Patents Assigned to Wyeth
  • MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION
    Publication number: 20090130137
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
    Type: Application
    Filed: January 22, 2009
    Publication date: May 21, 2009
    Applicant: Wyeth
    Inventors: William P. Hausdorff, George Rainer Siber, Peter R. Paradiso
  • 1,4,5,6,7,8-HEXAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY
    Publication number: 20090131409
    Abstract: Disclosed are chemical entities including compounds of Formula I and pharmaceutically acceptable salts thereof, wherein X is chosen from CN, CF3, CF2H, S(O)nR6, and S(O)2N(R9)R10; Y is chosen from CR11 and N; Z is chosen from O and NH; R3 is chosen from —C(O)R12 and —C(O)N(R9)R10; and n, R1, R2 and R4-R12 are defined herein; compositions comprising one or more such chemical entities; and methods of using one or more such chemical entities for modulating the activity of certain receptors (e.g., farnesoid X) or for the treatment or prevention of one or more symptoms of disease or disorder related to the activity of those receptors.
    Type: Application
    Filed: October 21, 2008
    Publication date: May 21, 2009
    Applicant: Wyeth
    Inventors: John Francis Mehlmann, Joseph Theodore Lundquist, IV, Paige Erin Mahaney, Matthew Lantz Crawley, Callain Younghee Kim
  • Glucuronide metabolites and epimers thereof of tigecycline
    Patent number: 7534766
    Abstract: A glucuronide metabolite of tigecycline, and its corresponding epimer, have been identified in humans treated with tigecycline. Mass spectral data have been used to identify these structures.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: May 19, 2009
    Assignee: Wyeth
    Inventors: Ronald A. Jordan, William DeMaio, Matthew Hoffmann
  • Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands
    Patent number: 7534801
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: May 19, 2009
    Assignee: Wyeth
    Inventor: Lynne Padilla Greenblatt
  • Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
    Patent number: 7534796
    Abstract: The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: May 19, 2009
    Assignee: Wyeth
    Inventors: Jeffrey C. Pelletier, John F. Rogers, Jr.
  • Biphenyloxy-acids
    Patent number: 7534894
    Abstract: The present invention relates generally to substituted biphenyloxy acids (such as 4?-aryl-amido-biphenyl-4(3)-yloxy-acids and 4?-aryl-amidomethyl-biphenyl-4(3)-yloxy-acids) and methods of using them, for example, as PAI-1 inhibitors.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: May 19, 2009
    Assignee: Wyeth
    Inventors: Thomas Joseph Commons, Susan Christman Croce, Eugene John Trybulski, Hassan Mahmoud Elokdah, David LeRoy Crandall
  • ALPHA-1D CALCIUM CHANNEL EXPRESSED IN ATRIUM
    Publication number: 20090124002
    Abstract: Novel calcium channel nucleic acids and polypeptides are disclosed herein. Methods of using the novel nucleic acids and polypeptides are also disclosed.
    Type: Application
    Filed: October 14, 2008
    Publication date: May 14, 2009
    Applicant: WYETH
    Inventor: RODRIGO FRANCO
  • Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
    Patent number: 7531542
    Abstract: The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: May 12, 2009
    Assignee: Wyeth
    Inventors: Daniel M. Green, Diane B. Hauze, Charles W. Mann, Jeffrey C. Pelletier, Matthew D. Vera
  • Phenylpiperazine cycloalkanol derivatives and methods of their use
    Patent number: 7531543
    Abstract: The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: May 12, 2009
    Assignee: Wyeth
    Inventors: Paige Erin Mahaney, Eugene John Trybulski, Lori Krim Gavrin, An Thien Vu
  • Substituted benzoxazoles as estrogenic agents
    Patent number: 7531564
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: May 12, 2009
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, C. Richard Lyttle
  • THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS
    Publication number: 20090118276
    Abstract: The present invention relates to compounds of formula la: and pharmaceutically acceptable salts thereof. The thieno[3,2-d]pyrimidine, thieno[2,3-d]pyrimidine, thieno[3,2-b]pyridine, thieno[2,3-b]pyridine, and pyrrolo[2,3-d]pyrimidine compounds selectively inhibit B-Raf kinase activity and are useful for treating disorders mediated by B-Raf kinase, and for the treatment of cancer.
    Type: Application
    Filed: October 31, 2008
    Publication date: May 7, 2009
    Applicant: Wyeth
    Inventors: Ariamala Gopalsamy, Mengxiao Shi, Dan Maarten Berger, Minu Dhanjisha Dutia, Nancy Torres, Darrin William Hopper
  • Mycoplasma Hyopneumoniae Avirulent Adjuvanted Live Vaccine
    Publication number: 20090117152
    Abstract: Provided are immunogenic and vaccine compositions and methods for their preparation and use, which compositions are effective in protecting against, minimizing the severity of, preventing, and/or ameliorating M. hyopneumoniae infection. Administration to an animal of one or two doses of an adjuvanted live avirulent M. hyopneumoniae composition disclosed herein is effective in providing immunity to the animal and protection from infection with a virulent strain of M. hyopneumoniae thereby reducing the severity of and/or preventing disease caused by one or more virulent strain of M. hyopneumoniae. Also provided are compositions, which further comprise one or more antigen such as, for example, one or more live bacteria, bacterin, toxoid, and/or virus and/or viral antigen. Exemplified are immunogenic compositions, comprising an adjuvanted live avirulent M.
    Type: Application
    Filed: November 5, 2008
    Publication date: May 7, 2009
    Applicant: Wyeth
    Inventors: Hsien-Jue Chu, Zhichang Xu, Wumin Li, Nicole Rae Gibson
  • Use of an mTOR inhibitor in treatment of uterine leiomyoma
    Patent number: 7528145
    Abstract: The invention provides for the use of an mTOR inhibitor in the treatment or inhibition of fibroids.
    Type: Grant
    Filed: October 21, 2005
    Date of Patent: May 5, 2009
    Assignee: Wyeth
    Inventor: Robert R. Ruffolo, Jr.
  • Polysaccharides of
    Patent number: 7527949
    Abstract: The invention is directed to immunogenic compositions comprising polysaccharides and polysaccharide-protein conjugates that are useful to induce or detect the production of antibodies specific for H. pylori. The invention is also directed to methods of purifying the H. pylori polysaccharides from bacteria. The polysaccharide may be incorporated into an immunogenic composition or used in vitro to assay for the presence of H. pylori antibodies in a sample or biological fluid.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: May 5, 2009
    Assignee: Wyeth Holdings Corporation
    Inventors: Mario Artur Monteiro, James Fulginiti, Deborah Ann Dilts
  • INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF
    Publication number: 20090111867
    Abstract: The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 receptor and to treat disorders responsive to such inhibition.
    Type: Application
    Filed: December 16, 2008
    Publication date: April 30, 2009
    Applicant: Wyeth
    Inventors: Youssef L. Bennani, Lawrence Nathan Tumey, Elizabeth Ann Gleason, Michael Joseph Robarge
  • CYCLOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS
    Publication number: 20090111802
    Abstract: This invention provides compounds of Formula (I): wherein R1 and R2 are independent substituents or are fused to form spirocyclic rings; R3, RC, and R4 are as defined herein; and R5 is a substituted benzene ring or a substituted five or six membered heterocyclic ring having in its backbone 1, 2, or 3 heteroatoms including O, S, SO, SO2 or NR6; or pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods using the compounds as antagonists of the progesterone receptor.
    Type: Application
    Filed: December 2, 2008
    Publication date: April 30, 2009
    Applicant: Wyeth
    Inventors: Puwen Zhang, Eugene A. Terefenko, Andrew Fensome, Jay E. Wrobel, Horace Fletcher, III, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley
  • Assay methods for detection of a virus in an avian tissue sample
    Patent number: 7524651
    Abstract: The invention relates to methods of detecting a virus in an avian tissue sample wherein genetic material derived from feathers is tested for the presence of genetic material from the virus.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: April 28, 2009
    Assignee: Wyeth
    Inventors: Venugopal K. Nair, Susan Jean Baigent, Richard John William Currie
  • 5-arylpyrimidines as anticancer agents
    Patent number: 7524849
    Abstract: This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: April 28, 2009
    Assignee: Wyeth Holdings Corporation
    Inventors: Nan Zhang, Semiramis Ayral-Kaloustian, Thai Nguyen
  • Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use
    Patent number: 7524846
    Abstract: The present invention is directed to arylalkyl- and cycloalkylalkyl-piperazine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: April 28, 2009
    Assignee: Wyeth
    Inventor: Paige Erin Mahaney
  • Calicheamicin conjugates
    Publication number: 20090105461
    Abstract: Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: August 4, 2008
    Publication date: April 23, 2009
    Applicant: Wyeth
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Erwin Raymond Arsene Boghaert, Philip Ross Hamann, Mark Edward Ruppen, Nitin Krishnaji Damle, Eugene Vidunas, Lyka Kalyandrug