Abstract: The present invention is directed to a method for determining a subject is afflicted with or having increased risk of developing an alpha-synuclein-associated disease or disorder, Parkinson's disease, or both. The method further includes administering to the subject determined as being afflicted with or having increased risk of developing an alpha-synuclein-associated disease or disorder a therapeutically effective amount of an agent characterized by being capable of decreasing signaling transduced by a member of PI4,5P2 PI3,4P2, PI3,5P2, PI3,4,5P3, PI3P, PI4P signal transduction pathway.
Type:
Application
Filed:
December 8, 2022
Publication date:
September 14, 2023
Applicant:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventors:
Ronit SHARON, Meir SCHECHTER, Suad ABD ALHADI
Abstract: Isolated polypeptides of CD44 are provided. Accordingly, there is provided an isolated polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-3. Also provided is an isolated end-capping modified polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-3, wherein the modified polypeptide comprises an anti-inflammatory activity. Also provided are compositions of matter, fusion proteins and pharmaceutical compositions and their use in the treatment of inflammatory disease.
Type:
Application
Filed:
December 20, 2022
Publication date:
July 6, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
David NAOR, Lora ESHKAR-SEBBAN, Keren-Or AMAR, Shmuel COHEN
Abstract: Disclosed are peptides that specifically bind to neutrophils and uses thereof for neutrophil-targeted delivery of drugs or diagnostic agents in medical conditions including cancer as well as infectious, inflammatory and autoimmune diseases or disorders.
Type:
Application
Filed:
December 27, 2022
Publication date:
June 29, 2023
Applicants:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
Abstract: Methods, compositions and kits for reducing renal tissue toxicity in a subject caused by a kidney damaging agent are provided. The methods comprise administering to the subject: (i) a kidney damaging agent; (ii) a PPARA activator; and (iii) an inhibitor of a cellular pathway selected from the group consisting of C/EBP, PPARG, ER stress, GLUT2 and SGLT1/2; or (i) a kidney damaging agent; (ii) a SGLT2 inhibitor; and (iii) a PPARA activator, a C/EBP inhibitor, a PPARG inhibitor, or an ER stress inhibitor.
Type:
Application
Filed:
February 20, 2023
Publication date:
June 29, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Methods of treating coronavirus infection, or decreasing the risk of symptomatic infection, by administering a peroxisome proliferator-activated receptor alpha (PPARA) agonist or an inositol-requiring enzyme 1 (IRE1) pathway inhibitor are provided.
Type:
Application
Filed:
October 13, 2022
Publication date:
June 22, 2023
Applicant:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: The invention disclosed herein concerns a novel class of compounds suitable for the treatment of neurodegenerative diseases, such as Parkinson’s Disease.
Type:
Application
Filed:
February 22, 2023
Publication date:
June 22, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided is a composite of a CNT assembly including a plurality of carbon nanotubes (CNTs) and at least one metalcone material, the composite being tunable, by a vapor phase chemical modification, to adopt one or more collective properties selected from mechanical, chemical, physical or electrical properties.
Type:
Grant
Filed:
February 21, 2018
Date of Patent:
June 20, 2023
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: A system and method are presented, for monitoring and/or imaging of a sample. The system comprises: a light unit configured for illuminating the sample in at least two different wavelength ranges; a collection unit configured for collecting a light emitted from the sample in at least a third wavelength range and directing said emitted light towards at least one detector; and an activation unit configured for providing activation signal to selectively activate at least a portion of fluorescent substance in the sample; and a processing circuitry configured for operating the light unit to determine a selected temporal illumination profile of said at least two different wavelength ranges and for operating the activation unit for controllable activation.
Type:
Grant
Filed:
January 14, 2021
Date of Patent:
June 13, 2023
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: Provided is a perovskite-based photovoltaic device including a layered scaffold material and at least one perovskite material interpenetrating the layered scaffold, wherein the at least one perovskite layer is removable and regenerable.
Type:
Application
Filed:
March 31, 2021
Publication date:
June 8, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides processes for producing food products, particularly juice beverages, with reduced sugar content enriched with dietary fibers and the food products produced. The processed food products are low in calories while preserving the palatable test of the starting material, and contain beneficial amount of dietary fibers. The processed food product further contains sorbitol and gluconic acid.
Type:
Application
Filed:
January 3, 2023
Publication date:
May 18, 2023
Applicant:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD,
Abstract: The invention relates to a process for treating food, in particular for curing meat, comprising adding to the food a compound of Formula III, which is a derivative of S-nitroso-cysteine. Use of the compound of Formula III as food preservative and compositions for curing meat are also provided by the invention.
Type:
Grant
Filed:
July 31, 2018
Date of Patent:
April 25, 2023
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventors:
Oren Tirosh, Joseph Kanner, Adi Spaizer-Katzenelson
Abstract: The present disclosure provides, in part, a cell culture medium supplement comprising at least one plant protein homologue of a serum protein, a cell culture medium comprising a serum-free base medium and one or more plant based proteins, and methods of growing cells in vitro and of producing cultured meat using the cell culture medium.
Type:
Application
Filed:
January 20, 2021
Publication date:
March 23, 2023
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Future Meat Technologies Ltd.
Inventors:
Yaakov Nahmias, Merav Cohen, Jonathan Caspi
Abstract: A method for generating reactive species in a medium in which light irradiates the medium including a nanoparticle. A photoinitiator composed of semiconductor nanoparticles for photo-polymerization and 2D and 3D printing.
Type:
Grant
Filed:
February 6, 2019
Date of Patent:
March 21, 2023
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventors:
Uri Banin, Shlomo Magdassi, Nir Waiskopf, Lior Efraim Verbitsky
Abstract: The present disclosure provides, in part, a cell culture medium comprising a serum-free medium and one or more fibroblast growth factor (FGF) activators, a kit comprising the cell culture medium and instructions for use, methods of growing cells in vitro and of producing a cultured meat using the cell culture medium, and a cultured meat so produced.
Type:
Application
Filed:
January 20, 2021
Publication date:
March 9, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Yaakov Nahmias, Muneef Ayyash, Laura Pasitka
Abstract: The present disclosure provides, in part, a receptacle for filtering a liquid. The receptacle comprises a plurality of hollow fibers extending the length of the receptacle and at least one solid absorbent material occupying a space between the plurality of hollow fibers. Each hollow fiber comprises at least one opening and a lumen defined by the walls thereof, allowing the liquid to flow through. The hollow fiber walls have a porosity profile selective to passage of waste materials contained in the liquid from the lumen to the solid absorbent material(s), thereby filtering the liquid. Also provided is a system as well as a method for filtering and recycling a cell culture medium.
Type:
Application
Filed:
January 29, 2021
Publication date:
March 9, 2023
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Future Meat Technologies Ltd.
Abstract: The present invention provides antimicrobial matrices comprising a water-insoluble polymer and a mixture comprising a plurality of synthetic peptides attached thereto via a linker, the peptides comprise cationic amino acid residues, hydrophobic amino acid residues, or combinations thereof, in random sequences. The invention further provides uses of the antimicrobial matrices for eliminating microorganisms, particularly pathogenic bacteria, from liquid or semi solid media including edible products or beverages.
Type:
Application
Filed:
February 9, 2021
Publication date:
March 9, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: A composition for reducing the weight loss and/or preserving the natural gloss of post-harvest edible plant matter, and methods for applying the compositions to the surface of the plant matter. The compositions include an edible wax having a melting temperature below 70° C.; a hydrocolloid; a fatty acid; an emulsifier; and water, wherein the edible wax is present in a weight percent ranging from about 10% to about 25% of the total weight of the composition.
Type:
Application
Filed:
September 9, 2022
Publication date:
February 16, 2023
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Amos NUSSINOVITCH, Tal MARMUR, Yonatan ELKIND