Abstract: Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring.
Type:
Grant
Filed:
April 4, 2012
Date of Patent:
February 10, 2015
Assignees:
The Board of Trustees of the University of Illinois, X-Body, Inc.
Inventors:
Brian T. Cunningham, Charles J. Choi, Alysia R. Watkins
Abstract: Provided are methods and compositions for the production of novel antibodies that bind specifically to a target anti gen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
Type:
Application
Filed:
March 14, 2012
Publication date:
April 24, 2014
Applicant:
X-BODY, INC.
Inventors:
Yan Chen, Tod M. Woolf, Richard W. Wagner
Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
Type:
Grant
Filed:
April 22, 2011
Date of Patent:
November 12, 2013
Assignee:
X-Body, Inc.
Inventors:
Brian T. Cunningham, Jane Pepper, Bo Lin, Peter Li, Homer Pien, Jean Qiu
Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
Type:
Grant
Filed:
June 19, 2012
Date of Patent:
October 8, 2013
Assignee:
X-Body, Inc.
Inventors:
Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, Bo Lin
Abstract: The present invention provides binding polypeptides (e.g., antibodies or fragments thereof) that specifically bind to a target antigen (e.g., a human antigen, e.g., human PDGFR?) with high affinity. The invention also provides, libraries of binding polypeptides, pharmaceutical compositions, as well as nucleic acids encoding binding polypeptides, recombinant expression vectors and host cells for making such binding polypeptides. Methods of using binding polypeptide of the invention to diagnose and treat disease are also encompassed by the invention.
Type:
Application
Filed:
December 5, 2012
Publication date:
July 11, 2013
Applicant:
X-Body, Inc.
Inventors:
Yan CHEN, Richard W. Wagner, Csaba Pazmany
Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.
Type:
Grant
Filed:
May 18, 2010
Date of Patent:
August 21, 2012
Assignee:
X-Body, Inc.
Inventors:
Homer Paul Pien, William C. Karl, Derek Puff, Peter Li, Brian Cunningham
Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
Type:
Grant
Filed:
April 13, 2010
Date of Patent:
June 19, 2012
Assignee:
X-Body, Inc.
Inventors:
Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
Abstract: The present invention features methods and compositions for the identification of molecules that facilitate the intracellular delivery of a, e.g., nucleic acid molecule. The methods and compositions of the invention utilize any display methodology wherein a library (e.g., a small molecule or protein library) is coupled to a nucleic acid (e.g., RNA or DNA) that encodes each library member.
Type:
Application
Filed:
February 16, 2010
Publication date:
January 5, 2012
Applicant:
X-Body, Inc.
Inventors:
Richard W. Wagner, Yan Chen, Steven Mark Shamah