Patents Assigned to XenoPort
  • Levodopa prodrugs, and compositions and uses thereof
    Patent number: 7956212
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: June 7, 2011
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • PRODRUGS OF GAMMA-AMINO ACID, ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    Publication number: 20110130454
    Abstract: Prodrugs of alpha-2-delta ligands, pharmaceutical compositions of prodrugs of alpha-2-delta ligands, methods of making prodrugs of alpha-2-delta ligands, and methods of using prodrugs of alpha-2-delta ligands and pharmaceutical compositions of prodrugs of alpha-2-delta ligands to treat various diseases are disclosed.
    Type: Application
    Filed: November 24, 2010
    Publication date: June 2, 2011
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, David J. Wustrow
  • PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    Publication number: 20110124705
    Abstract: Prodrugs of alpha-2-delta ligands, pharmaceutical compositions of prodrugs of alpha-2-delta ligands, methods of making prodrugs of alpha-2-delta ligands, and methods of using prodrugs of alpha-2-delta ligands and pharmaceutical compositions of prodrugs of alpha-2-delta ligands to treat various diseases are disclosed.
    Type: Application
    Filed: November 24, 2010
    Publication date: May 26, 2011
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, David J. Wustrow
  • Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
    Patent number: 7935686
    Abstract: Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof, pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof, methods of making prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof, methods of using prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof and pharmaceutical compositions thereof for treating or preventing diseases or disorders such as spasticity or gastroesophageal reflux disease are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof and sustained release oral dosage forms thereof, which are suitable for oral administration, are also disclosed.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: May 3, 2011
    Assignee: XenoPort, Inc.
    Inventor: Mark A. Gallop
  • Methods of treating using conjugates transported by a PEPT2 transporter
    Patent number: 7919454
    Abstract: The invention provides methods of screening agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the PEPT2 transporter. The invention also provides methods of treatment involving delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of the PEPT2 transporter. The invention also provides conjugates comprising a pharmaceutical agent which is linked to a conjugate moiety that is a substrate for a PEPT2 transporter.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: April 5, 2011
    Assignee: XenoPort, Inc.
    Inventors: Noa Zerangue, Tracy Dias, William J. Dower
  • Levodopa prodrug mesylate, compositions thereof, and uses thereof
    Patent number: 7893105
    Abstract: (2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: February 22, 2011
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Xuedong Dai, Cindy X. Zhou, Jianhua Li, Mark Q. Nguyen
  • CATECHOL PROTECTED LEVODOPA DIESTER PRODRUGS, COMPOSITIONS, AND METHODS OF USE
    Publication number: 20110028544
    Abstract: Catechol protected levodopa diester prodrugs pharmaceutical, compositions comprising catechol protected levodopa diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.
    Type: Application
    Filed: October 14, 2010
    Publication date: February 3, 2011
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Cindy X. Zhou, Fenmei Yao, Mark Q. Nguyen
  • ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
    Publication number: 20110021571
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Application
    Filed: September 16, 2010
    Publication date: January 27, 2011
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG
    Publication number: 20110021628
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: October 4, 2010
    Publication date: January 27, 2011
    Applicant: XenoPort, Inc.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Frauenfelder, Uwe Zacher
  • Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
    Patent number: 7872046
    Abstract: A crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug and methods of preparing a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug, and methods of using a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug are provided.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: January 18, 2011
    Assignee: Xenoport, Inc.
    Inventors: Fenmei Yao, Mark A. Gallop, Ronald W. Barrett, Peter A. Virsik
  • ACYLOXYALKYL CARBAMATE PRODRUGS OF TRANEXAMIC ACID, METHODS OF SYNTHESIS AND USE
    Publication number: 20110009483
    Abstract: Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.
    Type: Application
    Filed: July 13, 2010
    Publication date: January 13, 2011
    Applicant: XenoPort, Inc.
    Inventors: Noa Zerangue, Bernd Jandeleit, Yunxiao Li, Mark A. Gallop
  • Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 7868041
    Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: January 11, 2011
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
  • Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
    Patent number: 7868043
    Abstract: Mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs and methods of preparing and methods of using mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs are provided.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: January 11, 2011
    Assignee: Xenoport, Inc.
    Inventors: Fenmei Yao, Mark A. Gallop, Ronald W. Barrett, Peter A. Virsik
  • Catechol protected levodopa diester prodrugs, compositions, and methods of use
    Patent number: 7829592
    Abstract: Catechol protected levodopa diester prodrugs pharmaceutical, compositions comprising catechol protected levodopa diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: November 9, 2010
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Cindy X. Zhou, Fenmei Yao, Mark Q. Nguyen
  • PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF
    Publication number: 20100267946
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Application
    Filed: July 1, 2010
    Publication date: October 21, 2010
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fayang G. Qiu, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollmann
  • SUSTAINED RELEASE ORAL DOSAGE FORMS OF AN R-BACLOFEN PRODRUG
    Publication number: 20100255093
    Abstract: Sustained release oral dosage forms of an R-baclofen prodrug are disclosed.
    Type: Application
    Filed: March 3, 2010
    Publication date: October 7, 2010
    Applicant: XenoPort, Inc.
    Inventors: David E. Edgren, David J. Kidney, Nikhil Pargaonkar, Derrick K. Kim, Gorm Yoder, Sami Karaborni
  • Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
    Patent number: 7803785
    Abstract: The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions of using gemcitabine prodrugs to treat or prevent diseases or disorders such as cancer or viral infections.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: September 28, 2010
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Ge Peng, Thomas F. Woiwode, Kenneth C. Cundy
  • Acyloxyalkyl carbamate prodrugs of ?-amino acids, methods of synthesis and use
    Patent number: 7799829
    Abstract: Acyloxyalkyl carbamate prodrugs of ?-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of ?-amino acids and methods of using acyloxyalkyl carbamate prodrugs of ?-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of ?-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: September 21, 2010
    Assignee: XenoPort, Inc.
    Inventors: Xuedong Dai, Archana Gangakhedkar, Jia-Ning Xiang, Mark A Gallop
  • ORAL DOSAGE FORMS HAVING A HIGH LOADING OF A GABAPENTIN PRODRUG
    Publication number: 20100226981
    Abstract: Sustained release oral dosage forms with a high loading of a gabapentin prodrug are disclosed.
    Type: Application
    Filed: March 5, 2010
    Publication date: September 9, 2010
    Applicant: XenoPort, Inc.
    Inventors: Sami Karaborni, Laura E. Maurer, David J. Kidney
  • Prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 7790708
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: September 7, 2010
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fayang G. Qiu, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollmann