Patents Assigned to Wyeth
  • Mutant forms of cholera holotoxin as an adjuvant
    Publication number: 20070116715
    Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
    Type: Application
    Filed: December 15, 2006
    Publication date: May 24, 2007
    Applicants: Wyeth, University of Colorado
    Inventors: Bruce Green, Randall Holmes, Michael Jobling, Duzhang Zhu
  • Methods of treatment using oxytocin receptor agonists
    Publication number: 20070117794
    Abstract: Methods for treating and preventing anxiety, anxiety-related disorders, schizophrenia and schizophrenia-related disorders are described herein wherein said methods comprise the administration of oxytocin receptor agonists.
    Type: Application
    Filed: October 23, 2006
    Publication date: May 24, 2007
    Applicant: Wyeth
    Inventors: Zia Rahman, Lynn Resnick, Sharon Rosenzweig-Lipson, Robert Ring
  • Enantiomers of N-Desmethyl venlafaxine
    Publication number: 20070117870
    Abstract: The present invention provides enantiomers of N-Desmethyl venlafaxine, as well as their use in pharmaceutical compositions and medically useful treatments, particularly including central nervous system uses.
    Type: Application
    Filed: December 18, 2006
    Publication date: May 24, 2007
    Applicant: Wyeth
    Inventors: John Yardley, Andre Asselin
  • N-sulfonylheterocyclopyrrolyl-alkylamine compounds as 5-hydroxytryptamine-6 ligands
    Patent number: 7220756
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: May 22, 2007
    Assignee: Wyeth
    Inventor: Derek Cecil Cole
  • Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
    Patent number: 7220768
    Abstract: This Invention provides a compound of the Formula: wherein X is R1, R2, R3 and R4 are described in the specification and a pharmaceutical composition comprising the compound used for inhibiting replication of a herpes virus.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: May 22, 2007
    Assignee: Wyeth Holdings Corp.
    Inventor: Jonathan David Bloom
  • Methods of protein production using anti-senescence compounds
    Publication number: 20070110743
    Abstract: Methods of producing a protein in cell culture comprising an anti-senescence compound, such as the antioxidant carnosine, are provided. According to teachings of the present invention, cells grown in a cell culture medium comprising an anti-senescence compound exhibit increased viability and productivity. Furthermore, cell cultures grown in the presence of an anti-senescence compound exhibit decreased levels of high molecular weight aggregates in the cell culture medium.
    Type: Application
    Filed: October 24, 2006
    Publication date: May 17, 2007
    Applicant: Wyeth
    Inventors: Denis Drapeau, Yen-Tung Luan, Paul Thoday, Wenge Wang, Judy Chou
  • Methods for the treatment of anxiety and for identification of anxiolytic agents
    Publication number: 20070111929
    Abstract: Methods for the treatment of neuropsychiatric disorders such as anxiety are disclosed. The methods involve modulating the expression of the angiotensin IV receptor or modulating the biological activity of the angiotensin IV receptor by utilizing antagonists to the receptor. Also disclosed are methods for identifying antagonists of the angiotensin IV receptor that are effective to reduce anxiety in a subject.
    Type: Application
    Filed: August 23, 2006
    Publication date: May 17, 2007
    Applicant: Wyeth
    Inventors: Chad Beyer, Robert Mark
  • Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus
    Patent number: 7217730
    Abstract: The invention is directed to methods of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: Wherein substitutions at R1, R2, R3—R12, and Y are set forth in the specification.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: May 15, 2007
    Assignees: Wyeth, ViroPharma Incorporated
    Inventors: Ariamala Gopalsamy, John W. Ellingboe, Tarek S. Mansour, Stephen M. Condon, Matthew G. Laporte, Christopher J. Burns, Kaapjoo Park, Marc S. Collett
  • Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
    Publication number: 20070104721
    Abstract: A combination of temsirolimus and herceptin in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of herceptin and HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing herceptin, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described.
    Type: Application
    Filed: November 2, 2006
    Publication date: May 10, 2007
    Applicant: Wyeth
    Inventors: Laurence Moore, Charles Zacharchuk, Sridhar Rabindran
  • Antineoplastic combinations of temsirolimus and sunitinib malate
    Publication number: 20070105887
    Abstract: A combination of temsirolimus and sunitinib malate in the treatment of cancer is provided. Also provided are regimens and kits for treatment of renal cell carcinoma, containing temsirolium and sunitinib malate, optionally in combination with other anti-neoplastic or immune modulators.
    Type: Application
    Filed: November 2, 2006
    Publication date: May 10, 2007
    Applicant: Wyeth
    Inventor: Laurence Moore
  • 41-Methoxy isotope labeled rapamycin 42-ester
    Publication number: 20070105888
    Abstract: 41-methoxy-labeled rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) compounds are provided, along with methods for the synthesis and use thereof.
    Type: Application
    Filed: November 3, 2006
    Publication date: May 10, 2007
    Applicant: Wyeth
    Inventors: Jianxin Gu, Mark Ruppen
  • AGGRECANASE STRUCTURE
    Publication number: 20070105207
    Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
    Type: Application
    Filed: August 24, 2006
    Publication date: May 10, 2007
    Applicant: WYETH
    Inventors: Lydia Mosyak, Thomas Rush, Stephane Olland, Edward LaVallie, Lisa Collins-Racie, Christopher Corcoran, Stewart Mackie
  • Pharmaceutical dosage forms and compositions
    Publication number: 20070099931
    Abstract: The invention relates to, for example, novel formulations and methods for the delivery of 4-cyano-N-{(2R)—2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-N-pyridin-2-yl-benzamide, pharmaceutically acceptable salts thereof, structurally related compounds and/or metabolites; as well as to use of these formulations and methods for treating disease.
    Type: Application
    Filed: September 6, 2006
    Publication date: May 3, 2007
    Applicant: Wyeth
    Inventors: Krishnendu Ghosh, Arwinder Nagi, Xiaohong Pan, Melissa Lin, Leonid Linberg, Ping Cai, Eric Browne, Michel Bernatchez, Mark Lankau, Sangeeta Raje
  • Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20070099911
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: October 27, 2006
    Publication date: May 3, 2007
    Applicant: Wyeth
    Inventors: Michael Kelly, Steven Lenicek, Yvette Palmer
  • Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20070099912
    Abstract: The present invention provides a compound of formula I or II and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: October 27, 2006
    Publication date: May 3, 2007
    Applicant: Wyeth
    Inventors: Ping Zhou, Yanfang Li
  • Antibiotic P175-A and semisynthetic derivatives thereof
    Patent number: 7211417
    Abstract: This invention relates to a new antibiotic designated P175-A, to production of fermentation of Micromonospora echinospora NRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic esters and ethers of P175-A.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: May 1, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Hui Yu Yang, Scott William Luckman, Valerie S. Bernan
  • Infectious bursitis vaccine
    Patent number: 7211260
    Abstract: The present invention is concerned with isolated infectious bursitis (or bursal) disease virus(es) and a vaccine containing said virus(es) which is capable of protecting poultry against disease caused by infectious bursitis virus, characterized in that the vaccine virus(es) has/have the combined properties of, upon administration to a chicken, causing a reduction in the bursal size, expressed as bursa/body weight ratio, of less than 55%, and the capability to protect poultry having an ELISA antibody titer of at least about 500.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: May 1, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Frans Gerrit Davelaar, Bernarda Johanna Pitstra, Nico Van Wiltenburg
  • Use of agents that modulate the interaction between PD-1 and its ligands in the downmodulation of immune responses
    Publication number: 20070092504
    Abstract: Disclosed are methods for downmodulating an immune response comprising contacting an immune cell with an agent that modulates the interaction between PD-1 and a PD-1 ligand (e.g., soluble forms of PD-1 or PD-1 ligand or antibodies to PD-1) to thereby modulate the immune response.
    Type: Application
    Filed: February 17, 2006
    Publication date: April 26, 2007
    Applicant: Wyeth
    Inventors: Beatriz Carreno, John Leonard
  • 5-Lipoxygenase modulators
    Publication number: 20070093524
    Abstract: The present invention provides the use of Liver X Receptor (LXR) modulators that have been identified to downregulate 5-lipoxygenase gene expression in order to treat various diseases and disorders that involve the function of the 5-LO protein in intracellular signaling (or other cellular processes) or the function of protein products downstream of 5-LO in intracellular signaling (i.e., leukotrienes).
    Type: Application
    Filed: October 6, 2006
    Publication date: April 26, 2007
    Applicant: Wyeth
    Inventors: Ponnal Nambi, Liang Chen, Elaine Quinet, Jay Wrobel
  • Compositions and methods for the treatment of canine influenza virus disease
    Publication number: 20070092537
    Abstract: Compositions, including vaccine compositions, and methods for treating, preventing or ameliorating canine influenza virus (CIV) disease by utilizing one or more canine influenza virus (CIV) or equine influenza virus (EIV) strain or immunogens thereof are set forth herein. Also set forth are challenge models useful in assessing the efficacy of a composition against canine influenza virus, comprising an equine influenza virus (EIV) or canine influenza virus (CIV) strain or immunogens thereof.
    Type: Application
    Filed: October 18, 2006
    Publication date: April 26, 2007
    Applicant: Wyeth
    Inventors: Yu-Wei Chiang, Hsien-Jue Chu, Michael Gill, Kim Gugisberg