Patents Assigned to ZaCh System S.p.A.
  • Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
    Patent number: 9604915
    Abstract: The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: March 28, 2017
    Assignee: ZACH SYSTEMS S.P.A.
    Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • Process for preparing Cinacalcet hydrochloride
    Patent number: 9522869
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: December 20, 2016
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Process for preparing gabapentin
    Patent number: 9481635
    Abstract: The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: November 1, 2016
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Massimo Verzini, Livius Cotarca, Fabio Belluzzo, Giorgio Soriato, Daniele Urbani, Enrico Pace
  • Process for preparing enantiomerically enriched oxamides
    Patent number: 9481686
    Abstract: The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: November 1, 2016
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Antonio Nardi, Mauro Andretto, Ilaria Munari, Roberto Brescello, Anna Smaniotto, Livius Cotarca, Massimo Verzini
  • PROCESS FOR PREPARING GABAPENTIN
    Publication number: 20160237025
    Abstract: The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.
    Type: Application
    Filed: October 21, 2014
    Publication date: August 18, 2016
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Massimo Verzini, Livius Cotarca, Fabio Belluzzo, Giorgio Soriato, Daniele Urbani, Enrico Pace
  • Process for preparing a ketosulfone derivative
    Patent number: 9085532
    Abstract: The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 21, 2015
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Elisa Melotto, Ivan Michieletto, Vincenzo Frega, Livius Cotarca, Massimo Verzini, Franco Massaccesi, Ilaria Munari
  • Process for preparing nebivolol
    Patent number: 8969597
    Abstract: The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: March 3, 2015
    Assignee: Zach System S.p.A.
    Inventors: Livius Cotarca, Johnny Foletto, Paolo Maragni, Giorgio Soriato, Daniele Urbani, Massimo Verzini
  • Process for preparing Bosentan monohydrate and it's intermediates
    Patent number: 8933226
    Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: January 13, 2015
    Assignee: Zach Systems S.p.A.
    Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
  • Process for preparing Nebivolol
    Patent number: 8927742
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: January 6, 2015
    Assignee: Zach Systems S.p.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
  • Asymmetric reduction process
    Patent number: 8927740
    Abstract: The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: January 6, 2015
    Assignee: Zach System S.P.A.
    Inventors: Raffaella Volpicelli, Mauro Andretto, Livius Cotarca, Antonio Nardi, Massimo Verzini
  • Process for preparing olopatadine and/or a pharmaceutically acceptable salt thereof
    Patent number: 8835655
    Abstract: The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: September 16, 2014
    Assignee: Zach System S.p.A
    Inventors: Alberto Guidi, Filippo Chiarello, Gianmauro Orru', Massimo Verzini, Livius Cotarca, Jean-Claude Kizirian, Elisenda Trepat Guixer, Francisco Marquillas Olondriz
  • METHOD OF DETECTING POLYMORPHS USING SYNCHROTRON RADIATION
    Publication number: 20140185767
    Abstract: A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.
    Type: Application
    Filed: May 16, 2012
    Publication date: July 3, 2014
    Applicant: Zach System S.P.A.
    Inventors: Roberto Brescello, Livius Cotarca, Anna Smaniotta, Massimo Verzini, Maurizio Polentarutti, Giorgio Bais, Jasper Rikkert Plaisier
  • Process for preparing cinacalcet
    Patent number: 8637708
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: January 28, 2014
    Assignee: Zach System S.p.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Process for preparing Cinacalcet
    Patent number: 8614353
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb).
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: December 24, 2013
    Assignee: Zach System S.p.A.
    Inventors: Nicola Catozzi, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • ASYMMETRIC REDUCTION PROCESS
    Publication number: 20130338377
    Abstract: The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.
    Type: Application
    Filed: March 8, 2012
    Publication date: December 19, 2013
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Mauro Andretto, Livius Cotarca, Antonio Nardi, Massimo Verzini
  • PROCESS FOR PREPARING CINACALCET
    Publication number: 20120238778
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.
    Type: Application
    Filed: September 8, 2010
    Publication date: September 20, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Process for preparing nebivolol
    Patent number: 8258323
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: September 4, 2012
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Process for preparing dorzolamide
    Patent number: 8183391
    Abstract: A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S)-(+)-10-camphorsulfonic acid so obtaining the (4S,6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide camphorsulfonate), and neutralizing dorzolamide camphorsulfonate to obtain dorzolamide.
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: May 22, 2012
    Assignee: Zach Systems S.p.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Livius Cotarca
  • Process for preparing gabapentin
    Patent number: 8143443
    Abstract: A process for preparing gabapentin of formula 1, which comprises Formula (I) converting 1-allyl-cyclohexanecarboxaldehyde into 1-allyl-cyclohexanecarbonitrile; ozonizing 1-allyl-cyclohexanecarbonitrile to obtain 1-cyano-cyclohexaneacetaldehyde; acetalizing 1-cyano-cyclohexaneacetaldehyde with a suitable acetalizing agent to give the corresponding acetal and converting the latter into gabapentin.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: March 27, 2012
    Assignee: ZaCh System S.p.A.
    Inventors: Franco Ghelfi, Livius Cotarca, Fabrizio Roncaglia, Roberto Giovanetti, Andrea Nicoli
  • PROCESS FOR THE PREPARATION OF CARVEDILOL AND ITS ENANTIOMERS
    Publication number: 20120041044
    Abstract: The present invention relates to a process for the preparation of carvedilol as well as of the optically active R and S enantiomers thereof and of mixtures of these enantiomers and, more particularly, relates to an improved process for the preparation of carvedilol and its enantiomers characterized by the use of ethyl acetate as reaction solvent.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Elisenda Trepat Guixer, Anna Munoz Alvarez, Marta Pomares Marco, Francisco Marquillas Olondriz