Patents Assigned to Zafgen, Inc.
  • Methods of treating an overweight subject
    Patent number: 10406134
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: September 10, 2019
    Assignees: Zafgen, Inc., Vanderbilt University
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • Oxaspiro[2.5]octane derivatives and analogs
    Patent number: 10259796
    Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: April 16, 2019
    Assignee: Zafgen, Inc.
    Inventors: James E. Vath, Stuart Chaffee
  • Methods of treating ischemic organ damage and other disorders
    Patent number: 10231946
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 19, 2019
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Fumigillol compounds and methods of making and using same
    Patent number: 10220015
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: March 5, 2019
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, James E. Vath
  • Tricyclic sulphonamide compounds and methods of making and using same
    Patent number: 10174009
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: January 8, 2019
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Susan M. Cramp, Robert Zahler
  • Methods of treating liver diseases
    Patent number: 10064839
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: September 4, 2018
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Fumagillol heterocyclic compounds and methods of making and using same
    Patent number: 10023561
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: July 17, 2018
    Assignee: Zafgen, Inc.
    Inventors: James E. Vath, Robert Zahler
  • Fumagillol spirocyclic compounds and fused bicyclic compounds and methods of making and using same
    Patent number: 9944613
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: April 17, 2018
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, Zhenwei Cai, Zhixing Wu, James E. Vath
  • Methods of treating an overweight or obese subject
    Patent number: 9925166
    Abstract: The invention herein generally relates to pharmaceutical formulations and methods of treating an overweight or obese subject, and overweight- or obesity-related conditions.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: March 27, 2018
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • Fumigillol compounds and methods of making and using same
    Patent number: 9895339
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: February 20, 2018
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, James E. Vath
  • Tricyclic sulphonamide compounds and methods of making and using same
    Patent number: 9868717
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: January 16, 2018
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Susan M. Cramp, Hazel J. Dyke, Robert Zahler
  • Methods of treating impaired wound healing
    Patent number: 9849106
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: December 26, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Tricyclic compounds and methods of making and using same
    Patent number: 9839623
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 12, 2017
    Assignee: Zafgen, Inc.
    Inventors: David Clark, Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • Methods of treating hypothalamic obesity
    Patent number: 9839622
    Abstract: The invention generally relates to methods of treating a patient suffering from hypothalamic obesity using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: December 12, 2017
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • Crystalline solids of a metAP-2 inhibitor and methods of making and using same
    Patent number: 9827221
    Abstract: The disclosure is in part directed to crystalline forms of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol and variants thereof.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: November 28, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas Crawford, Hayley A. Reece
  • Methods of treating an overweight or obese subject
    Patent number: 9701651
    Abstract: The disclosure herein generally relates to methods of treating an overweight or obese condition, and overweight- or obesity-related conditions. In one embodiment, the disclosure provides a method of treating an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MetAP-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: July 11, 2017
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • Fumagillol heterocyclic compounds and methods of making and using same
    Patent number: 9682965
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 20, 2017
    Assignee: Zafgen, Inc.
    Inventors: James E. Vath, Robert Zahler
  • Methods of treating an overweight or obese subject
    Patent number: 9656979
    Abstract: The disclosure herein generally relates to methods of treating an overweight or obese condition, and overweight or obesity-related conditions. In one embodiment, the disclosure provides a method of treating an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MetAp-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: May 23, 2017
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • Methods of treating an overweight subject
    Patent number: 9649293
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 16, 2017
    Assignees: Zafgen, Inc., Vanderbilt University
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • Partially saturated tricyclic compounds and methods of making and using same
    Patent number: 9617237
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: April 11, 2017
    Assignee: Zafgen, Inc.
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler