Abstract: The present invention provides a time-resolved single-photon counting apparatus, including an excitation light source for generating pulsed excitation light, a specimen optics for collecting an optical signal caused by irradiating the pulsed excitation light to a specimen, a photoelectric converter for photoelectrically converting the optical signal to generate an analog single-photon signal, an analog-to-digital (AD) signal converter for sampling the analog single-photon signal to convert the same into a digital single-photon signal, a digital photon-discrimination and timing detector for generating a photon-discrimination signal by discriminating the single-photon property of the digital single-photon signal to count a pulse time point of the digital single-photon signal to generate a delay time signal having delay time information, and a time-signal processor for counting valid single-photon detection events according to the delay time with reference to the photon-discrimination signal.

Abstract: The use of Raman spectroscopy for the monitoring and assessment of viral titre is disclosed. A method of quantifying viral titre in a sample using Raman spectroscopy, comprises the steps of: (a) providing a sample and irradiating the sample with a light source; (b) measuring the total intensity of Raman scattered light within each one of a plurality of wavenumber ranges to obtain a wavenumber intensity data set for the sample, wherein the plurality of wavenumber ranges are pre-selected and are characteristic of the vims in the sample; (c) performing mathematical data processing steps on the wavenumber intensity data; and (d) quantifying the viral titre based upon the output of the mathematical data processing steps.

Abstract: Modulation-encoded light, using different spectral bin coded light components, can illuminate a stationary or moving (relative) target object or scene. Response signal processing can use information about the respective different time-varying modulation functions, to decode to recover information about a respective response parameter affected by the target object or scene. Electrical or optical modulation encoding can be used. LED-based spectroscopic analysis of a composition of a target (e.g., SpO2, glucose, etc.) can be performed; such can optionally include decoding of encoded optical modulation functions. Baffles or apertures or optics can be used, such as to constrain light provided by particular LEDs. Coded light illumination can be used with a focal plane array light imager receiving response light for inspecting a moving semiconductor or other target.

Abstract: Provided are an optical system capable of improving the spatial resolution of hyperspectral imaging and an optical alignment method using the same. The optical system includes a digital micromirror device (DMD) having a rectangular shape, a first cylindrical lens curved to focus and form an image on an axis corresponding to a shorter side of the DMD, and a second cylindrical lens curved in the same axial direction as the axis to collimate light reflected from the DMD.

Abstract: A spectrometer with a Schmidt reflector is described. The spectrometer may include a Schmidt corrector and a dispersive element as separate components. Alternatively, the Schmidt corrector and dispersive element may be combined into a single optical component. The spectrometer may further include a field-flattener lens.

Abstract: A fiber optic temperature probe is disclosed. The fiber optic temperature probe includes a probe shaft containing an optical fiber. An optical temperature sensor element is coupled to the probe shaft and configured to be excited by light from the optical fiber and emit light back to the optical fiber. A thermally conductive plate is coupled to the probe shaft and interfaces with the optical temperature sensor element. Baffling extends from the probe shaft and surrounds the edges of the thermally conductive plate.

Abstract: Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

Abstract: Pulsed fluorescence imaging in a light deficient environment is disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to synchronize timing of the emitter and the image sensor. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.

Abstract: A method comprises obtaining reference data about a 3D calibration object, the reference data comprising known coordinates for a plurality of points on the object, and obtaining measurement data comprising measurements for the plurality of points on the object, the measurement data having been generated based on scanning of the object by an uncalibrated intraoral scanner. The method comprises comparing the measurement data to the reference data to determine differences therebetween and applying the determined differences between the measurement data and the reference data for the plurality of points to a function to generate a compensation model that compensates for one or more inaccuracies of the intraoral scanner. The compensation model is then stored, wherein the compensation model causes the intraoral scanner to be a calibrated intraoral scanner and is usable to correct measurement errors of the intraoral scanner caused by the one or more inaccuracies of the intraoral scanner.

Abstract: The application provides a gemstone testing apparatus for testing a specimen. The gemstone testing apparatus includes a handheld casing, a plurality of light sources, a test probe, a photodetector, a processor unit, and a display unit. The test probe is placed at one end of the handheld casing. A first end of the test probe is placed outside the handheld casing. The plurality of light sources is provided for emitting light rays towards an area that is in the vicinity of the first end. The first end is adapted for receiving light rays from the specimen and for transmitting the light rays to a second end of the test probe. The photodetector is arranged to measure an intensity of the light rays from the second end. The processor unit is provided for determining a material of the specimen in accordance to a measurement of the intensity of the light rays.

Abstract: A method for identification of biochemical markers associated with cervical remodeling over the course of pregnancy of humans includes obtaining Raman signals from the cervix of each of a group of humans with pregnancy at each phase of pregnancy; finding Raman signatures corresponding to each type of cervical tissue from the obtained Raman signals; and identifying biochemical markers associated with cervical remodeling at each phase of pregnancy corresponding to the Raman signatures.

Abstract: Systems and methods include a fluorescence measurement apparatus. A single-wavelength light source generates an excitation light source. A sample holder holds a sample and includes a surface transparent to the excitation light source. Mounts attached to the single-wavelength light source(s) or the sample holder change an incident angle of the excitation light source on the surface. Optical components positioned in a path of a fluorescence emission emitted from the surface guide the fluorescence emission to a detector that obtains spectra from at least first and second angles-of-incidence. A device records spectra obtained by the detector from the first and second angles-of-incidence, normalizes and analyzes intensities of the spectra, subtracts a first spectrum corresponding to the first angle-of-incidence from a second spectrum corresponding to the second angle-of-incidence to obtain a difference, identifying a sample type of the sample based on an API gravity mapped to the difference.

Abstract: An imaging optical system including a plurality of imaging optical sub-systems, each having at least one optical element and receiving light from a source, and a plurality of spectrometer optical sub-systems, each spectrometer optical sub-system receiving light from at least one of the imaging optical sub-systems, each imaging optical sub-system and spectrometer optical sub-system combination having a spatial distortion characteristic, each spatial distortion characteristic having a predetermined relationship to the other spatial distortion characteristics.

Abstract: A meteorological lidar performs highly precise meteorological observation by primarily removing elastically scattered light and by detecting rotational Raman-scattered light without filtering it out. The meteorological lidar according to embodiments measures scattered light of a laser beam, and includes: a diffraction grating diffracting rotational Raman-scattered light contained in scattered light in accordance with the wavelength of rotational Raman-scattered light; a detector detecting the diffracted rotational Raman-scattered light; and a removing element primarily removing elastically scattered light of a specific wavelength contained in the scattered light.

Abstract: A method for retrieving a corrected spectrum from a measured spectrum (e.g., retrieving a top-of-water spectrum from a measured top-of-atmosphere spectrum) includes creating a scene-specific model of a region of interest and performing a ray-tracing simulation to simulate rays of light that would reach an airborne (or spaceborne) sensor. The region of interest can be an optically complex area such as an inland or coastal body of water. Based on the ray-tracing simulation, a scene-specific correction for unwanted effects (e.g., adjacency effects, variable atmospheric conditions, and/or other suitable effects) is obtained. A corrected spectrum is obtained by correcting the measured spectrum using the scene-specific correction. The ray-tracing simulation may be performed using a graphical processing unit, allowing the scene-specific correction to be performed in real time or near real time.

Abstract: The present invention relates to a method for the determination of processing influences on the quality of feedstuff raw materials and/or feedstuffs, in which the processing conditions indicator of the of feedstuff raw materials and/or feedstuffs is determined and the specific digestibility coefficient of an amino acid of a feedstuff raw material and/or feedstuff in an animal species is determined. The present invention also relates to a process for the optimization of feedstuffs considering the determined processing influences and the thus obtained and/or obtainable feedstuffs.

Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.

Abstract: An organic light emitting diode analyzer is provided to test electrical and spectroscopic characteristics organic light emitting diodes (OLED). The analyzer includes a spectrometer, a luminance and color meter, a header of the luminance and color meter, an OLED a source meter, an OLED holder and a computer. The OLED analyzer is a characterization system to measure the electrical and spectral characteristics and feature of the OLED. The luminance and color meter includes a color sensor, and the luminance and color meter measures a luminance of the OLED, a color temperature of the OLED, and color coordinates of the OLED. The spectrometer measures a wavelength of the OLED, an irradiance, a color index, the color temperature, color coordinates and the irradiance (W/m2·nm). The source meter applies positive voltages to the OLED, and the source meter measures a current through the OLED.

Abstract: Spectrometers include an optical assembly with optical elements arranged to receive light from a light source and direct the light along a light path to a multi-element detector, dispersing light of different wavelengths to different spatial locations on the multi-element detector. The optical assembly includes: (i) a collimator arranged in the light path to receive the light from the light source, the collimator including a mirror having a freeform surface; (2) a dispersive sub-assembly including an echelle grating, the dispersive sub-assembly being arranged in the light path to receive light from the collimator; and (3) a Schmidt telescope arranged in the light path to receive light from the dispersive sub-assembly and focus the light to a field, the multi-element detector being arranged at the field.

Abstract: A miniature Fourier transform mid-infrared (FT-MIR) spectrometer is provided. The FT-MIR includes a metasurface IR source to emit radiation when heated, a microelectromechanical (MEMS) interferometer, and a metasurface microbolometer to measure an interferogram from the MEMS interferometer, wherein the miniature FT-MIR spectrometer is less than about 20 mm in outer diameter.