Patents Assigned to XenoPort
  • Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
    Patent number: 8143437
    Abstract: The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: March 27, 2012
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat, Cindy X. Zhou
  • Treating or preventing restless legs syndrome using prodrugs of GABA analogs
    Patent number: 8114909
    Abstract: Disclosed herein are methods of using prodrugs of gamma aminobutyric acid (GABA) analogs and pharmaceutical compositions thereof to treat or prevent restless legs syndrome in humans, and pharmaceutical compositions of prodrugs of GABA analogs useful in treating or preventing restless legs syndrome.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: February 14, 2012
    Assignee: XenoPort, Inc.
    Inventors: Ronald W. Barrett, Daniel M. Canafax
  • METHODS OF USING PRODRUGS OF PREGABALIN
    Publication number: 20120035258
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 9, 2012
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollman, Fayang G. Qiu
  • METHODS OF TREATING FRAGILE X SYNDROME, DOWN'S SYNDROME, AUTISM AND RELATED DISORDERS
    Publication number: 20120016021
    Abstract: Disclosed herein are methods of treating fragile X syndrome, fragile X-associated tremor/ataxia syndrome, Down's syndrome and other forms of mental retardation, and/or autism comprising administering a GABAB agonist prodrug to a subject suffering therefrom. The GABAB agonist prodrugs can be compounds of Formula (I), (II) or (III) as disclosed herein.
    Type: Application
    Filed: July 15, 2011
    Publication date: January 19, 2012
    Applicant: XENOPORT, INC.
    Inventors: David J. Wustrow, Peter A. Virsik, Mark A. Gallop
  • SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF
    Publication number: 20120010425
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Application
    Filed: August 11, 2011
    Publication date: January 12, 2012
    Applicant: XENOPORT, INC.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG
    Publication number: 20110313036
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: June 20, 2011
    Publication date: December 22, 2011
    Applicant: XenoPort, Inc.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Frauenfelder, Uwe Zacher
  • METHOD OF TREATMENT OF FRAGILE X SYNDROME, DOWN'S SYNDROME, AUTISM AND RELATED DISORDERS
    Publication number: 20110294879
    Abstract: Disclosed herein are methods of treating fragile X syndrome, fragile X-associated tremor/ataxia syndrome, Down's syndrome and/or autism, comprising administering a prodrug of acamprosate to a subject suffering therefrom, wherein, in certain embodiments, the acamprosate prodrugs comprise compounds of Formula (I).
    Type: Application
    Filed: May 27, 2011
    Publication date: December 1, 2011
    Applicant: XENOPORT, INC.
    Inventors: Bernd Jandeleit, Mark A. Gallop, Peter A. Virsik, David J. Wustrow
  • Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
    Patent number: 8067455
    Abstract: The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: November 29, 2011
    Assignee: XenoPort, Inc.
    Inventors: Feng Xu, Mark A. Gallop, Vivek Sasikumar, Usha Dilip
  • Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
    Patent number: 8062870
    Abstract: Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamate prodrugs are disclosed.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: November 22, 2011
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Ge Peng, Stephen P. Raillard
  • 2?-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions and uses thereof
    Patent number: 8058260
    Abstract: The present disclosure provides 2?-C-methyl-ribofuranosyl cytidine prodrugs, methods of making 2?-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions of 2?-C-methyl-ribofuranosyl cytidine prodrugs, and methods of using 2?-C-methyl-ribofuranosyl cytidine prodrugs and pharmaceutical compositions thereof to treat viral diseases such as hepatitis C.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: November 15, 2011
    Assignee: XenoPort, Inc.
    Inventor: Mark A. Gallop
  • Prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 8048917
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: November 1, 2011
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fenmei Yao, Jia-Ning Xiang
  • Crystalline form of ?-aminobutyric acid analog
    Patent number: 8026279
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: September 27, 2011
    Assignee: XenoPort, Inc.
    Inventors: Tono Estrada, Stephen P. Raillard
  • CRYSTALLINE FORM OF A (3S)-AMINOMETHYL-5-METHYL-HEXANOIC ACID PRODRUG AND METHODS OF USE
    Publication number: 20110224295
    Abstract: A crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug and methods of preparing a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug, and methods of using a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug are provided.
    Type: Application
    Filed: December 7, 2010
    Publication date: September 15, 2011
    Applicant: XenoPort, Inc.
    Inventors: Fenmei Yao, Mark A. Gallop, Ronald W. Barrett, Peter A. Virsik
  • Methods for synthesis of acyloxyalkyl compounds
    Patent number: 8017776
    Abstract: Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: September 13, 2011
    Assignee: XenoPort, Inc.
    Inventors: Laxminarayan Bhat, Mark A. Gallop
  • USE OF (3R)-4--3-(4-CHLOROPHENYL) BUTANOIC ACID FOR TREATING URINARY INCONTINENCE
    Publication number: 20110212984
    Abstract: Use of (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl) butanoic acid for treating urinary incontinence is disclosed.
    Type: Application
    Filed: March 1, 2011
    Publication date: September 1, 2011
    Applicant: XenoPort, Inc.
    Inventors: Aetna W. Wun, David J. Wustrow
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Patent number: 8003809
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: August 23, 2011
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria J. Ludwikow, Ge Peng, Seema Bhat
  • LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF
    Publication number: 20110201817
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: April 27, 2011
    Publication date: August 18, 2011
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning XIANG, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • Simple pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
    Patent number: 7994218
    Abstract: Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: August 9, 2011
    Assignee: XenoPort, Inc.
    Inventors: Bernd Jandeleit, Yunxiao Li, Mark A. Gallop, Noa Zerangue, Peter A. Virsik, Wolf-Nicolas Fischer
  • Methods of synthesizing -hydroxysuccinimidyl carbonates
    Patent number: 7989641
    Abstract: The present disclosure relates to methods of synthesizing N-hydroxysuccinimidyl-carbonate intermediates from the corresponding sulfones useful in the preparation of 1-(acyloxy)-alkyl carbamate prodrugs.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: August 2, 2011
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Peng Liu, Qunying Dai, Hao Yin
  • Levodopa prodrug mesylate, compositions thereof, and uses thereof
    Patent number: 7968597
    Abstract: (2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: June 28, 2011
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Xuedong Dai, Cindy X. Zhou, Jianhua Li, Mark Q. Nguyen