Patents Assigned to Yale University
  • Publication number: 20220147266
    Abstract: Techniques for implementing a QRAM by routing quantum information through multiple modes of a bosonic system are described. According to some aspects, a single bosonic system may be configured to maintain quantum information in a large number of independent modes at the same time. Suitable operations upon these modes may allow a quantum address value to be routed to modes associated with respective bits such that the only modes altered by the operations are those associated with the addresses being accessed. These modes may be operated upon based on the stored values then extracted to obtain the desired correlated superposition of the stored bit values in the addresses. The bits stored at the address locations may be classical bits, or may be qubits.
    Type: Application
    Filed: February 28, 2020
    Publication date: May 12, 2022
    Applicant: Yale University
    Inventors: Connor Hann, Changling Zou, Yiwen Chu, Yaxing Zhang, Robert J. Schoelkopf III, Steven M. Girvin, Liang Jiang
  • Patent number: 11324793
    Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: May 10, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
  • Patent number: 11326167
    Abstract: In some aspects, the invention provides a method of treating atherosclerosis in a subject. The method comprises administering to the subject an agent that increases the activity or level of a let-7 miRNA or an agent that decreases activity or level of a TGF? signaling polypeptide in an endothelial cell in the subject. In some embodiments, the subject is administered an additional agent comprising a therapeutically effective amount of rapamycin or any derivative thereof. In some embodiments, the agent is a let-7 miRNA. In some other aspects, the invention provides a pharmaceutical composition comprising a let-7 miRNA. In some embodiments, the let-7 miRNA is encapsulated in a nanoparticle formulated for selective delivery to an endothelial cell.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: May 10, 2022
    Assignee: Yale University
    Inventors: Michael Simons, Pei-Yu Chen
  • Patent number: 11320505
    Abstract: A method for magnetic resonance imaging uses an electromagnet [304], which may have open geometry, to generate a spatially nonuniform magnetic field within an imaging region [306]. The current through the electromagnet is controlled to repeatedly cycle the nonuniform magnetic field between a high strength for polarizing spins and a low strength for spatial encoding and readout. Using RF coils [308], excitation pulses are generated at a frequency that selects a non-planar isofield slice for imaging. The RF coils are also used to generate refocusing pulses for imaging and to generate spatial encoding pulses, which may be nonlinear. Magnetic resonance signals originating from the selected non-planar isofield slice of the nonuniform magnetic field in the imaging region [306] are detected using the RF coils [308] in parallel receive mode. MRI images are reconstructed from the parallel received magnetic resonance signals, e.g., using algebraic reconstruction.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: May 3, 2022
    Assignee: Yale University
    Inventors: Robert T. Constable, Yuqing Wan
  • Patent number: 11315250
    Abstract: Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: April 26, 2022
    Assignee: YALE UNIVERSITY
    Inventors: David Rimm, Robert Camp
  • Patent number: 11311538
    Abstract: In various aspects and embodiments the invention provides a method of treating or preventing a cancer in a mammalian subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of at least one compound selected from the group consisting of a DNA repair inhibitor, a DNA strand break repair inhibitor, and a homologous recombination (HR) repair inhibitor, wherein cells in the cancer comprise a fumarate hydratase (FH) and/or succinate dehydrogenase (SDH) mutation.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: April 26, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Ranjit Bindra, Peter Glazer, Parker Sulkowski, Brian Shuch
  • Patent number: 11311543
    Abstract: The present invention provides compositions and methods for inhibiting PTPN22 for restoring human central B-cell tolerance or for treating or preventing an autoimmune disease or disorder.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: April 26, 2022
    Assignee: Yale University
    Inventors: Eric Meffre, Jean-Nicolas Schickel
  • Patent number: 11315660
    Abstract: Described herein are improved methods for the detection of endometriosis. Generally, the methods include, but are not limited to, applying machine learning algorithm to miRNA levels in order to detect, predict, diagnose, or monitor the presence or absence of endometriosis.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: April 26, 2022
    Assignees: Dot Laboratories, Inc., Yale University
    Inventors: Hugh Taylor, Heather Bowerman
  • Patent number: 11304947
    Abstract: The present invention provides methods and compositions for treating and preventing lung injuries due to or associated with coronavirus infections that cause Severe Acute Respiratory Syndrome, including COVID-19. More specifically the present invention provides methods for treating or preventing the lung injuries associated with SARS-CoV-2 infections, such as acute lung injury (ALI), lung fibrosis, and acute respiratory distress syndrome (ARDS). The methods comprise administering a therapeutically effective amount of a pharmaceutical composition comprising a protein kinase inhibitor compound having MAP3K2/MAP3K3 inhibition activity, such as pazopanib or nintedanib, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, to a patient in need thereof. The present invention also provides devices for administering the compositions.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: April 19, 2022
    Assignees: Qx Therapeutics Inc., Yale University
    Inventors: Dianqing Wu, Ho Yin Lo
  • Patent number: 11299790
    Abstract: The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and disorders. Thus, the invention relates to compositions and methods for detecting and identifying the constituents of a subject's microbiota, methods of modifying the constituents of the microbiota, and methods for treating inflammatory diseases and disorders in a subject in need thereof.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: April 12, 2022
    Assignee: Yale University
    Inventors: Richard Flavell, Noah Palm, Marcel de Zoete
  • Publication number: 20220103172
    Abstract: Parametrically pumped four-wave mixing is a key building block for many developments in the field of superconducting quantum information processing. However, undesired frequency shifts such as Kerr, cross-Ken and Stark shifts inherent with four-wave mixing, lead to difficulties in tuning up the desired parametric processes and, for certain applications, severely limit the fidelities of the resulting operations. Some embodiments include a Josephson four-wave mixing device consisting of a SQUID transmon coupled to a half-flux biased SNAIL transmon, a.k.a. capacitively shunted flux qubit. When the two transmon have matching frequencies, an interference effect cancels the negative Kerr of the SQUID transmon with the positive Kerr of the SNAIL transmon while preserving parametric four-wave mixing capabilities.
    Type: Application
    Filed: January 15, 2020
    Publication date: March 31, 2022
    Applicant: Yale University
    Inventors: Shantanu Mundhada, Nicholas Frattini, Shruti Puri, Shyam Shankar, Steven M. Girvin, Michel Devoret
  • Patent number: 11288846
    Abstract: In an image guidance method, a stream of cone-beam computed tomography (CBCT) images of an anatomical organ is acquired using a CBCT imaging device (34). For each CBCT image (44), the surface of the organ in the CBCT image is segmented to generate a segmented surface (70) of the anatomical organ in the CBCT image. Occluded shape reconstruction (66) using a statistical shape prior (68) may be used to reconstruct a missing or occluded surface portion. A pre-operative medical image (12) of the anatomical organ and the CBCT image are spatially registered by warping one of the images to the other of the images using point set registration of a segmented surface (30) of the organ in the preoperative medical image and the segmented surface of the organ in the CBCT image. A fused image (82) is displayed that combines the warped image and the other image.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 29, 2022
    Assignees: KONINKLIJKE PHILIPS N.V., YALE UNIVERSITY
    Inventors: John Treilhard, Ming De Lin, Jean-François Geschwind, James Duncan, Susanne Smolka
  • Patent number: 11286251
    Abstract: The present invention provides certain compounds, or salts or solvates thereof, which can be used as matrix metalloproteinase-targeted inhibitors or imaging agents.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: March 29, 2022
    Assignees: YALE UNIVERSITY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Mehran Sadeghi, Yunpeng Ye, Hye-Yeong Kim, Henry(Yiyun) Huang, Jakub Toczek
  • Patent number: 11285211
    Abstract: It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized. The magnetized devices are used to attract, capture, and/or retain magnetically labeled cells on the surface of the device in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe/Pt particle is very important for introducing a L10 interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e. starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a “Super Conducting Quantum Interference Device”, which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: March 29, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Tarek Fahmy, Albert Sinusas, Jung Seok Lee, Dongin Kim, Anthony Mathur, John Martin
  • Publication number: 20220088208
    Abstract: The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.
    Type: Application
    Filed: January 28, 2020
    Publication date: March 24, 2022
    Applicants: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman, Anna Moshnikova, John Deacon
  • Patent number: 11267875
    Abstract: The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of a humanized anti-DKK2 antibody, methods for providing anti-tumor immunity in a subject, methods of stimulating a T cell mediated immune response to a cell population or a tissue and suppressing tumor in a subject. Additionally, the current invention includes methods of diagnosing a cancer or a predisposition of developing a cancer or a metastasis and methods for determining the use of immunotherapy treatment or cancer vaccine for treating cancer. Furthermore, the invention encompasses a pharmaceutical composition for treating cancer as well as a kit for carrying out the aforementioned methods.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: March 8, 2022
    Assignee: Yale University
    Inventors: Dianqing Wu, Bo Chen, Hai Wu
  • Patent number: 11271533
    Abstract: A wireless Josephson-junction-based amplifier is described that provides improved tunability and increased control over both a quality factor Q and participation ratio p of the amplifier. The device may be fabricated on a chip and mounted in a waveguide. No wire bonding between the amplifier and coaxial cables or a printed circuit board is needed. At least one antenna on the chip may be used to couple energy between the waveguide and wireless JBA. The amplifier is capable of gains greater than 25 dB.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: March 8, 2022
    Assignee: Yale University
    Inventors: Anirudh Narla, Katrina Sliwa, Michael Hatridge, Shyam Shankar, Luigi Frunzio, Robert J. Schoelkopf, III, Michel Devoret
  • Patent number: 11266722
    Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: March 8, 2022
    Assignee: Yale University
    Inventors: Demetrios Braddock, Ronald Albright
  • Patent number: 11267853
    Abstract: The invention features a compositions and methods for inducing an immune response to targeted cells. The compositions induce targeting of a cell by positioning carbohydrate epitopes on the surface of the cell by conjugation of the epitope to a pH-triggered membrane peptide (pHLIP®).
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: March 8, 2022
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • Patent number: 11263546
    Abstract: Techniques are described in which a qubit is far off-resonantly, or dispersively, coupled to a quantum mechanical oscillator. In particular, a dispersive coupling between a physical qubit and a quantum mechanical oscillator may be selected such that control of the combined qubit-oscillator system can be realized. The physical qubit may be driven with an electromagnetic pulse (e.g., a microwave pulse) and the quantum mechanical oscillator simultaneously driven with another electromagnetic pulse, the combination of which results in a change in state of the qubit-oscillator system.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: March 1, 2022
    Assignee: Yale University
    Inventors: Reinier Heeres, Philip Reinhold, Victor V. Albert, Liang Jiang, Luigi Frunzio, Michel Devoret, Robert J. Schoelkopf, III