Abstract: The invention relates to a nasally administrable composition comprising at least one active substance in magnesium-containing vesicular carrier, said carrier comprising glycol, phospholipids, water and at least one magnesium source. Methods for nasal administration of the composition, for example, for pain relief, are also provided.
Type:
Grant
Filed:
March 10, 2020
Date of Patent:
July 19, 2022
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: Provided are sesame plants having a mutation conferring closed capsules at maturity and means and methods for producing same. The plants of the present subject matter produce high yield of sesame seeds, the seeds having improved content of at least one of zinc, iron and calcium.
Type:
Grant
Filed:
December 15, 2016
Date of Patent:
June 21, 2022
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: The present invention relates to electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.
Type:
Grant
Filed:
January 14, 2015
Date of Patent:
June 14, 2022
Assignees:
Nanyang Technological University, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
Abstract: Methods of identifying a druggable target in a subject suffering from cancer comprising determining at least one unbalanced process in the subject's expression data and selecting at least one gene and/or protein from the at least one unbalanced process wherein a drug that targets that gene or protein is known.
Type:
Application
Filed:
April 29, 2019
Publication date:
June 9, 2022
Applicant:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventors:
Nataly KRAVCHENKO-BALASHA, Raphael David LEVINE, Efrat FLASHNER-ABRAMSON
Abstract: Provided is a compound including at least one carrier moiety associated with a plurality of CT imaging moieties, and with at least one enzyme interacting moiety as well as uses thereof in diagnosis.
Type:
Grant
Filed:
February 16, 2017
Date of Patent:
May 31, 2022
Assignee:
Yissum Research Development Company of the Hebrew
University of Jerusalem Ltd.
Inventors:
Galia Blum, Darya Tsivrkun, Hanmant Gaikwad
Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.
Type:
Grant
Filed:
May 22, 2018
Date of Patent:
May 10, 2022
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Inventors:
Raphael Mechoulam, Vincenzo Di Marzo, Fabiana Piscitelli, Aron H. Lichtman, Imad M. Damaj, Linda Parker, Rami Yaka
Abstract: The invention provides a process for the preparation of bismuth oxyhalide, comprising a precipitation of bismuth oxyhalide in an acidic aqueous medium in the presence of a reducing agent. Also provided are bismuth oxyhalide compounds doped with elemental bismuth Bi(0). The use of Bi(0)doped-bismuth oxyhalide as photocatalysts in water purification is also described.
Type:
Grant
Filed:
June 10, 2020
Date of Patent:
May 3, 2022
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Abstract: Disclosed are peptides, compositions, combinations, kits and methods for the treatment of viral pathogen infection. Combinations and kits comprise the disclosed peptides together with an additional antiviral therapeutic agent.
Type:
Grant
Filed:
October 2, 2018
Date of Patent:
April 19, 2022
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
Abstract: The invention relates to a block co-polymer film having different morphologies within said film, uses thereof and processes for its preparation.
Type:
Application
Filed:
July 29, 2019
Publication date:
April 14, 2022
Applicant:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Inventors:
Roy SHENHAR, Elisheva MICHMAN, Marcus MULLER
Abstract: Device for accessing a pericardial space of a subject in need thereof, the device including a tubular member having an atraumatic distal end and a thread formed on, and at least partially around, the outer surface of the tubular member, proximally to the distal end; wherein the thread is configured to cut, puncture and/or penetrate a pericardium.
Type:
Grant
Filed:
June 17, 2018
Date of Patent:
April 12, 2022
Assignees:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
Inventors:
Ran Eliaz, Yonathan Avraham Demma, Ziv Menshes, Or Hazan, Eva Abramov, Yaakov Nahmias, Amnon Buxboim, Yoav Kan-Tor, Yoav Mintz, Elchanan Fried
Abstract: A method of preparing a bacterial composition is disclosed. The method comprises: (a) in vitro co-culturing beneficial bacteria with biofilm-producing bacteria in a growth substrate under conditions that generate a biofilm which comprises the beneficial bacteria and the non-pathogenic bacteria; and (b) isolating the biofilm from the growth substrate.
Type:
Grant
Filed:
May 29, 2017
Date of Patent:
April 12, 2022
Assignees:
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided are methods for extraction of various agents, e.g. active agent, from a plant source, specifically with the use of extraction formulations which are based on micellar liquid systems.
Type:
Application
Filed:
December 7, 2021
Publication date:
March 24, 2022
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present disclosure relates to solid phase synthesis of organic molecules and particularly to highly efficient methods for synthesizing polymers, such as peptides, nucleotides or saccharides, employing solid phase synthesis.
Type:
Grant
Filed:
March 12, 2019
Date of Patent:
March 8, 2022
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: The present invention provides prodrugs of somatostatin peptide and peptide analogs that are tissue permeable and oral bioavailable and enable activity of the somatostatin analog at the circulation or target tissue after cleavage of charge-masking lipophilic moieties. Pharmaceutical compositions comprising these prodrugs and their use in therapy and diagnosis are also provided.
Type:
Grant
Filed:
September 17, 2018
Date of Patent:
March 1, 2022
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventors:
Amnon Hoffman, Chaim Gilon, Adi Klinger, Johnny Naoum
Abstract: Disclosed herein is a process for preparing nicotinamide riboside (NR) from an NR precursor and a phosphate-binding agent in a solvent. The reaction-derived mixture comprising NR may be further used without further processing in a variety of products, particularly in a cosmetic product.
Type:
Grant
Filed:
February 21, 2017
Date of Patent:
February 15, 2022
Assignees:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HIKARI LABORATORIES LTD.
Inventors:
Dmitri Gelman, Amani Zoabi, Assaf Zeira, Raed Abu-Reziq
Abstract: Methods of generating organoids on multi-well plates are provided by depositing a polymeric solution comprising cells under conditions which result in a homogenous population of organoids, which can be used for high throughput analysis for drug screening and for determining treatment regimens of a drug.
Type:
Application
Filed:
August 22, 2021
Publication date:
February 10, 2022
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: A guided tracheal intubation system using an autonomous modulated light source, outputting modulated illumination at a constant level, and externally applied to the subject's larynx region. An optical imaging system receives a video stream from within the subject's throat, including modulated illumination from the subject's trachea. A display control system performs signal processing on the modulated content of the images, and outputs frames of those images in which the intensity level of illumination from the trachea can be controlled without any need to change the illumination output from the modulated light source. The light source has no connection with the rest of the system, and need contain no more than a battery, a power supply circuit and a light source. It can therefore be of low cost and can be made disposable, such as in the form of an adhesive patch applied to the subject's neck.
Type:
Grant
Filed:
May 16, 2014
Date of Patent:
February 8, 2022
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Hadasit Medical Research Services and Development Ltd.
Abstract: Described herein are methods of enhancing formation and/or growth of an adventitious root in a plant and/or plant tissue, and/or for promoting grafting unification, enhancing fruit size and/or reducing flowering in a plant. The method comprises contacting at least a portion of the plant and/or plant tissue with a compound having Formula I: wherein X, Y and R1-R7 are as defined herein. Further described are compositions for enhancing formation and/or growth of an adventitious root in a plant and/or plant tissue, and/or for promoting grafting unification, enhancing fruit size and/or reducing flowering in a plant, comprising the abovementioned compound and a horticulturally acceptable carrier. Novel compounds having Formula I are also described herein.
Type:
Application
Filed:
October 18, 2021
Publication date:
February 3, 2022
Applicants:
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Ramot at Tel-Aviv University Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Einat SADOT, Roy WEINSTAIN, Joseph RIOV, Leor ESHED-WILLIAMS