Patents Assigned to Wyeth
  • Methods for minimizing thioamide impurities
    Publication number: 20080071083
    Abstract: Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrile groups, and the products thereby are provided.
    Type: Application
    Filed: November 16, 2007
    Publication date: March 20, 2008
    Applicant: Wyeth
    Inventor: Bogdan Wilk
  • PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES
    Publication number: 20080071091
    Abstract: The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1 (PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.
    Type: Application
    Filed: November 28, 2007
    Publication date: March 20, 2008
    Applicant: Wyeth
    Inventors: Vladimir DRAGAN, John Potoski, Wayne McMahon, Jean Helom, Xinxu Shi
  • Use of LXR modulators for the prevention and treatment of skin aging
    Publication number: 20080070883
    Abstract: Disclosed herein are compounds for preventing or treating skin aging through the use of LXR modulators and methods of use thereof.
    Type: Application
    Filed: September 18, 2007
    Publication date: March 20, 2008
    Applicant: Wyeth
    Inventor: Sunil Nagpal
  • Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases
    Publication number: 20080070797
    Abstract: The present invention provides nucleic acid arrays and methods of using the same for expression profiling of human protease and/or osteoarthritis genes. The nucleic acid arrays of the present invention include one or more substrate supports. A substantial portion of all polynucleotide probes that are stably attached to the substrate support(s) can hybridize under stringent or nucleic acid array hybridization conditions to human protease or osteoarthritis genes. In one embodiment, the nucleic acid arrays of the present invention include a plurality of probe sets, each of which can hybridize under stringent or nucleic acid array hybridization conditions to a different respective tiling sequence selected from Attachment C, or the complement thereof.
    Type: Application
    Filed: August 8, 2007
    Publication date: March 20, 2008
    Applicant: Wyeth
    Inventor: William Mounts
  • Formulations for parenteral delivery of compounds and uses thereof
    Publication number: 20080070975
    Abstract: The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
    Type: Application
    Filed: August 3, 2007
    Publication date: March 20, 2008
    Applicant: Wyeth
    Inventors: Syed Shah, Christian Ofslager, Mahdi Fawzi, Natalyia Bazhina
  • Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2- methylpropionic acid and its pharmaceutical compositions
    Publication number: 20080070950
    Abstract: The present invention provides an amorphous form of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid. This invention also provides processes for preparing the amorphous form and pharmaceutical compositions including the amorphous form.
    Type: Application
    Filed: August 10, 2007
    Publication date: March 20, 2008
    Applicant: Wyeth
    Inventors: Eric Benjamin, Muhammad Ashraf, Ashwinkumar Jain
  • Methods for reducing or preventing liquid-liquid phase separation in high concentration protein solutions
    Publication number: 20080070230
    Abstract: Methods of formulating proteins at high concentrations in protein solutions, wherein the protein solutions lack or have reduced liquid-liquid phase separation are described. Such protein solutions are substantially clear and substantially homogenous. Additionally, methods of concentrating and purifying proteins using liquid-liquid phase separation are provided.
    Type: Application
    Filed: June 11, 2007
    Publication date: March 20, 2008
    Applicant: Wyeth
    Inventors: Li Li, Angela Kantor, Nicholas Warne
  • Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid and esters thereof
    Patent number: 7345032
    Abstract: The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid, and esters thereof.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: March 18, 2008
    Assignee: Wyeth
    Inventors: Bogdan K. Wilk, Galina Vid, Weiguo Liu, Xinxu Shi
  • Monoclonal antibody specific for an epitope of inactivated feline immunodeficiency-encoded glycoprotein
    Patent number: 7345152
    Abstract: The present invention provides a monoclonal antibody specific for an epitope which is unique to the surface protein component of an inactivated feline immunodeficiency virus (FIV) envelope glycoprotein. Said antibody is useful for the quantification of inactivated FIV or the determination of the potency of an inactivated FIV vaccine.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: March 18, 2008
    Assignee: Wyeth
    Inventor: Chengjin M. Huang
  • Method for excystation of sporocysts
    Patent number: 7344735
    Abstract: A process to excystate protozoal sporocysts involves treatment of an infected tissue sample with a sodium hypochlorite solution to stimulate excystation of the sporocysts from the tissue. Thereafter, removal of the sodium hypochlorite solution and treatment of the sample with a cell culture media as the excystation fluid eliminates incubation and subsequent washing steps using expensive reagents. The excystation fluid contains substantially no chelating agents, proteins, enzymes or bile acids.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: March 18, 2008
    Assignee: Wyeth
    Inventors: Neil J. Jennings, Kirsten I. Dinka
  • Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
    Patent number: 7345096
    Abstract: The present invention relates to the use of compounds and composition of compounds that modulate norepinephrine levels for the prevention and treatment of vasomotor symptoms, such as hot flush, caused by, inter alia, thermoregulatory dysfunctions.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: March 18, 2008
    Assignee: Wyeth
    Inventors: Darlene Coleman Deecher, Istvan Jozsef Merchenthaler, Liza Leventhal, Kimberly Jean Sipe, Lawrence Thomas O'Connor
  • UspA1 and UspA2 antigens of
    Patent number: 7344724
    Abstract: The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: March 18, 2008
    Assignees: Board of Regents, The University of Texas System, Wyeth Holdings Corporation
    Inventors: Eric J. Hansen, Christoph Aebi, Leslie D. Cope, Isobel Maciver, Michael J. Fiske, Ross A. Fredenburg
  • 1-Aryl- or 1-alkylsulfonyl-heterocyclybenzazoles as 5-hydroxytryptamine-6 ligands
    Publication number: 20080064684
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: September 6, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Michael Kelly, Derek Cole
  • Arginine derivative wash in protein purification using affinity chromatography
    Publication number: 20080064860
    Abstract: The invention relates to methods for isolating a product and/or reducing turbidity and/or impurities from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising an arginine derivative, and collecting the product using an elution solution. The invention further relates to a product prepared using a method as described herein.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Shujun Sun, Christopher Gallo
  • Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof
    Publication number: 20080064673
    Abstract: Progesterone receptor modulators of formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. These compounds are useful for contraception and hormone replacement therapy. Also provided are products containing these compounds.
    Type: Application
    Filed: September 12, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Casey McComas, Andrew Fensome, Edward Melenski
  • Dry powder compound formulations and uses thereof
    Publication number: 20080064743
    Abstract: The present invention provides lyophilized formulations comprising methylnaltrexone, and processes for preparation of provided formulations. Additionally provided are compositions and products containing the methylnaltrexone formulation, as well as methods for producing formulations, compositions and products. Provided formulations as well as compositions and products containing methylnaltrexone formulations are useful for preventing, treating delaying, diminishing or reducing the severity and/or incidence of side effects resulting from administration of analgesic opioids.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Syed Shah, Christian Ofslager
  • Methods for reducing protein aggregation
    Publication number: 20080064856
    Abstract: Methods of reducing aggregation of a protein or proteins in a formulation, and protein formulations having reduced aggregation properties are provided. The methods and formulations described herein maintain the biological activity of a protein and increase the shelf life of protein formulations.
    Type: Application
    Filed: March 19, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Nicholas Warne, Angela Kantor, Thomas Crowley, Erin Soley, Li Li, Nicholas Luksha, Edie Neidhardt
  • Arginine wash in protein purification using affinity chromotography
    Publication number: 20080064861
    Abstract: The invention relates to methods for isolating a product and/or reducing turbidity and/or impurities from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising arginine, and collecting the product using an elution solution. The invention further relates to a product prepared using a method as described herein.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventor: Shujun Sun
  • OXAZOLE DERIVATIVES OF TETRACYCLINES
    Publication number: 20080064667
    Abstract: This invention provides compounds of the formula: wherein A?, X and Y are defined in the specification. These compounds are useful as antibacterial agents.
    Type: Application
    Filed: December 13, 2006
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Phaik-Eng Sum, David How, Darrin Hopper, Matthew Vera, Joshua Sabatini
  • 6-Carboxy-normorphinan derivatives, synthesis and uses thereof
    Publication number: 20080064744
    Abstract: The present invention relates to compounds of formula I, synthesis thereof, and methods of using the same.
    Type: Application
    Filed: August 3, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Syed Shah, Kadum Ali, FangMing Kong, Tianmin Zhu, Charles Gombar