Patents Assigned to Yeshiva University
  • Radiosynthesis as an alternative energy utilization process in melanized organisms and uses thereof
    Patent number: 8652827
    Abstract: This present invention provides methods of enhancing the growth of a microorganism or plant by increasing its melanin content and exposing it to radiation, and methods of using melanized microorganisms to contain or exclude radiation.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: February 18, 2014
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Ekaterina Dadachova, Ruth Bryan, Arturo Casadevall
  • MELANIN NANOSHELLS FOR PROTECTION AGAINST RADIATION AND ELECTRONIC PULSES
    Publication number: 20140044789
    Abstract: This invention provides melanin nanoshells and their use for protection against radiation, particularly ionizing radiation, and electronic pulses, and methods of making materials comprising melanin nanoshells.
    Type: Application
    Filed: October 22, 2013
    Publication date: February 13, 2014
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Ekaterina Dadachova, Arturo Casadevall
  • ANTIBODIES TO HUMAN B7X FOR TREATMENT OF METASTATIC CANCER
    Publication number: 20140037551
    Abstract: Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Applicants: Sloan-Kettering Institute For Cancer Research, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Xingxing Zang, James P. Allison
  • ORAL ADMINISTRATION OF MELANIN FOR PROTECTION AGAINST RADIATION
    Publication number: 20140037674
    Abstract: Methods and compositions are provided for alleviating and/or preventing one or more side effects associated with exposure to radiation in a subject exposed to radiation or at risk for exposure to radiation comprising oral administration to the subject of an amount of an edible source of melanin effective to alleviate a side effect associated with radiation.
    Type: Application
    Filed: March 15, 2012
    Publication date: February 6, 2014
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Ekaterina Dadachova, Arturo Casadevall
  • ADJUVANTS THAT ACTIVATE ADAPTIVE IMMUNE SYSTEM BY STIMULATING NLRP3
    Publication number: 20140037685
    Abstract: A method of identifying an agent, or combination of agents, as a candidate immunological adjuvant is provided comprising contacting a cell comprising a Nod-like receptor (Nlrp3) with the agent. Methods of enhancing immune responses to vaccines are also provided.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 6, 2014
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Jurgen Brojatsch, Lee Jacobson
  • Tumor microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors
    Patent number: 8642277
    Abstract: Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor cell in direct apposition in a tumor sample from a subject.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: February 4, 2014
    Assignees: Albert Einstein College of Medicine of Yeshiva University, Massachusetts Institute of Technology, Cornell University
    Inventors: John S. Condeelis, Thomas E. Rohan, Frank B. Gertler, Joan G. Jones
  • Methods for determining cytosine methylation in DNA and uses thereof
    Patent number: 8642294
    Abstract: Methods are described for determining the pattern of cytosine methylation in a DNA specimen, where the methods involve comparing the amount of DNA fragments generated by a methylation-sensitive restriction enzyme with the amount of DNA fragments generated by a methylation-insensitive isoschizomer of the methylation-sensitive restriction enzyme.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: February 4, 2014
    Assignees: Albert Einstein College of Medicine of Yeshiva University, The Research Foundation State University of New York
    Inventors: John M. Greally, Eli Hatchwell
  • Methods for determining agents that treat or prevent obesity and/or obesity related diseases and methods for treatment therewith
    Patent number: 8632979
    Abstract: The present invention provides methods for determining a putative agent that treats or prevent obesity and/or obesity related diseases comprising contacting cells with the putative agent and measuring the activity and/or level of Maf1 and/or the activity and/or level of KIAA1875. The present invention also provides the agent identified by the methods herein and methods of treating or preventing obesity and/or obesity related diseases in a subject comprising administering to the subject a therapeutically effective amount of an agent that inhibits or downregulates Maf1 and/or activates or upregulates KIAA1875.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: January 21, 2014
    Assignees: Albert Einstein College of Medicine of Yeshiva University, University of Lausanne
    Inventors: Ian M. Willis, Nouria Hernandez, Wassim Hodroj
  • Cell extract promoted cloning
    Patent number: 8609374
    Abstract: Methods are disclosed for assembling a plurality of double-stranded DNA fragments into DNA molecules in a single in vitro recombination reaction comprising contacting the plurality of double-stranded DNA fragments with a bacterial extract derived from a RecA deficient bacterial strain so as to assemble the plurality of DNA fragments into DNA molecules.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: December 17, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Winfried Edelmann, Yongwei Zhang
  • Metastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors
    Patent number: 8603738
    Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: December 10, 2013
    Assignees: Albert Einstein College of Medicine of Yeshiva University, Massachusetts Institute of Technology, IFO-Regina Elena Cancer Institute
    Inventors: John S. Condeelis, Sumanta Goswami, Frank Gertler, Paola Nisticò
  • Human Endogenous Retrovirus Polypeptide Compositions and Methods of Use Thereof
    Publication number: 20130323279
    Abstract: The present invention provides isolated HERV polypeptides; and compositions, including immunogenic compositions, comprising a HERV polypeptide. The present invention provides immunogenic compositions comprising a nucleic acid comprising a nucleotide sequence encoding a HERV polypeptide. The immunogenic compositions are useful for stimulating a T cell immune response to a lentiviral peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers in which HERV polypeptides are expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a HERV polypeptide.
    Type: Application
    Filed: May 10, 2013
    Publication date: December 5, 2013
    Applicants: The J. David Gladstone Institutes, Albert Einstein College of Medicine of Yeshiva University, The Regents of the University of California, The Governing Counicl of University of Toronto
    Inventors: Douglas F. Nixon, Keith E. Garrison, Duncan A. Meiklejohn, Mario A. Ostrowski, R. Bradley Jones, Ashish Agrawal, Jack Lenz, Seth Rakoff-Nahoum, Frederick M. Hecht
  • Mycobacterial mutants inducing IL-12
    Patent number: 8591918
    Abstract: Provided are mycobacteria deleted in at least a portion of a region 3 ESAT-6-like gene cluster. Also provided are mycobacteria comprising a mutation in an roc-1 gene. Additionally, vaccines comprising these mycobacteria are provided. Further provided are methods of making a recombinant mycobacterium, methods of inducing an immune response in a mammal, methods of inhibiting IL-12 production in a mammal, and methods of stimulating IL-12 production in a mammal. Vaccine adjuvants are also provided, as are methods of inducing immunity to a target antigen in a mammal.
    Type: Grant
    Filed: March 10, 2008
    Date of Patent: November 26, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: William R. Jacobs, Jr., Kari Sweeney, Dee Dao, Steven A. Porcelli, John Chan, Tsungda Hsu
  • Melanin nanoshells for protection against radiation and electronic pulses
    Patent number: 8586090
    Abstract: This invention provides melanin nanoshells and their use for protection against radiation, particularly ionizing radiation, and electronic pulses, and methods of making materials comprising melanin nanoshells.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: November 19, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Ekaterina Dadachova, Arturo Casadevall
  • Intracellular domain of a mammalian Fat1 (Fat1IC)
    Patent number: 8586534
    Abstract: Provided is an extracellular domain of a mammalian Fat1 (Fat1EC). Also provided is an intracellular domain of a mammalian Fat1 (Fat1IC). Additionally provided is a vector comprising a nucleic acid sequence encoding the Fat1EC. A vector comprising a nucleic acid sequence encoding the Fat1IC is further provided. Also, a vascular stent coated with the Fat1EC is provided. Further provided is a vascular stent coated with a Fat1 ligand that activates Fat1. A method of treating a patient at risk for restenosis of a blood vessel is additionally provided. Further, methods of treating an injured blood vessel in a patient is provided. A method of treating a patient at risk for restenosis of a blood vessel or having an injured blood vessel is also provided.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: November 19, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Nicholas E. S. Sibinga, Rong Hou
  • Mitochondrial inhibitors to treat human disease
    Patent number: 8581005
    Abstract: The present invention relates to inhibitors of mitochondria-associated, granulocyte-macrophage colony stimulating factor signaling molecule (Magmas), and related compositions and uses thereof.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: November 12, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Paul Jubinsky, Bhaskar C. Das, Mary K. Short
  • CONSTRUCTS AND METHODS TO IDENTIFY ANTIBODIES THAT TARGET GLYCANS
    Publication number: 20130281317
    Abstract: Nucleic acid constructs for expressing an antibody on the surface of bacteriophage are disclosed, as are methods for using the constructs to identify antibodies that target glycans.
    Type: Application
    Filed: November 23, 2011
    Publication date: October 24, 2013
    Applicant: Allbert Einstein College of Medicine of Yeshiva University
    Inventors: Jonathan R. Lai, Alex Stewart
  • MACROPHAGE-SYNTHESIZED CCL3 PROMOTES BREAST CANCER METASTASIS
    Publication number: 20130280254
    Abstract: Methods and compositions are provided for inhibiting metastasis of a tumor in a subject, or of inhibiting progression of a primary tumor in a subject which requires macrophages for progression.
    Type: Application
    Filed: April 10, 2013
    Publication date: October 24, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Jeffrey W. Pollard
  • METHODS, ASSAYS AND COMPOUNDS FOR TREATING BACTERIAL INFECTIONS BY INHIBITING METHYLTHIOINOSINE PHOSPHORYLASE
    Publication number: 20130274220
    Abstract: The present invention discloses methods for treating bacterial infections in a subject comprising administering to the subject a sub-growth inhibiting amount of a 5?-methylthioinosine phosphorylase (MTIP) inhibitor, as well as assays for identifying such inhibitors, and compounds and pharmaceutical compositions comprising the inhibitors.
    Type: Application
    Filed: November 28, 2011
    Publication date: October 17, 2013
    Applicants: Industrial Research Limited, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Vern L. Schramm, Keith Clinch, Peter Charles Tyler, Gary Brian Evans, Richard Hubert Furneaux
  • Selective beta-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents
    Patent number: 8557808
    Abstract: Compounds, compositions and methods are provided that comprise selective ?-glucuronidase inhibitors for both aerobic and anaerobic bacteria, especially enteric bacteria normally associated with the gastrointestinal tract. The compounds, compositions and methods can be for inhibiting bacterial ?-glucuronidases and for improving efficacy of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds by attenuating the side effects caused by reactivation by bacterial ?-glucuronidases of glucuronidated metabolites of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: October 15, 2013
    Assignees: North Carolina Central University, The University of North Carolina at Chapel Hill, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Matthew R. Redinbo, Sridhar Mani, Alfred Williams, John Scott, Li-An Yeh, Bret David Wallace, Kimberly Terry Lane
  • METHOD OF ENHANCING EFFICACY OF BLOOD TRANSFUSIONS
    Publication number: 20130261061
    Abstract: A method of improving the efficacy of a blood transfusion into a subject is provided comprising administering a composition comprising an EAF PEGylated-blood protein into the subject, prior to, during, or subsequent to the blood transfusion.
    Type: Application
    Filed: March 12, 2013
    Publication date: October 3, 2013
    Applicants: The Regents of the University of California, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Seetharama A. Acharya, Marcos Intaglietta