Patents Assigned to Xencor, Inc.
  • Publication number: 20080167449
    Abstract: The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 10, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, John R. Desjarlais, Philip W. Hammond
  • Publication number: 20080161541
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: August 20, 2007
    Publication date: July 3, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Wei Dang, John R. Desjarlais, Sher Bahadur Karki, Omid Vafa, Robert Hayes
  • Publication number: 20080152649
    Abstract: The present invention describes antibodies that target IGF-1R, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification improves the sequence of said antibody and/or alters the effector function of said antibody. Also disclosed are methods of using the antibodies of the invention.
    Type: Application
    Filed: February 7, 2008
    Publication date: June 26, 2008
    Applicant: Xencor, Inc.
    Inventors: Aaron K. Chamberlain, Wei Dang, Gregory A. Lazar
  • Publication number: 20080154025
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: August 20, 2007
    Publication date: June 26, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Wei Dang, John R. Desjarlais, Sher Bahadur Karki, Omid Vafa, Robert Hayes
  • Patent number: 7381792
    Abstract: The present invention relates to novel, soluble, recombinant RANKL (Receptor Activator of Nuclear Factor—?B Ligand) variant proteins which may be expressed solubly in E. coli, variants that have substantially reduced binding to OPG, variants that act as RANKL antagonists, and methods for generating the same.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: June 3, 2008
    Assignee: Xencor, Inc.
    Inventors: John R. Desjarlais, Rene S. Hubert, Jamal El Yazal, Shannon A Marshall
  • Publication number: 20080113410
    Abstract: The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 15, 2008
    Applicant: Xencor, Inc.
    Inventors: John R. Desjarlais, Jonathan Zalevsky, Gregory L. Moore
  • Publication number: 20080070837
    Abstract: The invention relates to variants of BMP-4 with improved properties and methods for their use.
    Type: Application
    Filed: June 20, 2006
    Publication date: March 20, 2008
    Applicant: Xencor, Inc.
    Inventors: John R. Desjarlais, Shannon Alicia Marshall, Jonathan Zalevsky
  • Publication number: 20080057056
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: August 20, 2007
    Publication date: March 6, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20080051563
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: August 20, 2007
    Publication date: February 28, 2008
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Patent number: 7317091
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: January 8, 2008
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Publication number: 20070286859
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RI, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 21, 2007
    Publication date: December 13, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20070248602
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 25, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20070248603
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 21, 2007
    Publication date: October 25, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20070243188
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 21, 2007
    Publication date: October 18, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20070238665
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 11, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20070237765
    Abstract: The present invention relates to Fc variants having Increased affinity for Fc?RI, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 11, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20070237767
    Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 21, 2007
    Publication date: October 11, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20070237766
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 11, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Publication number: 20070231329
    Abstract: The present invention relates to Fc variants having increased affinity for Fc?RIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
    Type: Application
    Filed: June 15, 2007
    Publication date: October 4, 2007
    Applicant: Xencor, Inc.
    Inventors: Gregory Lazar, Wei Dang, John Desjarlais, Sher Karki, Omid Vafa, Robert Hayes
  • Patent number: 7276585
    Abstract: The present invention relates to antibody variants outside the Fc region that alter binding affinity to one or more effector ligands, methods for their generation, and their therapeutic application.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: October 2, 2007
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Sher Bahadur Karki