Patents Assigned to Yeshiva University
  • Myosin-IIA S1943 phosphorylation as a marker of tumor invasion
    Patent number: 8541181
    Abstract: Methods and kits are provided for determining if cells of a tumor in an organ or a tissue in a subject are likely to invade another organ or tissue in the subject and for determining if a cancer in a subject is likely to metastasize.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: September 24, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Anne Reba Bresnick
  • Transition state structure of 5?-methylthioadenosine/s-adenosylhomocysteine nucleosidases
    Patent number: 8541567
    Abstract: Provided are methods of designing a putative inhibitor of a 5?-methylthioadenosine/S-adenosylhomocysteine nucleosidase. The methods comprise designing a chemically stable compound that resembles the charge and geometry of the 5?-methylthioadenosine/S-adenosylhomocysteine nucleosidase transition state. Also provided are methods of inhibiting 5?-methylthioadenosine/S-adenosylhomocysteine nucleosidases using the inhibitors found by the above methods.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: September 24, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Vern L. Schramm
  • BIOLOGICAL MARKERS FOR LONGEVITY AND DISEASES AND USES THEREOF
    Publication number: 20130244333
    Abstract: This invention provides methods of using of the sizes and levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles, the ?641 allele of the promoter of the gene encoding apolipoprotein C-3 (APOC-3), the 405 allele of the gene encoding cholesteryl ester transfer protein (CETP), and plasma levels of insulin-like growth factor-1 (IGF-1), adiponectin, CETP and APOC-3, for determining and increasing an individual's likelihood of longevity and of retaining cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 19, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Nir Barzilai, Richard B. Lipton
  • Compounds and methods for detecting ricin and uses thereof
    Patent number: 8536319
    Abstract: This application provides fluorescent probes, substrates, kits and methods for detecting the presence or absence of an enzyme, such as ricin, that catalyzes the release of adenine from a GAGA RNA tetraloop.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 17, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Vern L. Schramm, Setu Roday
  • SIR2 REGULATION
    Publication number: 20130231351
    Abstract: Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.
    Type: Application
    Filed: January 23, 2013
    Publication date: September 5, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Vern L. Schramm, Anthony A. Sauve
  • VITAMIN K FOR PREVENTION AND TREATMENT OF SKIN RASH SECONDARY TO ANTI-EGFR THERAPY
    Publication number: 20130225690
    Abstract: The invention provides methods and compositions for treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (EGFR) therapy, where the method comprises applying a vitamin K analog or a phosphatase inhibitor to the skin.
    Type: Application
    Filed: September 20, 2012
    Publication date: August 29, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Roman Perez-Soler, Yi-He Ling
  • METHODS FOR QUANTITATIVE ASSESSMENT OF VOLUMETRIC IMAGE FROM A SUBJECT AND USES THEROF
    Publication number: 20130223714
    Abstract: Methods and systems are disclosed for assessing a quantitative image volume from an individual subject comprising comparing the image from the subject to images from a control group of subjects using voxel-wise comparison. The methods allow detection of pathologies or lesions in the individual subject being assessed.
    Type: Application
    Filed: February 25, 2013
    Publication date: August 29, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Albert Einstein College of Medicine of Yeshiva University
  • MODULATION OF AMINO ACID METABOLISM IN THE HYPOTHALAMUS
    Publication number: 20130209433
    Abstract: Methods for reducing peripheral blood glucose levels, food intake, glucose production, gluconeogenesis, triglyceride levels, and low density lipoprotein (VLDL) levels in mammals are provided. Also provided are methods of increasing glucose production and food intake in mammals. Further provided are methods of treating a disorder selected from the group consisting of obesity, type 2 diabetes, type 1 diabetes, hyperglycemia, insulin resistance, glucose intolerance, leptin resistance, metabolic syndrome, heart failure, ischemia, coronary heart disease, familial lipoprotein lipase deficiency, hypopituitarism, hyperlipidemia, hypertriglyceridemia, hyper-VLDLemia, atherosclerosis, hypercholesterolemia, hypertension, and any combination of the foregoing. The methods involve manipulations of amino acid presence or metabolism in the hypothalamus of the mammal.
    Type: Application
    Filed: December 12, 2012
    Publication date: August 15, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Albert Einstein College of Medicine of Yeshiva University
  • Restoration of nucleic acid from degraded or formalin-fixed and paraffin-embedded tissue and uses thereof
    Patent number: 8497067
    Abstract: This invention provides methods, primers and kits for restoration of nucleic acid from tissue, in particular degraded tissue and formalin-fixed and paraffin-embedded (FFPE) tissue, where the methods involve complementary-template reverse-transcription (CT-RT) where short single-stranded DNA sequences reverse-transcribed from mRNA are used for reverse-transcription of complementary sense-RNA templates. The methods can be used to determine patterns of gene expression and chromosomal alterations in archived tissue samples, and may be used to identify expression of disease-related genes.
    Type: Grant
    Filed: February 26, 2007
    Date of Patent: July 30, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Olivier Loudig
  • CERAMIDE-LIKE GLYCOLIPID-ASSOCIATED BACTERIAL VACCINES AND USES THEREOF
    Publication number: 20130164325
    Abstract: The invention is directed compositions and methods related to bacterial cells that are physically associated with ceramide-like glycolipids for use as antigen carriers for heterologous antigens. The invention further relates to methods of incorporating ceramide-like glycolipid to bacterial cell walls. The compositions and methods of the present invention are useful for the prevention and treatment of diseases.
    Type: Application
    Filed: July 6, 2011
    Publication date: June 27, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Steven A. Porcelli, Manjunatha M. Venkataswamy
  • Treatment of autism spectrum disorders with agents that activate the Locus Coeruleus-Noradrenergic system
    Patent number: 8470546
    Abstract: Methods are provided for treating autism spectrum disorders (ASD) using agents that activate the locus coeruleus-noradrenergic (LC-NA) system of the brain and for screening for compounds for treating ASD comprising determining whether or not the compounds activate the LC-NA system.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: June 25, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Dominick P. Purpura, Mark F. Mehler
  • MIR27B IS A NOVEL TARGET FOR TREATMENT OF LIVER FIBROSIS
    Publication number: 20130150428
    Abstract: Methods are provided for treating fibrosis of a tissue, including fibrosis of the liver, using combinations of antagomirs and/or locked nucleic acids. Compositions therefor are also provided.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 13, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Albert Einstein College of Medicine of Yeshiva University
  • Fenretinide derivatives and uses thereof as therapeutic, diagnostic and imaging agents
    Patent number: 8460635
    Abstract: Synthetic peptidomimetic derivatives and phenyl group derivatives of Fenretinide (4-HPR) are disclosed, as are their uses as therapeutic, diagnostic and imaging agents for cancer and other diseases.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: June 11, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Ganjam V. Kalpana, Bhaskar C. Das
  • Methods for determining chemotherapeutic agents targeting alpha-glucan pathways and uses thereof
    Patent number: 8455214
    Abstract: The present invention provides methods for determining a putative antibacterial, the methods comprising determining whether the putative antibacterial inhibits GlgE or Rv3032. The present invention also provides the antibacterial, the pharmaceutical composition and the method of making the antibacterial as well as a method of treating a subject infected with a bacterial comprising administration of the antibacterial.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: June 4, 2013
    Assignees: Albert Einstein College of Medicine of Yeshiva University, Plant Bioscience Limited
    Inventors: William R. Jacobs, Jr., Rainer Kalscheuer, Stephen Bornemann, Karl Syson
  • METHOD OF DETECTING TAU PROTEIN AND TAU FRAGMENTS IN SERUM
    Publication number: 20130095492
    Abstract: The present invention provides quantitative methods for the detection of tau protein and/or tau fragments. More specifically, the present invention provides quantitative methods for diagnosing a tauopathy or ruling out a tauopathy as the cause of disease, particularly the diagnosis and ruling of Alzheimer's disease. The present invention further provides a method for diagnosing a tauopathy by computing the ratio of two detected tau proteins or tau fragments.
    Type: Application
    Filed: March 4, 2011
    Publication date: April 18, 2013
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: John F. DeBernardis, Raymond P. Zinkowski
  • CHEMICAL AGENTS FOR THE PREVENTION OF INHIBITION OR TUMOR METASTASIS
    Publication number: 20130090355
    Abstract: The present invention provides methods of preventing or inhibiting tumor metastasis in a subject by administering a therapeutically effective amount of (1) a compound from a group of enumerated compounds, or a pharmaceutically acceptable salt thereof; (2) an agent that covalently modifies at least one cysteine residue of S100A4 protein; or (3) an agent that inhibits the interaction between S100A4 and myosin-IIA.
    Type: Application
    Filed: April 28, 2011
    Publication date: April 11, 2013
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventor: Anne R. Bresnick
  • ENHANCED NITRIC OXIDE DELIVERY AND USES THEREOF
    Publication number: 20130084336
    Abstract: Methods and compositions are disclosed that enhance delivery of nitric oxide (NO) by combining nitric oxide releasing nanoparticles (NO-np) with exogenous glutathione (GSH), as well as therapeutic uses of the methods and compositions.
    Type: Application
    Filed: June 26, 2012
    Publication date: April 4, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Adam Friedman, Joel Friedman, Joshua Nosanchuk, Parimala Nacharaju, Karin Blecher, Chaim Tuckman-Vernon
  • Biological markers for longevity and diseases and uses thereof
    Patent number: 8399258
    Abstract: This invention provides methods of using of the sizes and levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles, the ?641 allele of the promoter of the gene encoding apolipoprotein C-3 (APOC-3), the 405 allele of the gene encoding cholesteryl ester transfer protein (CETP), and plasma levels of insulin-like growth factor-1 (IGF-1), adiponectin, CETP and APOC-3, for determining and increasing an individual's likelihood of longevity and of retaining cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: March 19, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Nir Barzilai
  • Mycobacterial mutants affecting host apoptosis
    Patent number: 8394388
    Abstract: Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: March 12, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: William R. Jacobs, Jr., Steven A. Porcelli, Volker Briken, Miriam Braunstein
  • Analogues of coformycin and their use for treating protozoan parasite infections
    Patent number: 8394950
    Abstract: This invention relates to compounds that are analogues of coformycin, pharmaceutical compositions containing the compounds, and methods of using the compounds for treating protozoan parasite infections, especially malaria.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: March 12, 2013
    Assignees: Industrial Research Limited, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Richard Hubert Furneaux, Peter Charles Tyler, Gary Brian Evans, Vern L. Schramm, Kami Kim, Richard Fröhlich