Abstract: A nutritional supplement for adults fifty years and older, and methods of use thereof, are provided that are designed to be most effective in optimizing health, improving vitality and immunity, and improving, aiding, eye and bone health.
Type:
Grant
Filed:
January 21, 2010
Date of Patent:
July 26, 2016
Assignee:
Wyeth LLC
Inventors:
Richard Cotter, Charles Mohs, Lisa Dispensa, Paula Ziegler
Abstract: The present invention provides a taste-masked sunscreen composition comprising at least one sunscreen and a spider ester wherein the sunscreen and the spider ester are in intimate association. A method of making the taste—masked sunscreen composition is provided.
Type:
Grant
Filed:
February 19, 2015
Date of Patent:
July 26, 2016
Assignee:
Wyeth LLC
Inventors:
Bhalchandra Somabhai Patel, Jay Roberts Dickerson, Gary Robert Agisim, Richard John Kenny
Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
Type:
Grant
Filed:
July 2, 2014
Date of Patent:
July 26, 2016
Assignee:
Wyeth LLC
Inventors:
William P. Hausdorff, George Rainer Siber, Peter R. Paradiso
Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
Type:
Application
Filed:
December 16, 2015
Publication date:
June 30, 2016
Applicant:
WYETH LLC
Inventors:
Erwin R. BOGHAERT, Nitin K. DAMLE, Philip Ross HAMANN, Kiran KHANDKE, Arthur KUNZ, Kimberly A. MARQUETTE, Lioudmila TCHISTIAKOVA, Davinder GILL, Sreekumar R. KODANGATTIL
Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
Type:
Application
Filed:
February 12, 2016
Publication date:
June 9, 2016
Applicant:
Wyeth LLC
Inventors:
William P. Hausdorff, George Rainer Siber, Peter R. Paradiso
Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Type:
Grant
Filed:
March 7, 2014
Date of Patent:
May 31, 2016
Assignee:
WYETH HOLDINGS LLC
Inventors:
Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis DiJoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
Type:
Application
Filed:
January 29, 2016
Publication date:
May 26, 2016
Applicant:
Wyeth LLC
Inventors:
Mahdi B. FAWZI, Tianmin ZHU, Syed M. SHAH
Abstract: The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
Type:
Grant
Filed:
July 31, 2013
Date of Patent:
April 19, 2016
Assignee:
Wyeth, LLC
Inventors:
Syed M. Shah, Christopher Richard Diorio, Eric C. Ehrnsperger, Xu Meng, Kadum A. Al Shareffi, Jonathan Marc Cohen
Abstract: An implantable catheter or shunt for draining fluid from a body cavity. The catheter or shunt body has a wall structure that carries one or more therapeutic agents in a manner enabling release of the therapeutic agent from the wall structure in situ after surgical implantation of the catheter or shunt body. The therapeutic agent can be gradually released over time to prevent infection, inhibit tissue ingrowths, and/or provide some other desired medicinal purpose. As an example, the therapeutic agent can be rapamycin or an mTOR inhibitor. According to some contemplated embodiments of the present invention, the therapeutic agent carried by the catheter/shunt is rechargeable or refillable in situ so that the therapeutic agent can be gradually released from the catheter/shunt over the expected useful life of the catheter/shunt.
Type:
Application
Filed:
December 10, 2015
Publication date:
March 31, 2016
Applicant:
Wyeth LLC
Inventors:
Deborah L. Dragoon, Jonathan Marc Cohen
Abstract: Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesion carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
Type:
Grant
Filed:
March 4, 2004
Date of Patent:
March 29, 2016
Assignees:
WYETH HOLDINGS, LLC., INHIBITEX, INC.
Inventors:
Viliam Pavliak, Steven Morris Baker, Subramonia Padmanaba Pillai
Abstract: Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided.
Type:
Grant
Filed:
December 19, 2013
Date of Patent:
March 8, 2016
Assignee:
Wyeth LLC
Inventors:
Wei-Qiang Willie Sun, Earl Joseph Pursell
Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
Type:
Grant
Filed:
April 22, 2011
Date of Patent:
March 1, 2016
Assignees:
JANSSEN SCIENCES IRELAND UC, WYETH LLC
Inventors:
Ronald Black, Jack Steven Jacobsen, Lioudmila Tchistiakova, Angela Widom, Davinder Gill, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Wagner Zago, Manuel J. Buttini, Gene G. Kinney
Abstract: A combination of a 4-anilino-3-cyanoquinoline compound (e.g. HKI-272, SKI-606, EKB-569) and a capecitabine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described.
Type:
Grant
Filed:
January 30, 2014
Date of Patent:
February 23, 2016
Assignee:
WYETH LLC
Inventors:
Charles Michael Zacharchuk, Susan Elizabeth Quinn, Kenneth Kuan-Yuen Wang, Florence Marie Helene Binlich
Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
Type:
Grant
Filed:
January 26, 2015
Date of Patent:
February 9, 2016
Assignee:
Wyeth LLC
Inventors:
Mahdi B. Fawzi, Tianmin Zhu, Syed M. Shah
Abstract: A pharmaceutical composition is provided which contains a water soluble acid salt of a sympathomimetic amine, e.g., pseudoephedrine, and an additive, e.g., a volatile amine or other odorant, that is co-distillable, e.g., by steam distillation, with the sympathomimetic amine and/or its derivatives, e.g., its free base.
Type:
Grant
Filed:
April 12, 2006
Date of Patent:
January 19, 2016
Assignee:
Wyeth LLC
Inventors:
David Hugh Giamalva, Gary Bruce Anderson
Abstract: The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.
Type:
Application
Filed:
July 24, 2015
Publication date:
January 7, 2016
Applicant:
WYETH LLC
Inventors:
Kenneth G. GELES, Bin-Bing Stephen ZHOU, Lioudmila Gennadievna TCHISTIAKOVA, Yijie GAO, Joel BARD
Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
Abstract: An extended regimen for treatment of HER-2/neu overexpressed/amplified cancer is described, with involves delivering a course of neratinib therapy to HER-2/neu overexpressed/amplified cancer patients following the completion of surgical and adjuvant therapy. The neratinib regimen may be continued for upwards of twelve months to five years. Also provided are pharmaceutical kits designed to facilitate compliance with the regimen.
Type:
Grant
Filed:
March 24, 2010
Date of Patent:
December 15, 2015
Assignee:
WYETH LLC
Inventors:
Anna Berkenblit, Florence Marie Helene Binlich, Paul Goss