Patents Assigned to Xenon Pharmaceuticals Inc.
  • Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase
    Publication number: 20080167321
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, W, V, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 20, 2005
    Publication date: July 10, 2008
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Rajender Kamboj, Vishnumurthy Kodumuru
  • Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
    Patent number: 7390813
    Abstract: Novel compounds useful in the treatment of, prevention of or protection against diseases and/or conditions related to metabolic syndrome and lipid metabolism, especially diseases of fatty acid and cholesterol metabolism, such as those mediated by stearoyl-CoA desaturase, are disclosed along with methods of employing said compounds for such uses.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: June 24, 2008
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Mark P. Gray-Keller, Michael D. Winther, Richard M. Fine, Boris Klebansky, Heinz Gschwend, Daniel F. Harvey
  • Heterocyclic Derivatives and Their Use as Strearoyl-Coa Desaturase Inhibitors
    Publication number: 20080125434
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 20, 2005
    Publication date: May 29, 2008
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Rajender Kamboj, Zaihui Zhang, Jianmin Fu, Vandna Raina, Serguei Sviridov, Vishnumurthy Kodumuru, Nagasree Chakka, Shifeng Liu, Shaoyi Sun, Duanjie Hou
  • Heterocyclic Derivatives for the Treatment of Diseases Mediated by Stearoyl-Coa Desaturase Enzymes
    Publication number: 20080108629
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 20, 2005
    Publication date: May 8, 2008
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Rajender Kamboj, Zaihui Zhang, Jianmin Fu, Vishnumurthy Kodumuru, Shifeng Liu, Shaoyi Sun, Nagasree Chakka
  • Heterocyclic compounds and their uses as therapeutic agents
    Publication number: 20080103151
    Abstract: This invention is directed to heterocyclic compounds that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
    Type: Application
    Filed: April 20, 2006
    Publication date: May 1, 2008
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Mikhail Chafeev, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Rajender Kamboj, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Jianyu Sun, Serguei Sviridov
  • Heterocyclic Derivatives and Their Use as Stearoyl-Coa Desaturase Inhibitors
    Publication number: 20080096895
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 20, 2005
    Publication date: April 24, 2008
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Rajender Kamboj, Zaihui Zhang, Jian-Min Fu
  • Pyridazine derivatives and their use as therapeutic agents
    Patent number: 7335658
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: February 26, 2008
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael D Winther, Zaihui Zhang, Melwyn Abreo, Mark W Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz W Gschwend
  • HETEROCYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
    Publication number: 20080015230
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where y, G, K, L, M, W, V, R2, R3, R4, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 20, 2005
    Publication date: January 17, 2008
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Rajender Kamboj, Zaihui Zhang, Jian-Min Fu, Mehran Seid Bagherzadeh, Serguei Sviridov, Sultan Chowdhury, Shifeng Liu, Vishnumurthy Kodumuru
  • Heterocyclic Derivatives and Their Use as Mediators of Stearoyl-Coa Desaturase
    Publication number: 20070299081
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8, and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 20, 2005
    Publication date: December 27, 2007
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Rajender Kamboj, Zaihui Zhang, Jianmin Fu, Serguei Sviridov, Shaoyi Sun, Mehran Seid Bagherzadeh, Vandna Raina, Duanjie Hou, Sultan Chowdhury, Shifeng Liu, Vishnumurthy Kodumuru, Nagasree Chakka
  • Human elongase genes and uses thereof
    Patent number: 7297523
    Abstract: The present invention relates to elongase genes, their polypeptides and their control regions, and the use of such genes, polypeptides and control regions in determining compositions for use in the treatment of disease. The identified compositions regulate the expression of the elongase genes or modulate the activity of their protein products. The nucleotide and amino acid sequences are taught for ELG4, ELG6 and ELG7. The control sequences and function are taught for ELG1, ELG2, ELG3, ELG4, ELG5, ELG6 and ELG7.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: November 20, 2007
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Michael David Winther, Leah Christine Knickle, Martin Haardt, Stephen John Allen, Andre Ponton, Roberto Justo De Antueno, D. Kenneth Jenkins, Solomon O. Nwaka, Y. Paul Goldberg
  • High throughput screening assays using fatty acid synthetic enzymes
    Patent number: 7294480
    Abstract: High throughput screening assays for the identification of potential therapeutic agents able to modulate the activity of enzymes of fatty acid biosynthesis, especially desaturases and/or elongases, are disclosed along with therapeutic uses of the agents identified by such assays for the prevention and/or treatment of diseases related to fatty acid metabolism. Substrates useful in such assays are also described.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: November 13, 2007
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Michael D. Winther, Mark P. Gray-Keller
  • Bicyclic Heterocyclic Derivatives and Their Use as Inhibitors of Stearoyl-Coadesaturase (Scd)
    Publication number: 20070219211
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 20, 2005
    Publication date: September 20, 2007
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Rajender Kamboj, Jian-Min Fu, Vishnumurthy Kodumuru, Shifeng Liu, Kashinath Sadalapure, Nagasree Chakka, Duanjie Hou, Shaoyi Sun
  • Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5
    Patent number: 7232662
    Abstract: A cDNA encoding a novel human stearoy-CoA desaturase (dubbed “hSCD5”) as well as vectors and cells comprising such polynucleotide are disclosed. Also described are assay methods for determining the ability of small molecules and other chemical agents to increase or decrease the enzymatic activity and/or gene expression level of hSCD5 as well as processes for using such agents to treat, prevent or diagnose a variety of diseases and other conditions.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: June 19, 2007
    Assignee: Xenon Pharmaceuticals Inc.
    Inventor: Alison J. Brownlie
  • Oxindole compounds and their uses as therapeutic agents
    Publication number: 20070105820
    Abstract: This invention is directed to oxindole compounds that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
    Type: Application
    Filed: April 20, 2006
    Publication date: May 10, 2007
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Mikhail Chafeev, Nagasree Chakka, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Duanjie Hou, Tom Hsieh, Rajender Kamboj, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Jianyu Sun, Shaoyi Sun, Serguei Sviridov
  • Pyridyl derivatives and their use as therapeutic agents
    Publication number: 20060293308
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: July 29, 2004
    Publication date: December 28, 2006
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Melwyn Abreo, Daniel Harvey, Mikhail Kondratenko, Wenbao Li, Rajender Kamboj, Vishnumurthy Rodumuru, Michael Winther, Heinz Gschwend, Nagasres Chakka, Shifeng Liu, Serguei Sviridov, Shaoyi Sun
  • Heterocyclic compounds and their uses as therapeutic agents
    Publication number: 20060258659
    Abstract: This invention is directed to heterocyclic compounds that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
    Type: Application
    Filed: April 20, 2006
    Publication date: November 16, 2006
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Mikhail Chafeev, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Rajender Kamboj, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Jianyu Sun, Serguei Sviridov
  • Piperazine derivatives and their use as therapeutic agents
    Publication number: 20060252767
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: July 29, 2004
    Publication date: November 9, 2006
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael Winther, Heins Gschwend, Rajender Kamboj, Shaoyi Sun, Mark Holladay, Wenbao Li, Chi Tu
  • Spiroheterocyclic compounds and their uses as therapeutic agents
    Publication number: 20060252758
    Abstract: This invention is directed to spiroheterocyclic compounds of formula (I) wherein k, j, p, Q, R1, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
    Type: Application
    Filed: April 11, 2006
    Publication date: November 9, 2006
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Mikhail Chafeev, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Rajender Kamboj, Shifeng Liu, Mehran Seid Bagherzadeh, Jianyu Sun, Serguei Sviridov
  • Spiro-oxindole compounds and their uses as therapeutic agents
    Publication number: 20060252812
    Abstract: This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
    Type: Application
    Filed: April 11, 2006
    Publication date: November 9, 2006
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Mikhail Chafeev, Nagasree Chakka, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Duanjie Hou, Tom Hsieh, Rajender Kamboj, Shifeng Liu, Vandna Raina, Mehran Bagherzadeh, Jianyu Sun, Shaoyi Sun, Serguei Sviridov
  • Pyridazine derivatives and their use as therapeutic agents
    Publication number: 20060205713
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: July 29, 2004
    Publication date: September 14, 2006
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Heinz Gschwend, Vishnumurthy Kodumuru, Shifeng Liu, Rajender Kamboj