Patents Assigned to Yale University
  • Publication number: 20240082215
    Abstract: The present invention relates to the use of mavoglurant in the treatment of gambling disorder. The present invention also relates to the use of mavoglurant in the treatment of gaming disorder.
    Type: Application
    Filed: December 9, 2021
    Publication date: March 14, 2024
    Applicants: Novartis AG, Yale University
    Inventors: Fabrizio GASPARINI, Baltazar GOMEZ-MANCILLA, John KRYSTAL, Vincent MALATERRE, Stephanie O'MALLEY, Godfrey PEARLSON, Marc POTENZA
  • Patent number: 11926839
    Abstract: The present invention includes compositions and methods for T cell genome editing and screening in vivo. In certain aspects, the invention includes an sgRNA library for genome-scale mutagenesis.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: March 12, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Sidi Chen, Matthew Dong
  • Patent number: 11920172
    Abstract: The present invention relates to chimeric (preferably, bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including metastatic cancer where cancer cells exhibit overexpression (heightened expression) of cell surface urokinase-type plasminogen activator receptor (urokinase receptor) compared to normal (non-cancerous) cells. The compounds preferably covalently bind to the urokinase receptor and recruit native antibodies of the patient or subject where the antibodies can selectively degrade and/or deactivate targeted cancer cells through antibody-dependent cellular phagocytosis and/or antibody-dependent cellular cytotoxicity (ADCC) against a large number and variety of cancers, thus providing cancer cell death and/or an inhibition of growth, elaboration and/or metastasis of the cancer, including remission and cure of the patient's cancer.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: March 5, 2024
    Assignee: YALE UNIVERSITY
    Inventors: David A. Spiegel, Charles E. Jakobsche
  • Patent number: 11918695
    Abstract: Core-shell particles have a hydrophobic core and a shell formed of o containing hyperbranched polymers (HP). The HP can be covalently bound to the one or more materials that form the core or coated thereon. The HP coating can be modified to adjust the properties of the particles. For example, unmodified HP coatings resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HP coating can be chemically modified to form functional groups that react with functional groups on tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HP coated nanoparticles. In some embodiments, the particles include cosmetic, therapeutic, diagnostic, nutraceutical, and/or prophylactic agents, such as those used as sunblock compositions.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: March 5, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Yang Deng, Asiri Ediriwickrema, William M. Saltzman, Michael Girardi
  • Patent number: 11912742
    Abstract: The present disclosure includes a construct comprising a leupeptin biosynthesis operon, the operon comprising leupA, leupB, leupC, and leupD genes operably linked to a promoter. Also included are cells comprising the construct, and methods for production of leupeptin peptide.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: February 27, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Jason Crawford, Jhe-Hao Li, Joonseok Oh
  • Patent number: 11909451
    Abstract: Systems and methods for performing bosonic quantum error correction (QEC) using Gottesman-Kitaev-Preskill (GKP) states are provided. An ancilla quantum mechanical oscillator is used to probe Gaussian noise experienced by a data quantum mechanical oscillator without disturbing the state of the data quantum mechanical oscillator. The ancilla quantum mechanical oscillator is initialized with a GKP state and entangled with the state of a data quantum mechanical oscillator to correlate any noise experienced by the data state with the state of the ancilla quantum mechanical oscillator. The states are then disentangled, and momentum and position quadrature operators of the ancilla quantum mechanical oscillator are measured and used to perform QEC on the information stored in the data quantum mechanical oscillator.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: February 20, 2024
    Assignee: Yale University
    Inventors: Kyungjoo Noh, Steven M. Girvin, Liang Jiang
  • Patent number: 11896639
    Abstract: The invention relates to methods of evaluating the quality of a batch of an herbal composition, the method comprising subjecting a test batch of the herbal composition to one or more biological analysis methods and comparing the results derived from the test batch to the results of a known batch of herbal composition which has a known in vivo effect.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: February 13, 2024
    Assignee: YALE UNIVERSITY
    Inventor: Yung-Chi Cheng
  • Patent number: 11896686
    Abstract: Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: February 13, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Yang Deng, Asiri Ediriwickrema, William M. Saltzman
  • Patent number: 11890283
    Abstract: The invention includes methods of preventing or treating acute lung injury using a MAP3K2/MAP3K3 inhibitor. The invention further comprises compositions, and kits comprising compositions useful within the invention.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: February 6, 2024
    Assignee: Yale University
    Inventors: Dianqing Wu, Qianying Yuan, Abdul Basit, Wenwen Tang
  • Patent number: 11890335
    Abstract: Disclosed herein are peptide-adjuvant pharmaceutical compositions and vaccine compositions that trigger long lasting natural anti-tumor antibodies. Such compositions may be used alone, or in combination with anti-cancer agents, chemotherapeutic agents, anti-PD therapy, chemotherapy, radiation therapy, and surgery, in the prevention and treatment of cancer.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: February 6, 2024
    Assignees: L2 Diagnostics, LLC, Yale University
    Inventors: Mark Mamula, Raymond A. Koski
  • Patent number: 11883369
    Abstract: The present invention includes a low dose and sustained release formulation of a mitochondrial uncoupling agent The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.
    Type: Grant
    Filed: May 16, 2022
    Date of Patent: January 30, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Gerald I. Shulman, Rachel Jamison Perry
  • Publication number: 20240018591
    Abstract: Disclosed herein are kits and methods for assessing the risk of poor reading performance in an individual by detecting and identifying single nucleotide polymorphisms in chromosome 19, e.g. in the KIAA0355 (GARRE1) gene. Also disclosed herein are risk alleles in chromosome 19 that are associated with a latent measure for reading ability.
    Type: Application
    Filed: October 8, 2020
    Publication date: January 18, 2024
    Applicants: Yale University, Brock University
    Inventors: Jeffrey R. Gruen, Andrew Adams, Dongnhu Truong, Jan Frijters, Joan Bosson-Heenan
  • Patent number: 11872286
    Abstract: Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: January 16, 2024
    Assignee: Yale University
    Inventors: Elias Quijano, Peter Glazer
  • Patent number: 11865284
    Abstract: The present disclosure provides a fluidic device including (a) a first channel including a first inlet and a first outlet, (b) a second channel including a second inlet and a second outlet, wherein the second inlet of the second channel is in fluid communication with the first outlet of the first channel, and (c) a sensor positioned between the first outlet and the second inlet, wherein the sensor includes a sensor configured to deflect in response to a flow between the first channel and the second channel.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: January 9, 2024
    Assignees: University of Connecticut, Yale University
    Inventors: Kazunori Hoshino, Davina Jaiswal, Mengdi Bao, Garrett Soler, Ariane Garrett, Ryan Grant, Michael Diluna, Hitten Zaveri
  • Patent number: 11857504
    Abstract: Provided herein are patient-controlled oral liquid-medicine dispenser and deactivation systems. The system includes a dosing container having a defined volumetric capacity and a spillway adapted and configured to allow fluid in excess of the defined volumetric capacity to flow out of the dosing container; a sealed and tamperproof waste receptacle fluidly coupled to the dosing container, the waste receptacle adapted and configured to capture and prevent diversion of liquid medicine dispensed in excess of the defined volumetric capacity of the dosing container; and a suction apparatus extending between a lower region of the dosing container and outside of the dosing container. Also provided herein are methods of administering a medication using the system.
    Type: Grant
    Filed: June 2, 2023
    Date of Patent: January 2, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Daniel Wiznia, Jinlei Li, Claudia See
  • Patent number: 11858917
    Abstract: The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: January 2, 2024
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, Christopher Parker
  • Patent number: 11857509
    Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: January 2, 2024
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Patent number: 11850276
    Abstract: The present disclosure provides compositions and methods comprising stabilized IL-18 polypeptides for use in therapeutic and non-therapeutic applications. In some cases, the stabilized IL-18 proteins provide IL-18 signaling activity even in the presence of an inhibitory molecule such as IL-18BP. Also provide are methods of administration and methods for making active polypeptides.
    Type: Grant
    Filed: December 1, 2022
    Date of Patent: December 26, 2023
    Assignees: Simcha IL-18, Inc., Yale University
    Inventors: Aaron Ring, Tom Boone
  • Patent number: 11850284
    Abstract: Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: December 26, 2023
    Assignee: Yale University
    Inventors: Elias Quijano, Peter Glazer
  • Patent number: 11839639
    Abstract: In one embodiment, the present invention is directed to a composition comprising an aqueous or ethanolic extract of at least one herb selected from the group consisting of Aloe barbadensis (:F3), Rheum palmatum L. (:B6), Stephania tetrandra (:C4), Phellodendron chinense Schneid. (:D8), Euphorbia humifusa (:S6), Eclipta prostrata (:I2), A. venetum L. (:F1), Portulaca oleracea L. (:F5), and Sanguisorba officinalis L. (:E5), Camellia sinensis var. assamica (Mast.) Kitamura (:PE) and Punica granatum. (:PG), and mixtures thereof. The composition is administered to a patient, in an effective amount, in a method of treating, inhibiting, preventing, reducing the incidence of, ameliorating or resolving a disease state or condition caused in part or exacerbated by hyperactivity of the androgen receptor (AR), by inhibiting the androgen receptor protein. These compositions may also be used inhibit or stabilize hair loss or grow hair in a subject in need.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: December 12, 2023
    Assignee: YALE UNIVERSITY
    Inventors: Yung-Chi Cheng, Wing Lam, Zaoli Jiang