Patents Assigned to Xenon Pharmaceuticals Inc.
  • Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents
    Patent number: 6987001
    Abstract: The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids, wax esters, and the like, is disclosed. Also disclosed are conventions useful in the prevention and/or treatment of such diseases.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: January 17, 2006
    Assignees: Xenon Pharmaceuticals Inc., Wisconsin Alumni Research Foundation, University of British Columbia
    Inventors: Michael R. Hayden, Alison J. Brownlie, James M. Ntambi, Makoto Miyazaki, Mark P. Gray-Keller, Alan D. Attie
  • Pyridazine derivatives and their use as therapeutic agents
    Publication number: 20050065143
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: July 29, 2004
    Publication date: March 24, 2005
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael Winther, Zaihui Zhang, Melwyn Abreo, Mark Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz Gschwend