Patents Assigned to Yeda Research and Development Co., Ltd.
  • Combination therapy for the treatment of cancer
    Patent number: 11471504
    Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: October 18, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yardena Samuels, Rand Arafeh, Karen Flores, Rony Seger, Ehud Wainstein
  • Method for platinum group metals recovery from spent catalysts
    Patent number: 11473168
    Abstract: A method for recovery of platinum group metals from a spent catalyst is described. The method includes crushing the spent catalyst to obtain a catalyst particulate material including particles having a predetermined grain size. The method includes subjecting the catalyst particulate material in the reaction zone at a predetermined temperature for a predetermined time period in contact with solid chlorine-containing material and solid silicon-containing material to obtain volatile platinum group metal-containing chloride product, and cooling to convert the product into solid phase platinum group metal-containing materials.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: October 18, 2022
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Igor Lubomirsky, Valery Kaplan, Ilya Bronshtein
  • METHOD AND SYSTEM FOR PREDICTING GESTATIONAL DIABETES
    Publication number: 20220328185
    Abstract: A method of predicting likelihood for gestational diabetes, comprises: obtaining a plurality of parameters characterizing a female subject, accessing a computer readable medium storing a machine learning procedure trained for predicting likelihoods for gestational diabetes, feeding the procedure with the plurality of parameters, and receiving from the procedure an output indicative of a likelihood that the subject has, or expected to develop, gestational diabetes, wherein the output indicative is related non-linearly to the parameters.
    Type: Application
    Filed: May 24, 2020
    Publication date: October 13, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Eran SEGAL, Smadar SHILO, Nitzan ARTZI
  • MICROFLUIDIC DEVICE FOR ANALYZING GENE EXPRESSION
    Publication number: 20220314221
    Abstract: A microfluidic device is disclosed which comprises: (i) at least one reaction unit having a test chamber connected to at least one microchannel, wherein a surface of at least a portion of said reaction unit is attached to an isolated nucleic acid; and (ii) a flow-through channel having at least one inlet port and at least one outlet port, said flow-through channel and said microchannel being of dimensions to allow reactant diffusion to and from said reaction unit, wherein the diffusion time of said reactant along the microchannel is shorter than the flow time along the microchannel.
    Type: Application
    Filed: June 14, 2022
    Publication date: October 6, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Roy BAR-ZIV, Eyal KARZBRUN, Alexandra TAYAR
  • METHOD FOR STABILIZING INTRACELLULAR RNA
    Publication number: 20220307008
    Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 29, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Ido YOFE, Diego JAITIN, Yonatan KATZENELENBOGEN, Mami LENNIKOV, Assaf WEINER, Hadas KEREN-SHAUL
  • TREATING ALZHEIMER'S DISEASE
    Publication number: 20220306710
    Abstract: A method of treating Alzheimer's Disease (AD) is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which prevents the binding of amyloid precursor protein (APP) to Tau protein.
    Type: Application
    Filed: May 19, 2022
    Publication date: September 29, 2022
    Applicants: Yeda Research and Development Co. Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Ruth ARNON, Ruth MARON, Gad ARMONY, Michael Menachem TSOORY, Meir WILCHEK, Dan FRENKEL
  • Attenuation of encrustation of medical devices using coatings of inorganic fullerene-like nanoparticles
    Patent number: 11446413
    Abstract: A new approach is presented to reduce encrustation of catheters by the application of nanoparticles. It is demonstrated that the negatively surface charged nanoparticles produce coating films comprised of long-range domains in which the nanoparticles are self-assembled into a mosaic-like order, showing a relatively small tendency to agglomerate.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: September 20, 2022
    Assignees: YEDA RESEARCH AND DEVELOPMENT CO. LTD., MOR RESEARCH APPLICATIONS LTD.
    Inventors: Reshef Tenne, David Zbaida, Racheli Ron, Ilan Kafka, Ilan Leibovitch
  • Device for electric field induced local magnetization
    Patent number: 11437501
    Abstract: In a technique for inducing local electric field controlled magnetization, despite the absence of magnetic components, there is provided a novel heterostructure, a semiconductor device thereof, or an array of semiconductor devices. The heterostructure includes a semiconductor substrate carrying a plurality of layers forming at least one heterojunction and hosting a two-dimensional electron gas layer when one of the layer of the plurality of layers is bounded to an interacting layer being a chiral or a biological macromolecule assembly.
    Type: Grant
    Filed: April 7, 2019
    Date of Patent: September 6, 2022
    Assignees: Yeda Research and Development Co. Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yossef Paltiel, Ron Naaman, Karen Michaeli, Eilam Smolinsky
  • USE OF VETO CELLS FOR THE TREATMENT OF SICKLE CELL DISEASE
    Publication number: 20220265726
    Abstract: A method of treating or preventing a sickle cell disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting immature hematopoietic cells into the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of non-GVHD inducing anti-third party cells comprising cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and capable of homing to the lymph nodes following transplantation.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Applicants: Yeda Research and Development Co. Ltd., Board of Regents, The University of Texas System
    Inventors: Yair REISNER, Aloukick Kumar SINGH
  • USE OF VETO CELLS IN TREATMENT OF T CELL MEDIATED AUTOIMMUNE DISEASES
    Publication number: 20220265725
    Abstract: A method of treating or preventing a T cell mediated autoimmune disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting immature hematopoietic cells into the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of non-GVHD inducing anti-third party cells comprising cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and capable of homing to the lymph nodes following transplantation.
    Type: Application
    Filed: May 4, 2022
    Publication date: August 25, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yair REISNER, Rakefet SIDLIK MUSKATEL, Bar NATHANSOHN-LEVI
  • MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE- ASSOCIATED MEDICAL CONDITIONS
    Publication number: 20220265696
    Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.
    Type: Application
    Filed: May 2, 2022
    Publication date: August 25, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Alon CHEN, Eran HORNSTEIN, Orna ISSLER, Sharon HARAMATI, Naama VOLK
  • SYSTEM AND METHOD FOR GENERATING AN IMAGE
    Publication number: 20220260819
    Abstract: A method of generating an image of a sample is provided. The method comprises providing a plurality of photon detectors, scanning the sample with an excitation beam over a predetermined time period, the detectors receiving photons emitted by the sample due to the excitation during the time period. A plurality of intensity images associated with each of the detectors are generated, each being proportional to the mean number of photons detected per unit time. A plurality of correlation images associated with each combination of two of the detectors are generated, each of the correlation images being proportional to the variance of the distribution of detected photons per unit time. The image of the sample is generated using joint sparse recovery from the plurality of intensity and correlation images, wherein the intensity and correlation images have common support.
    Type: Application
    Filed: July 2, 2020
    Publication date: August 18, 2022
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Dan ORON, Uri ROSSMAN, Ron TENNE, Yonina C. ELDAR
  • METHOD FOR RECOVERING VALUABLE METALS FROM SPENT LITHIUM-ION-BATTERIE
    Publication number: 20220263147
    Abstract: This invention is directed to a method for recovering valuable metals from spent lithium-ion-batteries using CO2/CO/H2O gas mixture, or reducing gas comprising CH4, or solid carbon or combination thereof.
    Type: Application
    Filed: May 3, 2022
    Publication date: August 18, 2022
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Igor LUBOMIRSKY, Valery KAPLAN
  • Plant with altered content of steroidal alkaloids
    Patent number: 11412700
    Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: August 16, 2022
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Asaph Aharoni, Prashant Sonawane, Maxim Itkin
  • PEPTIDES AND USE OF SAME IN THE TREATMENT OF DISEASES, DISRODERS OR CONDITIONS ASSOCIATED WITH A MUTANT P53
    Publication number: 20220251159
    Abstract: An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.
    Type: Application
    Filed: December 13, 2021
    Publication date: August 11, 2022
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD
    Inventors: Varda ROTTER, Moshe OREN, Perry TAL, Shay EIZENBERGER, Avi BEN-SHIMON
  • Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the CNS
    Patent number: 11406670
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: August 9, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • Electromechanical resonators based on metal-chalcogenide nanotubes
    Patent number: 11411551
    Abstract: This invention provides electromechanical resonators based on metal chalcogenide nanotubes. The invention further provides methods of fabrication of electromechanical resonators and methods of use of such electromechanical resonators.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: August 9, 2022
    Assignees: YEDA RESEARCH AND DEVELOPMENT CO. LTD., B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
    Inventors: Reshef Tenne, Ernesto Joselevich, Yiftach Divon, Roi Levi, Assaf Yaakobovitz, Dan Yudilevich
  • PROCESS FOR THE PREPARATION OF FLUENSULFONE
    Publication number: 20220242838
    Abstract: This invention is directed to a method of oxidation of 5-chloro-2-((3,4,4-trifluorobut-3-en-1-yl)thio)-1?3,3?2-thiazole and analogs thereof to the corresponding sulfone, using an oxidant and a metal oxide-based catalyst.
    Type: Application
    Filed: August 4, 2020
    Publication date: August 4, 2022
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO.LTD.
    Inventors: Ronny NEUMANN, Alexander KHENKIN
  • IDENTIFICATION OF RECURRENT MUTATED NEOPEPTIDES
    Publication number: 20220241331
    Abstract: A method of treating cancer in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of T cells expressing a T cell receptor (TCR) having a CDR3 amino acid sequence selected from the group consisting of 199-210.
    Type: Application
    Filed: May 19, 2020
    Publication date: August 4, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yardena SAMUELS, Shelly KALAORA, Aviyah PERI, Nir FRIEDMAN, Shlomit REICH-ZELIGER, Erez GREENSTEIN
  • Methods of preventing secondary infections
    Patent number: 11400156
    Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: August 2, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Irit Sagi, Dalit Talmi-Frank, Inna Solomonov, Ido Amit