Patents Assigned to Yamanouchi Pharmaceutical Co., Ltd.
  • Genes coding for a protein having human MACIF activity, expression vectors containing said genes, transformant cells and proteins having human macif activity
    Patent number: 5795736
    Abstract: Genes coding for a protein having human MACIF activity, expression vectors containing the genes, transformed cells with the vectors and proteins having human MACIF activity.
    Type: Grant
    Filed: August 11, 1995
    Date of Patent: August 18, 1998
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Motowo Tomita, Yuji Sugita, Toshiyuki Takemoto, Kiyoshi Furuichi, Makoto Takayama, Ko Yasukawa, Katsuhisa Ito, Noboru Yamaji, Shinya Yano
  • Benzamidine derivatives and pharmaceutical composition containing them
    Patent number: 5773442
    Abstract: Disclosed are benzamidine derivatives of the following general formula (I), salts thereof, hydrates thereof or solvates thereof, and pharmaceutical compositions comprising the derivatives, salts thereof, hydrates thereof or solvates thereof along with pharmaceutically-acceptable carriers. ##STR1## The derivatives and their compositions have GPIIb/IIIa receptor antagonistic activity and are useful for the treatment and prophylaxis of vascular system disorders as medicines for ameliorating ischemic cardiac disorders, adminicula in cardiosurgery operations or in vascular surgery operations, medicines for ameliorating cerebrovascular disorders, and medicines for ameliorating peripheral artery disorders.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: June 30, 1998
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Seijiro Akamatsu, Yuzo Matsumoto, Masato Ichihara, Tomihisa Kawasaki, Seiji Kaku, Isao Yanagisawa
  • Tissue plasminogen activator and process of preparation
    Patent number: 5739012
    Abstract: The present invention relates to improved plasminogen activators (improved t-PA) which have a prolonged biological half life, an increased stability to heat and acids and can be expected to be effective as inhibiting inflammation around the site in which thrombus is formed.
    Type: Grant
    Filed: September 10, 1996
    Date of Patent: April 14, 1998
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Yasushi Kawauchi, Toshiyuki Takemoto, Makoto Takayama, Masami Yokota, Masao Kato, Kimio Katsuta
  • Process of preparing benzodiazepine compounds useful as antagonists of CCK or of gastrine
    Patent number: 5728829
    Abstract: A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: ##STR1## wherein: (a) R.sup.4 is an alkyl, cycloalkyl or aryl group.(b) R.sup.10 is chosen from halo, OH, CH.sub.3, OCH.sub.3, NR.sup.11 R.sup.12, NO.sub.2, NHCHO, CO.sub.2 H and CN, and R.sup.11 and R.sup.12 are independently selected from H and alkyl (C.sub.1 -C.sub.5) or together NR.sup.11 R.sup.12 form a cyclic structure II, ##STR2## wherein a is 1-6; and (c) R.sup.2 is an aromatic 5- or 6-membered, substituted or unsubstituted heterocycle containing at least two heteroatoms of which at least one is nitrogen.These compounds are gastrin and/or CCK-B receptor antagonists.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: March 17, 1998
    Assignees: Ferring-Research Limited, Yamanouchi Pharmaceutical Co. Ltd.
    Inventors: Graeme Semple, Hamish Ryder, Michael Szelke, Masato Satoh, Mitsuaki Ohta, Keiji Miyata, Akito Nishida, Masato Ishii
  • Condensed benzazepine derivative and pharmaceutical composition thereof
    Patent number: 5723606
    Abstract: This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) ##STR1## (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R.sup.1 and R.sup.2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group,A: a single bond; a group represented by the formula--NHCO--(CR.sup.3 R.sup.4).sub.n --,n: 0 or an integer of from 1 to 3,R.sup.3 and R.sup.4 : these may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group (provided that R.sup.3 and R.sup.
    Type: Grant
    Filed: January 19, 1996
    Date of Patent: March 3, 1998
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Akihiro Tanaka, Hiroyuki Koshio, Nobuaki Taniguchi, Akira Matsuhisa, Ken-ichiro Sakamoto, Atsuki Yamazaki, Takeyuki Yatsu
  • Benzazepine derivative, pharmaceutical composition thereof, and intermediate thereof
    Patent number: 5710150
    Abstract: Benzazepine derivatives represented by the following general formula (I) useful as arginine vasopressin antagonists or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and difluorobenzazepinone derivatives represented by the following general formulae (II) and (III) which are useful as production intermediates of the compound (I).
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: January 20, 1998
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Nobuaki Taniguchi, Akihiro Tanaka, Akira Matsuhisa, Ken-ichiro Sakamoto, Hiroyuki Koshio, Takeyuki Yatsu
  • Benzodiazepine derivatives useful as CCK-receptor antagonists
    Patent number: 5688943
    Abstract: This invention relates to benzodiazepine derivatives which are useful as drugs exhibiting antagonism at the gastrin and/or CCK-B receptor, and to their production.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: November 18, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Hamish Ryder, Graeme Semple, David Alan Kendrick, Michael Szelke, Masato Satoh, Mitsuaki Ohta, Keiji Miyata, Akito Nishida
  • N-(3-pyrrolidinyl) benzamide derivative
    Patent number: 5686482
    Abstract: N-(3-Pyrrodinyl)benzamide derivatives represented by the following general formula (I) which have potent and selective antagonism against dopamine D.sub.3 and/or D.sub.4 receptor and are useful as a psychotropic, a schizophrenia-treating agent and the like, or a pharmaceutically acceptable salt thereof or a pharmaceutical preparation thereof.
    Type: Grant
    Filed: October 2, 1996
    Date of Patent: November 11, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Junya Ohmori, Kyoichi Maeno, Kazuyuki Hidaka, Kazuhiro Nakato, Shuichi Sakamoto, Shin-ichi Tsukamoto
  • Triazolylated teritiary amine compound or salt thereof
    Patent number: 5674886
    Abstract: A triazolylated tertiary amine compound represented by general formula (I) or a salt thereof, having an aromatase inhibitory activity and being useful for preventing and treating breast cancer, mastopathy, endometriosis, prostatomergaly, etc., wherein A represents a single bond, lower alkylene or carbonyl; B represents lower alkyl, aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; D represents aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; and E represents 4H-1,2,4-triazolyl, 1H-1,2,4-triazolyl or 1H-1,2,3-triazolyl.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: October 7, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Minoru Okada, Eiji Kawaminami, Toru Yoden, Masafumi Kudou, Yasuo Isomura
  • Thiazole derivatives
    Patent number: 5656637
    Abstract: A novel thiazole derivative represented by general formula (I), which has a selected agonistic activity for 5-HT.sub.3 receptor, a pharmaceutical composition thereof, and a process for producing the same. In the said formula, R.sup.1 represents hydrogen or lower alkoxy; R.sup.2 and R.sup.3 are such that R.sup.2 represents hydrogen and R.sup.3 represents a group, --Y--Het, wherein Y represents a single bond or lower alkylene and Het represents a nitrogenous heterocyclic group, or alternatively R.sup.2 and R.sup.3 are combined together to form a group, --(CH.sub.2).sub.m --NR.sup.4 --(CH.sub.2).sub.n --, wherein m and n are each 1 or 2 and R.sup.4 represents lower alkyl; and X represents --NH--, --NHC(.dbd.O)NH--, --C(.dbd.O)NH-- or --NHC(.dbd.O)--.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: August 12, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Mitsuaki Ohta, Isao Yanagisawa, Keiji Miyata
  • Bisoxadiazolidine derivative
    Patent number: 5643931
    Abstract: A bisoxadiazolidine dione derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as an insulin sensitivity-increasing drug, and a pharmaceutical composition thereof. ##STR1## each represents a phenylene groupL:(1) an oxygen,(2) a ##STR2## (3) a --S(O).sub.n --, (4) a --CO--,(5) a ##STR3## (6) an alkylene group or an alkenylene group which may respectively be interrupted with an oxygen atom and/or a sulfur atom.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: July 1, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kunihiro Niigata, Takumi Takahashi, Tatsuya Maruyama, Takayuki Suzuki, Kyoichi Maeno, Kenichi Onda, Toru Kontani, Osamu Noshiro, Reiko Koike, Akiyoshi Shimaya, Jun Irie
  • Crystal form of benzodiazepine derivatives
    Patent number: 5637585
    Abstract: This invention provides the form B crystal of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazep in-3-yl]-3-(3-tolyl)urea which is produced by recrystallizing the compound from a mixed solvent of at least 1 volume of water and 5 volumes of an alcohol. The form B crystals have excellent filtration property and flowability, so that they can be handled markedly easily at the time of filtration for their large scale production or when they are made into pharmaceutical preparations and therefore are useful in view of their industrial production.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: June 10, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Makoto Nakamura, Kouichi Watanabe
  • Tri (lower alkoxy) benzene derivatives
    Patent number: 5633288
    Abstract: This invention relates to a tri(lower alkoxy)benzene derivative of the general formula (I), or its salt, optical isomer or solvate, ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 : same or different and each represents a lower alkyl group;A: a group of the formula ##STR2## and R.sup.4 and R.sup.5 : same or different and each represents a lower alkyl group, an aralkyl group or an aryl group, provided that R.sup.4 and R.sup.5 may, taken together with the adjacent nitrogen atom, form a pyrrolidinyl group, a piperidino group, a morpholino group, a thiomorpholino group, or a piperazinyl group optionally substituted by a lower alkyl group in 4-position;to pharmaceutical compositions containing the same, and to processes for their production. The compound of the invention is useful as value as a pulmonary-surfactant secretion promoting agent.
    Type: Grant
    Filed: November 22, 1995
    Date of Patent: May 27, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Hiromu Hara, Tatsuya Maruyama, Munetoshi Saito, Toshiyasu Mase
  • Quick-dissolution solid preparation
    Patent number: 5624687
    Abstract: The invention provides a solid preparation having a quick and pH-independent dissolution with an excellent bioavailability for a drug that is otherwise sharply depressed in solubility with pH elevation. This solid preparation contains granules each comprising a fine particulate core coated with a solid solution comprising a drug which is pH-dependent in solubility and may be released from an enteric base-containing composition at low pH and an enteric base.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: April 29, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Katsuhiko Yano, Yasuhiro Nishizono, Shigeru Yamazaki, Tadayoshi Ohmura, Shunji Hasumi
  • Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them
    Patent number: 5623074
    Abstract: A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## Wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt thereof.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: April 22, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Akihiro Tanaka, Takashi Fujikura, Ryuji Tsuzuki, Masaki Yokota, Takeyuki Yatsu
  • Dihydropyridine-3, 5-dicarboxylic acid ester derivatives
    Patent number: 5616715
    Abstract: A process is provided for producing diastereoisomer A or a pharmaceutically acceptable acid addition salt of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester which comprises subjecting a mixture of diastereoisomers A and B of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester to column chromatography using silica gel as a carrier and a mixture of ethyl acetate and acetic acid as an eluant, and then separating the acetate of diastereoisomer A from the eluate, or treating the acetate with a base, or further treating the resulting diastereoisomer A with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: April 1, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kazuharu Tamazawa, Tadao Kojima, Hideki Arima, Yukiyasu Murakami, Yasuo Isomura, Minoru Okada, Toichi Takenaka, Kiyoshi Takanobu
  • Dihydropyridine composition
    Patent number: 5591757
    Abstract: Pharmaceutical composition of certain dihydropyridine compounds and salts thereof are provided which exhibit both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities and therefore are useful for the treatment of ischemic heart diseases and hypertension. The pharmaceutical compositions contains either 4-(2-hydroxy-3-phenoxy-propylamino)-butyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or 6-(2-hydroxy-3-phenoxypropylamino) hexyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or their pharmaceutically acceptable salts.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: January 7, 1997
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Takashi Fujikura, Noriki Ito, Yuzo Matsumoto, Masaharu Asano, Toichi Takenaka
  • Quick release coated preparation
    Patent number: 5578322
    Abstract: A coated preparation prepared by coating drug particles having a disagreeable taste with a mixture comprising a hydrophobic substance with a melting point of 45.degree. to 90.degree. C. and a surfactant with a lower melting point and heat treating the coating layer at a temperature ranging from around the melting point of the surfactant up to the melting point of the hydrophobic substance to modify the nature of the coating layer. This preparation can release the drug quickly which sufficiently suppressing the disagreeable taste.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 26, 1996
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Hiroyoshi Shiozawa, Hiroya Sugao, Shigeru Yamazaki, Katsuhiko Yano
  • Intrabuccally dissolving compressed moldings and production process thereof
    Patent number: 5576014
    Abstract: Intrabuccally dissolving compressed moldings comprising a saccharide having low moldability having been granulated with a saccharide having high moldability. The moldings of the present invention show quick disintegration and dissolution in the buccal cavity and have an adequate hardness.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: November 19, 1996
    Assignee: Yamanouchi Pharmaceutical Co., Ltd
    Inventors: Takao Mizumoto, Yoshinori Masuda, Muneo Fukui
  • K-filter for serial high-speed rotatography and apparatus for the rotatography
    Patent number: 5568533
    Abstract: A K-filter is the one attached to an apparatus for serial high-speed rotatography for photographing an object to be examined by use of X-rays. The filter comprises two K-containers (5a and 5b) in which a space is defined for fluidly containing a radiopaque fluid substance, and a radiotransparent region (2) formed between the two K-containers (5a and 5b). The K-containers (5a and 5b) are pivotally supported by a supporting member (1a) and are of the inversion type which allows the radiotransparent region sides of the K-containers to move. Therefore, when this apparatus is rotated at a high speed to more than 180.degree., it is possible to conduct filtering under any conditions such as an inclined posture, not the horizontal posture, under which photographing is started.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: October 22, 1996
    Assignees: Tatsuo Kumazaki, Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Tatsuo Kumazaki, Hifumi Yamada