Patents Assigned to Wyeth
  • Compositions and methods for preparing serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
    Patent number: 9623100
    Abstract: The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carbonyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: April 18, 2017
    Assignee: Wyeth LLC
    Inventors: Stephen John Freese, Annaliesa Anderson, Viliam Pavliak, Kathrin Ute Jansen, Ingrid Lea Scully, Tracy Dee Scott, Jasdeep Singh Nanra, A. Krishna Prasad, Bruce Arthur Green
  • Immunogenic compositions for the prevention and treatment of meningococcal disease
    Patent number: 9623101
    Abstract: The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: April 18, 2017
    Assignee: Wyeth Holdings LLC
    Inventors: Gary W. Zlotnick, Leah Diane Fletcher, John Erwin Farley, Liesel A. Bernfield, Robert J. Zagursky, Benjamin J. Metcalf
  • Method to stabilize a dietary supplement to facilitate joint health in humans
    Patent number: 9592202
    Abstract: The present invention provides for compositions comprising glucosamine wherein the glucosamine has improved and/or enhanced stability. Additionally, the present invention provides for methods of stabilizing compositions for use in preparing an oral dosage form comprising glucosamine.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: March 14, 2017
    Assignee: WYETH LLC
    Inventors: Scott William Poxon, Denise Lowe Walters
  • Pharmaceutical Suspension Composition
    Publication number: 20170065567
    Abstract: An aqueous oral liquid pharmaceutical composition system with reduced propensity for agglomeration and phase separation which is particularly amendable to the suspension of one or more pharmaceutical actives that are substantially insoluble in water. The oral liquid pharmaceutical composition may further comprise pharmaceutical actives that are soluble in water and dissolve in the aqueous medium. In the composition of the invention both suspended and any dissolved active agents are distributed homogeneously.
    Type: Application
    Filed: November 11, 2016
    Publication date: March 9, 2017
    Applicant: Wyeth LLC
    Inventors: Jay Dickerson, William Mark, Annabelle Trimmer, David Jaeger, Amanda Alley
  • Membrane evaporation for generating highly concentrated protein therapeutics
    Patent number: 9586180
    Abstract: The present invention relates to methods of generating highly concentrated protein solutions, e.g., an antibody solution, a therapeutic protein solution, etc. The methods of the invention include membrane evaporation, such as evaporation of protein-free solvent from the protein solution, which concentrates the protein. The methods of the present invention result in protein solution concentrations not previously achievable by conventional ultrafiltration methods, e.g., protein solution concentrations of greater than about 260 grams of protein per liter of solution.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: March 7, 2017
    Assignee: Wyeth LLC
    Inventors: Glen Reed Bolton, Hari Acharya, Austin Wayne Boesch
  • Portable moist heat system
    Patent number: 9566186
    Abstract: A portable moist heat delivery system comprising a water vapor generating portion comprising a water vapor source and a heat source; a water vapor-air regulating portion, said water vapor-air regulating portion comprising a water vapor-air mixing layer, and a water vapor-air distribution layer; said water vapor generating portion and said water vapor-air regulating portion being in fluid communication; and said water vapor-air regulating portion having a latent heat delivery surface disposed adjacent said water vapor-air regulating portion which delivers moist heat at a preselected temperature range wherein about 15% to about 95% of the moist heat is latent heat of condensation. Methods include delivering improved pain relief, blood flow, relaxation, and reduced cardiac workload.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: February 14, 2017
    Assignee: Wyeth LLC
    Inventors: Vincent York-Leung Wong, Marina Belkin, Chad Kamil Hickson, Leroy Glenn Owens, Jr.
  • Stable formulations of rLP2086 antigens
    Patent number: 9556240
    Abstract: The present invention relates to stable formulations of Neisseria meningitis rLP2086 Subfamily B Antigens in immunogenic compositions. The present invention also relates to methods of preserving the conformation of Neisseria meningitis rLP2086 Antigens and methods for determining the potency of Neisseria meningitis rLP2086 antigens.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: January 31, 2017
    Assignee: Wyeth LLC
    Inventors: Lakshmi Khandke, Rasappa Arumugham, Bounthon Loun
  • Compatible display vector systems
    Patent number: 9523092
    Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: December 20, 2016
    Assignee: Wyeth LLC
    Inventors: Simon Evan Hufton, William James Jonathan Finlay
  • Antineoplastic combinations containing HKI-272 and vinorelbine
    Patent number: 9511063
    Abstract: A combination of HKI-272 compound and a vinorelbine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 6, 2016
    Assignee: WYETH LLC
    Inventor: Charles Michael Zacharchuk
  • Isolated cell comprising a nucleic acid encoding antibody inhibitors of gdf-8 and uses thereof
    Patent number: 9505831
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: November 29, 2016
    Assignee: Wyeth LLC
    Inventors: Jane Aghajanian, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein
  • FORMULATIONS FOR PARENTERAL DELIVERY OF COMPOUNDS AND USES THEREOF
    Publication number: 20160338946
    Abstract: The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
    Type: Application
    Filed: May 19, 2016
    Publication date: November 24, 2016
    Applicant: Wyeth, LLC
    Inventors: Syed M. Shah, Christian Ofslager, Mahdi B. Fawzi, Nataliya Bazhina
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 9492445
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 15, 2016
    Assignee: Wyeth, LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Single-Use, Disposable Strip for Application of Topical Compositions
    Publication number: 20160324735
    Abstract: A topical treatment strip comprising a substrate having two surfaces with a topical composition carried thereupon. The treatment strip can be used to treat two surfaces of subject such as both lips simultaneously. Methods include methods of manufacture and methods of use.
    Type: Application
    Filed: June 17, 2016
    Publication date: November 10, 2016
    Applicant: Wyeth LLC
    Inventor: Jian-Hwa Guo
  • TUMOR-INITIATING CELLS AND METHODS FOR USING SAME
    Publication number: 20160326496
    Abstract: Isolated and enriched tumor-initiating cell populations, methods for preparing the same, and uses thereof.
    Type: Application
    Filed: April 14, 2016
    Publication date: November 10, 2016
    Applicant: WYETH LLC
    Inventors: Marc Isaac Damelin, Kenneth G. Geles, Jonathon P. Golas, Erwin Boghaert, Bin-Bing S. Zhou
  • Multivalent pneumococcal polysaccharide-protein conjugate composition
    Patent number: 9480736
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 1 polysaccharide covalently linked to a carrier protein, the method including partial de-O-acetylation of the polysaccharide by mild hydrolysis in an alkaline pH buffer.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: November 1, 2016
    Assignee: Wyeth LLC
    Inventors: William P. Hausdorff, George Rainer Siber, Peter R. Paradiso, A. Krishna Prasad
  • CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES
    Publication number: 20160303252
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: May 3, 2016
    Publication date: October 20, 2016
    Applicant: Wyeth Holdings LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Burst Drug Release Compositions
    Publication number: 20160303051
    Abstract: Solid dose compositions comprising at least one low solubility pharmaceutically active ingredient, at least one low solubility filler and at least one controlled release agent. comprising at least one poorly soluble pharmaceutically active ingredient, a insoluble binder and at least one controlled release agent along with a method of manufacturing said composition are disclosed. Methods for making these compositions are also disclosed.
    Type: Application
    Filed: April 20, 2016
    Publication date: October 20, 2016
    Applicant: Wyeth LLC
    Inventors: Kevin Scott Kinter, Peter J. Ramsey
  • Removal of high molecular weight aggregates using hydroxyapatite chromatography
    Patent number: 9469672
    Abstract: This invention relates to the application of hydroxyapatite chromatography to the purification of at least one antibody from a preparation containing high molecular weight aggregates. Further, this invention relates to an integration of ceramic hydroxyapatite chromatography into a combination chromatographic protocol for the removal of high molecular weight aggregates from an antibody preparation.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: October 18, 2016
    Assignee: Wyeth LLC
    Inventors: Shujun Sun, Christopher Gallo, Brian Kelley
  • Composition and method for treating hemorrhoids and/or anorectal disorders
    Patent number: 9427416
    Abstract: The invention provides an oil-in-water emulsion useful in the treatment of anorectal disorders comprising a local anesthetic, vasoconstrictor, glycerin and water, and method of preparation of the emulsion and a method for treating hemorrhoids using the composition of the invention.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: August 30, 2016
    Assignee: Wyeth LLC
    Inventors: Gary Robert Agisim, Richard John Kenny, Miron Gerard Still, Ellen Bland Gilliam, Helen Elizabeth Taylor
  • Nutritional formulation
    Patent number: 9420819
    Abstract: The present invention relates to nutritional supplements that provide an adult with essential vitamins and minerals that may be lacking in the adult's diet and prevent chronic diseases, such as osteoporosis. A number of combinations of nutrients in set ratios are provided to increase the body's ability to absorb and use the nutrients. These combinations are important in helping the body reach the proper balance required for maximized function. Because adults over the age of 50 years have different nutritional needs, nutritional supplements specifically designed for them are also provided.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: August 23, 2016
    Assignee: Wyeth LLC
    Inventors: Richard Cotter, Randy Stodard