Patents Assigned to Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
  • Patent number: 10842745
    Abstract: The present disclosure provides a composition of matter comprising liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the liposomes having a diameter of at least 200 nm and being embedded in a water insoluble, water absorbed cross-linked polymeric matrix. In one embodiment, the composition of matter is held within an aqueous medium, preferably being in iso-osmotic equilibrium with the intraliposomal aqueous compartments of the liposomes.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: November 24, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yechezkel Barenholz, Rivka Cohen
  • Patent number: 10844050
    Abstract: The invention provides efficient cyclization processes of hydroxyalkenoic acids and products produced therefrom. The following reactions are claimed: Formula (I), (II), (V) and (VI).
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: November 24, 2020
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventor: Dmitry Tsvelikhovsky
  • Patent number: 10801028
    Abstract: An isolated nucleic acid agent is disclosed comprising a nucleic acid sequence which downregulates expression of a gene product of a Varroa destructor mite. Compositions comprising same and uses thereof are also disclosed.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: October 13, 2020
    Assignees: BEEOLOGICS INC., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Ilan Sela, Sharoni Shafir, Eyal Maori, Yael Garbian, Eyal Ben-Chanoch, Gal Yarden, Haim Kalev
  • Publication number: 20200318077
    Abstract: Provided are in-vitro methods and devices for sustaining a synchronized circadian rhythm in cells of a cell culture by exposing the cells to a continuous flow of medium and to at least two stimuli provided in an oscillating manner with a periodicity of 24±4 hours, wherein a first stimulus and a second stimulus of said at least two stimuli are distinct, wherein said first stimulus is provided in a first time period and reaches a first peak in a first peak time period, and wherein a second stimulus is provided in a second time period and reaches a second peak in a second peak time period, and wherein an interval between end of time period of said first peak and beginning of said time period of said second peak is at least about 2 hours.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 8, 2020
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Yaakov NAHMIAS
  • Patent number: 10781445
    Abstract: An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a splicing-factor binding site. The oligonucleotide is no more than 150 bases and may be devoid of a sequence that allows hybridization thereof to cellular RNA under physiological conditions. The oligonucleotide inhibits overall cellular splicing activity of a specific splicing factor. Pharmaceutical compositions comprising the oligonucleotide and uses thereof are further disclosed.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 22, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Rotem Karni
  • Patent number: 10777215
    Abstract: A method and system for enhancing a speech signal is provided herein. The method may include the following steps: obtaining an original video, wherein the original video includes a sequence of original input images showing a face of at least one human speaker, and an original soundtrack synchronized with said sequence of images; and processing, using a computer processor, the original video, to yield an enhanced speech signal of said at least one human speaker, by detecting sounds that are acoustically unrelated to the speech of the at least one human speaker, based on visual data derived from the sequence of original input images.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: September 15, 2020
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Shmuel Peleg, Asaph Shamir, Tavi Halperin, Aviv Gabbay, Ariel Ephrat
  • Patent number: 10772863
    Abstract: Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid, Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: September 15, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Yaakov Nahmias, Michal Zimerman, Gahl Levy, Yishai Avior
  • Patent number: 10761425
    Abstract: Provided is a novel class of solid water-dispersible powders, including a plurality of water-insoluble photoinitiators in nanoparticle forms for use in water-based ink formulations.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: September 1, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Shlomo Magdassi, Liraz Larush, Ido Cooperstein, Amol Ashok Pawar
  • Patent number: 10760122
    Abstract: The invention relates to a hybrid structure comprising perforated solid substrate having at least one nanopore perforating therethrough, and devices and uses thereof.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: September 1, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Danny Porath, Oded Shoseyov, Yuval Nevo, Ke Liu, Dvir Marom Rotem
  • Patent number: 10750701
    Abstract: Provided relates to a crop Lisianthus (Eustoma grandiflorum) plants that do not require cold treatment (vernalization) for the inductions of bolting and flowering, and to means and methods for producing same.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: August 25, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Avichai Amrad, Kfir Bandel, Tzili Pleban, Dani Zamir
  • Patent number: 10750693
    Abstract: Provided are tomato plants having fruit with red and yellow segments that appear across the fruit from the internal seed area to the most external layer of the epidermis. The present invention discloses that this phenotype, designated Arlecchino, is linked to insertion mutation within the Phytoene synthase 1 (Psy1) gene.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: August 25, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Joseph Hirschberg, Dani Zamir, Yaacov Micha Brog, Itay Zemach, Orly Dery
  • Publication number: 20200262997
    Abstract: The invention is a process of treating plastic waste, comprising converting one or more plastic polymers into a liquid form either by dissolving in an organic solvent or by melting, and degrading said polymer(s) with the aid of alkali hydroxide and hydrogen peroxide, optionally in the presence of a phase transfer catalyst.
    Type: Application
    Filed: January 3, 2017
    Publication date: August 20, 2020
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Yoel SASSON, Uri STOIN
  • Patent number: 10731156
    Abstract: Provided are oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, compositions including said oligonucleotides, kits including the compositions, and uses thereof. In particular, the subject matter provides compositions of oligonucleotides useful in methods for suppressing exon skipping optionally in combination with additional CFTR therapeutics.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: August 4, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Batsheva Kerem, Michal Tur Sinai, Loren Price, Stephen Donald Wilton, Sue Fletcher
  • Publication number: 20200239398
    Abstract: Methylene-cycloalkylacetate compounds and derivatives thereof and their use in methods for treatment of neurotropic conditions.
    Type: Application
    Filed: December 15, 2019
    Publication date: July 30, 2020
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Dmitry TSVELIKHOVSKY, Philip LAZAROVICI, Dikla HAHAM, David LANKRI
  • Patent number: 10722599
    Abstract: Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: July 28, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yechezkel Barenholz, Rivka Cohen, Kirill Makedonski, Eylon Yavin, Andreas Ingemann Jensen, Keren Turjeman
  • Patent number: 10723941
    Abstract: The present invention relates to a novel class of seeded nanoparticles and uses thereof.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: July 28, 2020
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Uri Banin, Itai Lieberman, Shany Neyshtadt, Lior Yedidya
  • Patent number: 10716864
    Abstract: An affinity binding moiety comprising an antigen recognition region which comprises complementarity determining region (CDR) amino acid sequences as set forth in heavy chain ordered N to C terminus: SEQ ID NOs: 4, 6 and 8, and light chain ordered N to C terminus: SEQ ID NOs: 12, 14 and 16 is disclosed. A pharmaceutical compositions comprising as an active ingredient the affinity binding moiety is also disclosed. Methods of diagnosing, preventing or treating an autoimmune disease or a cancer associated with an expression of NKp46 are also disclosed.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: July 21, 2020
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., UNIVERSITY OF RIJEKA FACULTY OF MEDICINE
    Inventors: Ofer Mandelboim, Stipan Jonjic, Orit Berhani, Ariella Glasner
  • Patent number: 10717664
    Abstract: The invention provides a process for the preparation of bismuth oxyhalide, comprising a precipitation of bismuth oxyhalide in an acidic aqueous medium in the presence of a reducing agent. Also provided are bismuth oxyhalide compounds doped with elemental bismuth Bi(0). The use of Bi(0) doped bismuth oxyhalide as photocatalysts in water purification is also described.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: July 21, 2020
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Yoel Sasson, Hani Gnayem
  • Publication number: 20200225579
    Abstract: Provided is a novel class of solid water-dispersible powders, including a plurality of water-insoluble photoinitiators in nanoparticle forms for use in water-based ink formulations.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 16, 2020
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Shlomo MAGDASSI, Liraz LARUSH, Ido COOPERSTEIN, Amol Ashok PAWAR
  • Patent number: 10695462
    Abstract: The invention disclosed herein generally provides implantable medical devices and implants that may be removed on-demand from a subject's body at any time after their implanting in the body, without necessitating invasive procedures.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: June 30, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Oded Shoseyov, Danny Porath, Ofra Benny, Yaron Bar-Lavie, Amos Ofer