Abstract: A funnel control device is fixed on a shear box or respective cells in various soil mechanics/dynamics testing devices, and the funnel control device enables to produce soil samples to be tested by discharging a soil through a funnel into a sample preparation mold at a given axis and rate. The funnel control device includes at least one supporting body for being placed on the soil mechanics/dynamics testing device, at least one holder, wherein the at least one holder is provided on the at least one supporting body to be movable in vertical axis and the funnel is placed on the at least one holder, at least one driving member, wherein the at least one driving member is located in or on the at least one supporting body and is used for moving the at least one holder in the vertical axis.

Abstract: A product including plant-derived nanovesicles which induce differentiation of the stem cell sources into cartilage and bone cells is provided. The objective of the invention is to improve the rate of differentiation into cartilage and bone cells, enhance strength of the obtained tissue and to provide a non-toxic application with lower cost by means of giving plant exosomes in addition to the differentiation media to the adipose-derived stem cells.

Abstract: The present invention is an exosome isolation method for obtaining high purity exosomes inexpensively from samples of large and small amounts and types of samples from which exosomes could not be obtained before such as plant lysates. The exosome isolation method incorporates a two phase fluid extraction system, and includes the steps of isolation using dextran and PEG for removing proteins and undesired substances therein, and the steps of washing and dextran removal to collect exosomes in a pure form.

Abstract: A formulation in gel form comprising erbium borate nanoparticles, at least one surfactant and at least one gelling agent with carrier gel properties for use in prevention and treatment of wound scars is provided.

Abstract: sodium borates are provided and alone as an active ingredient to prevent and/or treat fatty liver. In addition, the sodium borates reduce the expression levels of AADIPOR2, PRKAG2, IRS1, PIK3R1, NFKB1, MAP3K11, BID, CYCS, BAX, CASP3 and TGFB1 genes in the non-alcoholic fatty liver pathway and thereby to prevent and/or treat fatty liver by inhibiting the functioning of the non-alcoholic fatty liver pathway.

Abstract: 2-(3-(2-Methyl-6-(p-tolyl) pyridine-3-yl) ureido) benzenesulfonamide (formula I) compound and related pyridine based sulfonamide derivatives are disclosed. The compound of the invention is a carbonic anhydrase targeted small molecule and also an inhibitor of carbonic anhydrase activity and overexpression. Therefore, the compound is useful, as pharmaceutical agent, especially in the treatment and/or prevention of disorders associated with proliferative diseases, such as cancer.

Abstract: A method of producing plant-derived exosomes from plant tissue culture based cell suspension cultures is provided. The method includes: obtaining the plant tissue culture based cell suspension culture; mixing the the plant tissue culture based cell suspension culture with an isolation solution; centrifuging to obtain a supernatant and an infranatant; and obtaining the plant-derived exosomes from the infranatant. The objective of the present invention is to produce homogenous plant exosomes with high volume and purity by making use of the advantages of the plant suspension culture to be used for purposes such as therapeutics and drug carriers.

Abstract: A use of extracellular vesicles obtained from macrophages infected with parasites as immunotherapeutic and prophylactic agents in the disease Leishmaniasis is disclosed. The objective of the invention is the use of a drug formulation, which exhibits almost complete activity on Leishmania parasites and infected cells within 72 hours, but does not have any show side effects on healthy cells, in the treatment and prophylaxis of Leishmaniasis.

Abstract: A medium-based method for inducing specific differentiation of dental stem cells into dopaminergic neurons is provided. The method includes seeding the dental stem cells at a concentration of 5000 cells/cm2, following 24-hour incubation, introducing the cells into first part neurogenic induction medium and continuing the medium application for 4 days; subsequently, introducing the cells into the second part neurogenic induction medium and continuing the medium application for 2 days; and terminating the differentiation at the end of 6 days. The objective of the present invention is to develop cellular applications for use in treatment of neurodegenerative diseases and medications related to the said diseases.

Abstract: A product containing a boron compound for use in obesity treatment. By means of the present invention, a product can be obtained for obesity treatment which is not toxic to the other tissues and organs of the body. In obtaining the said product, sodium pentaborate pentahydrate, which is a poloxamer derivative, are used.

Abstract: A composition inhibiting MEIS proteins. The MEIS proteins are effective in proliferation of hematopoietic stem cells. A formulation capable of easily passing through the cell membrane and perform its activity in the cell, and can inhibit MEIS activity in a dose dependent manner. The combination includes isolated cells, medium, growth factors and MEISi inhibitor. The isolated cells are isolated from mouse bone marrow, human bone marrow and human umbilical cord blood. The medium has a pH value of 7.2 and contains bovine serum albumin, recombinant insulin, transferrin, 2-mercaptoethanol and IMDM medium. The growth factors are hematopoietic stem cell factor SCF, fetus liver tyrosine kinase-3 ligand Flt3L, and thrombopoietin. A chemical formula of the MEISi-1 is 4-[2-(benzylamino)-2-oxoethoxy]-N-(2,3-dimethylphenyl) benzamide. A chemical formula of MEISi-2 is 4-hydroxy-N?-[(Z)-(2-oxonaphthalen-1-ylidene)methyl] benzohydrazide.

Abstract: The present invention relates to a gelatin or pectin based antimicrobial surface coating material. In the present invention, boron compounds are mixed with gelatin or pectin and a surface coating material in the form of a film is obtained. The said coating material can be used in all packaging industry requiring hygiene particularly in food industry. The invention enables packages to be antifungal, anticandidal and antibacterial.

Abstract: An external fixator utilized in orthopedic surgeries such as the repair of segmental fractures, correction of congenital or development deformities, and limb lengthening. The external fixator is comprised of half rings that utilize connectors to form full rings, threaded rods that fit into rod holes, channel slots, wires that pass through bone and soft tissue, and fixation bolts that can be positioned with minimal effort by a surgeon, minimal pain to a patient, and minimal risk of infection.

Abstract: A production of a drug, wherein the drug is specific for SH-SY5Y neuroblastoma cancer by loading caffeic acid phenethyl ester (CAPE) to a plurality of microvesicles that a specialized skin cell leaves into a nutrient solution. The objective of the present invention is to provide a cell-specific targeted vesicle development by loading the CAPE to the plurality of microvesicles obtained as a result of culturing and subsequent specialization of a plurality of tissue cells; and to use the CAPE at lower concentrations compared to a state of the art applications to minimize a toxicity of the CAPE to both a plurality of cells other than a plurality of targeted cells and a body.

Abstract: The present invention relates to a chemotherapeutic agent comprising a combination of alexidine dihydrochloride and sodium pentaborate pentahydrate. The chemotherapeutic agent includes 2.9 mg alexidine dihydrochloride compound and 2.5 mg sodium pentaborate pentahydrate compound, and is obtained by adding 0.5 ml dimethylsulfoxide compound into the alexidine dihydrochloride compound. Upon injecting them to the media containing healthy cells and cancer cells, their effects on cell viability were observed. In accordance with the obtained results; it was observed that when alexidine dihydrochloride solution at concentrations not harming healthy cells is combined with sodium pentaborate pentahydrate, pancreatic cancer cell viability decreased 10% more compared to use of alexidine dihydrochloride alone, and it was realized that this combination can be used as a chemotherapeutic agent for treatment of pancreatic cancer.

Abstract: A method of producing a caffeic acid phenethyl ester loaded microvesicular cancer drug targeting SH-SY5Y neuroblastoma cancer. The method includes seeding a plurality of skin stem cells in a medium; enabling the plurality of skin stem cells in the medium to reach a confluency of 70-80% to be seeded in a plurality of culture plates; preparing a caffeic acid phenethyl ester stock solution by dissolving the caffeic acid phenethyl ester in dimethyl sulfoxide DMSO; performing a microvesicle isolation from specialized skin cells; adding the caffeic acid phenethyl ester into a plurality of microvesicles; and separating the caffeic acid phenethyl ester loaded microvesicles from the caffeic acid phenethyl ester which is free in the solution and not loaded to a microvesicle.

Abstract: A computer-implemented method, which enables the data to be clustered without being required to perform any distance calculations among the points of the dataset, includes assigning points of a dataset to cells of a cellular automaton; assigning each cell, having a data point assigned, a distinct state value and a constant temperature value; and assigning all cells, to which a data point is not assigned, a unique state value different from the state values utilized for cells having a data point and to a temperature lower than the constant temperature value; selecting a cell in the cellular automaton randomly; calculating the average temperature of the selected cell and its neighbor cells; setting the temperature of the cells having no data point, as the average temperature; if a neighbor cell temperature is above the predetermined threshold value, moving this neighbor cell to the state of the selected cell.

Abstract: A use of plant exosomes as a product having the effect of enhancing viability and, by stimulating the hair follicles, enhancing hair growth in skin cells. The plant exosomes are used to revitalize and strengthen unhealthy skin and hair that have lost their vitality, to stop hair loss, to provide faster hair growth by stimulating hair follicles, and to provide a regulating effect in improving the effects such as wrinkles and age spots caused by aging skin cells. The plant exosomes are isolated from single, double, or triple combinations of plants selected from a group consisting of pineapple plant, garlic plant, and pomegranate plant. For example, a triple combination includes 1 ng-1 mg of the plant exosomes isolated from the pineapple plant, 1 ng-10 ?g of the plant exosomes isolated from the garlic plant, and 1 ng-1 mg of plant exosomes isolated from the pomegranate plant.

Abstract: Plant exosomes can be used to reduce the protein aggregates formed in the cells and the damage they cause to the cells. Plant exosomes are of plant origin and not transgenic, and thus, they are reliable as an alternative to the drugs used in the treatment of neurodegenerative diseases, particularly ALS. Moreover, compared to the conventional applications, plant exosomes can provide a product with high efficacy and no side effects which can be produced in high amounts and at affordable prices due to the fact that it is plant-derived.

Abstract: A glycerol and sodium pentaborate based formulation developed for preventing postoperative adhesions occurring between manipulated tissues and organs is provided. An objective of the glycerol and sodium pentaborate based formulation is to provide a formulation comprising a mixture of glycerol, wherein the glycerol is one of the most abundant biomolecules in a human body, and sodium pentaborate, wherein the sodium pentaborate is known to have positive effects on a wound healing, with a purpose of preventing the postoperative adhesions.