Patents Assigned to Yissum Research Development Company of the Hebrew University of Jerusalem
  • Publication number: 20220017493
    Abstract: The present invention provides pyrazole derivatives, e.g., a compound of Formula (I), and their uses in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Application
    Filed: July 26, 2021
    Publication date: January 20, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Dansu Li, Irit Snir-Alkalay, Joseph P. Vacca, Yinon Ben-Neriah, Avanthika Venkatachalam
  • Publication number: 20220016218
    Abstract: The present invention relates to methods of preparing peptide-based prodrugs having enhanced oral bioavailability and intestinal penetration. Said prodrugs are characterized in improved lipophilicity, reduced electric charge and tendency to undergo biotransformation through enzymatic reaction (e.g. in the blood stream) to form biologically active peptides.
    Type: Application
    Filed: July 9, 2021
    Publication date: January 20, 2022
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Amnon HOFFMAN, Chaim GILON, Joseph FANOUS, Adi KLINGER
  • Patent number: 11224628
    Abstract: Provided is a process for extraction of a lipophilic agent from a plant source, the process including: mixing a first quantity of a plant source, the plant source being containing the lipophilic agent and a first quantity of an extraction medium to obtain a first mixture, the extraction medium being in the form of a microemulsion and comprising at least one oil, at least one hydrophilic surfactant, at least one co-surfactant and optionally at least one co-solvent; homogenizing the first mixture under conditions maintaining the microemulsion structure; and separating the homogenized mixture into a biomass slurry and an agent-loaded medium to obtain the agent-loaded medium in a microemulsion form.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 18, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Nissim Garti, Sharon Garti Levi, Rotem Edri
  • Publication number: 20220008381
    Abstract: Provided are cannabinoid-loaded formulations, as well as processes for their preparation.
    Type: Application
    Filed: September 28, 2021
    Publication date: January 13, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Nissim GARTI, Sharon GARTI LEVI, Rotem EDRI
  • Patent number: 11208443
    Abstract: The present invention provides peptides comprising a sequence derived from the human NAF-1 protein, analogs of said sequence or a retro-inverso sequence of said peptide or analog. The conjugates of such peptides are provided as well. The peptides and the conjugates of the present invention are useful in treating cancer, and in particular cancer in which the expression of NAF-1 is enhanced.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: December 28, 2021
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Rachel Nechushtai, Assaf Friedler, Anat Iosub-Amir, Merav Darash-Yahana, Yang-Sung Sohn, Dorit Michaeli
  • Publication number: 20210395690
    Abstract: An enriched population of connective tissue cells that are capable of anchorage-independent growth are provided. Compositions comprising those cells, as well as methods of producing those cells are also provided.
    Type: Application
    Filed: November 7, 2019
    Publication date: December 23, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Merav Cohen
  • Publication number: 20210379010
    Abstract: The invention provides compositions comprising at least one cannabinoid compound, for use in the method of treating and preventing a disease, condition or symptom caused by, or associated with fungi, bacteria and microbes.
    Type: Application
    Filed: October 30, 2019
    Publication date: December 9, 2021
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Doron STEINBERG, Raphael MECHOULAM
  • Publication number: 20210379094
    Abstract: A method for reducing renal tissue toxicity in a subject caused by a kidney damaging agent is disclosed. The method comprises administering to the subject: (i) a kidney damaging agent; and (ii) an inhibitor of glucose reabsorption.
    Type: Application
    Filed: August 22, 2021
    Publication date: December 9, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH, Aaron COHEN
  • Patent number: 11193034
    Abstract: Provided is a novel photoinitiator in the form of a hybrid nanoparticle constructed of a semiconductor and metallic regions, and uses thereof.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: December 7, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Uri Banin, Hermona Soreq, Shlomo Magdassi, Nir Waiskopf, Yuval Ben-Shahar, Amol Ashok Pawar, Shira Halivni
  • Patent number: 11175536
    Abstract: An optically active structure and a display device are presented. The device utilized an optically active structure comprising liquid crystal material and a plurality of nanorods configured to emit light in one or more predetermined ranges in response to pumping light. Variation in orientation of the liquid crystal varies orientation of the nanorods and modulated light emission therefrom.
    Type: Grant
    Filed: September 20, 2015
    Date of Patent: November 16, 2021
    Assignees: Yissum Research Development Company Of The Hebrew University of Jerusalem Ltd., Merck Patent GmbH
    Inventors: Uri Banin, Hagai Arbell, Bernhard Rieger, Ming-Chou Wu
  • Patent number: 11160244
    Abstract: The present invention relates to novel plants, in particular to pepper plants capable of producing fruits which can be kept a longer period of time on the plant as well as being stored after harvesting under refrigerated conditions without exhibiting excessive softening. The invention thus refers to pepper plant which produces fruits with significantly increased fruit firmness at the harvesting stage, wherein said increased fruit firmness is controlled by a genetic determinant, monogenic, wherein said increased fruit firmness is defined as a fruit deformation under a 1 kg load force that is lower than that of a fruit from a control pepper plant which does not have the said genetic determinant.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: November 2, 2021
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventor: Yonatan Elkind
  • Patent number: 11149014
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: October 19, 2021
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Publication number: 20210315803
    Abstract: Provided herein are compositions of injectable antibiotics for veterinary use. The compositions are characterized by forming a gel at animal physiological temperature, said gel being characterized by a stable and repeatable release profile of the antibiotic. The compositions comprise high loading of drug in poloxamer solutions with addition of a co-solvent, and preferably with an addition of a cellulose derivative at least partially soluble in organic solvents. Methods of treatment of veterinary infections are also provided.
    Type: Application
    Filed: September 5, 2019
    Publication date: October 14, 2021
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Michael FRIEDMAN, David KIRMAYER, Zakhar NUDELMAN, Amnon HOFFMAN, Eran LAVY, Ayala BAR-HAI, Irith GATI
  • Publication number: 20210299157
    Abstract: The technology concerns topical formulations including nanocellulose materials for application on a skin or tissue of a subject.
    Type: Application
    Filed: August 6, 2019
    Publication date: September 30, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Oded SHOSEYOV, Tal BEN SHALOM
  • Patent number: 11122972
    Abstract: Devices and method for determining a pupil size of a subject having closed eyelids.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: September 21, 2021
    Assignees: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Jose Cohen, Vladimir Goldman, Yousef Nadim Farraj, Amnon Buxboim, Yoav Mintz, Elchanan Fried, Gahl Levy, Tsevi Beatus, Yoav Kan-Tor
  • Patent number: 11109822
    Abstract: There is provided a method of locating a tip of a metallic instrument inserted in a body, utilizing a baseline sinogram comprising projections in N exposure directions and derived from a prior computerized tomography (CT) scanning of the body, the method comprising: performing three-dimensional Radon space registration of a sparse repeat sinogram to the baseline sinogram, the repeat CT scanning having the metallic instrument inserted into the body, the metallic instrument having an attached marker located at a known distance from the instrument tip; subtracting the baseline sinogram from the repeat sinogram in accordance with the registration parameters to obtain projection difference images; and using the projection difference images and the known distance of the attached marker from the metallic instrument tip to determine a three-dimensional location of the metallic instrument tip.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: September 7, 2021
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Leo Joskowicz, Guy Medan
  • Patent number: 11103547
    Abstract: Provided are methods for disrupting biofilms and/or preventing the formation of biofilms. Further provided are random-sequence peptide mixtures for use in disrupting bacterial biofilms. The random-sequence peptides include hydrophobic and/or cationic amino acids, and the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 31, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Zvi Hayouka
  • Patent number: 11104677
    Abstract: A method of preventing or treating a disease characterized by an excessive immune response in a subject in need thereof is provided. The method includes administering to the subject a composition including an active component, wherein the active component is a first compound, a second compound, a third compound, a pharmaceutically acceptable salt thereof, a solvate thereof, or a combination thereof, wherein the first, second, and third compounds include: respectively.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: August 31, 2021
    Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FĂ–RDERUNG DER ANGEWANDTEN FORSCHUNG E.V., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Anke Burger-Kentischer, Angela Mattes, Maria Zatsepin, Amriam Goldblum
  • Publication number: 20210251992
    Abstract: The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Application
    Filed: March 29, 2021
    Publication date: August 19, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yinon Ben-Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Irit Snir-Alkalay, Joseph P. Vacca, Dansu Li
  • Publication number: 20210253511
    Abstract: The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.
    Type: Application
    Filed: March 13, 2019
    Publication date: August 19, 2021
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Shmuel BEN-SASSON, Einav GROSS