Patents Assigned to Wyeth
  • METHODS OF IDENTIFYING MODULATORS OF HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNELS
    Publication number: 20090029366
    Abstract: Methods, including high-throughput methods, for identifying modulators of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
    Type: Application
    Filed: March 27, 2008
    Publication date: January 29, 2009
    Applicant: Wyeth
    Inventors: Dmytro Vasylyev, Qiang Lu, Mark Bowlby, Edward Kaftan, Qin Shan
  • Quinoline Intermediates of Receptor Tyrosine Kinase Inhibitors and the Synthesis Thereof
    Publication number: 20090030197
    Abstract: This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I): wherein substitutions at LG?, PG, A, G, R1 and R4 are set forth in the specification.
    Type: Application
    Filed: August 28, 2008
    Publication date: January 29, 2009
    Applicant: WYETH
    Inventors: Warren Chew, Maria Papamichelakis, Youchu Wang
  • Amino-5,5-diphenylimidazolone derivatives for the inhibition of ?-secretase
    Patent number: 7482349
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: January 27, 2009
    Assignee: Wyeth
    Inventors: Michael S. Malamas, James J. Erdei, Iwan S. Gunawan, Ping Zhou, Yinfa Yan, Dominic A. Quagliato
  • Sulfonyl-3-heterocyclylindazole derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7482461
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: January 27, 2009
    Assignee: Wyeth
    Inventors: Kevin Liu, Albert Jean Robichaud, Jennifer Rebecca Lo, Hassan Mahmoud Elokdah
  • Arthritis-associated B cell gene expression
    Publication number: 20090022731
    Abstract: The invention features methods and compositions benefiting from differential gene expression observed in arthritis-associated B cells.
    Type: Application
    Filed: August 16, 2007
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: David Johannes von Schack, Matthew James Whitters, Kyriaki Dunussi-Johannopoulos, Mary Collins, Eugene Lee Brown
  • Transgenic animal model of bone mass modulation
    Publication number: 20090023905
    Abstract: The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
    Type: Application
    Filed: July 3, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: G. Roger Askew, Philip Babij, Frederick James Bex, III, Peter Van Nest Bodine
  • AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS
    Publication number: 20090023707
    Abstract: The present invention provides a compound of formula I: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
    Type: Application
    Filed: July 15, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Jonathan Laird Gross, Albert Jean Robichaud, Marla Jean Williams, Alessandro Mazzacani
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF HETEROCYCLIC SULFONAMIDE COMPOUNDS
    Publication number: 20090023930
    Abstract: Methods for preparing compound of formula (I) are described, wherein R1-R3 are defined herein, as are methods for preparing the intermediates formed therein. Also described are methods for enantioselectively preparing a chiral compound of the following structure, wherein R2 and R3 are defined herein.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Asaf Alimardanov, Antonia Nikitenko, Gregg Feigelson, John Potoski
  • INHIBITORS OF BETA AMYLOID PRODUCTION
    Publication number: 20090023801
    Abstract: Novel sulfonamide compounds useful in the treatment of conditions related to the production of beta-amyloid are described, as are routes to their preparation. The sulfonamide compounds are of the following structure, wherein R1-R3 are defined herein. Also provided are pharmaceutical compositions containing these compounds and/or prodrugs of these compounds and a physiologically compatible carrier. These compounds are specifically useful for inhibiting beta amyloid production, and treating Alzheimer's Disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Thomas J. Caggiano, Koi M. Morris, Boyd L. Harrison, Anthony F. Kreft, III, Dennis M. Kubrak, Dane M. Springer
  • PROCESS FOR THE PREPARATION OF TRIFLUOROALKYL-PHENYL AND HETEROCYCLIC SULFONAMIDES
    Publication number: 20090023903
    Abstract: A novel trifluoroacetylating agent, i.e., N-trifluoroacetylmorpholine, is described. This reagent is useful in the preparation of phenyl and heterocyclic sulfonamide compounds. Methods are therefore described for preparing sulfonamide compounds of the following structure, wherein R1 and R2 are defined herein, using N-trifluoroacetylmorpholine. The sulfonamide compounds that may be prepared as described herein include 5-chloro-thiophene-2-sulfonic acid [(1S,2R)-2-(3,5-difluoro-phenyl)-3,3,3-trifluoro-1-hydroxymethyl-propyl]-amide using N-trifluoroacetylmorpholine.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Terrence Joseph Connolly, Anita Wai-Yin Chan, Zhixian Ding, Mousumi Ghosh, Xinxu Shi, Jianxin Ren, Eric Hansen, Roger Farr, Michael MacEwan, Asaf Alimardanov, Antonia Nikitenko, John Potoski
  • Surface proteins of streptococcus pyogenes
    Publication number: 20090022753
    Abstract: ?-hemolytic streptococci polynucleotides, polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, and antibodies of these polypeptides are described. The polynucleotides, polypeptides, and antibodies of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing ?-hemolytic streptococcal infection, and for detecting ?-hemolytic streptococci in a biological sample.
    Type: Application
    Filed: November 3, 2006
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Stephen Bruce Olmsted, Robert John Zagursky, Elliott Bruce Nickbarg, Laurie Anne Winter
  • N'-(2-HALOBENZYLIDENE)SULFONYLHYDRAZIDES AS INTERMEDIATES IN THE MANUFACTURE OF ARYLSULFONYLINDAZOLES
    Publication number: 20090023925
    Abstract: The present invention provides N?-(2-halobenzylidene)sulfonylhydrazides of formula I Compounds of formula I are useful for the manufacture of 1-arylsulfonylindazole 5-HT6 ligands.
    Type: Application
    Filed: June 27, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Anita Wai-Yin Chan, Mahmut Levent, David Place, Panolil Raveendranath, Sanjay Raveendranth, Vijay Raveendranath, Girija Raveendranath, Xinxu Shi, Charles Wu
  • Antidepressant piperidine derivatives of heterocyclefused benzodioxans
    Patent number: 7479500
    Abstract: Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: January 20, 2009
    Assignee: Wyeth
    Inventors: Michael Byron Webb, Gary Paul Stack, Magda Asselin, Deborah Ann Evrard
  • 4-(2,4-dichloro-5-methoxyphenyl)amino-6-methoxy-7-{[5-substituted-amino)methyl]-3-furyl}-3-quinolinecarbonitriles as kinase inhibitors
    Patent number: 7479561
    Abstract: This invention relates to compounds having the structure of Formula I wherein R1, R2, R3, and R4 are described herein.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: January 20, 2009
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Jay Thomas Afragola, Asaf Alimardanov, Biqi Wu
  • DIFFERENTIAL EXPRESSION PROFILING ANALYSIS OF CELL CULTURE PHENOTYPES AND USES THEREOF
    Publication number: 20090017460
    Abstract: The present invention provides, among other things, systems and methods for identifying genes and proteins that regulate and/or are indicative of cell phenotypes based on expression profiling analysis. The present invention further provides methods of manipulating identified genes and proteins to engineer improved cell lines.
    Type: Application
    Filed: June 13, 2008
    Publication date: January 15, 2009
    Applicants: Wyeth, Dublin City University
    Inventors: Karin Anderson, Niall Barron, Martin Clynes, Dana L. Di Nino, Padraig Doolan, Patrick Gammell, Kathleen Kopycinski, Kevin M. McCarthy, Paula Meleady, Mark Melville, Chee-keng Ng, Ryan Nolan
  • Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
    Publication number: 20090018332
    Abstract: The invention relates to processes for the preparation of the bicyclic oxazine carboxaldehyde Compound 1: The invention also relates to the use of Compound 1 in the preparation of ?-lactamase inhibitors.
    Type: Application
    Filed: June 24, 2008
    Publication date: January 15, 2009
    Applicant: Wyeth
    Inventors: Kenneth Alfred Martin Kremer, Lalitha Krishnan, Aranapakam Mudumbai Venkatesan, Mellard Norman Jennings, Joseph Zeldis, Takao Abe, Tarek Suhayl Mansour, Henry Lee Strong
  • Methods for Preparing O-Desmethylvenlafaxine
    Publication number: 20090018365
    Abstract: The present invention provides an efficient method of making O-desmethyl-venlafaxine.
    Type: Application
    Filed: September 11, 2008
    Publication date: January 15, 2009
    Applicant: Wyeth
    Inventor: Beat T. Weber
  • METHODS AND COMPOSITIONS FOR MODULATING BMP-10 ACTIVITY
    Publication number: 20090017019
    Abstract: Methods and compositions for modulating cardiac, renal and vascular cell function and homeostasis using agonists and antagonists of BMP-10 are disclosed. In particular, methods for treating, preventing and/or diagnosing BMP-10-associated vascular, renal, fibrotic and cardiac conditions and/or disorders are disclosed. Screening methods for evaluating BMP-10 modulators, e.g., agonists and antagonists, are also disclosed.
    Type: Application
    Filed: May 30, 2008
    Publication date: January 15, 2009
    Applicant: Wyeth
    Inventors: Kathleen M. Shields, Debra D. Pittman, Jeffrey L. Feldman, Robert Martinez, Christine Huard
  • Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
    Publication number: 20090017064
    Abstract: The present invention relates to compositions and methods of eliciting a cross-protective immune response against a pathogenic porcine circovirus by administering to a pig an immunogenically effective amount of a type 1-type 2 chimeric porcine circovirus vaccine. The chimeric vaccine utilized for cross-protection may be administered as a single dose or as multiple doses. The invention further relates to protection of the pig from any one or more of the symptoms or sequelae associated with postweaning multisystemic wasting syndrome (PMWS). Moreover, the administering of the chimeric vaccine also results in reduction in the higher than average mortality associated with the high mortality type 2B strains of porcine circovirus.
    Type: Application
    Filed: July 9, 2008
    Publication date: January 15, 2009
    Applicant: Wyeth
    Inventors: Stephen Qitu Wu, Michael A. Gill, Hsien-Jue Chu
  • Therapeutic device
    Patent number: D585141
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: January 20, 2009
    Assignee: Wyeth
    Inventors: Mary Elaine Freeland, Donald Stephen Bretl, Kyle William Harris, Rick Pack, Angela M. Reed