Patents Assigned to Wyeth
  • Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile
    Patent number: 7365203
    Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Sylvain Daigneault, Ronald Stanley Michalak, Michel Bernatchez
  • MK2 interacting proteins
    Patent number: 7364870
    Abstract: The present invention relates to uses of proteins that bind MK2 to modulate inflammation. More particularly, the invention relates to uses of proteins that bind MK2 for treating condition that are related to inflammation. The invention is useful for treating inflammatory conditions, particularly those in which a decrease in inflammation would be therapeutically beneficial.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Yvonne M. Yannoni, Lih-Ling Lin
  • Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
    Patent number: 7365197
    Abstract: This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Dan Maarten Berger, Gary Harold Birnberg, Yanong Wang
  • Oxazole derivatives of tetracyclines
    Patent number: 7365087
    Abstract: This invention provides compounds of the formula: wherein A?, X and Y are defined in the specification. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini
  • Agents and Methods for Specifically Blocking CD28-Mediated Signaling
    Publication number: 20080095774
    Abstract: The instant invention provides compositions and methods for downmodulation of immune responses, e.g., autoimmune responses. For example, methods of downmodulating an immune response using agents that specifically block CD28-mediated signaling are provided. The subject methods are useful for both prophylactic and therapeutic downmodulation of immune responses.
    Type: Application
    Filed: July 31, 2007
    Publication date: April 24, 2008
    Applicant: Wyeth
    Inventors: Richard O'Hara, Ann Nagelin
  • SULFAMOYL-CONTAINING DERIVATIVES AND USES THEREOF
    Publication number: 20080096903
    Abstract: Sulfamoyl-containing compounds are disclosed, having utility as inhibitors of disease-related targets, such as Heat Shock Protein 90 (HSP90), and which are useful for treating disorders, e.g., proliferative disorders, including HSP90-mediated disorders. Methods for preparing and using the disclosed compounds are also described.
    Type: Application
    Filed: October 19, 2007
    Publication date: April 24, 2008
    Applicant: Wyeth
    Inventors: Jianxin Chen, Gerhard Sperl, Vincent Gullo, Lalitha Sista, Dallas Hughes, Yucai Peng, William Pierceall, Andrew Weiskopf, Jeremy Levin, Russell Dushin, Mercy Otteng
  • Processes for the synthesis of individual isomers of mono-peg CCI-779
    Publication number: 20080097093
    Abstract: Processes for preparing individual diastereomers of mono-pegylated rapamycin 42 ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) are provided.
    Type: Application
    Filed: October 16, 2007
    Publication date: April 24, 2008
    Applicant: Wyeth
    Inventor: Jerauld Skotnicki
  • CALCIUM PHOSPHATE DELIVERY VEHICLES FOR OSTEOINDUCTIVE PROTEINS
    Publication number: 20080096797
    Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Application
    Filed: December 17, 2007
    Publication date: April 24, 2008
    Applicants: Wyeth, Etex Corporation
    Inventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
  • Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
    Patent number: 7361773
    Abstract: A process for making a compound of the formula comprising dialkylating a benzodioxane aniline
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: April 22, 2008
    Assignee: Wyeth
    Inventors: Anita Wai-Yin Chan, Gregg Brian Feigelson, Joseph Zeldis, Ivo Ladislav Jirkovsky
  • Rescue of mumps virus from cDNA
    Patent number: 7361496
    Abstract: This invention relates to a method for recombinantly producing, via rescue of mumps virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom. Additional embodiments relate to methods of producing the mumps virus as an attenuated and/or infectious virus. The recombinant viruses are prepared from cDNA clones, and, accordingly, viruses having defined changes, including nucleotide/polynucleotide deletions, insertions, substitutions and re-arrangements, in the place of the genome are obtained.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: April 22, 2008
    Assignee: Wyeth
    Inventors: David K. Clarke, J. Erik Johnson, Mohinderjit S. Sidhu, Stephen A. Udem
  • Mutant forms of cholera holotoxin as an adjuvant
    Patent number: 7361355
    Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: April 22, 2008
    Assignees: Wyeth Holdings Corporation, The Regents of the University of Colorado, A Body Corporate
    Inventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
  • Botanical butter stick lip balm
    Publication number: 20080089916
    Abstract: A stick lip balm with efficacious amounts of natural moisturizer and organoleptic/sensory attributes of lip feel associated with moisturizers and emollients is provided. The lip balm of the invention comprises at least 90% botanically derived materials and can be formed into a stick sufficiently robust to substantially retain the stick shape under normal conditions of shipping, storage and usage. A method of making the stick lip balm is also provided.
    Type: Application
    Filed: September 28, 2007
    Publication date: April 17, 2008
    Applicant: Wyeth
    Inventors: Sara Vest Magee, John Oliver Bachert, Neil Partridge, Jay R. Dickerson
  • ION CHANNEL MODULATORS
    Publication number: 20080090891
    Abstract: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
    Type: Application
    Filed: December 12, 2007
    Publication date: April 17, 2008
    Applicant: Wyeth
    Inventors: Robert Zelle, Vincent Galullo, Hormoz Mazdiyasni
  • ActRIIB Fusion Polypeptides and Uses Therefor
    Publication number: 20080089897
    Abstract: Methods and compositions for inhibiting growth and differentiation factor-8 (GDF-8) activity in vitro and in vivo are provided. The methods and composition can be used for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or glucose homeostasis.
    Type: Application
    Filed: August 7, 2007
    Publication date: April 17, 2008
    Applicant: Wyeth
    Inventor: Neil Wolfman
  • Avian vaccine for protection against colibacillosis
    Patent number: 7357935
    Abstract: A genetic deletion mutant live E. coli vaccine suitable for mass application to poultry, including chickens, is provided. Also provided is a safe and effective method to protect poultry against the ravages of Escherichia coli bacillosis infection and disease in which a live mutant aroA-gene deleted E. coli immunogen is administered to chickens, turkeys and the like via mass application routes such as coarse sprays and drinking water.
    Type: Grant
    Filed: May 3, 2004
    Date of Patent: April 15, 2008
    Assignee: Wyeth
    Inventors: Henry H. Fan, Mahesh Kumar, Roberto Marcello La Ragione, Martin John Woodward
  • Thioamide derivatives as progesterone receptor modulators
    Patent number: 7358246
    Abstract: Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: April 15, 2008
    Assignee: Wyeth
    Inventor: Bogdan Kazimierz Wilk
  • Sulfonyltetrahydro-3H-benzo(e)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands
    Publication number: 20080085925
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a CNS disorder related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: September 6, 2007
    Publication date: April 10, 2008
    Applicant: Wyeth
    Inventors: Derek Cole, Magda Asselin
  • Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof
    Publication number: 20080085890
    Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
    Type: Application
    Filed: March 26, 2007
    Publication date: April 10, 2008
    Applicant: Wyeth
    Inventors: Hwei-Ru Tsou, Semiramis Ayral-Kaloustian, Gary Birnberg, Middleton Floyd, Joshua Kaplan, Kristina Kutterer, Xiaoxiang Liu, Ramaswamy Nilakantan, Mercy Otteng, Zhilian Tang, Arie Zask, Tritin Tran, Scott Mayer, Annette Banker, Marvin Reich
  • Arylamino-Arylpropanolamine Derivatives and Methods of Their Use
    Publication number: 20080085938
    Abstract: The present invention is directed to arylamino-arylpropanolamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Application
    Filed: October 2, 2007
    Publication date: April 10, 2008
    Applicant: Wyeth
    Inventors: An Thien Vu, Stephen Todd Cohn, Eugene Anthony Terefenko, William Jay Moore, Puwen Zhang, Paige Erin Mahaney, Eugene John Trybulski
  • Methods for identifying and using amyloid-inhibitory compounds
    Publication number: 20080085244
    Abstract: The present invention relates to identification of agents that pay a role in regulating brain amyloid-? (A?) levels in vivo. The invention provides compounds and methods of using such compounds to treat amyloidogenic conditions. It also provides a useful animal model for screening for and evaluating candidate amyloid inhibiting or therapeutic compounds. In particular, ovariectomy (ovx) and estrogen replacement were found to affect brain A?, levels in guinea pigs. Long-term ovx of guinea pigs resulted in increased levels of total brain A?, as compared to intact animals, and the A?42/A?40 ratio was also elevated. Treatment of ovx guinea pigs with ?17-estradiol for ten days partially reversed the ovx-associated increase in brain A? levels.
    Type: Application
    Filed: December 7, 2007
    Publication date: April 10, 2008
    Applicants: Wyeth, Nathan S. Kline Research Institute
    Inventors: Suzana Petanceska, Sam Gandy, Donald Frail