Patents Assigned to Yale University
  • Patent number: 11826438
    Abstract: Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: November 28, 2023
    Assignee: YALE UNIVERSITY
    Inventors: Yang Deng, Asiri Ediriwickrema, W. Mark Saltzman
  • Patent number: 11814464
    Abstract: Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxylic and/or hydroxyl groups, and methods of making. Typically, the compositions are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the compositions are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: November 14, 2023
    Assignee: YALE UNIVERSITY
    Inventors: W. Mark Saltzman, Yuhang Jiang
  • Patent number: 11816018
    Abstract: Systems and methods for formal verification of programs. The systems and methods provide a new game-theoretical, strategy-based compositional semantic model for concurrency, a set of formal linking theorems for composing multithreaded and multicore concurrent layers, and a compiler that supports certified thread-safe compilation and linking. Verification of an overlay interface can include determining an intermediate strategy for a primitive operation running on an underlay interface and refining that intermediate strategy to a strategy running on the overlay interface by applying a vertical and a horizontal composition rule. The refined strategy can then be composed with compatible strategies running on the overlay interface according to a parallel composition rule. Strategies may be compatible when rely conditions imposed by each strategy satisfy guarantees provided by the other strategies. The system and method of formal verification can be applied to formal verification of smart contracts.
    Type: Grant
    Filed: July 12, 2022
    Date of Patent: November 14, 2023
    Assignee: Yale University
    Inventors: Zhong Shao, Ronghui Gu, Vilhelm Sjoberg, Jieung Kim, Jeremie Koenig
  • Patent number: 11801232
    Abstract: This application relates to methods and kits for treating ARID1A-mutant tumors, cancers, or aberrantly proliferating cells and subjects harboring the tumors, cancers, or aberrantly proliferating cells. In particular, the methods provided include administering to the subject or cell an effective amount of a pyrimidine synthesis inhibitor and administering to the subject or cell an effective amount of a DNA repair inhibitor. The kits include a) a composition comprising a pyrimidine synthesis inhibitor and b) a composition comprising a DNA repair inhibitor.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: October 31, 2023
    Assignee: YALE UNIVERSITY
    Inventor: Gloria Huang
  • Patent number: 11793794
    Abstract: The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition.
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: October 24, 2023
    Assignees: YALE UNIVERSITY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Chadi Abdallah, John Krystal, Ronald Duman, Gerard Sanacora
  • Patent number: 11786545
    Abstract: The present disclosure provides small hairpin nucleic acid molecules capable of stimulating interferon production. The nucleic acid molecules of the present disclosure has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises at least one 5?-triphosphate and/or at least one 5?-diphosphate. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection, and/or ameliorating, minimizing, reversing, and/or preventing persistent SARS-CoV-2 viral infection, and/or minimizing or preventing SARS-CoV-2 viral infection-derived mortality and/or lethality, in a subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in a tumor-bearing subject.
    Type: Grant
    Filed: March 30, 2022
    Date of Patent: October 17, 2023
    Assignee: Yale University
    Inventors: Anna Marie Pyle, Akiko Iwasaki, Tianyang Mao
  • Patent number: 11788111
    Abstract: Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNASec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNASec a recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNASec.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: October 17, 2023
    Assignee: YALE UNIVERSITY
    Inventors: Dieter Soll, Takahito Mukai, Kyle Hoffman
  • Patent number: 11791818
    Abstract: Parametrically pumped four-wave mixing is a key building block for many developments in the field of superconducting quantum information processing. However, undesired frequency shifts such as Kerr, cross-Ken and Stark shifts inherent with four-wave mixing, lead to difficulties in tuning up the desired parametric processes and, for certain applications, severely limit the fidelities of the resulting operations. Some embodiments include a Josephson four-wave mixing device consisting of a SQUID transmon coupled to a half-flux biased SNAIL transmon, a.k.a. capacitively shunted flux qubit. When the two transmon have matching frequencies, an interference effect cancels the negative Kerr of the SQUID transmon with the positive Kerr of the SNAIL transmon while preserving parametric four-wave mixing capabilities.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: October 17, 2023
    Assignee: Yale University
    Inventors: Shantanu Mundhada, Nicholas Frattini, Shruti Puri, Shyam Shankar, Steven M. Girvin, Michel Devoret
  • Patent number: 11791016
    Abstract: The present disclosure relates to computer generated topographies from computer correlations of neurobehavioral phenotype mapping data and gene expression mapping data. Neurobehavioral phenotype mapping data is obtained for a selected phenotype and correlated with gene expression mapping data for one or more genes to define a phenotype-gene pair topography for each phenotype-gene pair. A score for each phenotype-gene pair is determined based on the correlation. The scores are used to identify genes, or drug targets, associated with the respective gene of the respective phenotype-gene pair. Conversely, gene expression mapping data is obtained for a selected gene and correlated with neurobehavioral phenotype mapping data for one or more phenotypes to define a gene-phenotype topography for each gene-phenotype pair. A score for each gene-phenotype pair is determined based on the correlation. The scores are used to identify a phenotype associated with the respective phenotype-gene pair.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: October 17, 2023
    Assignees: Neumora Therapeutics, Inc., Yale University
    Inventors: John D. Murray, Alan Anticevic, William J. Martin
  • Patent number: 11778995
    Abstract: Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: October 10, 2023
    Assignees: Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)
    Inventors: Richard Flavell, Till Strowig, Markus G. Manz, Chiara Borsotti, Madhav Dhodapkar, Andrew J. Murphy, Sean Stevens, George D. Yancopoulos
  • Patent number: 11782779
    Abstract: Techniques for quantum error correction of a multi-level system are provided and described. In some aspects, techniques for encoding a state of a multi-level quantum system include encoding a quantum information in a two-mode state of two quantum mechanical oscillators. Techniques for protecting the two-mode state against dephasing and energy loss are described.
    Type: Grant
    Filed: January 5, 2019
    Date of Patent: October 10, 2023
    Assignee: Yale University
    Inventors: Victor V. Albert, Shantanu Mundhada, Alexander Grimm, Steven Touzard, Michel Devoret, Liang Jiang
  • Publication number: 20230310534
    Abstract: A method for decreasing formation of one or more chemiexcitation-induced dark cyclobutane pyrimidine dimers (dCPDs) in a cell or DNA molecule in a subject, who has been exposed to UV radiation, is provided. The method comprises administering to the subject an effective amount of a dCPD quencher within 8 hours after the exposure. The dCPD quencher is selected from the group consisting of ellagic acid, Porphyra Umbilicalis Extract (including Porphyra Umbilicalis Extract (and) Sodium Lactate (and) Lecithin), mycosporine-like amino acids (MAAs) and synthetic analogues thereof, Scutellaria Baicalensis Root Extract, Chrysanthemum Morifolium Leaf Extract, ferulic acid, fused-ring cyanoacrylates, curcumin, epigallocatechin gallate, Scutellaria Baicalensis Root Extract (and) Acacia Catechu Wood Extract, sorbic acid, Polygonum Cuspidatum Root Extract, Acacia Catechu Extract, dipicolinic acid, squalene, Lonicera Japonica (Honeysuckle) Flower Extract, beta-carotene and combinations thereof.
    Type: Application
    Filed: March 7, 2023
    Publication date: October 5, 2023
    Applicants: L'OREAL, Yale University
    Inventors: Kelly Marie GEORGE, Zhi PAN, Laurent MARROT, Miao WANG, Douglas Edgar BRASH, Sanjay PREMI, Leticia C.P. GONCALVES
  • Patent number: 11771731
    Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.
    Type: Grant
    Filed: April 6, 2022
    Date of Patent: October 3, 2023
    Assignee: YALE UNIVERSITY
    Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
  • Patent number: 11773096
    Abstract: The present-disclosure relates to the discovery of novel 2-amino-dihydropteridinone compounds and analogues thereof, which are capable of inhibiting phosphatidylinositol phosphate kinases. In certain embodiments, the compounds of the present disclosure can be used to treat p53-null cancer in a subject. In other embodiments, the compounds of the present disclosure can be used to treat metabolic disorders in a subject, including but not limited to type 2 diabetes and/or obesity.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: October 3, 2023
    Assignee: YALE UNIVERSITY
    Inventors: Ya Ha, Jonathan Ellman, Song Chen, Caroline Chandra Tjin, Fabrizio Micheli, Agostino Cianciulli, Claudia Beato
  • Patent number: 11766032
    Abstract: Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: September 26, 2023
    Assignees: Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)
    Inventors: Andrew J. Murphy, Sean Stevens, Richard Flavell, Markus Gabriel Manz, Liang Shan
  • Patent number: 11767301
    Abstract: The present invention is directed to bi-functional compounds which find use as pharmaceutical agents in the treatment of disease states and/or conditions which are mediated through macrophage migration inhibitory factor (MIF) or immunoglubin G (IgG). The present invention is also directed to pharmaceutical compositions which comprise these bi-functional compounds as well as methods for treating disease states and/or conditions which are mediated through MIF/IgG or where MIF/IgG is a contributing factor to the development and perpetuation of diseases and/or conditions, especially including autoimmune diseases and cancer, among others. The purpose of the present invention is to provide a molecular strategy to lower plasma MIF/IgG level in patients with autoimmune diseases or certain types of cancers.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: September 26, 2023
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, David Caianiello
  • Patent number: 11766400
    Abstract: Biodegradable contraceptive implants and methods of making and using thereof, are preferably formed of poly(?-pentadecalactone-co-p-dioxanone) [poly(PDL-co-DO)], a family of polyester copolymers that degrade slowly in the presence of water. The material is suitable as the basis of a biodegradable contraceptive implant that provides sustained release of a progestin at a rate similar to a commercially available nondegradable implant. In a preferred embodiment, the progestin is levonorgestrel (LNG), a hormone that prevents pregnancy by preventing the release of an egg from the ovary or by preventing fertilization of the egg by sperm. The implant may be inserted subcutaneously, allowing degradation over a period of up to about 18 or 24 months, eliminating the need for removal by a trained practitioner.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: September 26, 2023
    Assignees: YALE UNIVERSITY, FAMILY HEALTH INTERNATIONAL
    Inventors: W. Mark Saltzman, Elias Quijano, Fan Yang, Zhaozhong Jiang, Derek Owen
  • Patent number: 11760708
    Abstract: The invention relates to novel, scalable synthetic routes that allow for direct reduction of enones to the corresponding saturated alcohols. The invention relates, in certain aspects, to synthetic routes that allow for the reduction of enones to the corresponding ketones. Such reactions take place under mild conditions, are compatible with a wide range of functional groups, and expand the repertoire of existing green chemistry methodology. In certain embodiments, the reactions are run in aqueous solvent.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: September 19, 2023
    Assignee: YALE UNIVERSITY
    Inventors: Laurene Petitjean, Paul Thomas Anastas, Tamara Marie DeWinter, Philip Coish, Hanno Christian Erythropel, Predrag Petrovic
  • Publication number: 20230290467
    Abstract: The invention features methods that are useful for treatment of a patient at increased risk for infection and for selecting a patient for treatment for an infection. In various embodiments, the infection is coronavirus disease 2019 (COVID-19), sepsis, or other respiratory infections.
    Type: Application
    Filed: March 14, 2023
    Publication date: September 14, 2023
    Applicants: The Broad Institute, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic, Yale University, The General Hospital Corporation
    Inventors: Pradeep NATARAJAN, Giulio GENOVESE, Seyedeh Maryam ZEKAVAT, Mitchell J. MACHIELA, Shu-Hong LIN
  • Patent number: 11753743
    Abstract: Provided herein, in some embodiments, are devices, systems and methods for high-throughput single-cell polyomics (e.g., genomic, epigenomic, proteomic and/or phenotypic profile) analyses.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: September 12, 2023
    Assignee: Yale University
    Inventors: Rong Fan, Burak Dura