Patents Assigned to Yeda Research and Development Co., Ltd.
  • QUANTUM COMPUTING DEVICE
    Publication number: 20230004850
    Abstract: Provided is a quantum computing device comprising a carbon nanotube, a superconducting substrate in quantum proximity to the nanotube and being in a superconducting state having a pairing correlation matrix with a substantial spin-triplet component in a direction perpendicular to the nanotube, and a magnet arranged to provide a longitudinal magnetic field along a longitudinal axis of the nanotube. Further provided is a quantum computing device comprising at least three substrates made of a superconductor material and each in a superconducting state, and a non-superconducting structure made of a material in which the electrons' closed trajectories experience strong spin-orbit coupling interactions and being in quantum proximity to the substrates. The sum of the phase differences between the order parameters of all of the substrates is at least ?.
    Type: Application
    Filed: December 2, 2020
    Publication date: January 5, 2023
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD., UNIVERSITY OF COPENHAGEN
    Inventors: Yuval OREG, Gal SHAVIT, Omri LESSER, Erez BERG, Adiel STERN, Karsten FLENSBERG
  • Systems and methods for generating 3D images based on fluorescent illumination
    Patent number: 11540725
    Abstract: There is provided a computer implemented method for generating a three dimensional (3D) image based of fluorescent illumination, comprising: receiving in parallel by each of at least three imaging sensors positioned at a respective parallax towards an object having a plurality of regions with fluorescent illumination therein, a respective sequence of a plurality of images including fluorescent illumination of the plurality of regions, each of the plurality of images separated by an interval of time; analyzing the respective sequences, to create a volume-dataset indicative of the depth of each respective region of the plurality of regions; and generating a 3D image according to the volume-dataset.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: January 3, 2023
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Alon Harmelin, Vyacheslav Kalchenko, Guillaume Molodij
  • Isolated polynucleotides and polypeptides and methods of using same for expressing an expression product of interest
    Patent number: 11542508
    Abstract: Methods of expressing an expression product of interest are provided. Accordingly there is provided a method comprising introducing into a cell a polynucleotide comprising an AimR responsive element operatively linked to a nucleic acid sequence encoding the expression product of interest, and contacting said cell with an AimP peptide comprising an amino acid sequence of XXXXGG/A, wherein said AimP peptide is capable of binding said AimR polypeptide and dissociating said AimR polypeptide from said AimR responsive element. Also provided are articles of manufacture, isolated peptides, polynucleotides and nucleic acid constructs.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: January 3, 2023
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Rotem Sorek, Gil Amitai, Erez Zohar
  • Phosphatidylcholine lipid liposomes as boundary lubricants in aqueous media
    Patent number: 11541008
    Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: January 3, 2023
    Assignees: YEDA RESEARCH AND DEVELOPMENT CO., LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Jacob Klein, Ronit Goldberg, Yechezkel Barenholtz, Avi Schroeder
  • PLANT WITH ALTERED CONTENT OF STEROIDAL ALKALOIDS
    Publication number: 20220408679
    Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.
    Type: Application
    Filed: July 7, 2022
    Publication date: December 29, 2022
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Asaph AHARONI, Prashant SONAWANE, Maxim ITKIN
  • MULTISPECIFIC ANTIBODIES FOR USE IN TREATING DISEASES
    Publication number: 20220403043
    Abstract: A multispecific antibody is provided. The antibody comprising a first moiety, which binds and activates CD40, a second moiety, which specifically binds a dendritic cell (DC) and a third moiety comprising a modified Fc region of the multispecific antibody for enhancing specificity and affinity of binding to Fc?RIIb and uses of same.
    Type: Application
    Filed: July 22, 2022
    Publication date: December 22, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Rony DAHAN, Ran SALOMON
  • METHOD FOR ANALYZING CELL CLUSTERS
    Publication number: 20220392571
    Abstract: A method of determining cell members of a cell cluster in a tissue of interest is disclosed. The cell members physically interact with one another in the cell cluster. Computer software products capable of carrying out the method are also disclosed.
    Type: Application
    Filed: August 10, 2022
    Publication date: December 8, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Amos TANAY, Amir GILADI, Merav COHEN
  • METHODS OF TREATING ATOPIC DERMATITIS
    Publication number: 20220370517
    Abstract: A method of treating atopic dermatitis (AD) in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of at least two species of bacteria.
    Type: Application
    Filed: June 30, 2022
    Publication date: November 24, 2022
    Applicants: Ichilov Tech Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Eran SEGAL, Jacob MASHIAH, Nitsan MAHARSHAK
  • METHODS OF TREATING CANCER
    Publication number: 20220372145
    Abstract: A method of reducing the immune suppressor activity of myeloid cells is disclosed. The method comprises contacting myeloid cells with an effective amount of an agent which specifically reduces the amount and/or activity of myeloid cells expressing both Triggering Receptor Expressed On Myeloid Cells 2 (Trem2) and Transmembrane glycoprotein NMB (Gpnmb). The method can be used for treating cancer. Antibodies and bi-specific antibodies are also disclosed.
    Type: Application
    Filed: July 29, 2022
    Publication date: November 24, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Assaf WEINER, Yonatan KATZENELENBOGEN, Adam YALIN, Fadi SHEBAN
  • Combination therapy for a stable and long term engraftment using specific protocols for T/B cell depletion
    Patent number: 11504399
    Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×CD34+ cells per kilogram body weight of the subject, and wherein the T cell depleted immature hematopoietic cells are obtained by separating the T cells from the immature hematopoietic cells by magnetic cell sorting, and (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per body weight, thereby treating the subject.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: November 22, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yair Reisner, Esther Bachar-Lustig
  • TREATING ACUTE LIVER DISEASE WITH TLR-MIK INIHIBITORS
    Publication number: 20220362329
    Abstract: Methods of treating acute liver disease acute liver diseases are provided. Accordingly, there is provided a method of treating acute liver disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent capable of binding a component of a TLR-MYC signaling pathway selected from the group consisting of MYC, MYD88, TRIF and p38 and inhibiting expression and/or activity of the component.
    Type: Application
    Filed: July 28, 2022
    Publication date: November 17, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Eran ELINAV, Ido AMIT, Aleksandra Anna KOLODZIEJCZYK
  • DIAGNOSIS OF FRONTOTEMPORAL DEMENTIA
    Publication number: 20220364175
    Abstract: A method of diagnosing Frontotemporal dementia (FTD) in a subject in need thereof is provided. The method comprising detecting a level of at least one micro RNA (miR) selected from the group consisting of hsa-miR-361-5p, hsa-miR-629-5p, hsa-miR-628-3p, hsa-miR-379-5p, hsa-miR-1-3p, hsa-miR-26a-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-142-5p and hsa-miR-340-5p in a biological sample of the subject, wherein when said level of said at least one micro RNA (miR) is higher than that in a control sample, it is indicative of FTD.
    Type: Application
    Filed: June 22, 2022
    Publication date: November 17, 2022
    Applicants: Yeda Research and Development Co. Ltd., UCL Business Ltd
    Inventors: Eran HORNSTEIN, Iddo MAGEN, Nancy-Sarah YACOVZADA, Jonathan ROHRER, Pietro FRATTA
  • Combination therapy for a stable and long term engraftment
    Patent number: 11497776
    Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: November 15, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yair Reisner, Esther Bachar-Lustig
  • Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the CNS
    Patent number: 11492405
    Abstract: The present specification discloses a pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS. The pharmaceutical composition is administered by a dosage regimen comprising at least one course of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: November 8, 2022
    Assignee: Yeda Research and Development Co. Ltd
    Inventors: Michal Eisenbach-Schwartz, Kuti Baruch, Neta Rosenzweig
  • Device and method for controlling respiration during sleep
    Patent number: 11491301
    Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: November 8, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Anat Arzi, Lee Sela, Anton Plotkin, Aharon Weissbrod, Noam Sobel
  • CRISP-seq, an integrated method for massively parallel single cell RNA-seq and CRISPR pooled screens
    Patent number: 11485971
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 1, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ido Amit, Diego Jaitin, David Lara-Astiaso, Assaf Weiner, Ido Yofe
  • System and method for ultrasound analysis
    Patent number: 11478226
    Abstract: An exemplary system, method and computer-accessible medium for detecting an anomaly(ies) in an anatomical structure(s) of a patient(s) can be provided, which can include, for example, receiving imaging information related to the anatomical structure(s) of the patient(s), classifying a feature(s) of the anatomical structure(s) based on the imaging information using a neural network (s), and detecting the anomaly(ies) based on data generated using the classification procedure. The imaging information can include at least three images of the anatomical structure(s).
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: October 25, 2022
    Assignees: New York University, Yeda Research And Development Co., Ltd.
    Inventors: Itay Kezurer, Achiau Ludomirsky, Yaron Lipman
  • Diagnosis of autoimmune diseases
    Patent number: 11480568
    Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 25, 2022
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Rachel Sorek, Keren Jakobi-Brook, Pennina Safer, Irun R. Cohen
  • ELECTROMECHANICAL RESONATORS BASED ON METAL-CHALCOGENIDE NANOTUBES
    Publication number: 20220337222
    Abstract: This invention provides electromechanical resonators based on metal chalcogenide nanotubes. The invention further provides methods of fabrication of electromechanical resonators and methods of use of such electromechanical resonators.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD., B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., at Ben-Gurion University
    Inventors: Reshef TENNE, Ernesto JOSELEVICH, Yiftach DIVON, Roi LEVI, Assaf YAAKOBOVITZ, Dan YUDILEVICH
  • Sphingosine analogs and use thereof against bacterial lung infections
    Patent number: 11471430
    Abstract: Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: October 18, 2022
    Assignees: Yeda Research and Development Co. Ltd., University of Duisburg-Essen
    Inventors: Anthony H. Futerman, Tammar Joseph, Walter A. Shaw, Stephen W. Burgess, Shengrong Li