Patents Assigned to ZaCh System
  • PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATED
    Publication number: 20130253195
    Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
    Type: Application
    Filed: September 22, 2011
    Publication date: September 26, 2013
    Applicant: ZACH SYSTEM SPA
    Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
  • PROCESS FOR PREPARING CINACALCET
    Publication number: 20120238778
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.
    Type: Application
    Filed: September 8, 2010
    Publication date: September 20, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Process for preparing nebivolol
    Patent number: 8258323
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: September 4, 2012
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Method for the chemo-selective enzymatic hydrolysis if a diester compound for preparing a monoester monoacid compound
    Patent number: 8198054
    Abstract: This disclosure relates to the synthesis of the compound of formula (I) according to Scheme A below: in which R1, R2 and R3, which may be identical or different, represent, individually and independently, an alkyl group, characterized by an enzymatic hydrolysis reaction that involves placing the compound of formula (II) in contact with an enzyme that performs a chemoselective hydrolysis of only one of the two ester functions of the compound of formula (II) to obtain the compound of formula (I).
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: June 12, 2012
    Assignees: Zach System, Novacta Biosystem Limited
    Inventors: Alain Burgos, Jean-Claude Caille, Michelle Lorraine-Gradley
  • Process for preparing dorzolamide
    Patent number: 8183391
    Abstract: A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S)-(+)-10-camphorsulfonic acid so obtaining the (4S,6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide camphorsulfonate), and neutralizing dorzolamide camphorsulfonate to obtain dorzolamide.
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: May 22, 2012
    Assignee: Zach Systems S.p.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Livius Cotarca
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20120108826
    Abstract: The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.
    Type: Application
    Filed: July 23, 2010
    Publication date: May 3, 2012
    Applicant: ZACH SYSTEM SPA
    Inventors: Livius Cotarca, Johnny Foletto, Paolo Maragni, Giorgio Soriato, Daniele Urbani, Massimo Verzini
  • Process for preparing gabapentin
    Patent number: 8143443
    Abstract: A process for preparing gabapentin of formula 1, which comprises Formula (I) converting 1-allyl-cyclohexanecarboxaldehyde into 1-allyl-cyclohexanecarbonitrile; ozonizing 1-allyl-cyclohexanecarbonitrile to obtain 1-cyano-cyclohexaneacetaldehyde; acetalizing 1-cyano-cyclohexaneacetaldehyde with a suitable acetalizing agent to give the corresponding acetal and converting the latter into gabapentin.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: March 27, 2012
    Assignee: ZaCh System S.p.A.
    Inventors: Franco Ghelfi, Livius Cotarca, Fabrizio Roncaglia, Roberto Giovanetti, Andrea Nicoli
  • PROCESS FOR THE PREPARATION OF CARVEDILOL AND ITS ENANTIOMERS
    Publication number: 20120041044
    Abstract: The present invention relates to a process for the preparation of carvedilol as well as of the optically active R and S enantiomers thereof and of mixtures of these enantiomers and, more particularly, relates to an improved process for the preparation of carvedilol and its enantiomers characterized by the use of ethyl acetate as reaction solvent.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Elisenda Trepat Guixer, Anna Munoz Alvarez, Marta Pomares Marco, Francisco Marquillas Olondriz
  • PROCESS FOR PREPARING OLOPATADINE AND/OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20120016138
    Abstract: The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.
    Type: Application
    Filed: February 1, 2010
    Publication date: January 19, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Alberto Guidi, Filippo Chiarello, Gianmauro Orru', Massimo Verzini, Livius Cotarca, Jean-Claude Kizirian, Elisenda Trepat Guixer, Francisco Marquillas Olondriz
  • Process for preparing nebivolol
    Patent number: 8084629
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 27, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE
    Publication number: 20110306794
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.
    Type: Application
    Filed: February 16, 2010
    Publication date: December 15, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • METHOD FOR PREPARING NEBIVOLOL
    Publication number: 20110237808
    Abstract: The present invention relates to a process for the preparation of nebivolol and, more particularly, to an improved process of synthesizing an alpha-haloketone of formula a key intermediate in the preparation of nebivolol.
    Type: Application
    Filed: September 22, 2009
    Publication date: September 29, 2011
    Applicant: ZACH SYSTEM
    Inventors: Yvon Derrien, Eric Chenard, Alain Burgos
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110207948
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.
    Type: Application
    Filed: October 28, 2009
    Publication date: August 25, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
  • PROCESS FOR PREPARING CINACALCET
    Publication number: 20110207965
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb).
    Type: Application
    Filed: October 16, 2009
    Publication date: August 25, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Process for preparing Nebivolol
    Patent number: 8003810
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 23, 2011
    Assignee: Zach System S.p.A.
    Inventors: Elio Ullucci, Paolo Maragni, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110201831
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Application
    Filed: April 29, 2011
    Publication date: August 18, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella VOLPICELLI, Paolo MARAGNI, Livius COTARCA, Johnny FOLETTO, Franco MASSACCESI
  • Process for preparing nebivolol
    Patent number: 7999124
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 16, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Process for the purification of gabapentin
    Patent number: 7989658
    Abstract: The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: August 2, 2011
    Assignee: ZaCh System S.p.A.
    Inventors: Roberto Giovanetti, Andrea Nicoli, Livius Cotarca
  • Process for preparing nebivolol
    Patent number: 7960572
    Abstract: The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: June 14, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto
  • PROCESS FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULFATE CRYSTALLINE FORM I
    Publication number: 20110118467
    Abstract: The present invention relates to a process for the preparation of clopidogrel and, more particularly, to an improved process for the preparation of clopidogrel hydrogen sulfate crystalline Form I by addition of dilute sulfuric acid to a solution of clopidogrel free base in butyl acetate.
    Type: Application
    Filed: June 11, 2009
    Publication date: May 19, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Giorgio Soriato, Roberto Brescello, Daniele Urbani, Livius Cotarca