Abstract: To provide an effective factor extraction system in which samples are generated artificially from a sample group and a virtual sample set is created so that even when the number of sample is relatively small, specific factors can be selected/extracted with high reliability by using the virtual sample set. The effective factor extraction system comprises a section for extracting samples arbitrarily from sample sets and creating a plurality of paired virtual sample sets, a statistical quantity operating section for reading out the feature value held by sample contained in respective virtual sample sets and operating the average value and the variance, a section for operating Fisher ratio from the average value and the variance, and a section for testing significant factors using the operated Fisher ratio.

Abstract: The present invention has its main object of providing a method for determining prognosis scientifically by searching an early marker for predicting neurological prognosis in order to grasp the disease state of a patient with an acute central nervous system disorder in the early stage and enabling an appropriate treatment to be performed. The method for determining the prognosis is provided in which the expression level of SH3BGRL3 in the biological fluid of the patient within 48 hours after resuscitation from cardiopulmonary arrest is measured, and the prognosis of the disorder classified into a good prognosis group and a poor prognosis group depending on the expression level or the presence or absence of the expression based on the Glasgow Outcome Scale (GOS) is predicted.

Abstract: A three-dimensional left-handed metamaterial having a completely new constitution, which functions as a three-dimensional electromagnetic wave propagation medium and in which an equivalent permittivity and a permeability of the medium simultaneously take negative values. The three-dimensional left-handed metamaterial is structured such that cubic unit cells 5 are disposed repeatedly in three orthogonal directions of a three-dimensional space, and includes: a first particle 1 constituted by a conductor and disposed in positions centering on respective vertices of the unit cell; a second particle 2 constituted by a conductor and disposed in positions centering on face center points, which are centers of respective faces of the unit cell; a first connecting portion constituted by a conductor, which connects the first particles to a center point of the unit cell; and a second connecting portion constituted by a conductor, which connects the second particles to the center point.

Abstract: There is provided an ion-exchange membrane comprising an ion-exchange layer made of a cationic polymer and/or an anionic polymer and a supporting layer, wherein the ion-exchange layer is formed on the supporting layer by printing. Such an ion-exchange membrane exhibits excellent anti-organic fouling and low membrane resistance, thereby high efficient and long-time stable electrodialysis can be achieved. Formation of the ion-exchange layer as a charge-mosaic layer consisting of the cationic polymer domains and the anionic polymer domains provides a charge-mosaic membrane exhibiting excellent electrolyte permselectivity and mechanical strength.

Abstract: There is provided a charge-mosaic membrane comprising a cationic block copolymer (P) having a vinyl alcohol polymer block (A) and a cationic-group containing polymer block (B) as components; and an anionic block copolymer (Q) having a vinyl alcohol polymer block (C) and an anionic-group containing polymer block (D) as components. Such a charge-mosaic membrane is useful as a charge-mosaic membrane for piezodialysis because it exhibits higher membrane strength and higher permselectivity and has a larger charge density and a larger salt permeation flux.

Abstract: This invention provides a novel graft polymer that has excellent proton conductivity, is capable of regulating hydrogen permeability, methanol permeability, and the like, and can serve as a starting material for a polymer electrolyte membrane, which facilitates moisture balance control and efficient operation of a fuel cell. A polymer electrolyte membrane composed of such graft polymer is also provided. This graft polymer comprises a main chain comprising a hydroxyl group-containing polymer and a graft chain comprising a polymer containing a sulfonic acid group-containing monomer.

Abstract: The electrolyte solution for a lithium ion secondary battery according to the present invention contains a nonaqueous solvent, a lithium salt and a compound represented by the general formula (Z) shown below. Thereby, a lithium ion secondary battery having high battery characteristics and simultaneously achieving a high safety as well can be provided. R—SO2—Ar1—O—R1??(Z) wherein Ar1 denotes a substituted or nonsubstituted divalent aromatic group having 5 to 30 atoms of the nucleus(es); R1 denotes a saturated or unsaturated monovalent hydrocarbon group having 1 to 20 carbon atoms; and R denotes a saturated or unsaturated monovalent hydrocarbon group having a perfluoroalkyl group and having 2 to 22 carbon atoms.

Abstract: In a semiconductor device fabricated by growing a compound semiconductor layer on a sapphire substrate, a sapphire substrate enabling the semiconductor device to have a high light-extraction efficiency is provided. A plurality of projections 2, 2, . . . are provided at random on a surface of a sapphire substrate 1, and a GaN layer 10 is grown on this surface. Then, a multi-quantum well layer 12, a p-AlGaN layer 14, a p-GaN layer 16, and an ITO layer 18 are formed on the GaN layer 10, and two electrodes 21 and 22 are also formed. In this manner, a semiconductor light-emitting device is fabricated.

Abstract: An image-processing unit, comprising an exposure conversion circuit, a standard image-setting circuit, a contour extraction circuit, a contour comparison circuit, a final setting circuit, and an image synthesis circuit, is provided. The exposure conversion circuit generates first and second exposure level image data. The standard image-setting circuit sets standard image data. The contour extraction circuit extracts standard and first comparison contours on the basis of the standard image data. The contour comparison circuit detects a first accordance indicator on the basis of the contours. The final setting circuit sets the first conclusive threshold on the basis of the first accordance indicator. The image synthesis circuit generates the rendered image data based on the first conclusive threshold.

Abstract: A drug effect-adverse effect prediction system includes a clinical data analysis table generating part, for each combination of genotypes relating to a drug effect or adverse effect, for generation of an analysis table for handling cases related to presence or absence of the drug effect or adverse effect. The system also includes a reliability analysis part, a discrimination formula generating part, a prediction part, and a discrimination formula optimizing part.

Abstract: The present invention provides a sripline-type transmission line which can easily change and control transmission characteristics by changing the permittivity of a substrate, and also provides an antenna that can extensively change and control the direction of radiation with the frequency of an electromagnetic wave constant, by using this transmission line.

Abstract: An ultrasonic diagnostic apparatus which can measure a time difference of motion between a plurality of sites of a cardiac muscle for the heart of a fetus is provided. On a tomographic image of the heart, a user sets a plurality of observation points. Each observation point is tracked, and a plurality of displacement waveforms representing a temporal displacement of the plurality of observation points are generated. A time difference between a plurality of representative points is calculated between the plurality of displacement waveforms. Such a time difference is displayed as a numerical value or as a graph. The representative point is a peak point, a zero-cross point, an inflection point, or the like. The plurality of observation points are set along conduction pathways in the heart for the electric signal.

Abstract: A chemical reaction transition state search system includes an input device, an arithmetic processing unit, and a storage device in order to find a chemical structure being in a targeted transition state in a chemical reaction. The arithmetic processing unit includes an IG forming unit, a CG-search calculating unit, a TS optimization calculating unit, a reactive-site fixing unit, a substituent processing unit, and a structural optimization calculating unit.

Abstract: A method for determining the risk of adverse effects of irinotecan (CPT-11), a synthetic anticancer drug, by detecting polymorphisms in the TATA box within the promoter region of the UDP-glucuronosyl transferase gene. A kit for detecting the adverse effects of irinotecan containing at least one pair of nucleic acid probes.

Abstract: A synthetic route evaluation system extracts an optimal synthetic route from a plurality of synthetic routes for a target compound to be synthetically produced. The synthetic route evaluation system includes an arithmetic processing device, which is composed of a quantum chemistry calculation unit, a reaction mechanism analysis unit, and a synthetic route ranking unit, and a storage device for storing data relative to the synthetic routes.

Abstract: The present invention has its main object of providing a method for determining prognosis scientifically by searching an early marker for predicting neurological prognosis in order to grasp the disease state of a patient with an acute central nervous system disorder in the early stage and enabling an appropriate treatment to be performed. The method for determining the prognosis is provided in which the expression level of SH3BGRL3 in the biological fluid of the patient within 48 hours after resuscitation from cardiopulmonary arrest is measured, and the prognosis of the disorder classified into a good prognosis group and a poor prognosis group depending on the expression level or the presence or absence of the expression based on the Glasgow Outcome Scale (GOS) is predicted.

Abstract: [Object] It is to provide a method and a kit capable of detecting or quantifying a target RNA simply and rapidly from trace amounts of RNA in a sample, in a case such as when one or more kinds of pathogenic microorganisms are to be detected or quantified. [Solving Means] The method comprises the steps of 1) synthesizing cDNA from a sample containing the target RNA using a liquid-phase primer having a promoter sequence and a reverse transcriptase to obtain a cDNA-RNA complex, 2) degrading the RNA of the complex, 3) synthesizing a double-stranded DNA via the cDNA obtained in the step 2) and the solid-phase primer, 4) synthesizing RNA from the double-stranded DNA, 5) synthesizing cDNA via the RNA obtained in the step 4) and the solid-phase primer to obtain a cDNA-RNA complex, 6) degrading the RNA of the complex obtained in step 5), 7) synthesizing a double-stranded DNA via the cDNA obtained in the step 6) and the liquid-phase primer, and 8) quantifying the double-stranded DNAs obtained in the steps 3) and 7).

Abstract: It is to provide a novel Kluyveromyces marxianus transformant having thermotolerance and flocculation property, suitable for the industrial production of bioethanol, by introducing a foreign flocculation gene into Kluyveromyces marxianus, and an efficient method for producing the transformant. The present inventors focused on the flocculation gene FLO of Saccharomyces cerevisiae as a foreign gene to confer flocculation property to Kluyveromyces marxianus and produced a linear DNA fragment comprising a known expression promoter sequence and a FLO gene sequence derived from Saccharomyces cerevisiae. As a result of introducing this linear DNA fragment into Kluyveromyces marxianus, the present inventors have confirmed that Kluyveromyces marxianus transformant can be obtained efficiently, and that the flocculation property of the above transformant is unexpectedly and significantly enhanced. The present invention has been thus completed.

Abstract: Each of unit cells constituting a negative permeability medium includes a metal patch formed on a surface of a dielectric substrate. The dielectric substrate has a rear surface having a ground conductor formed on its entire surface. A positive permeability medium is an existing micro strip line and each of unit cells has a two-dimensional structure having a metal strip connected in four directions. The dielectric substrate has a rear surface having a ground conductor formed on its entire surface. The negative permeability medium is arranged at the left side adjacent to the positive permeability medium formed by unit cells arranged at the right side so that the media oppose to each other. A waveguide formed by the positive/negative permittivity medium or the positive/negative permeability medium of the meta material for propagation of a surface wave is formed at the boundary of the two media.

Abstract: It is a main object of the present invention to provide a drug delivery system in which drugs can be changed or which can be recharged with drugs, which continuously delivers drugs at effective concentrations to local lesional sites in a body and allows the use of drugs for which it has thus far been difficult to achieve effective local concentrations for a variety of reasons and drugs which have been difficult to use due to adverse effects on tissues that are not sites of action. The present invention provides a drug delivery system comprising an indwelling medical device on which a biocompatible material having target molecules on its surface has been coated, and target-recognizing nanocarriers (e.g., bio-nanocapsules, liposomes, liposome preparations, and nanoparticles) in which drugs are encapsulated and which have target-recognizing molecules capable of specifically binding to the target molecules.