Patents Assigned to Xencor, Inc.
  • BAFF variants and methods thereof
    Patent number: 7553930
    Abstract: The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of BAFF or APRIL-related disorders.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: June 30, 2009
    Assignee: Xencor, Inc.
    Inventors: John R. Desjarlais, Adam Read Thomason, Eugene Alexander Zhukovsky
  • Optimized Fc Variants and Methods for Their Generation
    Publication number: 20090142340
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 29, 2007
    Publication date: June 4, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Methods and compositions for inhibiting CD32B expressing cells
    Publication number: 20090136485
    Abstract: The present invention relates to immunoglobulins that bind Fc?RIIb+ cells and coengage the antigen on the cell's surface and an Fc?RIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
    Type: Application
    Filed: May 30, 2008
    Publication date: May 28, 2009
    Applicant: Xencor, Inc.
    Inventors: Seung Yup Chu, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Gregory L. Moore, Igor Vostiar
  • Optimized Fc variants and methods for their generation
    Publication number: 20090092599
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 9, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Publication number: 20090081208
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 26, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized Fc variants and methods for their generation
    Publication number: 20090068177
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 12, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Optimized FC Variants and Methods for Their Generation
    Publication number: 20090068175
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 29, 2007
    Publication date: March 12, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Novel Immunoglobulin Insertions, Deletions and Substitutions
    Publication number: 20090053240
    Abstract: An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more Fc?Rs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.
    Type: Application
    Filed: January 25, 2008
    Publication date: February 26, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Sher Bahadur Karki
  • Optimized Fc variants
    Publication number: 20090053211
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: May 5, 2005
    Publication date: February 26, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes, Jost Vielmetter
  • Optimized Fc variants
    Publication number: 20090042291
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: May 30, 2008
    Publication date: February 12, 2009
    Applicant: Xencor, Inc.
    Inventors: Seung Yup Chu, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Gregory L. Moore, Igor Vostiar
  • Fc Variants Having Decreased Affinity for FcyRIIb
    Publication number: 20090010920
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 15, 2007
    Publication date: January 8, 2009
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Wei Dang, John R. Desjartais, Sher Bahadur Karki, Omid Vafa, Robert Hayes
  • BMP-7 variants with improved properties
    Patent number: 7459527
    Abstract: The invention relates to variants of BMP-7 with improved properties and methods for their use.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: December 2, 2008
    Assignee: Xencor, Inc.
    Inventors: John R. Desjarlais, Shannon Alicia Marshall, Jonathan Zalevsky
  • Optimized Fc Variants and Methods for Their Generation
    Publication number: 20080292621
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 29, 2007
    Publication date: November 27, 2008
    Applicant: Xencor, Inc,
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Protein based TNF-? variants for the treatment of TNF-? related disorders
    Patent number: 7446174
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: November 4, 2008
    Assignee: Xencor, Inc.
    Inventors: John R. Desjarlais, Paul Michael Steed, Jonathan Zalevsky, David Edmund Szymkowski
  • Immunoglobulin Variants Outside the Fc Region
    Publication number: 20080248028
    Abstract: The present invention relates to antibody variants outside the Fc region that alter binding affinity to one or more effector ligands, methods for their generation, and their therapeutic application.
    Type: Application
    Filed: August 20, 2007
    Publication date: October 9, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Sher Bahadur Karki
  • Fc variants with optimized properties
    Publication number: 20080242845
    Abstract: The present invention relates to Fc variants with optimized properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized properties, and methods for using Fc variants with optimized properties.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 2, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Wei Dang, John R. Desjarlais, Sher Bahadur Karki
  • METHOD OF TREATMENT OF TH2-MEDIATED CONDITIONS USING OPTIMIZED ANTI-CD30 ANTIBODIES
    Publication number: 20080206242
    Abstract: A method of treating Th2-mediated conditions, e.g., atopic conditions, e.g., atopic asthma and/or atopic dermatitis, using effective amount of an antibody that targets CD30, where the antibody has at least one modification relative to a parent antibody and the antibody binds with altered affinity to an Fc?R or alters effector function as compared to the parent antibody.
    Type: Application
    Filed: February 1, 2008
    Publication date: August 28, 2008
    Applicant: Xencor, Inc.
    Inventors: Christopher E. Lawrence, Philip W. Hammond
  • Optimized Fc Variants and Methods for Their Generation
    Publication number: 20080181890
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 31, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kokl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Variants of RANKL protein
    Patent number: 7399829
    Abstract: The present invention relates to novel, soluble, recombinant variants RANKL (Receptor Activator of Nuclear Factor—?B Ligand) proteins, which may be expressed solubly in E. coli, variants that act as RANKL antagonists, and methods for generating the same.
    Type: Grant
    Filed: January 6, 2003
    Date of Patent: July 15, 2008
    Assignee: Xencor, Inc.
    Inventors: John R. Desjarlais, Jamal El Yazal, Rene S. Hubert, Shannon A. Marshall
  • Protein Design Automation for Protein Libraries
    Publication number: 20080167194
    Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 10, 2008
    Applicant: Xencor, Inc.
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Jorg Bentzien, Klaus M. Fiebig