing the same, and uses thereof.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: May 17, 2016
    Assignee: Wyeth LLC
    Inventors: Marc Isaac Damelin, Kenneth G. Geles, Jonathon P. Golas, Erwin Boghaert, Bin-Bing S. Zhou
  • Patent number: 9314461
    Abstract: The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: April 19, 2016
    Assignee: Wyeth, LLC
    Inventors: Syed M. Shah, Christopher Richard Diorio, Eric C. Ehrnsperger, Xu Meng, Kadum A. Al Shareffi, Jonathan Marc Cohen
  • Publication number: 20160089521
    Abstract: An implantable catheter or shunt for draining fluid from a body cavity. The catheter or shunt body has a wall structure that carries one or more therapeutic agents in a manner enabling release of the therapeutic agent from the wall structure in situ after surgical implantation of the catheter or shunt body. The therapeutic agent can be gradually released over time to prevent infection, inhibit tissue ingrowths, and/or provide some other desired medicinal purpose. As an example, the therapeutic agent can be rapamycin or an mTOR inhibitor. According to some contemplated embodiments of the present invention, the therapeutic agent carried by the catheter/shunt is rechargeable or refillable in situ so that the therapeutic agent can be gradually released from the catheter/shunt over the expected useful life of the catheter/shunt.
    Type: Application
    Filed: December 10, 2015
    Publication date: March 31, 2016
    Applicant: Wyeth LLC
    Inventors: Deborah L. Dragoon, Jonathan Marc Cohen
  • Patent number: 9296795
    Abstract: Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesion carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: March 29, 2016
    Assignees: WYETH HOLDINGS, LLC., INHIBITEX, INC.
    Inventors: Viliam Pavliak, Steven Morris Baker, Subramonia Padmanaba Pillai
  • Patent number: 9279000
    Abstract: Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: March 8, 2016
    Assignee: Wyeth LLC
    Inventors: Wei-Qiang Willie Sun, Earl Joseph Pursell
  • Patent number: 9272030
    Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: March 1, 2016
    Assignees: JANSSEN SCIENCES IRELAND UC, WYETH LLC
    Inventors: Ronald Black, Jack Steven Jacobsen, Lioudmila Tchistiakova, Angela Widom, Davinder Gill, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Wagner Zago, Manuel J. Buttini, Gene G. Kinney