Patents Assigned to Wyeth
  • 3-QUINOLINECARBONITRILE PROTEIN KINASE INHIBITORS
    Publication number: 20090062281
    Abstract: This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
    Type: Application
    Filed: September 23, 2008
    Publication date: March 5, 2009
    Applicant: Wyeth
    Inventors: Dan Maarten Berger, Dennis William Powell, Biqi Wu
  • Anti-IL-13 antibody formulations and uses thereof
    Publication number: 20090060906
    Abstract: Formulations suitable for treatment of disorders associated with undesirable expression or activity of IL-13 are provided.
    Type: Application
    Filed: January 9, 2008
    Publication date: March 5, 2009
    Applicant: Wyeth
    Inventors: Anthony B. Barry, Thomas J. Crowley, Daniel A. Dixon, Erin Christine Soley
  • NUCLEIC ACID ARRAYS FOR DETECTING GENE EXPRESSION IN ANIMAL MODELS OF INFLAMMATORY DISEASES
    Publication number: 20090062131
    Abstract: The present invention provides nucleic acid arrays and methods of using the same for detecting gene expression in animal models of osteoarthritis or other inflammatory diseases. The nucleic acid arrays of the present invention comprise polynucleotide probes for genes that are differentially expressed in osteoarthritis-affected cartilage tissues as compared to non-osteoarthritic cartilage tissues. In one embodiment, a nucleic acid array of the present invention comprises a plurality of polynucleotide probe sets, each of which is capable of hybridizing under stringent or nucleic acid array hybridization conditions to a different respective tiling sequence selected from Table C, or the complement thereof.
    Type: Application
    Filed: May 5, 2008
    Publication date: March 5, 2009
    Applicant: Wyeth
    Inventor: William Martin MOUNTS
  • Indolylalkylamine metabolites as 5-hydroxytryptamine-6 ligands
    Patent number: 7498327
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: March 3, 2009
    Assignee: Wyeth
    Inventors: Youchu Wang, Chia-Cheng Shaw, Ronald Charles Bernotas, Chung-Chiee Paul Wang, Ping Cai, Zhi Wang
  • Compositions containing piperacillin and tazobactam useful for injection
    Patent number: 7498312
    Abstract: An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: March 3, 2009
    Assignee: Wyeth Holdings Corporation
    Inventors: Jonathan Marc Cohen, Syed Muzafar Shah, Christian Luther Ofslager, Mahdi Bakir Fawzi
  • NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM
    Publication number: 20090054392
    Abstract: The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-?-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.
    Type: Application
    Filed: August 19, 2008
    Publication date: February 26, 2009
    Applicant: Wyeth
    Inventors: Jeffrey Claude Pelletier, Luciana de Araujo Felix, Daniel Michael Green, Diane Barbara Hauze, Joseph Theodore Lundquist, IV, Charles William Mann, John Francis Mehlmann, John Francis Rogers, JR., Matthew Douglas Vera, Albert John Molinari
  • COUPLING PROCESS FOR GENERATING REACTIVE BORON-CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2-CARBONITRILES TO PRODUCE BIARYLS
    Publication number: 20090054663
    Abstract: A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
    Type: Application
    Filed: September 26, 2008
    Publication date: February 26, 2009
    Applicant: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Jean Louise Helom
  • Nucleic acid molecule encoding a novel estrogen receptor beta variant
    Publication number: 20090054244
    Abstract: This invention relates to an isolated nucleotide fragment of a novel estrogen receptor, in particular, a novel ER? variant protein and isolated nucleic acid fragment comprising the coding regions of the genes encoding such variant proteins. Also provided are vectors, host cells, and methods for producing the novel ER? variant protein. The invention further relates to method of obtaining such nucleotide fragment and the method of determining the presence of such ER? variant protein in a sample.
    Type: Application
    Filed: November 21, 2007
    Publication date: February 26, 2009
    Applicant: Wyeth
    Inventors: Elaine Marie Quinet, Ermei Fan
  • SUBSTITUTED HETEROARYL BENZOFURAN ACIDS
    Publication number: 20090054484
    Abstract: The present invention relates generally to substituted heteroaryl benzofuran acids and methods of using them.
    Type: Application
    Filed: October 27, 2008
    Publication date: February 26, 2009
    Applicant: Wyeth
    Inventors: Hassan Mahmoud ELOKDAH, Geraldine Ruth McFARLANE, Scott Christian MAYER
  • 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof
    Patent number: 7495027
    Abstract: The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: February 24, 2009
    Assignee: Wyeth
    Inventors: Craig Eugene Caufield, Schuyler Adam Antane, Koi Michele Morris, Shaughnessy McGrath Naughton, Dominick Anthony Quagliato, Patrick Michael Andrae, Annmarie Enos, John F. Chiarello
  • Design of progesterone receptor ligands
    Patent number: 7496489
    Abstract: This invention relates to progesterone receptor/ligand complex, and related methods and software systems. Methods for designing and/or selecting ligands of the progesterone receptor using the three-dimensional structural coordinates of the progesterone receptor and/or nonsteroidal ligands are disclosed.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: February 24, 2009
    Assignee: Wyeth
    Inventors: Andrea M. Olland, James M. Wilhelm, Karl Malakian, Rayomand J. Unwalla
  • Antibodies against human or mouse IL-21 receptor
    Patent number: 7495085
    Abstract: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: February 24, 2009
    Assignees: Wyeth, Cambridge Antibody Technology Limited
    Inventors: Viia Valge-Archer, Andrew James Williams, Deborah A. Young, Matthew J. Whitters, Mary Collins, Joann Witek
  • Compounds useful as serotonin inhibitors and 5-HTagonists and antagonists
    Patent number: 7495111
    Abstract: 3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT1A receptor (agonizing or antagonizing) in a patient. These compounds are further useful for inhibiting binding to a serotonin receptor. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: February 24, 2009
    Assignee: Wyeth
    Inventors: P. Sivaramakrishnan Ramamoorthy, Zhongqi Shen, Boyd L. Harrison
  • Inhibitors of Protein Tyrosine Phosphatase 1B
    Publication number: 20090048286
    Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
    Type: Application
    Filed: September 23, 2008
    Publication date: February 19, 2009
    Applicant: Wyeth
    Inventors: Jinbo Lee, Steven J. Kirincich, Michael J. Smith, Douglas P. Wilson, Bruce C. Follows, Zhao-Kui Wan, Diane M. Joseph-McCarthy, David V. Erbe, Yan-Ling Zhang, Weixin Xu, Steve Y. Tam
  • AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE
    Publication number: 20090048320
    Abstract: The present invention provides compounds and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: March 21, 2008
    Publication date: February 19, 2009
    Applicant: WYETH
    Inventors: Michael Sotirios Malamas, Albert Jean Robichaud, Alexander Michael Porte, Koi Michele Morris, William R. Solvibile, Ji-In Kim
  • PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM
    Publication number: 20090048282
    Abstract: The present invention relates to pyrimidine sulfonamide analogs, methods of making pyrimidine sulfonamide analogs, compositions comprising a pyrimidine sulfonamide analog, and methods for treating canonical Wnt-?-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a pyrimidine sulfonamide analog.
    Type: Application
    Filed: August 14, 2008
    Publication date: February 19, 2009
    Applicant: Wyeth
    Inventors: Diane Barbara Hauze, Matthew Gregory Bursavich, Luciana de Araujo Felix, Adam Matthew Gilbert, Jeffrey Claude Pelletier
  • MODULATION OF BONE FORMATION
    Publication number: 20090047287
    Abstract: This invention relates to modulating Ror activity (e.g., Ror2 protein activity) and/or 14-3-3 ? to affect bone formation or resorption. The invention further relates to compositions and methods for the screening, diagnosis and development of therapies for bone-related disorders such as osteoporosis and bone fracture. Antibodies and antibody fragments directed to Ror2 protein are particularly useful in causing dimerization of Ror2 proteins, thereby leading to the activation of Ror2.
    Type: Application
    Filed: February 16, 2007
    Publication date: February 19, 2009
    Applicant: Wyeth
    Inventors: Julia Billiard, Yan Liu
  • Bench scale apparatus to model and develop biopharmaceutical cleaning procedures
    Patent number: 7490508
    Abstract: An apparatus for testing a cleaning procedure for a material. The apparatus includes a rack having a seat configured to retain a plurality of test coupons at a predetermined angle, an upper tray that distributes a solution along the lines of the rack, a lower tray for receiving solution passed over coupons disposed on the rack, a meter that gauges a flow rate of the solution, a thermostatic heater adapted to bring the solution to a predetermined temperature, and a variable speed pump that directs the solution from a reservoir to the upper tray.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: February 17, 2009
    Assignee: Wyeth Research Ireland Limited
    Inventors: Alfredo J. Canhoto, Rod J. Azadan, John Putnam, Michael Kreuze, Brian Williams, Kristen Nobles, Jeff Chapman, Kelli Barrett
  • Alkanol and cycloalkanol-amine derivatives and methods of their use
    Patent number: 7491723
    Abstract: The present invention is directed to alkanoyl and cycloalkanoyl-amine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: February 17, 2009
    Assignee: Wyeth
    Inventors: Eugene John Trybulski, Paige Erin Mahaney, Lori Krim Gavrin, William Jay Moore, Joseph Peter Sabatucci
  • Composition and method for treating lupus nephritis
    Patent number: 7491513
    Abstract: The present invention provides novel isolated BFLP0169 polynucleotides and polypeptides encoded by the BFLP0169 polynucleotides. Also provided are the antibodies that immunospecifically bind to a BFLP0169 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the BFLP0169 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the BFLP0169 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: February 17, 2009
    Assignee: Wyeth
    Inventors: Margot O'Toole, William Martin Mounts, Negin Shojaee