Patents Assigned to Yale University
  • Patent number: 12290575
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: May 6, 2025
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Publication number: 20250139386
    Abstract: The disclosed technology relates to methods, transcriptomics systems, and non-transitory computer readable media for enabling natural language transcriptomics analysis. In some examples, genomic data including gene expression profiles for cells is transformed into sequences of genes ordered by expression level for each of the cells. The sequences of genes are annotated with metadata in a natural language format. A large language model (LLM) is then fine-tuned using the annotated sequences. The LLM is pretrained for natural language processing (NLP) tasks. The fine-tuned LLM is applied to generate and output a result in response to a received prompt in the natural language format. Thus, the LLMs of this technology advantageously both generate and interpret transcriptomics data and interact in natural language to generate meaningful text from cells and valid genes, among many other types of results.
    Type: Application
    Filed: October 28, 2024
    Publication date: May 1, 2025
    Applicant: Yale University
    Inventors: Rahul Dhodapkar, David Van Dijk
  • Patent number: 12286398
    Abstract: Provided herein are novel antibacterial compounds of Formula I. The compounds can be made through enzymatic oxidative dimerization in the presence of a suitable organism and one or more metal salts. Pathogenic bacteria exposed to the compound of Formula I do not develop resistance to these compounds even after prolonged exposure. Also provided herein are methods of treating bacterial infections, and method of killing or disinfecting bacteria.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: April 29, 2025
    Assignee: Yale University
    Inventors: Jason Crawford, Tyler Goddard, Hyun Bong Park, Jaymin Patel
  • Patent number: 12285462
    Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP? construct comprising an antibody recruiting molecule linked to one or more pHLIP? peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
    Type: Grant
    Filed: May 30, 2023
    Date of Patent: April 29, 2025
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • Patent number: 12288135
    Abstract: Techniques for performing quantum information processing using an asymmetric error channel are provided. According to some aspects, a quantum information processing includes a data qubit and an ancilla qubit, the ancilla qubit having an asymmetric error channel. The data qubit is coupled to the ancilla qubit. The ancilla qubit may be driven with a stabilizing microwave field to create the asymmetric error channel.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 29, 2025
    Assignee: Yale University
    Inventors: Shruti Puri, Alexander Grimm, Philippe Campagne-Lbarcq, Steven M. Girvin, Michel Devoret
  • Patent number: 12274756
    Abstract: In various aspects and embodiments the invention provides a method of treating epilepsy in a subject in need thereof, the method comprising contacting a target cell of the subject with an effective amount of an HCN4 disrupting agent.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: April 15, 2025
    Assignee: Yale University
    Inventors: Angelique Bordey, Lawrence Hsieh, Jianbing Zhou
  • Publication number: 20250115947
    Abstract: Provided herein, in some embodiments, are compositions and methods for producing a molecular expression map of a biological sample using Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq).
    Type: Application
    Filed: October 25, 2024
    Publication date: April 10, 2025
    Applicant: Yale University
    Inventors: Rong Fan, Yang Liu, Yanxiang Deng
  • Publication number: 20250116662
    Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.
    Type: Application
    Filed: August 19, 2024
    Publication date: April 10, 2025
    Applicant: Yale University
    Inventors: Rong Fan, Yao Lu, Jonathan Chen
  • Patent number: 12268807
    Abstract: A medication delivery assistance device includes a chamber housing that defines an interior space. A first input port is at a first end of the chamber housing, an output port is at a second end of the chamber housing, and a second input port is in the chamber housing. The first input port is configured to receive a portion of an inhaler that is configured to deliver medication into the interior space. The output port has a user interface that is configured to define a medication flow path from the first input port through the interior space and out the output port. The second input port is configured to receive at least a portion of an external fluid source that is configured to deliver a fluid into the interior space to accelerate movement of the medication along the medication flow path.
    Type: Grant
    Filed: December 20, 2023
    Date of Patent: April 8, 2025
    Assignee: Yale University
    Inventor: Peter Kahn
  • Patent number: 12264157
    Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: April 1, 2025
    Assignees: Arvinas Operations, Inc., Yale University
    Inventors: Andrew P. Crew, Craig M. Crews, Xin Chen, Hanqing Dong, Caterina Ferraro, Yimin Qian, Kam Siu, Jing Wang, Meizhong Jin, Michael Berlin, Kurt Zimmermann, Lawrence Snyder
  • Patent number: 12247998
    Abstract: A scattering-type scanning near-field optical microscope at cryogenic temperatures (cryo-SNOM) configured with Akiyama probes for studying low energy excitations in quantum materials present in high magnetic fields. The s-SNOM is provided with atomic force microscopy (AFM) control, which predominantly utilizes a laser-based detection scheme for determining the cantilever tapping motion of metal-coated Akiyama probes, where the cantilever tapping motion is detected through a piezoelectric signal. The Akiyama-based cryo-SNOM attains high spatial resolution, good near-field contrast, and is able to perform imaging with a significantly more compact system capable of handling simultaneous demands of vibration isolation, low base temperature, precise nano-positioning, and optical access. Results establish the potential of s-SNOM based on self-sensing piezo-probes, which can easily accommodate near-IR and far-infrared wavelengths and high magnetic fields.
    Type: Grant
    Filed: September 22, 2022
    Date of Patent: March 11, 2025
    Assignees: The Research Foundation for The State University of New York, Yale University
    Inventors: Michael Dapolito, Mengkun Liu, Xinzhong Chen, Adrian Gozar
  • Publication number: 20250078960
    Abstract: Systems and methods for implementing holographic quantum circuits on compact quantum computing systems are provided. Compact quantum computing systems include systems having fewer physical qubits than the number of quantum modes to be instantiated during execution of the quantum circuit. Techniques described herein may be used to perform boson sampling techniques, including with application to molecular docking simulations.
    Type: Application
    Filed: August 30, 2024
    Publication date: March 6, 2025
    Applicant: Yale University
    Inventors: Ningyi Lyu, Victor Batista
  • Publication number: 20250067739
    Abstract: In one aspect, the invention provides a method for detecting a viral-only or a bacterial-associated respiratory infection in a patient, the method comprising analyzing a respiratory sample to determine levels of at least two respiratory virus infection-associated molecules, at least two bacterial respiratory infection-associated molecules, and comparing the levels of the respiratory virus infection-associated molecules and/or the levels of the bacterial respiratory infection-associated molecules with a predetermined reference level.
    Type: Application
    Filed: December 22, 2022
    Publication date: February 27, 2025
    Applicant: Yale University
    Inventor: Ellen Foxman
  • Patent number: 12236246
    Abstract: One aspect of the invention provides a computer processing architecture including: a plurality of processors, each processor configured to: receive a set of data from one or more input channels or from another processor; execute at least one of a plurality of individualized processes on the data; and output the processed data according to an independent clock domain of the processor; a plurality of switches, wherein each switch connects a processor to an input channel of the one or more input channels or to another processor; and a micro-controller configured to: receive the processed data; control the plurality of switches by activating or deactivating each switch; generate a pipeline of processors from activating and deactivating the plurality of switches; and select one or more individualized processes of the plurality of individualized processes that each processor within the pipeline executes.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: February 25, 2025
    Assignee: Yale University
    Inventors: Ioannis Karageorgos, Karthik Sriram, Jan Vesely, Rajit Manohar, Abhishek Bhattacharjee
  • Patent number: 12233402
    Abstract: The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. The present invention further provides methods of making and using the precatalysts of the invention.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: February 25, 2025
    Assignee: Yale University
    Inventors: Nilay Hazari, Patrick Melvin
  • Patent number: 12234500
    Abstract: The present invention relates to compositions and methods for binding and detecting or measuring renalase. In one embodiment, the renalase binding molecule measures renalase amount or activity. Thus, in diseases and conditions where a measurement of renalase is beneficial, such renalase binding molecules may act as diagnostics.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: February 25, 2025
    Assignee: Yale University
    Inventors: Gary Desir, Jeffrey Testani, Veena Rao
  • Publication number: 20250061366
    Abstract: Systems and methods for performing fault tolerant quantum operations for the 4-legged cat code are provided. The quantum systems include an ancilla qubit dispersively coupled to a first logical qubit. and the quantum system may be operated at least in part by: generating and applying a first drive waveform to the ancilla qubit. the first drive waveform comprising a first comb of 7t-pulses having selective frequencies corresponding to a first selection of even and odd cavity resonance frequencies of the first logical qubit: and reading out a state of the ancilla qubit.
    Type: Application
    Filed: December 22, 2022
    Publication date: February 20, 2025
    Applicant: Yale University
    Inventors: James Teoh, Neel Thakur, Benjamin Chapman, Stijn de Graaf, Steven M. Girvin, Shruti Puri, Robert J. Schoelkopf III
  • Patent number: 12227595
    Abstract: The present invention relates to compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules may act as therapeutics.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: February 18, 2025
    Assignee: Yale University
    Inventors: Gary Desir, Bryce Nelson
  • Publication number: 20250032433
    Abstract: Described herein are methods and compositions useful to reduce (partially/inhibit or completely—prevent) skin cancer development in an individual in need thereof.
    Type: Application
    Filed: August 5, 2024
    Publication date: January 30, 2025
    Applicant: Yale University
    Inventors: Michael Girardi, Julia Lewis
  • Publication number: 20250036996
    Abstract: Quantum systems and techniques are described to generate fault tolerant cluster states for use in quantum computation, quantum networking, and other applications. The systems and techniques include initializing states in first qubits and generating initial resource states by performing first Pauli product measurements on sets of X-type and/or Z-type qubits of the first qubits, the initial resource states comprising qubit cluster states comprising at least three qubits. The final cluster state may then be generated by fusing two or more initial resource states, the fusing comprising performing second Pauli product measurements between qubits of two or more of the initial resource states.
    Type: Application
    Filed: December 6, 2022
    Publication date: January 30, 2025
    Applicant: Yale University
    Inventors: Shruti Puri, Jahan Claes, Kaavya Sahay