Abstract: The present invention is directed to a method for determining a subject is afflicted with or having increased risk of developing an alpha-synuclein-associated disease or disorder, Parkinson's disease, or both. The method further includes administering to the subject determined as being afflicted with or having increased risk of developing an alpha-synuclein-associated disease or disorder a therapeutically effective amount of an agent characterized by being capable of decreasing signaling transduced by a member of PI4,5P2 PI3,4P2, PI3,5P2, PI3,4,5P3, PI3P, PI4P signal transduction pathway.

Abstract: Isolated polypeptides of CD44 are provided. Accordingly, there is provided an isolated polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-3. Also provided is an isolated end-capping modified polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-3, wherein the modified polypeptide comprises an anti-inflammatory activity. Also provided are compositions of matter, fusion proteins and pharmaceutical compositions and their use in the treatment of inflammatory disease.

Abstract: Disclosed are peptides that specifically bind to neutrophils and uses thereof for neutrophil-targeted delivery of drugs or diagnostic agents in medical conditions including cancer as well as infectious, inflammatory and autoimmune diseases or disorders.

Abstract: Methods, compositions and kits for reducing renal tissue toxicity in a subject caused by a kidney damaging agent are provided. The methods comprise administering to the subject: (i) a kidney damaging agent; (ii) a PPARA activator; and (iii) an inhibitor of a cellular pathway selected from the group consisting of C/EBP, PPARG, ER stress, GLUT2 and SGLT1/2; or (i) a kidney damaging agent; (ii) a SGLT2 inhibitor; and (iii) a PPARA activator, a C/EBP inhibitor, a PPARG inhibitor, or an ER stress inhibitor.

Abstract: Devices and method for determining a pupil size of a subject having closed eyelids.

Abstract: Methods of treating coronavirus infection, or decreasing the risk of symptomatic infection, by administering a peroxisome proliferator-activated receptor alpha (PPARA) agonist or an inositol-requiring enzyme 1 (IRE1) pathway inhibitor are provided.

Abstract: The invention disclosed herein concerns a novel class of compounds suitable for the treatment of neurodegenerative diseases, such as Parkinson’s Disease.

Abstract: Provided is a composite of a CNT assembly including a plurality of carbon nanotubes (CNTs) and at least one metalcone material, the composite being tunable, by a vapor phase chemical modification, to adopt one or more collective properties selected from mechanical, chemical, physical or electrical properties.

Abstract: A system and method are presented, for monitoring and/or imaging of a sample. The system comprises: a light unit configured for illuminating the sample in at least two different wavelength ranges; a collection unit configured for collecting a light emitted from the sample in at least a third wavelength range and directing said emitted light towards at least one detector; and an activation unit configured for providing activation signal to selectively activate at least a portion of fluorescent substance in the sample; and a processing circuitry configured for operating the light unit to determine a selected temporal illumination profile of said at least two different wavelength ranges and for operating the activation unit for controllable activation.

Abstract: The technology disclosed herein concerns compounds capable of binding to CB1Rs in the periphery and not in the CNS.

Abstract: Provided is a perovskite-based photovoltaic device including a layered scaffold material and at least one perovskite material interpenetrating the layered scaffold, wherein the at least one perovskite layer is removable and regenerable.

Abstract: The present invention provides processes for producing food products, particularly juice beverages, with reduced sugar content enriched with dietary fibers and the food products produced. The processed food products are low in calories while preserving the palatable test of the starting material, and contain beneficial amount of dietary fibers. The processed food product further contains sorbitol and gluconic acid.

Abstract: The invention relates to a process for treating food, in particular for curing meat, comprising adding to the food a compound of Formula III, which is a derivative of S-nitroso-cysteine. Use of the compound of Formula III as food preservative and compositions for curing meat are also provided by the invention.

Abstract: Disclosed are peptides comprising amino acid residues of the dimer interface of human B7-1 and B7-2 and compositions and uses thereof.

Abstract: The present disclosure provides, in part, a cell culture medium supplement comprising at least one plant protein homologue of a serum protein, a cell culture medium comprising a serum-free base medium and one or more plant based proteins, and methods of growing cells in vitro and of producing cultured meat using the cell culture medium.

Abstract: A method for generating reactive species in a medium in which light irradiates the medium including a nanoparticle. A photoinitiator composed of semiconductor nanoparticles for photo-polymerization and 2D and 3D printing.

Abstract: The present disclosure provides, in part, a cell culture medium comprising a serum-free medium and one or more fibroblast growth factor (FGF) activators, a kit comprising the cell culture medium and instructions for use, methods of growing cells in vitro and of producing a cultured meat using the cell culture medium, and a cultured meat so produced.

Abstract: The present disclosure provides, in part, a receptacle for filtering a liquid. The receptacle comprises a plurality of hollow fibers extending the length of the receptacle and at least one solid absorbent material occupying a space between the plurality of hollow fibers. Each hollow fiber comprises at least one opening and a lumen defined by the walls thereof, allowing the liquid to flow through. The hollow fiber walls have a porosity profile selective to passage of waste materials contained in the liquid from the lumen to the solid absorbent material(s), thereby filtering the liquid. Also provided is a system as well as a method for filtering and recycling a cell culture medium.

Abstract: The present invention provides antimicrobial matrices comprising a water-insoluble polymer and a mixture comprising a plurality of synthetic peptides attached thereto via a linker, the peptides comprise cationic amino acid residues, hydrophobic amino acid residues, or combinations thereof, in random sequences. The invention further provides uses of the antimicrobial matrices for eliminating microorganisms, particularly pathogenic bacteria, from liquid or semi solid media including edible products or beverages.

Abstract: A composition for reducing the weight loss and/or preserving the natural gloss of post-harvest edible plant matter, and methods for applying the compositions to the surface of the plant matter. The compositions include an edible wax having a melting temperature below 70° C.; a hydrocolloid; a fatty acid; an emulsifier; and water, wherein the edible wax is present in a weight percent ranging from about 10% to about 25% of the total weight of the composition.