Patents Assigned to Wyeth
  • Use of progesterone receptor modulators
    Publication number: 20070093548
    Abstract: A progesterone receptor modulator of the structure is provided. Use of compositions containing this compound for contraception, hormone replacement therapy, treating hormone-dependent disease, synchronizing estrus, treating dysmenorrhea, treating dysfunctional uterine bleeding, inducing amenorrhea, or treating symptoms of premenstrual syndrome and premenstrual dysphoric disorder in a mammal are described.
    Type: Application
    Filed: October 12, 2006
    Publication date: April 26, 2007
    Applicant: Wyeth
    Inventors: Jason Diffendal, Cuijian Yang, Richard Mewshaw
  • Compositions and methods for diagnosing and treating cancers
    Publication number: 20070092529
    Abstract: Compositions and methods for diagnosing, monitoring, or treating cancers. Genes encoding transmembrane proteins that are over-expressed in colon, lung, breast, prostate, liver, stomach, esophagus, or kidney cancer tissues are identified. These transmembrane genes can be used as biological markers for the detection or diagnosis of cancers. These genes can also serve as targets for cancer therapeutics. In addition, these genes can also be used for screening for anti-cancer drugs.
    Type: Application
    Filed: August 23, 2006
    Publication date: April 26, 2007
    Applicant: Wyeth
    Inventors: Xiaobing Be, Wei Liu, Donna Slonim, Steve Howes
  • Compositions employing a novel human protein phosphatase
    Patent number: 7208306
    Abstract: This invention provides compositions, organisms and methodologies employing a novel human gene encoding a protein that has sequence homology to a consensus sequence of calcineurin-like phosphoesterase family are disclosed. The novel protein is encoded by a human gene comprising 4 exons. The human gene is localized in the 10p15 locus of human chromosome 10. The sequence similarities between the novel human protein and the consensus sequence of calcineurin-like phosphoesterases indicate that the novel human protein may function as a calcineurin-like protein phosphatase.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: April 24, 2007
    Assignee: Wyeth
    Inventors: Wei Liu, Leeying Wu, Roger Ford, Xiaobing Be
  • Member of the lysyl oxidase gene family
    Patent number: 7208300
    Abstract: The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: April 24, 2007
    Assignee: Wyeth
    Inventors: Mark J. Evans, Marshall S. Scicchitano, Ashok R. Bapat, Ramesh A. Bhat, Robert Mastroeni, Sotirios K. Karathanasis
  • Ovo immunization against infectious bronchitis
    Patent number: 7208164
    Abstract: The present invention is directed to processes and compositions for protecting host animals (e.g., chickens) from exposure to virulent infectious bronchitis virus. In ovo administration of live, avirulent strains of IB at appropriate dosage levels on a per egg basis provides an effective and efficient vaccination having acceptable safety and efficacy features.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: April 24, 2007
    Assignee: Wyeth
    Inventors: Berend Jongsma, Frans Gerrit Davelaar, Marinus Wynand Westrate
  • Methods for preparing glutamic acid derivatives
    Publication number: 20070088172
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Application
    Filed: July 11, 2006
    Publication date: April 19, 2007
    Applicant: Wyeth
    Inventors: Ronald Michalak, Joseph Zeldis, Mel Jennings, David Blum, Timothy Doyle
  • Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections
    Publication number: 20070087014
    Abstract: Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesion carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
    Type: Application
    Filed: March 4, 2004
    Publication date: April 19, 2007
    Applicants: Wyeth, Inhibitex, Inc.
    Inventors: Viliam Pavliak, Steven Baker, Subramonia Pillai, Joseph Patti, Bradley Prater
  • Tetrahydroquinolines, synthesis thereof, and intermediates thereto
    Publication number: 20070088022
    Abstract: The present invention relates to methods for synthesizing compounds useful as 5HT2C agonists or partial agonists, derivatives thereof, and to intermediates thereto.
    Type: Application
    Filed: October 16, 2006
    Publication date: April 19, 2007
    Applicant: Wyeth
    Inventor: Gregg Feigelson
  • Rat TRPM7 polynucleotide and encoded protein
    Publication number: 20070083941
    Abstract: This invention relates to isolated nucleic acid and amino acid sequences of rat TRPM7 gene, expression cassettes nucleic acid sequences of rat TRPM7 gene, recombinant host cells comprising nucleic acid and amino acid sequences of rat TRPM7 gene, and methods of screening for modulators of the TRPM7 gene and protein.
    Type: Application
    Filed: October 3, 2006
    Publication date: April 12, 2007
    Applicant: Wyeth
    Inventors: Lan He, Kodangattil Sreekumar
  • Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
    Patent number: 7202239
    Abstract: The present invention provides novel tricyclic benzodiazepine carboxamides compounds and methods and pharmaceutical compositions utilizing them for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression suppression of preterm labor, suppression of labor at term prior to caesarean delivery, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: April 10, 2007
    Assignee: Wyeth
    Inventors: Amedeo Arturo Failli, Eugene John Trybulski, Jay Scott Shumsky, John Paul Dusza, Kevin Anthony Memoli
  • Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
    Patent number: 7202256
    Abstract: Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: April 10, 2007
    Assignee: Wyeth
    Inventors: Jianxin Gu, Mark E. Ruppen, Panolil Raveendranath, Warren Chew, Chia-Cheng Shaw
  • Modified and stabilized GDF propeptides and uses thereof
    Patent number: 7202210
    Abstract: Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: April 10, 2007
    Assignee: Wyeth
    Inventors: Neil M. Wolfman, Soo-Peang Khor, Kathleen N. Tomkinson
  • Multifunctional molecular complexes for gene transfer to cells
    Patent number: 7202227
    Abstract: A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided The complex is comprised of A) said nucleic acid composition and B) a transfer moiety comprising 1) one or more cationic polyamines bound to said nucleic acid composition, 2) one or more endosome membrane disrupting components attached to at least one nitrogen of the polyamine and 3) one or more receptor specific binding components.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: April 10, 2007
    Assignee: Wyeth
    Inventor: Raymond H. Boutin
  • Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors
    Patent number: 7199155
    Abstract: Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-?, such as rheumatoid arthritis, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease or HIV infection.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: April 3, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy Ian Levin, Mila Ti Du
  • Pharmaceutical compositions and methods of using secreted frizzled related protein
    Publication number: 20070072239
    Abstract: Methods and pharmaceutical compositions of use in regulation of mammalian bone-forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes such as tissue polarity, embryonic development, and tumorigenesis. Methods can be used to identify compounds which target the Wnt-antagonizing function of an SFRP by way of one or more domains or specific amino acids. Pharmaceutical compositions can be prepared using these compounds, and bone disorders can be treated using these pharmaceutical compositions.
    Type: Application
    Filed: September 1, 2006
    Publication date: March 29, 2007
    Applicant: Wyeth
    Inventors: Ramesh Bhat, Peter Bodine
  • Phenylaminopropanol derivatives and methods of their use
    Publication number: 20070072897
    Abstract: The present invention is directed to phenylaminopropanol derivatives of formulae I, II, and III: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.
    Type: Application
    Filed: September 27, 2006
    Publication date: March 29, 2007
    Applicant: Wyeth
    Inventors: Paige Mahaney, Gavin Heffernan, Richard Coghlan, Stephen Cohn, Callain Kim, Douglas Jenkins, Michael Marella, Casey McComas, Joseph Sabatucci, Eugene Terefenko, Eugene Trybulski, An Vu, Fei Ye, Puwen Zhang
  • Wnt-frizzled chimera
    Publication number: 20070072238
    Abstract: The present invention relates to a Wnt-Frizzled chimera. The present invention also relates to pharmaceutical compositions that can be screened or developed using Wnt-Frizzled chimeras. The methods and pharmaceutical compositions of the present invention can be used to treat bone disorders and cancer.
    Type: Application
    Filed: September 1, 2006
    Publication date: March 29, 2007
    Applicant: Wyeth
    Inventor: Ramesh Bhat
  • Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase
    Publication number: 20070072925
    Abstract: The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: September 25, 2006
    Publication date: March 29, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, William Fobare, Dominick Quagliato, Schuyler Antane, Albert Robichaud
  • Substituted propylamine derivatives and methods of their use
    Publication number: 20070072928
    Abstract: The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Application
    Filed: September 27, 2006
    Publication date: March 29, 2007
    Applicant: Wyeth
    Inventors: Casey McComas, Puwen Zhang, Eugene Terefenko, An Vu, Stephen Cohn
  • Benzothiadiazolylphenylalkylamine derivatives and methods of their use
    Publication number: 20070072918
    Abstract: The present invention is directed to benzothiadiazolylphenylalkylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Application
    Filed: September 27, 2006
    Publication date: March 29, 2007
    Applicant: Wyeth
    Inventors: Casey McComas, Puwen Zhang, Eugene Trybulski, An Vu, Eugene Terefenko