Patents Assigned to Yissum Research Development Company of the Hebrew University of Jerusalem
  • Device for electric field induced local magnetization
    Patent number: 11437501
    Abstract: In a technique for inducing local electric field controlled magnetization, despite the absence of magnetic components, there is provided a novel heterostructure, a semiconductor device thereof, or an array of semiconductor devices. The heterostructure includes a semiconductor substrate carrying a plurality of layers forming at least one heterojunction and hosting a two-dimensional electron gas layer when one of the layer of the plurality of layers is bounded to an interacting layer being a chiral or a biological macromolecule assembly.
    Type: Grant
    Filed: April 7, 2019
    Date of Patent: September 6, 2022
    Assignees: Yeda Research and Development Co. Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yossef Paltiel, Ron Naaman, Karen Michaeli, Eilam Smolinsky
  • ANTICANCER AGENTS
    Publication number: 20220251126
    Abstract: The claimed subject matter provides for a method for conjugating an active material to a Pt complex.
    Type: Application
    Filed: August 5, 2020
    Publication date: August 11, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Dan GIBSON, Amrita SARKAR
  • COMPOSITIONS FOR DELIVERY OF LADOSTIGIL
    Publication number: 20220226276
    Abstract: The invention provides compositions comprising ladostigil, being a colonic delivery composition, including methods and uses thereof.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 21, 2022
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventor: Marta WEINSTOCK-ROSIN
  • Compositions and methods for nasal administration of drugs to brain and for systemic effect
    Patent number: 11389404
    Abstract: The invention relates to a nasally administrable composition comprising at least one active substance in magnesium-containing vesicular carrier, said carrier comprising glycol, phospholipids, water and at least one magnesium source. Methods for nasal administration of the composition, for example, for pain relief, are also provided.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: July 19, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Elka Touitou, Hiba Natsheh
  • COMBINATION TREATMENTS FOR CYSTIC FIBROSIS CHARACTERIZED BY A 3849 + 10KB C-TO-T CFTR MUTATION
    Publication number: 20220220486
    Abstract: The present invention provides methods for treating Cystic Fibrosis (CF) and methods for suppressing the inclusion of a cryptic exon between exon 22 and 23 as a result of the mutation 3849+10 Kb C-to-T comprising the step of administering a pharmaceutical composition comprising synthetic oligonucleotides complementary to a region of the CFTR comprising the 3849+10 Kb C-to-T mutation oligonucleotides and a composition comprising one or more CFTR modifiers.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 14, 2022
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, SPLISENSE LTD.
    Inventors: Bat Sheva KEREM, Efrat OZERI-GALAI, Yifat OREN, Ofra BARCHAD-AVITZUR
  • RESTORATION OF THE CFTR FUNCTION BY SPLICING MODULATION
    Publication number: 20220213479
    Abstract: The present invention provides oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, including compositions comprising the oligonucleotides, and uses thereof, such as for suppressing the inclusion of a cryptic exon between exon 22 and 23 as a result of the mutation 3849 +10 Kb C-to-T, optionally in combination with additional CF therapeutics.
    Type: Application
    Filed: May 5, 2020
    Publication date: July 7, 2022
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, SpliSense Ltd.
    Inventors: Bat Sheva KEREM, Efrat OZERI-GALAI, Yifat OREN, Ofra BARCHAD-AVITZUR
  • Sesame cultivars suitable for mechanical harvest with enhanced yield and quality
    Patent number: 11363792
    Abstract: Provided are sesame plants having a mutation conferring closed capsules at maturity and means and methods for producing same. The plants of the present subject matter produce high yield of sesame seeds, the seeds having improved content of at least one of zinc, iron and calcium.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: June 21, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Zvi Peleg, Naama Teboul, Yaron Gadri
  • Electroactive bioadhesive compositions
    Patent number: 11357884
    Abstract: The present invention relates to electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: June 14, 2022
    Assignees: Nanyang Technological University, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Terry W. J. Steele, Daniel Mandler
  • METHOD FOR SELECTING PATIENT SPECIFIC THERAPY
    Publication number: 20220180963
    Abstract: Methods of identifying a druggable target in a subject suffering from cancer comprising determining at least one unbalanced process in the subject's expression data and selecting at least one gene and/or protein from the at least one unbalanced process wherein a drug that targets that gene or protein is known.
    Type: Application
    Filed: April 29, 2019
    Publication date: June 9, 2022
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Nataly KRAVCHENKO-BALASHA, Raphael David LEVINE, Efrat FLASHNER-ABRAMSON
  • Activity based probe and uses thereof for imaging
    Patent number: 11344634
    Abstract: Provided is a compound including at least one carrier moiety associated with a plurality of CT imaging moieties, and with at least one enzyme interacting moiety as well as uses thereof in diagnosis.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: May 31, 2022
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Galia Blum, Darya Tsivrkun, Hanmant Gaikwad
  • Fatty acid amides and uses thereof in the treatment of addiction disorder and addiction related conditions
    Patent number: 11324709
    Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 10, 2022
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Raphael Mechoulam, Vincenzo Di Marzo, Fabiana Piscitelli, Aron H. Lichtman, Imad M. Damaj, Linda Parker, Rami Yaka
  • Photocatalysts based on bismuth oxyhalide, process for their preparation and uses thereof
    Patent number: 11319227
    Abstract: The invention provides a process for the preparation of bismuth oxyhalide, comprising a precipitation of bismuth oxyhalide in an acidic aqueous medium in the presence of a reducing agent. Also provided are bismuth oxyhalide compounds doped with elemental bismuth Bi(0). The use of Bi(0)doped-bismuth oxyhalide as photocatalysts in water purification is also described.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: May 3, 2022
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Yoel Sasson, Hani Gnayem
  • Peptides for use in the treatment of viral infections
    Patent number: 11304989
    Abstract: Disclosed are peptides, compositions, combinations, kits and methods for the treatment of viral pathogen infection. Combinations and kits comprise the disclosed peptides together with an additional antiviral therapeutic agent.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: April 19, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raymond Kaempfer, Gila Arad
  • MULTI-MORPHOLOGY BLOCK CO-POLYMER FILMS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20220112342
    Abstract: The invention relates to a block co-polymer film having different morphologies within said film, uses thereof and processes for its preparation.
    Type: Application
    Filed: July 29, 2019
    Publication date: April 14, 2022
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Roy SHENHAR, Elisheva MICHMAN, Marcus MULLER
  • Device, system and method for pericardial access
    Patent number: 11298151
    Abstract: Device for accessing a pericardial space of a subject in need thereof, the device including a tubular member having an atraumatic distal end and a thread formed on, and at least partially around, the outer surface of the tubular member, proximally to the distal end; wherein the thread is configured to cut, puncture and/or penetrate a pericardium.
    Type: Grant
    Filed: June 17, 2018
    Date of Patent: April 12, 2022
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Ran Eliaz, Yonathan Avraham Demma, Ziv Menshes, Or Hazan, Eva Abramov, Yaakov Nahmias, Amnon Buxboim, Yoav Kan-Tor, Yoav Mintz, Elchanan Fried
  • Method of generating bacterial compositions
    Patent number: 11297868
    Abstract: A method of preparing a bacterial composition is disclosed. The method comprises: (a) in vitro co-culturing beneficial bacteria with biofilm-producing bacteria in a growth substrate under conditions that generate a biofilm which comprises the beneficial bacteria and the non-pathogenic bacteria; and (b) isolating the biofilm from the growth substrate.
    Type: Grant
    Filed: May 29, 2017
    Date of Patent: April 12, 2022
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Moshe Shemesh, Ram Reifen
  • METHOD FOR EXTRACTION OF AN AGENT FROM A PLANT SOURCE
    Publication number: 20220088099
    Abstract: Provided are methods for extraction of various agents, e.g. active agent, from a plant source, specifically with the use of extraction formulations which are based on micellar liquid systems.
    Type: Application
    Filed: December 7, 2021
    Publication date: March 24, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Nissim GARTI, Sharon GARTI LEVI, Rotem EDRI
  • High shear solid phase synthesis
    Patent number: 11267846
    Abstract: The present disclosure relates to solid phase synthesis of organic molecules and particularly to highly efficient methods for synthesizing polymers, such as peptides, nucleotides or saccharides, employing solid phase synthesis.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: March 8, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Chaim Gilon, Moshe Bentolila
  • Somatostatin prodrugs
    Patent number: 11261215
    Abstract: The present invention provides prodrugs of somatostatin peptide and peptide analogs that are tissue permeable and oral bioavailable and enable activity of the somatostatin analog at the circulation or target tissue after cleavage of charge-masking lipophilic moieties. Pharmaceutical compositions comprising these prodrugs and their use in therapy and diagnosis are also provided.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 1, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Amnon Hoffman, Chaim Gilon, Adi Klinger, Johnny Naoum
  • Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent
    Patent number: 11248018
    Abstract: Disclosed herein is a process for preparing nicotinamide riboside (NR) from an NR precursor and a phosphate-binding agent in a solvent. The reaction-derived mixture comprising NR may be further used without further processing in a variety of products, particularly in a cosmetic product.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: February 15, 2022
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HIKARI LABORATORIES LTD.
    Inventors: Dmitri Gelman, Amani Zoabi, Assaf Zeira, Raed Abu-Reziq