Patents Assigned to Zafgen, Inc.
  • Methods of treating renal disease and other disorders
    Patent number: 9597309
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 21, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Fumigillol compounds and methods of making and using same
    Patent number: 9573918
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: February 21, 2017
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, James E. Vath
  • Oxaspiro[2.5]Octane Derivatives and Analogs
    Publication number: 20170044122
    Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
    Type: Application
    Filed: March 14, 2016
    Publication date: February 16, 2017
    Applicant: Zafgen, Inc.
    Inventors: James E. Vath, Stuart Chaffee
  • Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
    Patent number: 9561230
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2. For example, the invention relates in part to tricyclic sulfonamide compounds represented by Formula I: or pharmaceutically acceptable salts or stereoisomers thereof, wherein A, B, D, RA1, RA2, Y, X and n are as defined herein.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: February 7, 2017
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Methods of treating liver diseases
    Patent number: 9561209
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: February 7, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of treating age related disorders
    Patent number: 9446016
    Abstract: The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: September 20, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Tricyclic sulfone compounds and methods of making and using same
    Patent number: 9440943
    Abstract: The invention provides tricyclic sulfone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: September 13, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Hazel J. Dyke, Susan M. Cramp, Robert Zahler
  • Crystalline solids of a MetAP-2 inhibitor and methods of making and using same
    Patent number: 9371312
    Abstract: The disclosure is in part directed to crystalline forms of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol and variants thereof.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: June 21, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas Crawford, Hayley A. Reece
  • Tricyclic sulfonamide compounds and methods of making and using same
    Patent number: 9359369
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: June 7, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Hazel J. Dyke, Susan M. Cramp, Robert Zahler
  • Oxaspiro[2.5]octane derivatives and analogs
    Patent number: 9328082
    Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: May 3, 2016
    Assignee: Zafgen, Inc.
    Inventors: James E. Vath, Stuart Chaffee
  • Tetrazole compounds and methods of making and using same
    Patent number: 9321740
    Abstract: Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tetrazole compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 26, 2016
    Assignee: Zafgen, Inc.
    Inventors: Hazel Joan Dyke, Thomas David Pallin, Susan Mary Cramp
  • Partially saturated tricyclic compounds and methods of making and using same
    Patent number: 9290472
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: March 22, 2016
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • METHODS OF TREATING LIVER DISEASES
    Publication number: 20160058731
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 3, 2016
    Applicant: ZAFGEN, INC.
    Inventors: Thomas E. HUGHES, James E. VATH
  • Tricyclic compounds and methods of making and using same
    Patent number: 9266896
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: February 23, 2016
    Assignee: Zafgen, Inc.
    Inventors: David Clark, Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Polymorphic salt of a metap-2 inhibitor and methods of making and using same
    Patent number: 9260419
    Abstract: The disclosure is in part directed to crystalline forms of an oxalate salt of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: February 16, 2016
    Assignee: Zafgen, Inc.
    Inventor: Thomas Crawford
  • Tricyclic pyrazole sulphonamide compunds and methods of making and using same
    Patent number: 9242997
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: January 26, 2016
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Sulphonamine compounds and methods of making and using same
    Patent number: 9221787
    Abstract: The invention provides sulphonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: December 29, 2015
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, Hazel Joan Dyke, Thomas David Pallin, Susan Mary Cramp
  • Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
    Patent number: 9187494
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2. For example, the invention relates in part to tricyclic sulfonamide compounds represented by Formula I: or pharmaceutically acceptable salts or stereoisomers thereof, wherein A, B, D, RA1, RA2, Y, X, and n are as defined herein.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: November 17, 2015
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Treatment of obesity using non-daily administration of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol
    Patent number: 9173865
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions using non-daily administration of e.g, a MetAP-2 inhibitor.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: November 3, 2015
    Assignee: Zafgen, Inc.
    Inventor: Thomas E. Hughes
  • TREATMENT OF OBESITY USING NON-DAILY ADMINISTRATION OF 6-O-(4-DIMETHYLAMINOETHOXY) CINNAMOYL FUMAGILLOL
    Publication number: 20150209321
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions using non-daily administration of e.g, a MetAP-2 inhibitor.
    Type: Application
    Filed: April 2, 2015
    Publication date: July 30, 2015
    Applicant: ZAFGEN, INC.
    Inventor: Thomas E. Hughes