Abstract: Techniques are provided to optomechanically couple light to a crystal structure, thereby producing stable, coherent bulk acoustic modes within the structure. In some embodiments, a resonator may comprise a plano-convex crystal structure to which pump light may be applied. The pump light may transfer energy to acoustic phonon modes of the crystal structure so as to create acoustic phonon modes with a coherence length greater than a length of the crystal structure. High frequency and high quality factor resonators may thereby be produced and operated.

Abstract: The present disclosure provides methods of making and methods of using IL-18 mimic polypeptides for use in therapeutic and non-therapeutic applications. The synthetic IL-18 mimics an increase IL-18R signaling activity even in the presence of an inhibitory molecule such as IL-18BP.

Abstract: Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESR1) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.

Abstract: The present invention provides octave-spanning optical frequency combs. The octave-spanning optical frequency combs employ microresonators having improved stability using a smaller form factor. In some embodiments, the octave-spanning optical frequency combs are fabricated using aluminum nitride (AlN). AlN is a more robust Kerr material for generating octave-spanning soliton comb (e.g., 1.5 octaves or more).

Abstract: A structure for monitoring and stimulation includes an external power supply unit. The structure also includes an internal hub communicatively coupled to the external power supply unit. The structure further includes a plurality of sensor modules communicatively coupled to the internal hub by a plurality of flexible interconnects. The plurality of sensor modules include three-dimensional (3D) comb sensor devices.

Abstract: A method for forming an isoporous graded film comprising multiblock copolymers and isoporous graded films. The films have a surface layer and a bulk layer. The surface layer can have at least 1×1014 pores/m2 and a pore size distribution (dmax/dmin)) of less than 3. The bulk layer has an asymmetric structure. The films can be used in filtration applications.

Abstract: A method for classifying human blastocysts includes obtaining images of a set of artificially fertilized (AF) embryos incubating in an incubator. A morphological quality of the AF embryos is determined based on a classification of the images by a convolutional neural network trained using images of pre-classified embryos. Each of the AF embryos is graded based on the morphological quality. A probability that a given graded AF embryo will result in a successful pregnancy after the given AF embryo is implanted in a gestating female is computed for each of the AF embryos from the set based on a grade of the given AF embryo and clinical parameters associated with the gestating female. One or more graded AF embryos to be recommended to be implanted in the gestating female from the set are selected based on the probability of successful pregnancy.

Abstract: Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex.

Abstract: The invention provides a system for normothermic, ex vivo restoration and preservation of an intact mammalian brain, and other organs. In certain aspects, the system is capable of preserving a brain as well as other organs, maintaining cellular integrity and cellular function for hours post mortem or after global ischemia. The invention also provides synthetic brain perfusate formulations, including a novel brain perfusion medium (BPM), which are able to reduce reperfusion injury, stimulate recovery from hypoxia, prevent edema and metabolically support the energy needs of brain function.

Abstract: In one aspect, the invention comprises compounds that bind and inhibit macrophage migration inhibitory factor. In another aspect, the invention provides methods of treating, ameliorating, and/or preventing inflammatory disease, neurological disorders and cancer using the compounds of the invention.

Abstract: This disclosure demonstrates an approach that translates synthetic DNA codes to spatial codes registered in nanoliter microchambers for multiplexed measurement of nearly any type of molecular targets (e.g., miRNAs, mRNAs, intracellular and surface proteins) in single cells.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.

Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5? triphosphate or a 5? diphosphate.

Abstract: Provided herein are methods for decoding nucleic acid barcodes in situ by using rolling circle amplification and labeled probes. Also provided herein are methods of performing an in situ genetic screen, using the nucleic acid barcode decoding techniques described herein.

Abstract: Techniques are described to construct an electromagnetic resonator by arranging a resonant structure within a super-conducting cavity. The architecture of the design may provide a low loss superconducting cavity resonator that may exhibit multiple modes. The multimode nature of this resonator is produced in part by the resonant structure in such a way that allows the modes of the resonator to be adjusted through adjustment of the resonant structure rather than by having to alter the physical dimensions of the cavity, as would otherwise be required in a conventional superconducting cavity resonator. In some embodiments, the resonant structure may include a suspended superconductor comprising metal and/or metallized parts.

Abstract: The present disclosure relates, in part, to enhanced weathering systems and/or apparatuses and methods of use thereof. In one aspect, the present disclosure provides a method of at least partially sequestering CO2 from an influent aqueous solution comprising aqueous and/or gaseous CO2. In another aspect, the present disclosure provides a method of at least partially sequestering CO2 from a gaseous CO2 source. In another aspect, the present disclosure provides systems and/or apparatuses suitable for use in the methods described herein. In another aspect, the present disclosure provides a method of optimizing the design and operation of a system for at least partial sequestration of CO2 from a water source.

Abstract: The present disclosure concerns methods of detecting viral respiratory infections by analyzing biomarkers in a viral transport medium sample. In various embodiments the biomarkers are assessed by measuring mRNA or protein. In certain embodiments the biomarkers are nasal-virus induced molecules.

Abstract: In its various aspects and embodiments, the invention comprises a method for treating vitiligo in a patient comprising administering a composition comprising an effective amount of at least one Janus kinase inhibitor and phototherapy.

Abstract: A method for producing uniform-size liposomes is provided. The liposomes are coated with a sorting agent to yield a plurality of density-modified liposomes of different sizes. These liposomes are then separated using a densitometric method. The sorting agent includes both a density-modifying moiety and a targeting moiety.

Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.