Patents Assigned to ZaCh System S.p.A.
  • PROCESS FOR PREPARING OLOPATADINE AND/OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20120016138
    Abstract: The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.
    Type: Application
    Filed: February 1, 2010
    Publication date: January 19, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Alberto Guidi, Filippo Chiarello, Gianmauro Orru', Massimo Verzini, Livius Cotarca, Jean-Claude Kizirian, Elisenda Trepat Guixer, Francisco Marquillas Olondriz
  • Process for preparing nebivolol
    Patent number: 8084629
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 27, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE
    Publication number: 20110306794
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.
    Type: Application
    Filed: February 16, 2010
    Publication date: December 15, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110207948
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.
    Type: Application
    Filed: October 28, 2009
    Publication date: August 25, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
  • PROCESS FOR PREPARING CINACALCET
    Publication number: 20110207965
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb).
    Type: Application
    Filed: October 16, 2009
    Publication date: August 25, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Process for preparing Nebivolol
    Patent number: 8003810
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 23, 2011
    Assignee: Zach System S.p.A.
    Inventors: Elio Ullucci, Paolo Maragni, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110201831
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Application
    Filed: April 29, 2011
    Publication date: August 18, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella VOLPICELLI, Paolo MARAGNI, Livius COTARCA, Johnny FOLETTO, Franco MASSACCESI
  • Process for preparing nebivolol
    Patent number: 7999124
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 16, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Process for the purification of gabapentin
    Patent number: 7989658
    Abstract: The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: August 2, 2011
    Assignee: ZaCh System S.p.A.
    Inventors: Roberto Giovanetti, Andrea Nicoli, Livius Cotarca
  • Process for preparing nebivolol
    Patent number: 7960572
    Abstract: The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: June 14, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto
  • PROCESS FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULFATE CRYSTALLINE FORM I
    Publication number: 20110118467
    Abstract: The present invention relates to a process for the preparation of clopidogrel and, more particularly, to an improved process for the preparation of clopidogrel hydrogen sulfate crystalline Form I by addition of dilute sulfuric acid to a solution of clopidogrel free base in butyl acetate.
    Type: Application
    Filed: June 11, 2009
    Publication date: May 19, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Giorgio Soriato, Roberto Brescello, Daniele Urbani, Livius Cotarca
  • Process for the preparation of levetiracetam
    Patent number: 7939676
    Abstract: A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: May 10, 2011
    Assignee: Zach System S.p.A.
    Inventors: Corrado Colli, Massimiliano Forcato, Livius Cotarca
  • Process for the preparation of Levetiracetam
    Publication number: 20110065932
    Abstract: A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (?)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
    Type: Application
    Filed: September 17, 2009
    Publication date: March 17, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Corrado Colli, Massimiliano Forcato, Livius Cotarca
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110021793
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a di-astereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Application
    Filed: March 16, 2009
    Publication date: January 27, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
  • Process for the preparation of gabapentin
    Patent number: 7759517
    Abstract: The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of ?, -diaminocarbonyl-?,?-pentamethylene glutarimide.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: July 20, 2010
    Assignee: Zach System S.P.A.
    Inventors: Marco Villa, Maurizio Paiocchi, Katiuscia Arrighi, Francesco Corcella, Vincenzo Cannata, Giorgio Soriato, Massimo Verzini
  • STABLE GABAPENTIN COMPOSITIONS
    Publication number: 20100160436
    Abstract: Stable compositions containing gabapentin compositions, methods of preparing such compositions, and methods of using such compositions.
    Type: Application
    Filed: March 1, 2010
    Publication date: June 24, 2010
    Applicant: ZaCh System S.p.A.
    Inventors: Vincenzo CANNATA, Francesco Corcella, Andrea Nicoli
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20100076206
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.
    Type: Application
    Filed: November 23, 2007
    Publication date: March 25, 2010
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Elio Ullucci, Paolo Maragni, Livius Cotarca, Johnny Foletto
  • PROCESS FOR THE PREPARATION OF LEVETIRACETAM
    Publication number: 20100076204
    Abstract: The present invention relates to a process for the preparation of levetiracetam and, more particularly, to an improved process for the preparation of levetiracetam characterized by a crystallization-induced dynamic resolution of a diastereoisomeric mixture of an (±)-alpha-ethyl-2-oxo-1-pyrrolidine acetamide derivative.
    Type: Application
    Filed: July 20, 2007
    Publication date: March 25, 2010
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Massimiliano FORCATO, Ivan MICHIELETTO, Paolo MARAGNI, Franco MASSACCESI, Livius COTARCA
  • The Process for Preparing Nebivolol
    Publication number: 20100069652
    Abstract: The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.
    Type: Application
    Filed: October 2, 2007
    Publication date: March 18, 2010
    Applicant: ZACH SYSTEM S.P.A.
    Inventor: Raffaella Volpicelli
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20100056813
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Application
    Filed: November 23, 2007
    Publication date: March 4, 2010
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi